The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACLARIS THERAPEUTICS INC COM 00461U105   5,374,514 341,239 SH   SOLE   341,239 0 0
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   34,650,524 3,007,858 SH   SOLE   3,007,858 0 0
ACUMEN PHARMACEUTICALS INC COM 00509G209   1,876,230 347,450 SH   SOLE   347,450 0 0
ADMA BIOLOGICS INC COM 000899104   46,172,989 11,900,255 SH   SOLE   11,900,255 0 0
AKERO THERAPEUTICS INC COM 00973Y108   19,208,770 350,525 SH   SOLE   350,525 0 0
ALBIREO PHARMA INC COM 01345P106   37,972,228 1,757,160 SH   SOLE   1,757,160 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106   78,996,592 11,350,085 SH   SOLE   11,350,085 0 0
AMICUS THERAPEUTICS INC COM 03152W109   337,520,017 27,642,917 SH   SOLE   27,642,917 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   224,963,904 6,088,333 SH   SOLE   6,088,333 0 0
ARCELLX INC COMMON STOCK 03940C100   80,495,489 2,598,305 SH   SOLE   2,598,305 0 0
ARTIVION INC COM 228903100   13,160,623 1,085,860 SH   SOLE   1,085,860 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   32,601,089 2,189,462 SH   SOLE   2,189,462 0 0
ATHENEX INC COM 04685N103   2,291,039 15,532,467 SH   SOLE   15,532,467 0 0
ATHIRA PHARMA INC COM 04746L104   15,207,371 4,797,278 SH   SOLE   4,797,278 0 0
AXOGEN INC COM 05463X106   13,853,497 1,388,126 SH   SOLE   1,388,126 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204   73,084,242 8,891,027 SH   SOLE   8,891,027 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   52,415,719 506,481 SH   SOLE   506,481 0 0
BRIDGEBIO PHARMA INC COM 10806X102   12,931,391 1,697,033 SH   SOLE   1,697,033 0 0
CABALETTA BIO INC COM 12674W109   2,936,450 317,454 SH   SOLE   317,454 0 0
CAREMAX INC COM CL A 14171W103   11,421,562 3,129,195 SH   SOLE   3,129,195 0 0
CAREMAX INC *W EXP 06/08/202 14171W111   31,308 60,000 SH   SOLE   60,000 0 0
CASSAVA SCIENCES INC COM 14817C107   4,431,000 150,000 SH Put SOLE   150,000 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128   205,379,869 6,511,727 SH   SOLE   6,511,727 0 0
CINCOR PHARMA INC COM 17240Y109   31,663,034 2,576,325 SH   SOLE   2,576,325 0 0
CLOVER HEALTH INVESTMENTS CO COM CL A 18914F103   1,394,250 1,500,000 SH   SOLE   1,500,000 0 0
COGENT BIOSCIENCES INC COM 19240Q201   37,078,018 3,207,441 SH   SOLE   3,207,441 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   73,918,751 4,039,276 SH   SOLE   4,039,276 0 0
CYMABAY THERAPEUTICS INC COM 23257D103   4,445,386 708,993 SH   SOLE   708,993 0 0
CYTEK BIOSCIENCES INC COM 23285D109   13,166,142 1,289,534 SH   SOLE   1,289,534 0 0
DARIOHEALTH CORP COM NEW 23725P209   1,403,279 327,869 SH   SOLE   327,869 0 0
DICE THERAPEUTICS INC COM 23345J104   9,152,894 293,362 SH   SOLE   293,362 0 0
ENVVENO MEDICAL CORPORATION COM 29415J106   3,986,236 781,615 SH   SOLE   781,615 0 0
EQRX INC *W EXP 12/17/202 26886C115   67,050 250,000 SH   SOLE   250,000 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108   32,684,312 497,857 SH   SOLE   497,857 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104   22,690,400 411,804 SH   SOLE   411,804 0 0
HILLEVAX INC COM 43157M102   6,792,782 406,024 SH   SOLE   406,024 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101   109,248,000 960,000 SH   SOLE   960,000 0 0
IMMATICS N.V SHS N44445109   30,410,965 3,491,500 SH   SOLE   3,491,500 0 0
IMMUNOVANT INC COM 45258J102   2,662,500 150,000 SH   SOLE   150,000 0 0
INHIBRX INC COM 45720L107   81,651,613 3,313,783 SH   SOLE   3,313,783 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   10,614,000 40,000 SH   SOLE   40,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100   63,719,674 9,971,780 SH   SOLE   9,971,780 0 0
ISOPLEXIS CORP COM 465005106   6,348,021 4,095,498 SH   SOLE   4,095,498 0 0
IVERIC BIO INC COM 46583P102   12,576,234 587,400 SH   SOLE   587,400 0 0
KRONOS BIO INC COM 50107A104   2,839,446 1,752,745 SH   SOLE   1,752,745 0 0
LANDOS BIOPHARMA INC COM 515069102   7,434,957 14,869,915 SH   SOLE   14,869,915 0 0
LARIMAR THERAPEUTICS INC COM 517125100   11,811,800 2,860,000 SH   SOLE   2,860,000 0 0
LEAP THERAPEUTICS INC COM 52187K101   3,026,923 6,726,496 SH   SOLE   6,726,496 0 0
LIANBIO SPONSORED ADS 53000N108   94,395,859 57,558,451 SH   SOLE   57,558,451 0 0
LYRA THERAPEUTICS INC COM 55234L105   28,720,732 9,146,730 SH   SOLE   9,146,730 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   212,443,263 731,932 SH   SOLE   731,932 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   87,075,000 300,000 SH Put SOLE   300,000 0 0
MEIRAGTX HLDGS PLC COM G59665102   45,375,686 6,963,277 SH   SOLE   6,963,277 0 0
MIRATI THERAPEUTICS INC COM 60468T105   99,293,467 2,191,425 SH   SOLE   2,191,425 0 0
MORPHIC HLDG INC COM 61775R105   9,715,520 363,197 SH   SOLE   363,197 0 0
MOTUS GI HLDGS INC COM NEW 62014P405   75,623 90,027 SH   SOLE   90,027 0 0
NANOBIOTIX SPONSORED ADS 63009J107   3,889,466 1,059,800 SH   SOLE   1,059,800 0 0
NATERA INC COM 632307104   5,222,100 130,000 SH   SOLE   130,000 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108   16,400,071 9,111,151 SH   SOLE   9,111,151 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   11,949,972 100,050 SH   SOLE   100,050 0 0
NEVRO CORP COM 64157F103   1,188,000 30,000 SH   SOLE   30,000 0 0
NUVALENT INC COM 670703107   67,154,108 2,255,007 SH   SOLE   2,255,007 0 0
OUTSET MED INC COM 690145107   28,129,005 1,089,427 SH   SOLE   1,089,427 0 0
PEAR THERAPEUTICS INC CLASS A COM 704723105   1,062,646 900,548 SH   SOLE   900,548 0 0
PENUMBRA INC COM 70975L107   5,650,484 25,400 SH   SOLE   25,400 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109   3,645,000 500,000 SH   SOLE   500,000 0 0
PRIVIA HEALTH GROUP INC COM 74276R102   2,043,900 90,000 SH   SOLE   90,000 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105   2,680,867 64,537 SH   SOLE   64,537 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108   133,396,340 1,212,694 SH   SOLE   1,212,694 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107   777,337 290,051 SH   SOLE   290,051 0 0
PROTHENA CORP PLC SHS G72800108   14,318,172 237,646 SH   SOLE   237,646 0 0
RAIN ONCOLOGY INC COM 75082Q105   19,868,952 2,483,619 SH   SOLE   2,483,619 0 0
RAPT THERAPEUTICS INC COM 75382E109   35,619,309 1,798,955 SH   SOLE   1,798,955 0 0
RELAY THERAPEUTICS INC COM 75943R102   29,029,869 1,943,097 SH   SOLE   1,943,097 0 0
REVANCE THERAPEUTICS INC COM 761330109   13,459,131 729,097 SH   SOLE   729,097 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   21,100,452 1,078,204 SH   SOLE   1,078,204 0 0
ROIVANT SCIENCES LTD SHS G76279101   15,832,744 1,981,570 SH   SOLE   1,981,570 0 0
SAREPTA THERAPEUTICS INC COM 803607100   84,129,815 649,250 SH   SOLE   649,250 0 0
SCPHARMACEUTICALS INC COM 810648105   6,828,565 952,380 SH   SOLE   952,380 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100   6,597,373 3,282,275 SH   SOLE   3,282,275 0 0
SOLID BIOSCIENCES INC COM NEW 83422E204   18,808,120 3,495,933 SH   SOLE   3,495,933 0 0
SOMALOGIC INC CLASS A COM 83444K105   3,765,000 1,500,000 SH   SOLE   1,500,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   68,086,143 2,617,691 SH   SOLE   2,617,691 0 0
SURROZEN INC *W EXP 08/01/203 86889P117   9,183 166,666 SH   SOLE   166,666 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103   19,005,459 1,296,416 SH   SOLE   1,296,416 0 0
TRAVERE THERAPEUTICS INC COM 89422G107   1,908,430 90,748 SH   SOLE   90,748 0 0
TREACE MEDICAL CONCEPTS INC COM 89455T109   44,747,805 1,946,403 SH   SOLE   1,946,403 0 0
TYRA BIOSCIENCES INC COM 90240B106   3,757,463 494,403 SH   SOLE   494,403 0 0
VAXCYTE INC COM 92243G108   56,101,500 1,170,000 SH   SOLE   1,170,000 0 0
VBI VACCINES INC CDA COM NEW 91822J103   20,410,650 52,335,002 SH   SOLE   52,335,002 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   127,533,187 4,880,719 SH   SOLE   4,880,719 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108   13,857,203 5,038,983 SH   SOLE   5,038,983 0 0
VERU INC COM 92536C103   41,490,298 7,858,011 SH   SOLE   7,858,011 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   35,652,996 1,220,575 SH   SOLE   1,220,575 0 0
XENON PHARMACEUTICALS INC COM 98420N105   75,755,794 1,921,273 SH   SOLE   1,921,273 0 0
ZYMEWORKS DEL INC COM 98985Y108   35,458,621 4,511,275 SH   SOLE   4,511,275 0 0