The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Agenus Inc COM 00847G705   608,160 253,400 SH Call SOLE   253,400 0 0
Agenus Inc COM 00847G705   2,432,640 1,013,600 SH Call SOLE   1,013,600 0 0
Agenus Inc COM 00847G705   6,945,737 2,894,057 SH   SOLE   2,894,057 0 0
Align Technology Inc COM 016255101   17,525,790 83,100 SH   SOLE   83,100 0 0
Alnylam Pharmaceuticals Inc COM 02043Q107   23,765,000 100,000 SH Call SOLE   100,000 0 0
Alnylam Pharmaceuticals Inc COM 02043Q107   13,414,867 56,448 SH   SOLE   56,448 0 0
Arcus Biosciences Inc COM 03969F109   6,510,291 314,811 SH   SOLE   314,811 0 0
AstraZeneca PLC SPONSORED ADR 046353108   41,607,029 613,673 SH   SOLE   613,673 0 0
Biomarin Pharmaceutical Inc COM 09061G101   40,841,604 394,643 SH   SOLE   394,643 0 0
CTI Biopharma Corp COM 12648L601   27,685,227 4,606,527 SH   SOLE   4,606,527 0 0
CTI Biopharma Corp COM 12648L601   2,464,100 410,000 SH Call SOLE   410,000 0 0
Chinook Therapeutics Inc COM 16961L106   21,129,226 806,459 SH   SOLE   806,459 0 0
Cytokinetics Inc COM 23282W605   4,582,000 100,000 SH Call SOLE   100,000 0 0
Cytokinetics Inc COM 23282W605   23,319,173 508,930 SH   SOLE   508,930 0 0
Dexcom Inc COM 252131107   15,930,377 140,678 SH   SOLE   140,678 0 0
Fulcrum Therapeutics Inc COM 359616109   4,596,672 631,411 SH   SOLE   631,411 0 0
Geron Corp COM 374163103   3,532,205 1,459,589 SH   SOLE   1,459,589 0 0
Geron Corp COM 374163103   5,733,222 2,369,100 SH Call SOLE   2,369,100 0 0
Horizon Therapeutics PLC SHS G46188101   47,019,087 413,173 SH   SOLE   413,173 0 0
IDEAYA Biosciences Inc COM 45166A102   8,622,210 474,530 SH   SOLE   474,530 0 0
Immatics NV SHS N44445109   17,426,759 2,000,776 SH   SOLE   2,000,776 0 0
ImmunoGen Inc COM 45253H101   8,363,324 1,686,154 SH   SOLE   1,686,154 0 0
Inhibrx Inc COM 45720L107   27,354,909 1,110,183 SH   SOLE   1,110,183 0 0
Iveric Bio Inc COM 46583P102   13,668,101 638,398 SH   SOLE   638,398 0 0
Karuna Therapeutics Inc COM 48576A100   134,210 683 SH   SOLE   683 0 0
Kura Oncology Inc COM 50127T109   7,366,092 593,561 SH   SOLE   593,561 0 0
Merck & Co Inc COM 58933Y105   66,942,348 603,356 SH   SOLE   603,356 0 0
Prometheus Biosciences Inc COM 74349U108   19,419,950 176,545 SH   SOLE   176,545 0 0
Reata Pharmaceuticals Inc CL A 75615P103   37,687,182 992,029 SH   SOLE   992,029 0 0
Sanofi SA SPONSORED ADR 80105N105   95,187,954 1,965,475 SH   SOLE   1,965,475 0 0
Sarepta Therapeutics Inc COM 803607100   32,130,009 247,955 SH   SOLE   247,955 0 0
Syndax Pharmaceuticals Inc COM 87164F105   17,893,233 703,074 SH   SOLE   703,074 0 0
Travere Therapeutics Inc COM 89422G107   12,160,976 578,268 SH   SOLE   578,268 0 0
United Therapeutics Corp COM 91307C102   24,807,575 89,207 SH   SOLE   89,207 0 0
Vertex Pharmaceuticals Inc COM 92532F100   45,335,283 156,989 SH   SOLE   156,989 0 0
Zentalis Pharmaceuticals Inc COM 98943L107   20,221,466 1,004,045 SH   SOLE   1,004,045 0 0
Aerovate Therapeutics Inc COM 008064107   110,129,500 3,758,686 SH   SOLE   3,758,686 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101   107,572,104 880,800 SH   SOLE   880,800 0 0
Bolt Biotherapeutics Inc COM 097702104   3,580,768 2,754,437 SH   SOLE   2,754,437 0 0
Cincor Pharma Inc COM 17240Y109   74,648,833 6,073,949 SH   SOLE   6,073,949 0 0
Fusion Pharmaceuticals Inc COM 36118A100   368,862 117,099 SH   SOLE   117,099 0 0
Galera Therapeutics Inc COM 36338D108   4,594,731 3,083,712 SH   SOLE   3,083,712 0 0
Inozyme Pharma Inc COM 45790W108   3,838,073 3,655,308 SH   SOLE   3,655,308 0 0
Karuna Therapeutics Inc COM 48576A100   407,234,657 2,072,441 SH   SOLE   2,072,441 0 0
Natera Inc COM 632307104   124,549,495 3,100,560 SH   SOLE   3,100,560 0 0
Nextcure Inc COM 65343E108   3,767,317 2,671,856 SH   SOLE   2,671,856 0 0
Nucana PLC SPONSORED ADR 67022C106   3,695,999 5,599,999 SH   SOLE   5,599,999 0 0
Nucana PLC COMMON SHARES GB00BYWYV   1,584,000 2,400,000 SH   SOLE   2,400,000 0 0
ObsEva SA COM H5861P103   688,695 4,749,623 SH   SOLE   4,749,623 0 0
PDS Biotechnology Corp COM 70465T107   1,882,782 142,635 SH   SOLE   142,635 0 0
Synlogic Inc COM 87166L100   436,979 574,972 SH   SOLE   574,972 0 0
Vera Therapeutics Inc CL A 92337R101   61,560,903 3,181,442 SH   SOLE   3,181,442 0 0
Y-mAbs Therapeutics Inc COM 984241109   10,708,077 2,194,278 SH   SOLE   2,194,278 0 0