Overview Financials News + Filings Key Docs Charts Holdings Ownership Insiders
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| In millions, except per share items | Dec-31-21 | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 | Dec-31-14 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
| Revenues: |
| Royalty revenues | | | | | | | 41.0 | 40.0 |
| Net product sales | | | | | | | 226.1 | 178.2 |
| Other | | | | | | | 69.8 | 68.6 |
| Total revenues [+] | 1,574.4 | 2,175.5 | 916.7 | 654.7 | 482.3 | 418.1 | 336.8 | 286.8 |
| Royalties | | | | | | | 41.0 | 40.0 |
| Products | | | | | | | 226.1 | 178.2 |
| License and services | | | | | | | 69.8 | 68.6 |
| Revenue growth [+] | -27.6% | 137.3% | 40.0% | 35.8% | 15.3% | 24.2% | 17.5% | 6.5% |
| Royalty revenues | | | | | | | 2.4% | 124.5% |
| Net product sales | | | | | | | 26.9% | 23.2% |
| Cost of goods sold | 311.6 | 217.7 | 44.0 | 88.3 | 54.1 | 42.3 | 24.5 | 17.5 |
| Gross profit | 1,262.8 | 1,957.8 | 872.8 | 566.4 | 428.1 | 375.8 | 312.3 | 269.2 |
| Gross margin | 80.2% | 90.0% | 95.2% | 86.5% | 88.8% | 89.9% | 92.7% | 93.9% |
| Selling, general and administrative | 716.2 | 533.8 | 373.9 | 261.1 | 167.2 | 139.2 | 125.8 | 104.3 |
| Research and development | 1,228.7 | 827.1 | 719.4 | 565.3 | 456.7 | 379.3 | 294.5 | 230.7 |
| Other operating expenses | | | | | | | 13.0 | 11.5 |
| EBITDA [+] | -616.1 | 649.2 | -196.8 | -234.0 | -171.5 | -124.7 | -106.4 | -64.9 |
| EBITDA growth | -194.9% | -429.9% | -15.9% | 36.4% | 37.6% | 17.1% | 64.1% | 19.6% |
| EBITDA margin | -39.1% | 29.8% | -21.5% | -35.7% | -35.6% | -29.8% | -31.6% | -22.6% |
| Depreciation | 42.9 | 36.0 | 23.8 | 25.3 | 24.3 | 18.0 | 13.7 | 11.7 |
| EBITA | -659.0 | 613.2 | -220.5 | -259.3 | -195.8 | -142.7 | -120.2 | -76.6 |
| EBITA margin | -41.9% | 28.2% | -24.1% | -39.6% | -40.6% | -34.1% | -35.7% | -26.7% |
| Amortization of intangibles | 23.1 | 16.3 | 0.0 | 0.7 | | | 0.8 | 0.8 |
| EBIT [+] | -682.1 | 596.9 | -220.5 | -260.0 | -195.8 | -142.7 | -121.0 | -77.4 |
| EBIT growth | -214.3% | -370.6% | -15.2% | 32.8% | 37.2% | 18.0% | 56.3% | 23.1% |
| EBIT margin | -43.3% | 27.4% | -24.1% | -39.7% | -40.6% | -34.1% | -35.9% | -27.0% |
| Interest income | 1.6 | 7.2 | 11.8 | 6.3 | 3.1 | 2.6 | 0.5 | 1.2 |
| Interest income | 1.6 | 7.2 | 11.8 | 6.3 | 3.1 | 2.6 | 0.5 | 1.2 |
| Other income (expense), net | 4.7 | 11.6 | 50.1 | 7.3 | 33.8 | | | |
| Pre-tax income | -675.7 | 615.7 | -158.7 | -246.3 | -158.9 | -140.1 | -120.5 | -76.1 |
| Income taxes | -1.2 | 2.0 | 0.0 | -23.7 | -33.4 | 0.0 | 0.0 | 0.0 |
| Tax rate | 0.2% | 0.3% | 0.0% | 9.6% | 21.0% | 0.0% | 0.0% | 0.0% |
| Net income | -674.5 | 613.7 | -158.7 | -222.7 | -125.5 | -140.1 | -120.5 | -76.1 |
| Net margin | -42.8% | 28.2% | -17.3% | -34.0% | -26.0% | -33.5% | -35.8% | -26.6% |
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| Basic EPS [+] | ($3.70) | $3.51 | ($0.96) | ($1.41) | ($0.88) | ($1.00) | ($0.93) | ($0.62) |
| Growth | -205.6% | -466.2% | -32.1% | 61.1% | -11.9% | 6.7% | 51.2% | 20.0% |
| Diluted EPS [+] | ($3.70) | $3.37 | ($0.96) | ($1.41) | ($0.88) | ($1.00) | ($0.93) | ($0.62) |
| Growth | -210.1% | -451.2% | -32.1% | 61.1% | -11.9% | 6.7% | 51.2% | 20.0% |
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| Shares outstanding (basic) [+] | 182.0 | 174.8 | 165.5 | 157.7 | 143.2 | 140.7 | 129.2 | 123.4 |
| Growth | 4.1% | 5.6% | 5.0% | 10.1% | 1.7% | 9.0% | 4.7% | 1.5% |
| Shares outstanding (diluted) [+] | 182.0 | 182.3 | 165.5 | 157.7 | 143.2 | 140.7 | 129.2 | 123.4 |
| Growth | -0.1% | 10.1% | 5.0% | 10.1% | 1.7% | 9.0% | 4.7% | 1.5% |
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| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |
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