AngioDynamics First Quarter 2024 Earnings Presentation October 4, 2023

AngioDynamics First Quarter 2024 Earnings Forward-Looking Statement Notice Regarding Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements regarding AngioDynamics’ expected future financial position, results of operations, cash flows, business strategy, budgets, projected costs, capital expenditures, products, competitive positions, growth opportunities, plans and objectives of management for future operations, as well as statements that include the words such as “expects,” “reaffirms,” “intends,” “anticipates,” “plans,” “projects,” “believes,” “seeks,” “estimates,” “optimistic,” or variations of such words and similar expressions, are forward-looking statements. These forward-looking statements are not guarantees of future performance and are subject to risks and uncertainties. Investors are cautioned that actual events or results may differ materially from AngioDynamics’ expectations, expressed or implied. Factors that may affect the actual results achieved by AngioDynamics include, without limitation, the scale and scope of the COVID-19 global pandemic, the ability of AngioDynamics to develop its existing and new products, technological advances and patents attained by competitors, infringement of AngioDynamics’ technology or assertions that AngioDynamics’ technology infringes the technology of third parties, the ability of AngioDynamics to effectively compete against competitors that have substantially greater resources, future actions by the FDA or other regulatory agencies, domestic and foreign health care reforms and government regulations, results of pending or future clinical trials, overall economic conditions (including inflation, labor shortages and supply chain challenges including the cost and availability of raw materials), the results of on-going litigation, challenges with respect to third-party distributors or joint venture partners or collaborators, the results of sales efforts, the effects of product recalls and product liability claims, changes in key personnel, the ability of AngioDynamics to execute on strategic initiatives, the effects of economic, credit and capital market conditions, general market conditions, market acceptance, foreign currency exchange rate fluctuations, the effects on pricing from group purchasing organizations and competition, the ability of AngioDynamics to obtain regulatory clearances or approval of its products, or to integrate acquired businesses, as well as the risk factors listed from time to time in AngioDynamics’ SEC filings, including but not limited to its Annual Report on Form 10-K for the year ended May 31, 2023. AngioDynamics does not assume any obligation to publicly update or revise any forward-looking statements for any reason. In the United States, the NanoKnife System has received a 510(k) clearance by the Food and Drug Administration for use in the surgical ablation of soft tissue, and is similarly approved for commercialization in Canada, the European Union and Australia. The NanoKnife System has not been cleared for the treatment or therapy of a specific disease or condition. Notice Regarding Non-GAAP Financial Measures Management uses non-GAAP measures to establish operational goals and believes that non-GAAP measures may assist investors in analyzing the underlying trends in AngioDynamics’ business over time. Investors should consider these non-GAAP measures in addition to, not as a substitute for or as superior to, financial reporting measures prepared in accordance with GAAP. In this presentation, AngioDynamics has reported pro-forma results, adjusted EBITDA (income before interest, taxes, depreciation and amortization and stock-based compensation); adjusted net income and adjusted earnings per share. Management uses these measures in its internal analysis and review of operational performance. Management believes that these measures provide investors with useful information in comparing AngioDynamics’ performance over different periods. By using these non-GAAP measures, management believes that investors get a better picture of the performance of AngioDynamics’ underlying business. Management encourages investors to review AngioDynamics’ financial results prepared in accordance with GAAP to understand AngioDynamics’ performance taking into account all relevant factors, including those that may only occur from time to time but have a material impact on AngioDynamics’ financial results. Please see the tables that follow for a reconciliation of non-GAAP measures to measures prepared in accordance with GAAP. 2

IDE Clinical Studies and Pathway Expansion Corporate Developments – Q1 FY24 AngioDynamics First Quarter 2024 Earnings 3 Divested the Dialysis and BioSentry tract sealant system businesses for $100.0 million $50.1 million of proceeds used to extinguish outstanding debt U.S. District Court for the District of Delaware entered a judgement as a matter of law in favor of AngioDynamics in the litigation with C.R. Bard Continued gross margin headwinds in raw material and labor inflation Q1 Highlights and Operational Developments PRESERVE study for the treatment of prostate cancer with NanoKnife completed enrollment in July 2023 APEX AV study for the treatment of pulmonary embolism with AlphaVac F18 More than 75% enrolled On track to complete enrollment in early calendar 2024 Received FDA Breakthrough designation for AngioVac for the non-surgical removal of right heart vegetation Continued focused investment in our 3 key Med Tech platforms: Auryon, Thrombus Management & NanoKnife Med Tech up 13.3% Med Device up 2.3%* $11.1 million in Auryon sales; growth of 25.7% YOY Mechanical Thrombectomy down 5.8% YOY $1.8 million in AlphaVac sales AngioVac sales declined 7.7% YOY; up 3.6% sequentially 34.5% YOY growth in NanoKnife disposables 5.7% Q1 Pro-Forma Revenue Growth* Pro-Forma Revenue $78.0 mil * On a pro-forma basis, excluding the sale of Dialysis and BioSentry

Q1 FY24 Results (unaudited) AngioDynamics First Quarter 2024 Earnings 4 $ in thousands (except per share data) Q1 FY24 As Reported Q1 FY23 As Reported Change Q1 FY24 Pro-Forma Q1 FY23 Pro-Forma Change Revenue $78,679 $81,537 (3.5%) $78,008 $73,791 5.7% Med Tech Med Device $25,860 $52,819 $22,817 $58,720 13.3% (10.0%) $25,860 $52,148 $22,817 $50,974 13.3% 2.3% United States International $64,399 $14,280 $69,023 $12,514 (6.7%) 14.1% $63,749 $14,259 $62,447 $11,344 2.1% 25.7% Gross Margin Med Tech Med Device 50.9% 64.7% 44.2% 51.9% 63.2% 47.5% (100 bps) 150 bps (330 bps) 50.8% 64.7% 43.9% 51.0% 63.2% 45.6% (20 bps) 150 bps (170 bps) Net Income (Loss) Non-GAAP Adjusted Net Loss $45,884 ($4,831) ($13,004) ($2,486) $58,888 ($2,345) $45,462 ($5,156) ($17,060) ($5,994) $62,522 $838 GAAP EPS Non-GAAP Adjusted EPS $1.15 ($0.12) ($0.33) ($0.06) $1.48 ($0.06) $1.14 ($0.13) ($0.43) ($0.15) $1.57 $0.02 Adjusted EBITDA $814 $2,961 ($2,147) $392 ($1,602) $1,994 $ in thousands Q1 FY24 Q4 FY23 Change Cash $57,586 $44,620 $12,966 Debt Revolving Facility Delayed-Draw Term Loan $0 $0 $0 $50,000 $25,000 $25,000 ($50,000) ($25,000) ($25,000) Net Cash (Debt) $57,586 ($5,380) $62,966

Q1 FY24 Results (pro-forma) 5 Med Device Med Tech 13.3% growth 2.3% growth Q1 Revenue Growth Q1 FY23 Q1 FY24 Q1 Revenue Contribution Q1 FY23 Q1 FY24 Med Tech Gross Margin 64.7% Med Device Gross Margin 43.9% AngioDynamics First Quarter 2024 Earnings

Sales Comparison to Prior-Year Period AngioDynamics First Quarter 2024 Earnings 6 Med Tech Q1 FY24 Auryon 25.7% Thrombus Management* AngioVac AlphaVac (6.7%) (7.7%) 1.8% NanoKnife® Disposables 34.5% NanoKnife® Capital 41.4% Med Device Q1 FY24 Core Peripheral (0.4%) Venous (5.8%) PICCs (9.9%) Midlines 9.7% Ports 22.4% Solero® Microwave 25.1% RadioFrequency Ablation (26.1%) Alatus and IsoLoc Balloons 7.3% * Thrombus Management includes AngioVac, AlphaVac and Thrombolytics

FY24 Guidance Reaffirmed 7 * FY23 pro-forma results excluding the divested assets were $306.3 million for revenue, 50.5% for gross margin and adjusted loss per share of $0.43. AngioDynamics First Quarter 2024 Earnings Guidance* Revenue $328 - $333 million Gross Margin Med Tech Med Device 50.0% - 52.0% 63.0% – 65.0% 43.0% - 45.0% Adjusted EPS ($0.28) – ($0.34)

GAAP to Non-GAAP Reconciliation

9 Reconciliation of GAAP to Non-GAAP Pro Forma Results for the Consolidated Income Statements (in thousands, except per share data) (in thousands) Reconciliation of GAAP to Non-GAAP Pro Forma Results for Sales and Gross Margin by Product Category

Reconciliation of GAAP to Non-GAAP Adjusted Net Income (Loss) and EPS Reconciliation of Net Income (Loss) to Adjusted EBITDA Includes costs related to merger and acquisition activities, restructurings, and unusual items, including asset impairments and write-offs, certain litigation, and other items. Adjustment to reflect the income tax provision on a non-GAAP basis has been calculated assuming no valuation allowance on the Company's U.S. deferred tax assets and an effective tax rate of 23% for the periods ended August 31, 2023 and August 31, 2022. Diluted shares may differ for non-GAAP measures as compared to GAAP due to a GAAP loss. Includes costs related to merger and acquisition activities, restructurings, and unusual items, including asset impairments and write-offs, certain litigation, and other items. (in thousands, except per share data) (in thousands) 10

Reconciliation of Non-GAAP Pro Forma Net Income (Loss) to Adjusted Pro Forma Net Loss and EPS Reconciliation of Non-GAAP Pro Forma Net Income (Loss) to Adjusted Pro Forma EBITDA Includes costs related to merger and acquisition activities, restructurings, and unusual items, including asset impairments and write-offs, certain litigation, and other items. Adjustment to reflect the income tax provision on a non-GAAP basis has been calculated assuming no valuation allowance on the Company's U.S. deferred tax assets and an effective tax rate of 23% for the periods ended August 31, 2023 and August 31, 2022. Diluted shares may differ for non-GAAP measures as compared to GAAP due to a GAAP loss. Includes costs related to merger and acquisition activities, restructurings, and unusual items, including asset impairments and write-offs, certain litigation, and other items. (in thousands, except per share data) (in thousands) 11

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