In millions, except per share items | Dec-31-21 | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 | Dec-31-14 |
| 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
Operating activities | | | | | | | | |
Net income | 19.7 | -39.4 | -116.5 | -199.5 | -114.8 | -78.2 | -41.9 | -21.3 |
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Adjustments to reconcile net income to net cash from operating activities: | | | | | | | | |
Non-cash interest expense | 7.1 | 6.4 | 8.8 | 6.8 | | | | |
Share-based compensation expense | 4.5 | 6.2 | 23.7 | 35.2 | 21.8 | 14.5 | 11.6 | 9.0 |
Amortization of intangible assets | 1.6 | 0.6 | | | | | | |
Amortization of right-of-use lease assets | 0.2 | 1.2 | 1.3 | | | | | |
Depreciation expense | 0.1 | 2.2 | 4.6 | 4.4 | 1.3 | 0.7 | 0.3 | 0.0 |
Inventory fair value step-up adjustment included in cost of product sales | 0.9 | 2.5 | | | | | | |
Changes in operating assets and liabilities: | | | | | | | | |
Accounts receivable, net | -2.8 | -1.7 | -1.6 | -1.4 | | | | |
Inventory, net | -1.1 | -1.5 | -0.2 | -2.0 | | | | |
Prepaid expenses and other current assets | -2.4 | 2.3 | 0.6 | -2.0 | -1.6 | -0.7 | 0.8 | -0.1 |
Accounts payable | -1.2 | -14.2 | -3.2 | 5.1 | 7.5 | 4.8 | 2.7 | 1.0 |
Accrued expenses and other current liabilities | -0.7 | -11.4 | 0.4 | 5.5 | -0.2 | 0.2 | -0.2 | 0.7 |
Lease liabilities | -0.2 | -2.1 | -2.5 | | | | | |
Net cash provided by operating activities | 28.2 | -37.6 | -85.0 | -152.4 | -85.1 | -58.7 | -25.2 | -12.9 |
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Investing activities | | | | | | | | |
Net cash provided by investing activities | 0.0 | -30.9 | -0.7 | -2.3 | -9.2 | -2.2 | -1.8 | -0.3 |
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Financing activities | | | | | | | | |
Purchases of common stock under stock repurchase plan | -3.4 | | | | | | | |
Net proceeds from issuance of common stock under ESPP | 0.4 | 0.5 | 0.8 | | | | | |
Net proceeds from issuance of common stock under 2013 Equity Plan | 0.2 | 0.6 | 0.0 | 109.8 | 117.5 | | 104.6 | 53.1 |
Net cash (used for) provided by financing activities | -2.8 | 1.1 | 0.9 | 236.4 | 120.2 | 0.1 | 104.9 | 53.1 |
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Supplemental disclosure of non-cash investing and financing activities | | | | | | | | |
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Reconciliation of cash, cash equivalents and restricted cash to the condensed consolidated balance sheets | | | | | | | | |
Cash and cash equivalents | | | | | | | | |
Restricted cash | | | | | | | | |