| In millions, except per share items | Dec-31-22 | Dec-31-21 | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 20-F | 20-F | 20-F |
| Revenues: |
| NUZYRA | 5.2 | 0.0 | | | | | | |
| Optune | 47.3 | 38.9 | 16.4 | | | | | |
| ZEJULA | 145.2 | 93.6 | 32.1 | | | | | |
| QINLOCK | 15.0 | 11.6 | 0.4 | | | | | |
| Other | 2.4 | 0.2 | | | | | | |
| Total revenues [+] | 215.0 | 144.3 | 49.0 | 13.0 | 0.1 | 0.0 | 0.0 | 0.0 |
| Products | 212.7 | 144.1 | 49.0 | | | | | |
| Net interest income | | | | 7.8 | 2.4 | | | |
| Revenue growth [+] | 49.0% | 194.8% | 277.0% | 9965.9% | | | | |
| NUZYRA | 173233.3% | | | | | | | |
| Optune | 21.6% | 137.0% | | | | | | |
| ZEJULA | 55.2% | 191.2% | | | | | | |
| QINLOCK | 28.7% | 2790.5% | | | | | | |
| Cost of goods sold | 74.0 | 52.2 | 16.7 | 3.7 | 0.0 | 0.0 | 0.0 | 0.0 |
| Gross profit | 141.0 | 92.1 | 32.2 | 9.2 | 0.1 | 0.0 | 0.0 | 0.0 |
| Gross margin | 65.6% | 63.8% | 65.8% | 71.1% | 66.7% | | | |
| Selling, general and administrative [+] | 259.0 | 218.8 | 111.3 | 70.2 | 21.6 | 12.0 | 6.4 | 2.8 |
| General and administrative | | | | | | | | 2.8 |
| Research and development | 286.4 | 573.3 | 222.7 | 142.2 | 120.3 | 39.3 | 32.1 | 13.6 |
| Equity in earnings | -0.2 | -1.1 | -1.1 | -0.8 | -0.6 | | | |
| EBITDA [+] | -396.4 | -694.6 | -298.3 | -200.2 | -140.7 | -50.8 | -38.3 | -16.2 |
| EBITDA growth | -42.9% | 132.9% | 49.0% | 42.3% | 176.7% | 32.6% | 136.3% | |
| EBITDA margin | -184.3% | -481.3% | -609.3% | -1541.6% | -109073.6% | | | |
| Depreciation | 7.7 | 6.0 | 4.3 | 3.5 | 1.6 | 0.5 | 0.2 | 0.1 |
| EBITA | -404.1 | -700.6 | -302.6 | -203.6 | -142.3 | -51.4 | -38.5 | -16.3 |
| EBITA margin | -187.9% | -485.5% | -618.1% | -1568.3% | -110341.1% | | | |
| Amortization of intangibles | 0.5 | 0.5 | 0.3 | 0.3 | 0.0 | 0.0 | 0.0 | 0.0 |
| EBIT [+] | -404.6 | -701.1 | -302.9 | -203.9 | -142.4 | -51.4 | -38.5 | -16.3 |
| EBIT growth | -42.3% | 131.5% | 48.5% | 43.3% | 177.0% | 33.4% | 135.7% | |
| EBIT margin | -188.1% | -485.8% | -618.7% | -1570.6% | -110352.7% | | | |
| Interest income, net [+] | 14.6 | 2.2 | 4.9 | 7.9 | 3.2 | 0.5 | 0.4 | 0.0 |
| Interest expense | | | 0.2 | 0.3 | 0.0 | | | |
| Interest income | 14.6 | 2.2 | 5.1 | 8.2 | 3.3 | 0.5 | 0.4 | 0.0 |
| Other income (expense), net [+] | -53.3 | -5.5 | 29.1 | 1.7 | 0.1 | 0.5 | 0.6 | -1.7 |
| Gain (loss) on foreign currency transactions | -56.4 | 4.7 | 21.7 | | | | | |
| Change in fair value of warrants | | | | | | 0.2 | -1.9 | -2.0 |
| Other non-operating gains/losses | 0.6 | 0.3 | 0.1 | | | | | |
| Other non-operating income | | | | | | | 2.5 | 0.3 |
| Other non-ooperating expenses | | | | | | | 0.0 | 0.0 |
| Other | 3.1 | -10.2 | 7.4 | 0.9 | 0.1 | 0.5 | | |
| Pre-tax income | -443.3 | -704.5 | -268.9 | -194.3 | -139.1 | -50.4 | -37.5 | -18.0 |
| Income taxes | 0.0 | 0.0 | 0.0 | 0.8 | 0.0 | 0.0 | 0.0 | 0.0 |
| Tax rate | 0.0% | 0.0% | 0.0% | | 0.0% | 0.0% | 0.0% | 0.0% |
| Net income | -443.3 | -704.5 | -268.9 | -195.1 | -139.1 | -50.4 | -37.5 | -18.0 |
| Net margin | -206.1% | -488.2% | -549.3% | -1502.3% | -107810.1% | | | |
| |
| Basic EPS [+] | ($0.46) | ($0.76) | ($0.35) | ($3.03) | ($2.64) | ($2.32) | ($3.97) | ($2.07) |
| Growth | -38.9% | 118.8% | -88.6% | 14.6% | 14.1% | -41.7% | 91.7% | |
| Diluted EPS [+] | ($0.46) | ($0.76) | ($0.35) | ($3.03) | ($2.64) | ($2.32) | ($3.97) | ($2.07) |
| Growth | -38.9% | 118.8% | -88.6% | 14.6% | 14.1% | -41.7% | 91.7% | |
| |
| Shares outstanding (basic) [+] | 958.1 | 929.9 | 776.7 | 64.4 | 52.6 | 21.8 | 9.4 | 8.7 |
| Growth | 3.0% | 19.7% | 1106.6% | 22.4% | 141.9% | 130.5% | 8.6% | |
| Shares outstanding (diluted) [+] | 958.1 | 929.9 | 776.7 | 64.4 | 52.6 | 21.8 | 9.4 | 8.7 |
| Growth | 3.0% | 19.7% | 1106.6% | 22.4% | 141.9% | 130.5% | 8.6% | |
| |
| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |