| In millions, except per share items | Dec-31-22 | Dec-31-21 | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 20-F | 20-F | 20-F |
| Revenues: | | | | | | | | |
| Product revenue, net | 215.0 | 144.3 | 49.0 | 13.0 | 0.1 | | | |
| Product revenue, net growth | 49.0% | 194.8% | 277.0% | 9965.9% | | | | |
| Collaboration revenue | 2.4 | 0.2 | | | | | | |
| Total revenues | 215.0 | 144.3 | 49.0 | 13.0 | 0.1 | | | |
| Total revenues growth | 49.0% | 194.8% | 277.0% | 9965.9% | | | | |
| Expenses: | | | | | | | | |
| Cost of sales | -74.0 | -52.2 | -16.7 | -3.7 | 0.0 | | | |
| Research and development | 286.4 | 573.3 | 222.7 | 142.2 | 120.3 | 39.3 | 32.1 | 13.6 |
| Selling, general, and administrative | 259.0 | 218.8 | 111.3 | 70.2 | 21.6 | 12.0 | 6.4 | |
| Loss from operations | -404.4 | -700.1 | -301.8 | -203.2 | -141.8 | -51.4 | -38.5 | -16.3 |
| Operating margin | -188.0% | -485.1% | -616.4% | -1564.9% | -109897.7% | | | |
| Interest income | 14.6 | 2.2 | 5.1 | 8.2 | 3.3 | 0.5 | 0.4 | 0.0 |
| Foreign currency loss | -56.4 | 4.7 | 21.7 | | | | | |
| Other expense, net | 3.1 | -10.2 | 7.4 | 0.9 | 0.1 | 0.5 | | |
| Loss before income tax and share of loss from equity method investment | -443.1 | -703.4 | -267.8 | -194.3 | -138.5 | -50.1 | -37.5 | -18.0 |
| Income tax expense | | | | -0.8 | | | | |
| Tax rate | 0.0% | 0.0% | 0.0% | | 0.0% | 0.0% | 0.0% | 0.0% |
| Share of loss from equity method investment | -0.2 | -1.1 | -1.1 | -0.8 | -0.6 | | | |
| Net loss | -443.3 | -704.5 | -268.9 | -195.1 | -139.1 | -50.4 | -37.5 | -18.0 |
| Net loss attributable to ordinary shareholders - basic | | | | -195.1 | -139.1 | -50.4 | -37.5 | -18.0 |
| Net loss attributable to ordinary shareholders - diluted | | | | -195.1 | -139.1 | -50.4 | -37.5 | -18.0 |
| |
| Loss per share/ADS - basic (in dollars per share) | ($0.46) | ($0.76) | ($0.35) | ($3.03) | ($2.64) | ($2.32) | ($3.97) | ($2.07) |
| Loss per share/ADS - diluted (in dollars per share) | ($0.46) | ($0.76) | ($0.35) | ($3.03) | ($2.64) | | | |
| |
| Weighted-average shares/ADSs used in calculating net loss per ordinary share/ADS - basic | 958.1 | 929.9 | 776.7 | 64.4 | 52.6 | 21.8 | 9.4 | 8.7 |
| Weighted-average shares/ADSs used in calculating net loss per ordinary share/ADS - diluted | 958.1 | 929.9 | 776.7 | | | | | |