EX-99.2 3 d197971dex992.htm EX-99.2 EX-99.2

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Phase 1 Dataset September 2022 Exhibit 99.2


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Forward Looking Statements This presentation has been prepared by TCR2 Therapeutics Inc. (“we,” “us,” or “our”) and contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 and other federal securities laws. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, our development plans, our clinical results and other future conditions. All statements, other than statements of historical facts, contained in this presentation, including express or implied statements regarding our expectations for the Phase 2 clinical trial of gavo-cel and the Phase 1/2 clinical trial of TC-510, including expected progress and timing of updates; our expectations for the safety and efficacy of, and enhancements to, gavo-cel, TC-510 and our other product candidates including compared to other T-cell therapy approaches; our expectations regarding the estimated patient populations and related market opportunities in gavo-cel’s, TC-510’s and our other product candidates’ targeted indications; our expectations regarding manufacturing of gavo-cel, TC-510 and our other product candidates, our expectations regarding our development programs and IND-enabling studies; our expectations regarding expansion opportunities for our TRuC platform; and our expectations regarding our financial position are forward-looking statements. These statements are based on management’s current expectations and beliefs and are forward-looking statements which involve risks and uncertainties that could cause actual results to differ materially from those discussed in such forward-looking statements. Such risks and uncertainties include, among others: uncertainties inherent in clinical studies and in the availability and timing of data from ongoing clinical studies; whether interim results from a clinical trial will be predictive of the final results of a trial; the possibility that positive results from preclinical studies and correlative studies may not necessarily be predictive of the results of our planned clinical trials, including the Phase 2 clinical trial of gavo-cel and Phase 1/2 clinical trial of TC-510; the risk that the results from the Phase 2 clinical trial of gavo-cel and Phase 1/2 clinical trial of TC-510 will not support further development and marketing approval; the risk that we may be unable to gain approval of gavo-cel, TC-510 and our other product candidates on a timely basis, if at all; the risk that we have over-estimated the potential patient population for our product candidates, if approved; the risk that the current COVID-19 pandemic will impact our clinical trials and other operations; and the other risks set forth under the caption “Risk Factors” in our most recent Annual Report on Form 10-K for the year ended December 31, 2021, as filed with the SEC on March 22, 2022, as updated in our most recent Quarterly Report on Form 10-Q for the quarter ended June 30, 2022, as filed with the SEC on August 8, 2022, and in our future filings with the SEC available at the SEC’s website at www.sec.gov. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. You should not place undue reliance on any forward‐looking statements, which speak only as of the date they are made.  While we may elect to update these forward-looking statements at some point in the future, we assume no obligation to update or revise any forward-looking statements except to the extent required by applicable law. Although we believe the expectations reflected in such forward-looking statements are reasonable, we can give no assurance that such expectations will prove to be correct. Accordingly, readers are cautioned not to place undue reliance on these forward-looking statements. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements. 


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Agenda Phase 1 Key Takeaways | Garry Menzel, PhD Gavo-cel Phase 1 Data | Alfonso Quintás-Cardama, MD KOL: Gavo-cel Experience in the Clinic | Raffit Hassan, MD KOL: Standard of Care in Mesothelioma | Patrick Forde, MD Gavo-cel Phase 2 Trial Design | Garry Menzel, PhD Q&A


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Phase 1 Key Takeaways Baseline Established Additional strategies in the Phase 2 clinical trial are designed to improve preliminary profile Combination with checkpoint inhibitors Redosing Earlier lines of therapy RP2D: manageable safety profile and reversible adverse events Most frequent Grade ≥ 3 AE: CRS in 15% of patients Safety Data Ovarian Cancer: earlier focus due to encouraging early activity MPM: potential frontline setting if CPI combo improves durability of benefit NSCLC: expansion opportunity with new MSLN threshold Path Forward DCR, Disease Control Rate; ORR, Overall Response Rate; PFS, Progression Free Survival; OS, Overall Survival; RP2D, Recommended Phase 2 Dose; AE, Adverse Event; CRS, Cytokine Release Syndrome; MPM, Malignant Pleural/Peritoneal Mesothelioma; CPI, Checkpoint Inhibitor; NSCLC, Non-Small Cell Lung Cancer; MSLN, Mesothelin 93% - Heavily pretreated patients that experienced tumor regression 77% - Disease Control Rate (DCR) New RECIST Responses in ovarian cancer (29% ORR), MPM (21% ORR) MPM: 5.6 PFS, 11.2 OS Efficacy Data


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TRuCs Represent Advancement Upon Existing T Cell Therapies Antibody binder Costimulatory domain ζ ζ ζ CAR-T Cell (Chimeric Antigen Receptor) Modified TCRα and β TCR-T Cell (T Cell Receptor) ε δ α ζ β γ ε ζ ε δ α ζ β γ ε ζ TRuC-T Cell (T Cell Receptor Fusion Construct) Utilizes Full TCR Complex Signaling HLA Independent


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Preclinically, TRuCs Show Superiority Over CARs Superior Intratumoral Infiltration Superior Tumor Control vs. CAR-Ts Optimal Metabolic Profile for Enhanced Fitness Higher Gene Expression Associated with T Cell Activation and Migration Glucose uptake Mitochondrial load


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Clinically, gavo-cel Has Shown Activity Where Others Have Failed Patients treated with anti-mesothelin CAR-T monotherapy 74 Total RECIST Responses reported 1 Patients evaluable treated with gavo-cel (TRuC-T cell) monotherapy 30 Total RECIST Responses reported 6 1Maus et al., 2013, Cancer Immunol. Res.; 2Beatty et al., 2014, Cancer Immunol. Res.; 3Hass et al., 2019, Mol. Therapy.; 4www.med.upenn.edu/cellicon2021/assets/user-content/documents/tanyi.pdf; 5Adusumilli et al., 2021, Cancer Discovery; 6Wang et al., 2021, Cell Mol. Immunol. First Anti-Mesothelin Cell Therapy to Demonstrate Tolerability and Clinical Benefit


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gavo-cel Achieved Consistent Tumor Regression in 93% of Evaluable Patients 21/22 MPM 6/7 Ovarian 1/1 CHO Data Cutoff – September 9, 2022 MPM, Malignant Pleural/Peritoneal Mesothelioma; CHO, Cholangiocarcinoma ** CHO PR by Investigator Assessment * Tumor volume decrease based on best response assessed


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Promising Signal in Platinum Refractory Ovarian Cancer Ovarian Highlights 6/7 patients experienced tumor regression 2/7 patients experienced RECIST partial responses Most recent RECIST response (Patient 33) is ongoing at month 4; experiencing continuous monthly improvement of radiological response Efficacy Data ORR: 29% (gavo-cel + LD) PFS: 5.8 months OS: 8.1 months Data Cutoff – September 9, 2022 -49 Month 1 Month 2 Month 3 ORR, Overall Response Rate; PFS, Progression Free Survival; OS, Overall Survival; LD, Lymphodepletion * Tumor volume decrease based on best response assessed


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Patient 33 – Platinum Refractory Ovarian Cancer Partial Response (RECIST v1.1), Tumor Regression Deepened Over 3 Months (49%) 66-year-old female, High grade, Stage IV serous ovarian cancer TP53 mutated Total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy Carboplatin/paclitaxel Bevacizumab/Paclitaxel Bevacizumab maintenance Weekly Paclitaxel Enrolled in gavo-cel Clinical Trial Lymphodepletion with Flu/Cy gavo-cel at 1x108/m2 (RP2D) Week 4 16mm, 5cm3 Target Lesion 1 Lymph Node Week 8 13mm, 2.7cm3 Week 12 12mm, 2.1cm3 Target Lesion 2 Lymph Node Baseline 28mm, 18.5cm3 Week 4 20mm, 8.5cm3 Week 8 15mm, 4.3cm3 Week 12 13mm, 2.3cm3 Baseline 21mm, 14.9cm3 Days from gavo-cel infusion Change from baseline Diameters Volumes


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Phase 1 Data Support a Path Forward as Mesothelioma Leader MPM Highlights 21/22 patients experienced tumor regression 5/22 patient partial responses by target lesion assessment; 4/22 experienced RECIST partial responses 1 patient experienced complete metabolic response Efficacy Data ORR: 21% (gavo-cel + LD) PFS: 5.6 months OS: 11.2 months ORR, Overall Response Rate; PFS, Progression Free Survival; OS, Overall Survival; LD, Lymphodepletion * Tumor volume decrease based on best response assessed Data Cutoff – September 9, 2022


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Significant Potential Opportunity in Mesothelin-Expressing Solid Tumors Refs: Inaguma 2017, SEER Statistics, Morello 2016, Tozbikian 2014 ~215,000 Patients Across Multiple Target Indications NSCLC, Non-Small Cell Lung Cancer; ORR, Overall Response Rate 76% Mesothelioma Population: 1,800 Orphan Drug Designation 4 RECIST Partial Responses 21/22 Tumor Regression ORR 21% 31% NSCLC Population: 62,600 50% Cholangiocarcinoma Population: 4,000 Orphan Drug Designation 1 Partial Response (by Investigator Assessment) 1/1 Tumor Regression 58% Ovarian Cancer Population: 12,400 2 RECIST Partial Responses 6/7 Tumor Regression ORR 29% 30% 36% 66% 40% 20% 55% Esophageal Cancer Population: 5,000 Triple Negative Breast Cancer Population: 15,000 Pancreatic Cancer Population: 38,000 Gastric Cancer Population: 11,000 Endometrial Cancer Population: 13,000 Colorectal Cancer Population: 81,000 Percent of Patients with Mesothelin Surface Expression


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Phase 2 Modifications Aim to Further Improve Outcomes and Patient Access  01 02 03 Better Clinical Responses and Persistence CPI Combination Increasing Depth and Duration of Response Redosing Improved Immune Health Limit Prior Lines of Therapy Ovarian Cancer + Mesothelioma 04 Increased Patient Eligibility New Mesothelin Threshold NSCLC + Cholangiocarcinoma NSCLC, Non-Small Cell Lung Cancer


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Phase 1 Data


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gavo-cel Phase 1 Trial in MSLN+ Solid Tumors LD, Lymphodepletion; RP2D, Recommended Phase 2 Dose; MPM, Malignant Pleural/Peritoneal Mesothelioma; NSCLC, Non-Small Cell Lung Cancer RP2D Phase 1: Dose Finding (‒ LD) Cohorts = 1 patient (+ LD) Cohorts = 3 patients Dose Level 1 (+ LD) Dose Level 0 (- LD) 1 Dose Level 3 (+ LD) Dose Level 2 (- LD) 2 Dose Level 5 (+ LD) Dose Level 4 (- LD) 3 Dose Level 7 (+ LD) Dose Level 6 (- LD) 4 (5x107 cells/m2) (1x108 cells/m2) (5x108 cells/m2) (1x109 cells/m2) Lymphodepletion (LD) Fludarabine: 30 mg/m2 x4d Cyclophosphamide: 600 mg/m2 x3d Mesothelin Expression IHC assay Central lab (Roche/Ventana) Cut-off: ≥50% 2+/3+ Indications MPM Ovarian cancer NSCLC Cholangiocarcinoma Phase 1 Objective: Determine RP2D


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Patient Tumor Characteristics Dose Level (gavo-cel dose) No. Patients DL 0 (no LD) 5x107/m2 n=1 DL 1 5x107/m2 n=8 DL 2 (no LD) 1x108/m2 n=1 DL 3 1x108/m2 n=13 DL 3.5 3x108/m2 n=5 DL 4 (no LD) 5x108/m2 n=1 DL 5 5x108/m2 n=3 Overall n=32 (%) Age, Median (Range) 61 70 (36-84) 46 59 (28-70) 63 (43-69) 67 52 (37-66) 63 (28-84) Diagnosis 1 MPM 7 MPM 1 Ovarian 1 MPM 6 MPM, 6 Ovarian 1 Cholangio 4 MPM, 1 Ovarian 1 MPM 3 MPM 23 MPM 8 Ovarian 1 Cholangio MSLN 2+/3+ 90 72 (55-100) 90 70 (50-95) 75 (50-92) 60 65 (65-73) 70 (50-100) Median No. Prior Rx 8 5 9 5 7 7 4 5 (1-13) Prior ICI, n (%) 1 (100) 6 (75) 1 (100) 6 (46) 4 (80) 1 (100) 2 (66) 21 (66) Prior Anti-MSLN Therapy, n (%) 1 (100) 1 (13) 1 (100) 1 (8) 2 (40) 0 1 (33) 6 (19) Bridging Therapy, n (%) 0 6 (75) 0 12 (92) 5 (100) 1 (100) 1 (33) 25 (78) Data Cutoff – September 9, 2022 RP2D DL, Dose Level; RP2D, Recommended Phase 2 Dose; MSLN, Mesothelin; ICI, Immune Checkpoint Inhibitors; MPM, MPM, Malignant Pleural/Peritoneal Mesothelioma; Cholangio, Cholangiocarcinoma


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Grade ≥3 Treatment Emergent Adverse Events Adverse Event DL 0 (no LD) 5x107/m2 n=1 (%) DL 1 5x107/m2 n=8 (%) DL 2 (no LD) 1x108/m2 n=1 (%) DL 3 1x108/m2 n=13 (%) DL 3.5 3x108/m2 n=5 DL 4 (no LD) 5x108/m2 n=1 (%) DL 5 5x108/m2 n=3 (%) Overall n=32 (%) Hematologic Lymphopenia 0 8 (100) 0 13 (100) 5 (100) 0 3 (100) 29 (91) Neutropenia 1 (100) 8 (100) 0 13 (100) 5 (100) 1 (100) 3 (100) 31 (97) Thrombocytopenia 0 2 (25) 0 2 (15) 1 (20) 0 2 (67) 7 (22) On Target / On Tumor CRS 0 2 (25) 0 2 (15) 1 (20) 0 3 (100) 8 (25) HLH/ MAS 0 0 0 0 0 0 0 0 Neurotoxicity 0 0 0 0 0 0 0 0 On Target / Off Tumor Pericarditis / Pericardial effusion 0 0 0 0 1 (20) 0 0 1 (3) Pleuritis / Pleural effusion 0 0 0 1 (8) 1 (20) 0 0 2 (6) Peritonitis / Ascites 0 0 0 1 (8) 0 0 0 1 (3) Other Pneumonitis 0 1 (13)* *0 0 3 (60) 0 1 (33) 5 (16) Sepsis 0 1 (13) 0 0 0 0 0 1 (3) Hemorrhage 0 0 0 0 0 0 1 (33)* 1 (3) RP2D Data Cutoff – September 9, 2022 *Dose Limiting Toxicity DL, Dose Level; LD, Lymphodepletion; RP2D, Recommended Phase 2 Dose; HLH, Hemophagocytic Lymphohistiocytosis; MAS, Macrophage Activation Syndrome


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Consistent Tumor Regression in Patients with gavo-cel Tumor Regression in 93% of Patients, Disease Control Rate 77%  Blinded Independent Central Review All gavo-cel + LD ORR 20% 22% MPM ORR 18% 21% Ovarian ORR 29% 29% * DCR = PR or SD lasting at least 3 months * DL0 (5x107/m2) DL1 (5x107/m2, + LD) DL2 (1x108/m2) DL3 (1x108/m2, + LD) DL3.5 (3x108/m2,+ LD) DL4 (5x108/m2) DL5 (5x108/m2, + LD) Data Cutoff – September 9, 2022 MPM OVA MPM OVA MPM MPM MPM MPM MPM MPM OVA MPM MPM MPM MPM MPM MPM MPM OVA OVA MPM MPM MPM OVA OVA CHO MPM MPM MPM MPM DL, Dose Level; LD, Lymphodepletion; DCR, Disease Control Rate; ORR, Overall Response Rate; PR, Partial Response; SD, Stable Disease * Tumor volume decrease based on best response assessed


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Patient Response and Follow-up as of September 9th, 2022 Months Patients alive  at 6 months *   70% Patients alive at 1 year *   31% Patients alive as of cutoff 12 Data Cutoff – September 9, 2022 *Kaplan-Meier survival estimates ** CHO PR by Investigator Assessment CHO, Cholangiocarcinoma; SD, Stable Disease; PR, Partial Response; CR, Complete Response; PD, Progressive Disease; FU, Follow-Up


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Survival in Mesothelioma ORR 21%, PFS 5.6 Months, OS 11.2 Months Benchmarks in Second Line Post Platinum-Based Therapy Fennell et al Phase 2 VIM Study. ASCO 2021 Popat et al Phase 3 PROMISE-meso Study. Ann Oncol 2020 Fennell et al Phase 3 CONFIRM Study. Lancet Oncol 2021 Study n ORR (%) PFS (mo) OS (mo) Vinorelbine vs Supportive Care1 98 3.1 4.2 9.3 56 1.8 2.8 9.1 Pembrolizumab vs Vinorelbine or Gemcitabine2 73 22 2.5 10.7 71 6 3.4 12.4 Nivolumab vs Placebo3 221 11 3 10.2 111 1 1.8 6.9 Data Cutoff – September 9, 2022 Overall Survival Median 11.2 months Progression Free Survival Median 5.6 months ORR, Overall Response Rate; PFS, Progression Free Survival; OS, Overall Survival


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Survival in Ovarian Cancer after gavo-cel Infusion ORR 29%, PFS 5.8 Months, OS 8.1 Months Median 8.1 months Median 5.8 months Progression Free Survival Overall Survival -49 DL1 (5x107/m2, + LD) DL3 (1x108/m2, + LD) ORR, Overall Response Rate; PFS, Progression Free Survival; OS, Overall Survival; DL, Dose Level; LD, Lymphodepletion * Tumor volume decrease based on best response assessed Data Cutoff – September 9, 2022


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Patient 5 – Platinum Refractory Ovarian Cancer Partial Response (RECIST v1.1), Tumor Regression (61%) 70-year-old female High grade, Stage IV serous ovarian cancer TP53R248Q, CCNE1 amplified, wild type BRCA1/2 Failed 6 prior lines of chemotherapy Enrolled in gavo-cel Clinical Trial Lymphodepletion with Flu/Cy gavo-cel at 5x107/m2 (Dose Level 1) Week 4 14mm, 4cm3 Target Lesion 1 Lymph Node Week 12 10mm, 2.3cm3 Week 24 9mm, 1.3cm3 Target Lesion 2 Lymph Node Baseline 19mm, 7.6cm3 Week 4 14mm, 3.3cm3 Week 12 9mm, 2.9cm3 Week 24 10mm, 1.7cm3 Baseline 27mm, 24cm3 Week 24 19mm New Lesion Lymph Node Days from gavo-cel infusion Change from baseline Diameters Volumes


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gavo-cel Displayed Dose-Dependent Expansion and Cytokine Release Peak Expansion Peak IFN-�� Peak IL-6 Data Cutoff – September 9, 2022


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Intratumor Infiltration and Persistence Greater Than in Blood TRuC-T Cell Migration and Infiltration Evident from Serous Effusions Diagnosis MPM CHO MPM MPM Ovarian MPM Response SD PR* PR SD SD PR MPM: Malignant Pleural/Peritoneal Mesothelioma; CHO: Cholangiocarcinoma; PR: Partial Response; SD: Stable Disease day 10 day 10 day 16 day 21 day 64 day 57 day 76 day 43 day 58 day 56 day 70 day 86 - Undetectable day 35 day 27 - Undetectable serosal effusion peripheral blood peritoneal nodule * PR by Investigator Assessment Analysis performed in a subset of patients (n=6); all analyzable samples showed detectable levels of gavo-cel, but not all showed increased expansion at disease sites Data Cutoff – September 9, 2022


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gavo-cel: SMRP and MPF Data vs. Best Target Lesion Response Patients with baseline levels of SMRP in normal range were excluded *CHO PR by Investigator Assessment SMRP -24.5 -23.3 -20.8 -3.8 -19.4 -15.5 -5.3 -3.7 -9.1 -17.9 -10.9 -9.6 -39.4 -49.0 -10.4 -3.8 -5.0 -67.4 -65.7 -79.5 -11.8 48.4 Best target lesion response 26.2 -63.6 MPF -25.0 -23.3 -20.8 -5.0 -19.4 -15.5 -49.0 -10.9 -9.1 -17.9 -3.7 -9.6 -39.4 -63.6 -10.4 -3.8 -3.8 -67.4 -65.7 -79.5 -11.8 48.4 -12.7 -53.6 -60.9 -24.5 Best target lesion response 26.2 -5.3 * SMRP, Soluble Mesothelin-Related Peptides; MPF, Megakaryocyte Potentiating Factor; PR, Partial Response; SD, Stable Disease; PD, Progressive Disease; CHO, Cholangiocarcinoma Data Cutoff – September 9, 2022


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Phase 2 Trial Trial Modifications & Design


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Clinical Activity At or Below gavo-cel RP2D Manageable safety profile Clinical activity at ≤RP2D in 3/3 tumor indications 5 RECIST PRs Multiple patients near 30% tumor regression DL0 (5x107/m2) DL1 (5x107/m2, + LD) DL2 (1x108/m2) DL3 (1x108/m2, + LD) DL, Dose Level; LD, Lymphodepletion; RP2D, Recommended Phase 2 Dose; PR, Partial Response * Tumor volume decrease based on best response assessed Data Cutoff – September 9, 2022


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Phase 2 Incorporates Four Changes Aiming to Boost Patient Outcomes Durability and Persistence Checkpoint Inhibitor Combinations 3 Limit Prior Lines of Therapy ≤5 4 Broadening Patient Access Increased Patient Eligibility with New MSLN Threshold for NSCLC and Cholangiocarcinoma 1 Redosing (LD + gavo-cel) 2 MSLN, Mesothelin, NSCLC, Non-Small Cell Lung Cancer; LD, Lymphodepletion


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LD, Lymphodepletion; CPI, Checkpoint Inhibitor; RP2D, Recommended Phase 2 dose; MPM, Malignant Pleural/Peritoneal Mesothelioma; NSCLC, Non-Small Cell Lung Cancer; Cholangio, Cholangiocarcinoma Phase 2 Expansion Cohorts in MSLN+ Solid Tumors RP2D 1x108 cells/m2 PATIENT POPULATION: ≤5 PRIOR LINES OF THERAPY n=20 NSCLC gavo-cel + nivolumab Mesothelin Expression MPM, Ovarian: ≥50%, 2+/3+ NSCLC, Cholangio: ≥50%, 1+/2+/3+ Key Objectives Primary: ORR (RECIST v1.1), DCR (ORR+SD) Secondary: PFS, OS Retreatment Patient with a confirmed response (i.e. PR or CR) and then exhibits symptoms or signs of PD Patients with SD for at least 8 weeks In Collaboration with n=20 Cholangio gavo-cel + nivolumab Futility analysis near midpoint in each MPM arm n=15 MPM gavo-cel n=10 n=15 MPM gavo-cel + nivolumab n=10 n=15 MPM gavo-cel + nivolumab + ipilumumab n=10 Randomization (1:1:1) n=20 Ovarian Cancer gavo-cel + nivolumab


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Increase in Patient Eligibility with New MSLN Threshold Data based on internal analysis in September 2022 MSLN Threshold Comparison Non-Small Cell Lung Cancer patients eligible for therapy based on Phase 2 threshold 29% Cholangiocarcinoma patients eligible for therapy based on Phase 2 threshold 16% New Threshold: ≥50% tumor cells irrespective of MSLN intensity (1+/2+/3+) MSLN, Mesothelin


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Source: CRISPR public materials, Trial: NCT04035434 (CARBON) Redosing Allowed from 12 Weeks, Could Deepen Patient Responses CRISPR Highlights: Evaluated safety and efficacy of CTX110 with the option of as second consolidation dose in aggressive 2L+ LBCL; n=29 Option for 2nd CTX110 infusion with LD following disease progression 5 out of 8 patients receiving a second dose saw an improved response Based on gavo-cel Phase 1 manufacturing experience:  Patients had 2 doses from one manufacturing run 100% Patients had 3 doses from one manufacturing run 97% Patients eligible for a redosing based on Phase 2 protocols 46% LD, Lymphodepletion


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CPIs Expected to Improve Activity of TRuC-T Cells Immunoinhibitory Mechanisms May Play A Role in Resistance Multiparameter immunofluorescence assay performed using MultiOmxyTM (Neogenomics) Patient #3 – MPM 64% Target Lesion Regression Patient #21 – MPM 10% Target Lesion Regression PanCK = tumor marker; CD3 = T cell marker; CD68 = TAM marker; CD155 = TIGIT ligand; PD-L1 = PD-1 ligand Baseline Post-tx (wk8) PanCK CD3 CD155 PanCK CD3 CD155 PanCK CD68 PD-L1 PanCK CD68 PD-L1 MPM, Malignant Pleural/Peritoneal Mesothelioma; CPI, Checkpoint Inhibitor


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Refocused Pipeline to Deliver Near-Term Clinical Data MSLN, Mesothelin; MPM, Malignant Pleural/Peritoneal Mesothelioma; NSCLC, Non-Small Cell Lung Cancer; TNBC, Triple Negative Breast Cancer; RCC, Renal Cell Carcinoma; AML, Acute Myeloid Leukemia


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Q&A