| In millions, except per share items | Dec-31-21 | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 | Dec-31-14 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
| Revenues: |
| U.S. | 115.7 | 146.3 | 137.2 | 95.4 | | | | |
| ex U.S. | 33.1 | 18.3 | 5.8 | | | | | |
| Total revenues [+] | 148.8 | 164.5 | 143.0 | 95.4 | 55.5 | 396.5 | 0.0 | 13.6 |
| Products | 148.8 | 164.5 | 143.0 | 95.4 | | | | |
| Revenue growth [+] | -9.6% | 15.0% | 49.9% | 71.8% | -86.0% | | -100.0% | |
| U.S. | -20.9% | 6.6% | 43.8% | | | | | |
| ex U.S. | 81.2% | 213.9% | | | | | | |
| Cost of goods sold | 23.6 | 37.5 | 25.0 | 0.0 | 0.0 | 0.0 | -389.3 | 0.0 |
| Gross profit | 125.2 | 127.0 | 118.0 | 95.4 | 55.5 | 396.5 | 389.3 | 13.6 |
| Gross margin | 84.1% | 77.2% | 82.5% | 100.0% | 100.0% | 100.0% | | 100.0% |
| Selling, general and administrative | 128.4 | 163.9 | 182.8 | 175.8 | 138.9 | 40.7 | 30.5 | 21.5 |
| Research and development | 186.6 | 257.7 | 283.1 | 231.3 | 142.5 | 251.1 | 269.3 | 137.7 |
| Other operating expenses | 30.4 | 42.7 | 19.4 | 22.1 | 117.2 | 372.8 | 376.7 | 9.5 |
| EBITDA [+] | -211.8 | -329.1 | -359.5 | -329.2 | -340.6 | -267.1 | -286.4 | -154.6 |
| EBITDA growth | -35.6% | -8.5% | 9.2% | -3.3% | 27.5% | -6.7% | 85.2% | 85.1% |
| EBITDA margin | -142.4% | -200.0% | -251.4% | -345.1% | -613.6% | -67.4% | | -1134.7% |
| Depreciation and amortization | 8.5 | 8.2 | 7.8 | 4.6 | 2.5 | 1.1 | 0.8 | 0.4 |
| EBIT [+] | -220.3 | -337.3 | -367.3 | -333.8 | -343.1 | -268.2 | -287.2 | -155.1 |
| EBIT growth | -34.7% | -8.2% | 10.0% | -2.7% | 27.9% | -6.6% | 85.2% | 85.1% |
| EBIT margin | -148.1% | -205.0% | -256.8% | -350.0% | -618.1% | -67.7% | | -1138.0% |
| Non-recurring items [+] | 5.5 | -35.1 | 9.4 | | -105.5 | 104.5 | 89.6 | 3.4 |
| Asset impairment | | | | | | 104.5 | 89.6 | 3.4 |
| Legal settlement | | | | | -105.5 | | | |
| (Gain) loss on debt repurchase | | -35.1 | | | | | | |
| In-process research & development | 5.5 | | 9.4 | | | | | |
| Interest expense | 34.1 | 30.5 | 19.4 | 13.2 | 10.4 | 8.5 | 8.4 | 2.6 |
| Interest expense | 34.1 | 30.5 | 19.4 | 13.2 | 10.4 | 8.5 | 8.4 | 2.6 |
| Other income (expense), net [+] | -5.1 | -37.1 | -2.5 | -20.4 | -101.9 | 0.1 | 3.2 | 3.3 |
| Litigation settlement | -2.3 | | -26.8 | -28.0 | | | | |
| Gain (loss) on debt retirement | | -3.3 | -18.5 | | | | | |
| Gain (loss) on foreign currency transactions | -3.2 | -0.1 | -0.5 | -0.3 | -0.1 | -0.6 | 2.7 | 3.6 |
| Other | 0.4 | 1.4 | 6.3 | 7.9 | 3.6 | 0.6 | 0.4 | -0.2 |
| Pre-tax income | -264.9 | -369.8 | -398.6 | -367.4 | -350.0 | -381.2 | -381.9 | -157.7 |
| Income taxes | -0.4 | -0.5 | 1.8 | 0.6 | -3.6 | -32.0 | -29.1 | 2.3 |
| Tax rate | 0.2% | 0.1% | | | 1.0% | 8.4% | 7.6% | |
| Net income | -264.5 | -369.2 | -400.4 | -368.0 | -346.4 | -349.1 | -352.9 | -160.0 |
| Net margin | -177.8% | -224.4% | -280.0% | -385.8% | -624.0% | -88.1% | | -1174.5% |
| |
| Basic EPS [+] | ($2.29) | ($4.38) | ($7.43) | ($7.07) | ($7.36) | ($9.07) | ($9.79) | ($4.72) |
| Growth | -47.7% | -41.1% | 5.2% | -4.0% | -18.9% | -7.4% | 107.4% | 60.2% |
| Diluted EPS [+] | ($2.29) | ($4.38) | ($7.43) | ($7.07) | ($7.36) | ($9.07) | ($9.79) | ($4.72) |
| Growth | -47.7% | -41.1% | 5.2% | -4.0% | -18.9% | -7.4% | 107.4% | 60.2% |
| |
| Shares outstanding (basic) [+] | 115.5 | 84.3 | 53.9 | 52.1 | 47.0 | 38.5 | 36.0 | 33.9 |
| Growth | 37.0% | 56.5% | 3.5% | 10.7% | 22.3% | 6.8% | 6.3% | 18.2% |
| Shares outstanding (diluted) [+] | 115.5 | 84.3 | 53.9 | 52.1 | 47.0 | 38.5 | 36.0 | 33.9 |
| Growth | 37.0% | 56.5% | 3.5% | 10.7% | 22.3% | 6.8% | 6.3% | 18.2% |
| |
| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |