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2northerntrust.com | © 2022 Northern Trust Corporation This presentation may include statements which constitute “forward-looking statements” within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Forward- looking statements are identified typically by words or phrases such as “believe,” “expect,” “anticipate,” “intend,” “estimate,” “project,” “likely,” “plan,” “goal,” “target,” “strategy,” and similar expressions or future or conditional verbs such as “may,” “will,” “should,” “would,” and “could.” Forward-looking statements include statements, other than those related to historical facts, that relate to Northern Trust’s financial results and outlook, capital adequacy, dividend policy and share repurchase program, accounting estimates and assumptions, credit quality including allowance levels, future pension plan contributions, effective tax rate, anticipated expense levels, contingent liabilities, acquisitions, strategies, market and industry trends, and expectations regarding the impact of accounting pronouncements and legislation. Forward-looking statements also include statements, other than those related to historical facts, that relate to the ongoing COVID-19 pandemic and its impact on global economic and market conditions and Northern Trust’s business, financial condition, and results of operations. These statements are based on Northern Trust’s current beliefs and expectations of future events or future results, and involve risks and uncertainties that are difficult to predict and subject to change. These statements are also based on assumptions about many important factors, including the factors discussed in Northern Trust’s most recent annual report on Form 10-K and other filings with the U.S. Securities and Exchange Commission, all of which are available on Northern Trust’s website. We caution you not to place undue reliance on any forward-looking statement as actual results may differ materially from those expressed or implied by forward-looking statements. Northern Trust assumes no obligation to update its forward-looking statements. FORWARD-LOOKING STATEMENTS

7northerntrust.com | © 2022 Northern Trust Corporation $ IN MILLIONS EPS AND ROE ARE ACTUAL NUMBERS FISCAL YEAR 2021 % CHANGE VS. 2020 Noninterest Income $5,082 +9% Net Interest Income 1,383 (4%) Total Revenue 6,465 6% Provision for Credit Losses (82) N/M Total Expenses 4,536 +4% Net Income 1,545 28% Earnings Per Share (EPS) $7.14 $5.48 Return on Average Common Equity (ROE) 13.9% 11.2% As of December 31, 2021. N/M = not meaningful TRUE PERFORMANCE $16.2T AS S E T S UN D E R CUS T OD Y / AD M I N I S T R AT I ON $1.6T AS S E T S UN D E R M AN AG E M E N T $184B B ALAN CE S HE E T

8northerntrust.com | © 2022 Northern Trust Corporation MOVING FORWARD TOGETHER Service Relentless drive to provide exceptional service Resolving complex challenges with world class capabilities Integrity Consistently acting with the highest ethics, utmost honesty and unfailing reliability