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The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108   37,831,794 2,376,369 SH   SOLE   2,376,369 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106   1,119,168 160,800 SH   SOLE   160,800 0 0
ALIGN TECHNOLOGY INC COM 016255101   15,734,195 74,605 SH   SOLE   74,605 0 0
ALIMERA SCIENCES INC COM 016259202   544,490 200,919 SH   SOLE   200,919 0 0
ALKERMES PLC COM G01767105   15,766,842 603,400 SH   SOLE   603,400 0 0
AMICUS THERAPEUTICS INC COM 03152W109   128,128,346 10,493,722 SH   SOLE   10,493,722 0 0
ANAPTYSBIO INC COM 032724106   13,357,434 431,024 SH   SOLE   431,024 0 0
BIOGEN INC COM 09062X103   105,252,307 380,082 SH   SOLE   380,082 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   195,162,580 1,885,811 SH   SOLE   1,885,811 0 0
CYTOKINETICS INC COM 23282W605   5,118,873 111,717 SH   SOLE   111,717 0 0
EHEALTH INC COM 28238P109   12,024,878 2,484,479 SH   SOLE   2,484,479 0 0
GOSSAMER BIO INC COM 38341P102   81,918 37,750 SH   SOLE   37,750 0 0
GRITSTONE ONCOLOGY INC COM 39868T105   2,298,138 666,127 SH   SOLE   666,127 0 0
INSMED INC COM 457669307   117,308,394 5,871,291 SH   SOLE   5,871,291 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106   19,229,298 5,655,676 SH   SOLE   5,655,676 0 0
KEZAR LIFE SCIENCES INC COM 49372L100   4,619,648 656,200 SH   SOLE   656,200 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   1,261,650 64,700 SH   SOLE   64,700 0 0
PEAK BIO INC COM 70470P108   2,021,792 497,528 SH   SOLE   497,528 0 0
PROTHENA CORP PLC COM G72800108   99,929,264 1,658,577 SH   SOLE   1,658,577 0 0
PROVENTION BIO INC COM 74374N102   4,130,756 390,800 SH   SOLE   390,800 0 0
REVANCE THERAPEUTICS INC COM 761330109   97,535,422 5,283,609 SH   SOLE   5,283,609 0 0
SAGE THERAPEUTICS INC COM 78667J108   32,667,558 856,517 SH   SOLE   856,517 0 0
STAAR SURGICAL CO COM 852312305   60,193,338 1,240,077 SH   SOLE   1,240,077 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   15,590,670 612,600 SH   SOLE   612,600 0 0
TACTILE SYSTEMS TECHNOLOGY I COM 87357P100   311,108 27,100 SH   SOLE   27,100 0 0
TRAVERE THERAPEUTICS INC COM 89422G107   3,492,431 166,069 SH   SOLE   166,069 0 0
UNITED THERAPEUTICS CORP COM 91307C102   173,921,379 625,414 SH   SOLE   625,414 0 0
UROGEN PHARMA LTD COM M96088105   217,315 24,500 SH   SOLE   24,500 0 0
VANDA PHARMACEUTICALS INC COM 921659108   8,037,416 1,087,607 SH   SOLE   1,087,607 0 0