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| In millions, except per share items | Dec-31-22 | Jun-30-22 | Mar-31-22 | Dec-31-21 | Sep-30-21 | Jun-30-21 | Mar-31-21 | Dec-31-20 |
| | 8-K | 10-Q | 10-Q | 10-K | 10-Q | 10-Q | 10-Q | 10-K |
| Revenues: |
| United States | | | | | 196.2 | | | |
| Net product revenues | 525.5 | | | | | | | |
| Other | 12.0 | | | | 212.5 | | | |
| Total revenues [+] | 537.5 | 533.8 | 519.4 | 449.8 | 408.7 | 501.7 | 486.0 | 452.1 |
| Royalties | 12.0 | | | | | | | |
| Products | 525.5 | | | | | | | |
| Revenue growth [+] | 19.5% | 6.4% | 6.9% | -0.5% | -14.3% | 16.8% | -3.2% | -0.5% |
| United States | | | | | -22.4% | | | |
| Cost of goods sold | 127.3 | 123.1 | 117.0 | 119.8 | 103.5 | 127.1 | 120.2 | 126.1 |
| Gross profit | 410.2 | 410.7 | 402.4 | 330.1 | 305.2 | 374.6 | 365.9 | 326.0 |
| Gross margin | 76.3% | 76.9% | 77.5% | 73.4% | 74.7% | 74.7% | 75.3% | 72.1% |
| Selling, general and administrative [+] | 245.7 | 196.8 | 194.6 | 217.6 | 183.3 | 184.2 | 174.3 | 195.5 |
| General and administrative | | | | 217.6 | | | | 195.5 |
| Research and development | | 158.2 | 160.8 | 161.1 | 157.9 | 161.1 | 148.7 | 156.7 |
| Equity in earnings | | | | 1.3 | 0.2 | | | 1.1 |
| Other operating expenses | 189.0 | 16.5 | 17.6 | 17.3 | 17.2 | 17.7 | 17.7 | 18.6 |
| EBITDA [+] | | 64.4 | 56.7 | -38.5 | -26.2 | 38.9 | 53.1 | -16.4 |
| EBITDA growth | -36.4% | 65.6% | 6.8% | 135.0% | -13.3% | -346.1% | -25.6% | -321.4% |
| EBITDA margin | -4.6% | 12.1% | 10.9% | -8.6% | -6.4% | 7.8% | 10.9% | -3.6% |
| Depreciation and amortization | | 25.3 | 27.3 | 26.0 | 26.8 | 27.2 | 28.0 | 27.4 |
| EBIT [+] | -24.5 | 39.2 | 29.3 | -64.5 | -53.0 | 11.7 | 25.1 | -43.8 |
| EBIT growth | -62.0% | 235.4% | 16.9% | 47.5% | -6.7% | -128.5% | -44.7% | 138.1% |
| EBIT margin | -4.6% | 7.3% | 5.6% | -14.3% | -13.0% | 2.3% | 5.2% | -9.7% |
| Non-recurring items [+] | | | -108.0 | | | | | 6.7 |
| Loss (gain) on sale of assets | | | -108.0 | | | | | 6.7 |
| Interest expense, net [+] | -5.1 | 1.4 | 2.0 | 2.1 | 2.0 | -0.7 | 1.4 | 1.7 |
| Interest expense | 3.6 | 3.9 | 3.8 | 3.8 | 3.9 | 3.8 | 3.8 | 4.7 |
| Interest income | 8.7 | 2.5 | 1.8 | 1.7 | 1.8 | 4.5 | 2.4 | 3.1 |
| Other income (expense), net | 1.9 | -2.9 | -1.2 | 0.1 | 8.9 | 1.8 | -0.5 | 5.3 |
| Pre-tax income | -17.6 | 34.9 | 134.2 | -66.6 | -46.2 | 14.2 | 23.2 | -46.9 |
| Income taxes | -17.3 | 7.2 | 13.4 | -8.7 | -9.7 | 1.2 | 5.9 | -63.9 |
| Tax rate | 98.6% | 20.6% | 10.0% | 13.0% | 20.9% | 8.6% | 25.2% | 136.3% |
| Net income | -0.2 | 27.7 | 120.8 | -57.9 | -36.5 | 12.9 | 17.4 | 17.0 |
| Net margin | 0.0% | 5.2% | 23.3% | -12.9% | -8.9% | 2.6% | 3.6% | 3.8% |
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| Basic EPS [+] | $0.00 | $0.15 | $0.66 | ($0.32) | ($0.20) | $0.07 | $0.10 | $0.09 |
| Growth | -99.6% | 111.0% | 587.0% | -436.2% | -104.6% | -143.8% | -78.9% | 12.2% |
| Diluted EPS [+] | $0.00 | $0.15 | $0.62 | ($0.32) | ($0.20) | $0.07 | $0.09 | $0.09 |
| Growth | -99.6% | 111.5% | 557.9% | -456.4% | -105.0% | -143.2% | -78.3% | 5.9% |
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| Shares outstanding (basic) [+] | 186.0 | 185.3 | 184.0 | 182.9 | 183.2 | 182.8 | 181.8 | 180.8 |
| Growth | 1.7% | 1.3% | 1.2% | 1.1% | 1.1% | 1.2% | 1.0% | 1.0% |
| Shares outstanding (diluted) [+] | 186.0 | 187.4 | 194.9 | 182.9 | 183.2 | 185.4 | 184.4 | 191.7 |
| Growth | 1.7% | 1.1% | 5.7% | -4.6% | -7.3% | 2.6% | -1.5% | 7.1% |
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| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |
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