| In millions, except per share items | Dec-31-15 | Dec-31-14 | Dec-31-13 | Dec-31-12 | Dec-31-11 | Dec-31-10 | Dec-31-09 | Dec-31-08 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
| Revenues: |
| Product sales | 21.1 | 14.3 | 10.0 | 5.0 | | | | |
| Grant and contract revenue | | | | 0.0 | 0.1 | | 1.1 | 0.3 |
| Other | | | | | 2.4 | | 1.1 | 1.0 |
| Total revenues [+] | 21.1 | 14.3 | 10.0 | 5.1 | 2.5 | 2.0 | 2.2 | 1.4 |
| Royalties | 15.2 | 21.7 | 18.6 | 19.7 | | | | 23.7 |
| Products | 21.1 | 14.3 | 10.0 | 5.0 | 2.4 | 1.4 | 1.1 | 1.0 |
| Revenue growth [+] | 47.5% | 42.9% | 97.0% | 100.5% | 25.0% | -8.5% | 62.0% | 17.1% |
| Product sales | 47.5% | 42.9% | 98.7% | | | | | |
| Grant and contract revenue | | | | -56.0% | | | 215.0% | -67.3% |
| Cost of goods sold | 12.4 | 8.5 | 6.4 | 3.5 | 1.8 | 2.6 | 2.2 | 1.5 |
| Gross profit | 8.7 | 5.8 | 3.6 | 1.5 | 0.7 | -0.6 | 0.0 | -0.1 |
| Gross margin | 41.4% | 40.5% | 35.8% | 30.3% | 28.1% | -28.2% | 1.8% | -7.1% |
| Selling, general and administrative | 20.7 | 21.8 | 18.7 | 14.7 | 15.1 | 22.0 | 14.5 | 13.6 |
| Research and development | 15.2 | 21.7 | 18.6 | 19.7 | 21.1 | 18.8 | 18.6 | |
| Other operating expenses | | | | | | | | 23.7 |
| EBITDA [+] | -25.4 | -35.8 | -31.7 | -30.4 | -32.8 | -38.1 | -30.0 | -34.2 |
| EBITDA growth | -29.1% | 13.0% | 4.2% | -7.3% | -13.8% | 27.0% | -12.4% | 6.9% |
| EBITDA margin | -120.5% | -250.7% | -316.8% | -598.7% | -1294.4% | -1878.4% | -1353.8% | -2503.1% |
| Depreciation | 1.5 | 1.6 | 1.7 | 2.2 | 2.5 | 2.8 | 3.1 | 3.2 |
| EBITA | -26.9 | -37.4 | -33.4 | -32.6 | -35.3 | -40.9 | -33.0 | -37.4 |
| EBITA margin | -127.6% | -261.7% | -334.1% | -642.1% | -1391.8% | -2018.7% | -1492.4% | -2735.0% |
| Amortization of intangibles | 0.3 | 0.3 | 0.3 | 0.3 | 0.2 | 0.5 | | |
| EBIT [+] | -27.2 | -37.7 | -33.7 | -32.9 | -35.5 | -41.4 | -33.0 | -37.4 |
| EBIT growth | -27.9% | 11.8% | 2.5% | -7.2% | -14.4% | 25.3% | -11.6% | 10.6% |
| EBIT margin | -129.0% | -263.8% | -337.1% | -648.0% | -1399.7% | -2043.4% | -1492.4% | -2735.0% |
| Non-recurring items | 0.5 | | | | | | | |
| Interest expense, net [+] | 2.9 | 1.4 | 0.9 | 0.0 | 0.0 | 0.2 | 0.9 | -0.4 |
| Interest expense | 2.9 | 1.4 | 0.9 | 0.0 | | 0.3 | 1.3 | 2.1 |
| Interest income | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | 0.1 | 0.4 | 2.5 |
| Other income (expense), net [+] | | | 0.0 | 0.0 | 0.0 | 1.0 | 0.0 | 0.0 |
| Gain (loss) on foreign currency transactions | | | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Other | -2.9 | -1.4 | -0.9 | 0.0 | 0.0 | 0.8 | -0.9 | |
| Pre-tax income | -30.6 | -39.1 | -34.6 | -32.9 | -35.4 | -40.6 | -33.9 | -37.0 |
| Income taxes | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Tax rate | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
| Net income | -42.8 | -39.1 | -34.6 | -32.9 | -35.4 | -40.6 | -33.9 | -37.0 |
| Net margin | -203.3% | -273.4% | -346.4% | -647.3% | -1398.3% | -2004.5% | -1533.4% | -2709.7% |
| |
| Basic EPS [+] | ($6.02) | ($9.35) | ($0.56) | ($0.67) | ($0.94) | ($1.46) | ($1.46) | ($1.67) |
| Growth | -35.6% | 1576.6% | -16.6% | -28.7% | -36.0% | 0.4% | -12.6% | -88.2% |
| Diluted EPS [+] | ($6.02) | ($9.35) | ($0.56) | ($0.67) | ($0.94) | ($1.46) | ($1.46) | ($1.67) |
| Growth | -35.6% | 1576.6% | -16.6% | -28.7% | -36.0% | 0.4% | -12.6% | -88.2% |
| |
| Shares outstanding (basic) [+] | 7.1 | 4.2 | 62.1 | 49.2 | 37.8 | 27.8 | 23.3 | 22.2 |
| Growth | 70.4% | -93.3% | 26.3% | 30.1% | 36.2% | 19.1% | 4.9% | 431.3% |
| Shares outstanding (diluted) [+] | 7.1 | 4.2 | 62.1 | 49.2 | 37.8 | 27.8 | 23.3 | 22.2 |
| Growth | 70.4% | -93.3% | 26.3% | 30.1% | 36.2% | 19.1% | 4.9% | 431.3% |
| |
| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |