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| In millions, except per share items | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 | Dec-31-14 | Dec-31-13 | Dec-31-12 | Dec-31-11 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
| Revenues: |
| Net product sales | | | | | | | | 4,699.7 |
| Collaborative agreements and other revenue | | | | | | | | 19.5 |
| Royalty revenue | | | | | | | | 122.9 |
| Total revenues [+] | 15,281.0 | 13,003.0 | 11,229.0 | 9,256.0 | 7,670.4 | 6,493.9 | 5,506.7 | 4,842.1 |
| Royalties | | | | | | | | 122.9 |
| Products | | | | 9,161.0 | 7,563.8 | 6,362.3 | 5,385.6 | 4,699.7 |
| Other | | | | 95.0 | 106.6 | 131.6 | 121.1 | 19.5 |
| Revenue growth [+] | 17.5% | 15.8% | 21.3% | 20.7% | 18.1% | 17.9% | 13.7% | 33.5% |
| Net product sales | | | | | | | | 34.0% |
| Royalty revenue | | | | | | | | 15.1% |
| Cost of goods sold | 587.0 | 461.0 | 438.0 | 420.0 | 385.9 | 340.4 | 299.1 | 425.9 |
| Gross profit | 14,694.0 | 12,542.0 | 10,791.0 | 8,836.0 | 7,284.5 | 6,153.5 | 5,207.6 | 4,416.2 |
| Gross margin | 96.2% | 96.5% | 96.1% | 95.5% | 95.0% | 94.8% | 94.6% | 91.2% |
| Selling, general and administrative | 3,250.0 | 2,941.0 | 2,658.0 | 2,305.0 | 2,027.9 | 1,684.5 | 1,373.5 | 1,226.3 |
| Research and development | 5,673.0 | 5,915.0 | 4,470.0 | 3,697.0 | 2,430.6 | 2,226.2 | 1,724.2 | 1,600.3 |
| Equity in earnings | | | | | | | | |
| Other operating expenses | 507.0 | -1,019.0 | 459.0 | 279.0 | 258.3 | 262.8 | 194.5 | 289.2 |
| EBITDA [+] | 5,899.0 | 5,176.0 | 3,709.0 | 2,957.0 | 2,937.1 | 2,354.1 | 2,198.9 | 1,663.3 |
| EBITDA growth | 14.0% | 39.6% | 25.4% | 0.7% | 24.8% | 7.1% | 32.2% | 28.3% |
| EBITDA margin | 38.6% | 39.8% | 33.0% | 31.9% | 38.3% | 36.3% | 39.9% | 34.4% |
| Depreciation | 161.0 | 135.0 | 39.0 | 117.0 | 105.5 | 104.0 | 87.3 | 72.6 |
| EBITA | 5,738.0 | 5,041.0 | 3,670.0 | 2,840.0 | 2,831.6 | 2,250.1 | 2,111.6 | 1,590.7 |
| EBITA margin | 37.5% | 38.8% | 32.7% | 30.7% | 36.9% | 34.6% | 38.3% | 32.9% |
| Amortization of intangibles | 474.0 | 336.0 | 466.0 | 285.0 | 263.9 | 270.1 | 196.2 | 290.3 |
| EBIT [+] | 5,264.0 | 4,705.0 | 3,204.0 | 2,555.0 | 2,567.7 | 1,980.0 | 1,915.4 | 1,300.4 |
| EBIT growth | 11.9% | 46.8% | 25.4% | -0.5% | 29.7% | 3.4% | 47.3% | 25.4% |
| EBIT margin | 34.4% | 36.2% | 28.5% | 27.6% | 33.5% | 30.5% | 34.8% | 26.9% |
| Non-recurring items | 73.0 | -2.0 | 38.0 | 300.0 | 48.7 | 171.1 | 169.0 | -142.3 |
| Interest expense, net [+] | 741.0 | 522.0 | 500.0 | 280.0 | 147.9 | 69.6 | 47.9 | 16.8 |
| Interest expense | 741.0 | 522.0 | 500.0 | 311.0 | 176.1 | 91.6 | 63.2 | 42.7 |
| Interest income | | | | 31.0 | 28.2 | 22.0 | 15.3 | 25.9 |
| Other income (expense), net | 382.0 | 129.0 | -294.0 | 48.0 | -43.7 | -73.9 | -17.0 | -6.4 |
| Pre-tax income | 4,832.0 | 4,314.0 | 2,372.0 | 2,023.0 | 2,327.4 | 1,665.4 | 1,681.5 | 1,419.5 |
| Income taxes | 786.0 | 1,374.0 | 373.0 | 421.0 | 327.5 | 215.5 | 225.3 | 102.1 |
| Tax rate | 16.3% | 31.8% | 15.7% | 20.8% | 14.1% | 12.9% | 13.4% | 7.2% |
| Minority interest | | | | | | | | 0.7 |
| Net income | 4,046.0 | 2,940.0 | 1,999.0 | 1,602.0 | 1,999.9 | 1,449.9 | 1,456.2 | 1,318.1 |
| Net margin | 26.5% | 22.6% | 17.8% | 17.3% | 26.1% | 22.3% | 26.4% | 27.2% |
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| Basic EPS [+] | $5.65 | $3.77 | $2.57 | $2.02 | $2.49 | $1.75 | $1.69 | $2.90 |
| Growth | 49.7% | 46.7% | 27.2% | -18.8% | 42.2% | 3.7% | -41.6% | 52.0% |
| Diluted EPS [+] | $5.51 | $3.64 | $2.49 | $1.94 | $2.39 | $1.68 | $1.65 | $2.85 |
| Growth | 51.7% | 46.1% | 28.2% | -18.8% | 42.0% | 2.0% | -42.0% | 51.9% |
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| Shares outstanding (basic) [+] | 716.3 | 779.2 | 777.2 | 792.2 | 802.7 | 827.7 | 861.9 | 455.3 |
| Growth | -8.1% | 0.3% | -1.9% | -1.3% | -3.0% | -4.0% | 89.3% | -1.5% |
| Shares outstanding (diluted) [+] | 733.8 | 808.7 | 803.3 | 825.0 | 836.0 | 860.6 | 881.6 | 462.7 |
| Growth | -9.3% | 0.7% | -2.6% | -1.3% | -2.9% | -2.4% | 90.5% | -1.5% |
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| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |
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