The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109   16,161,000 100,000 SH Call DFND   0 100,000 0
ABBVIE INC COM 00287Y109   53,225,284 329,344 SH   DFND   0 329,344 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   7,071,525 4,843,510 SH   DFND   0 4,843,510 0
AGILENT TECHNOLOGIES INC COM 00846U101   27,461,374 183,504 SH   DFND   0 183,504 0
APELLIS PHARMACEUTICALS INC COM 03753U106   16,465,602 318,422 SH   DFND   0 318,422 0
ARCELLX INC COMMON STOCK 03940C100   19,099,635 616,515 SH   DFND   0 616,515 0
ARCUS BIOSCIENCES INC COM 03969F109   55,903,975 2,703,287 SH   DFND   0 2,703,287 0
ARGENX SE SPONSORED ADR 04016X101   39,675,624 104,732 SH   DFND   0 104,732 0
ASTRAZENECA PLC SPONSORED ADR 046353108   39,107,040 576,800 SH   DFND   0 576,800 0
AVANTOR INC COM 05352A100   33,904,537 1,607,612 SH   DFND   0 1,607,612 0
AXSOME THERAPEUTICS INC COM 05464T104   23,061,870 299,000 SH Call DFND   0 299,000 0
AXSOME THERAPEUTICS INC COM 05464T104   84,290,055 1,092,831 SH   DFND   0 1,092,831 0
BELLUS HEALTH INC NEW COM NEW 07987C204   524,962 63,864 SH   DFND   0 63,864 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   24,824,478 2,162,411 SH   DFND   0 2,162,411 0
BIOGEN INC COM 09062X103   43,105,090 155,659 SH   DFND   0 155,659 0
BIOHAVEN LTD COM G1110E107   152,513 10,988 SH   DFND   0 10,988 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   25,148,070 243,000 SH Call DFND   0 243,000 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   32,123,399 310,401 SH   DFND   0 310,401 0
BIOMARIN PHARMACEUTICAL INC NOTE 0.599% 8/0 09061GAH4   38,201,058 35,910,000 PRN   DFND   0 35,910,000 0
BLUEBIRD BIO INC COM 09609G100   1,694,480 244,867 SH   DFND   0 244,867 0
BLUEPRINT MEDICINES CORP COM 09627Y109   5,711,334 130,366 SH   DFND   0 130,366 0
CARDINAL HEALTH INC COM 14149Y108   49,180,119 639,783 SH   DFND   0 639,783 0
CARIBOU BIOSCIENCES INC COM 142038108   28,007,437 4,459,783 SH   DFND   0 4,459,783 0
CELCUITY INC COM 15102K100   9,976,675 712,111 SH   DFND   0 712,111 0
CENTENE CORP DEL COM 15135B101   91,234,485 1,112,480 SH   DFND   0 1,112,480 0
CHARLES RIV LABS INTL INC COM 159864107   15,867,478 72,820 SH   DFND   0 72,820 0
CIGNA CORP NEW COM 125523100   46,818,342 141,300 SH   DFND   0 141,300 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101   4,092,289 509,625 SH   DFND   0 509,625 0
CYTOKINETICS INC COM NEW 23282W605   109,947,152 2,399,545 SH   DFND   0 2,399,545 0
DANAHER CORPORATION COM 235851102   46,631,640 175,690 SH   DFND   0 175,690 0
DEXCOM INC COM 252131107   15,340,057 135,465 SH   DFND   0 135,465 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201   40,489,137 3,805,370 SH   DFND   0 3,805,370 0
EDITAS MEDICINE INC COM 28106W103   13,009,913 1,466,732 SH   DFND   0 1,466,732 0
EDWARDS LIFESCIENCES CORP COM 28176E108   39,545,538 530,030 SH   DFND   0 530,030 0
ELEVANCE HEALTH INC COM 036752103   34,427,982 67,115 SH   DFND   0 67,115 0
ERASCA INC COM 29479A108   20,677,053 4,797,460 SH   DFND   0 4,797,460 0
ESSA PHARMA INC COM NEW 29668H708   9,687,717 3,844,332 SH   DFND   0 3,844,332 0
GENERATION BIO CO COM 37148K100   11,409,545 2,903,192 SH   DFND   0 2,903,192 0
HCA HEALTHCARE INC COM 40412C101   22,063,122 91,945 SH   DFND   0 91,945 0
HORIZON THERAPEUTICS PUB L SHS G46188101   124,251,392 1,091,840 SH   DFND   0 1,091,840 0
HUMANA INC COM 444859102   85,057,345 166,066 SH   DFND   0 166,066 0
ICON PLC SHS G4705A100   15,875,081 81,725 SH   DFND   0 81,725 0
INTUITIVE SURGICAL INC COM NEW 46120E602   30,369,308 114,450 SH   DFND   0 114,450 0
IO BIOTECH INC COM 449778109   1,167,572 507,640 SH   DFND   0 507,640 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100   85,223 13,337 SH   DFND   0 13,337 0
IQVIA HLDGS INC COM 46266C105   46,936,406 229,081 SH   DFND   0 229,081 0
IRHYTHM TECHNOLOGIES INC COM 450056106   46,246,846 493,721 SH   DFND   0 493,721 0
ITEOS THERAPEUTICS INC COM 46565G104   1,385,107 70,922 SH   DFND   0 70,922 0
IVERIC BIO INC COM 46583P102   19,644,895 917,557 SH   DFND   0 917,557 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105   20,471,335 128,500 SH Put DFND   0 128,500 0
JOHNSON & JOHNSON COM 478160104   24,332,831 137,746 SH   DFND   0 137,746 0
JOHNSON & JOHNSON COM 478160104   79,492,500 450,000 SH Put DFND   0 450,000 0
JOUNCE THERAPEUTICS INC COM 481116101   383,978 345,926 SH   DFND   0 345,926 0
KARUNA THERAPEUTICS INC COM 48576A100   25,602,575 130,293 SH   DFND   0 130,293 0
KEROS THERAPEUTICS INC COM 492327101   768,272 15,999 SH   DFND   0 15,999 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409   52,983,000 225,000 SH Call DFND   0 225,000 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409   3,193,344 13,561 SH   DFND   0 13,561 0
LILLY ELI & CO COM 532457108   109,255,555 298,643 SH   DFND   0 298,643 0
MCKESSON CORP COM 58155Q103   39,691,822 105,811 SH   DFND   0 105,811 0
MERCK & CO INC COM 58933Y105   96,692,925 871,500 SH Call DFND   0 871,500 0
MERCK & CO INC COM 58933Y105   40,788,992 367,634 SH   DFND   0 367,634 0
MOLINA HEALTHCARE INC COM 60855R100   47,478,701 143,779 SH   DFND   0 143,779 0
NEVRO CORP NOTE 2.750% 4/0 64157FAC7   16,056,250 17,500,000 PRN   DFND   0 17,500,000 0
OAK STR HEALTH INC COM 67181A107   12,158,291 565,239 SH   DFND   0 565,239 0
OAK STR HEALTH INC NOTE 3/1 67181AAB3   48,002,100 63,000,000 PRN   DFND   0 63,000,000 0
PENUMBRA INC COM 70975L107   52,834,250 237,500 SH Call DFND   0 237,500 0
PENUMBRA INC COM 70975L107   80,092,274 360,030 SH   DFND   0 360,030 0
PMV PHARMACEUTICALS INC COM 69353Y103   2,903,329 333,716 SH   DFND   0 333,716 0
POINT BIOPHARMA GLOBAL INC COM 730541109   33,780,417 4,633,802 SH   DFND   0 4,633,802 0
PRAXIS PRECISION MEDICINES I COM 74006W108   6,610,371 2,777,467 SH   DFND   0 2,777,467 0
PROCEPT BIOROBOTICS CORP COM 74276L105   21,498,030 517,526 SH   DFND   0 517,526 0
PROTHENA CORP PLC SHS G72800108   9,176,075 152,300 SH Call DFND   0 152,300 0
PROTHENA CORP PLC SHS G72800108   52,746,706 875,464 SH   DFND   0 875,464 0
PULMONX CORP COM 745848101   12,272,141 1,455,770 SH   DFND   0 1,455,770 0
SANA BIOTECHNOLOGY INC COM 799566104   247,965 62,776 SH   DFND   0 62,776 0
SEAGEN INC COM 81181C104   24,723,268 192,384 SH   DFND   0 192,384 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   46,182,435 1,814,634 SH   DFND   0 1,814,634 0
TENET HEALTHCARE CORP COM NEW 88033G407   11,021,661 225,900 SH Call DFND   0 225,900 0
TENET HEALTHCARE CORP COM NEW 88033G407   12,418,275 254,525 SH   DFND   0 254,525 0
THERMO FISHER SCIENTIFIC INC COM 883556102   34,221,529 62,143 SH   DFND   0 62,143 0
UNIQURE NV SHS N90064101   52,193,458 2,302,314 SH   DFND   0 2,302,314 0
UNITEDHEALTH GROUP INC COM 91324P102   36,900,528 69,600 SH Call DFND   0 69,600 0
UNITEDHEALTH GROUP INC COM 91324P102   61,536,402 116,067 SH   DFND   0 116,067 0
UNIVERSAL HLTH SVCS INC CL B 913903100   17,529,675 124,421 SH   DFND   0 124,421 0
VECTIVBIO HLDG AG ORD SHS H9060V101   221,313 25,541 SH   DFND   0 25,541 0
VERVE THERAPEUTICS INC COM 92539P101   4,204,794 217,302 SH   DFND   0 217,302 0
WATERS CORP COM 941848103   32,416,290 94,624 SH   DFND   0 94,624 0
WEREWOLF THERAPEUTICS INC COM 95075A107   2,651,251 1,293,293 SH   DFND   0 1,293,293 0
XENON PHARMACEUTICALS INC COM 98420N105   689,552 17,488 SH   DFND   0 17,488 0