The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | |||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | ||||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | (to the nearest dollar) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 16,053,692 | 1,019,282 | SH | DFND | 1,2 | 0 | 1,019,282 | 0 | ||
| ACUMEN PHARMACEUTICALS INC | COM | 00509G209 | 6,029,537 | 1,116,581 | SH | DFND | 1,2 | 0 | 1,116,581 | 0 | ||
| AEROVATE THERAPEUTICS INC | COM | 008064107 | 11,090,695 | 378,522 | SH | DFND | 1,2 | 0 | 378,522 | 0 | ||
| ALBIREO PHARMA INC | COM | 01345P106 | 5,775,986 | 267,283 | SH | DFND | 1,2 | 0 | 267,283 | 0 | ||
| ALKERMES PLC | SHS | G01767105 | 1,206,814 | 46,185 | SH | DFND | 1,2 | 0 | 46,185 | 0 | ||
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 26,737,227 | 3,637,718 | SH | DFND | 1,2 | 0 | 3,637,718 | 0 | ||
| AMYLYX PHARMACEUTICALS INC | COM | 03237H101 | 7,020,500 | 190,000 | SH | DFND | 1,2 | 0 | 190,000 | 0 | ||
| ANAPTYSBIO INC | COM | 032724106 | 464,850 | 15,000 | SH | DFND | 1,2 | 0 | 15,000 | 0 | ||
| CINCOR PHARMA INC | COM | 17240Y109 | 12,525,390 | 1,019,153 | SH | DFND | 1,2 | 0 | 1,019,153 | 0 | ||
| CYMABAY THERAPEUTICS INC | COM | 23257D103 | 9,718,500 | 1,550,000 | SH | DFND | 1,2 | 0 | 1,550,000 | 0 | ||
| DAY ONE BIOPHARMACEUTICALS I | COM | 23954D109 | 11,716,586 | 544,451 | SH | DFND | 1,2 | 0 | 544,451 | 0 | ||
| ERASCA INC | COM | 29479A108 | 6,630,767 | 1,538,461 | SH | DFND | 1,2 | 0 | 1,538,461 | 0 | ||
| EVOLUS INC | COM | 30052C107 | 1,429,371 | 190,329 | SH | DFND | 1,2 | 0 | 190,329 | 0 | ||
| GENERATION BIO CO | COM | 37148K100 | 4,018,570 | 1,022,537 | SH | DFND | 1,2 | 0 | 1,022,537 | 0 | ||
| GRACELL BIOTECHNOLOGIES INC | SPONSORED ADS | 38406L103 | 4,513,518 | 1,962,399 | SH | DFND | 1,2 | 0 | 1,962,399 | 0 | ||
| HERON THERAPEUTICS INC | COM | 427746102 | 15,900,403 | 6,360,161 | SH | DFND | 1,2 | 0 | 6,360,161 | 0 | ||
| IMMUNIC INC | COM | 4525EP101 | 885,058 | 632,184 | SH | DFND | 1,2 | 0 | 632,184 | 0 | ||
| INTERCEPT PHARMACEUTICALS IN | COM | 45845P108 | 6,541,875 | 528,850 | SH | DFND | 1,2 | 0 | 528,850 | 0 | ||
| IVERIC BIO INC | COM | 46583P102 | 17,663,250 | 825,000 | SH | DFND | 1,2 | 0 | 825,000 | 0 | ||
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 25,489,600 | 160,000 | SH | DFND | 1,2 | 0 | 160,000 | 0 | ||
| KALVISTA PHARMACEUTICALS INC | COM | 483497103 | 7,137,215 | 1,055,801 | SH | DFND | 1,2 | 0 | 1,055,801 | 0 | ||
| LARIMAR THERAPEUTICS INC | COM | 517125100 | 5,260,113 | 1,273,635 | SH | DFND | 1,2 | 0 | 1,273,635 | 0 | ||
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 6,026,230 | 133,000 | SH | DFND | 1,2 | 0 | 133,000 | 0 | ||
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 6,746,943 | 642,566 | SH | DFND | 1,2 | 0 | 642,566 | 0 | ||
| NOVOCURE LTD | ORD SHS | G6674U108 | 17,677,350 | 241,000 | SH | Put | DFND | 1,2 | 0 | 241,000 | 0 | |
| OPTINOSE INC | COM | 68404V100 | 14,605,262 | 7,894,736 | SH | DFND | 1,2 | 0 | 7,894,736 | 0 | ||
| PLIANT THERAPEUTICS INC | COM | 729139105 | 25,571,077 | 1,322,870 | SH | DFND | 1,2 | 0 | 1,322,870 | 0 | ||
| POINT BIOPHARMA GLOBAL INC | COM | 730541109 | 18,529,569 | 2,541,779 | SH | DFND | 1,2 | 0 | 2,541,779 | 0 | ||
| PRECISION BIOSCIENCES INC | COM | 74019P108 | 4,523,553 | 3,801,305 | SH | DFND | 1,2 | 0 | 3,801,305 | 0 | ||
| PTC THERAPEUTICS INC | COM | 69366J200 | 11,532,493 | 302,135 | SH | DFND | 1,2 | 0 | 302,135 | 0 | ||
| RAPT THERAPEUTICS INC | COM | 75382E109 | 28,444,066 | 1,436,569 | SH | DFND | 1,2 | 0 | 1,436,569 | 0 | ||
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 8,826,070 | 451,000 | SH | Call | DFND | 1,2 | 0 | 451,000 | 0 | |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 9,459,340 | 73,000 | SH | DFND | 1,2 | 0 | 73,000 | 0 | ||
| SEAGEN INC | COM | 81181C104 | 20,625,855 | 160,500 | SH | DFND | 1,2 | 0 | 160,500 | 0 | ||
| TRAVERE THERAPEUTICS INC | COM | 89422G107 | 9,989,250 | 475,000 | SH | DFND | 1,2 | 0 | 475,000 | 0 | ||
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 15,858,759 | 342,300 | SH | DFND | 1,2 | 0 | 342,300 | 0 | ||
| UROGEN PHARMA LTD | COM | M96088105 | 4,967,200 | 560,000 | SH | DFND | 1,2 | 0 | 560,000 | 0 | ||
| VAXCYTE INC | COM | 92243G108 | 38,360,000 | 800,000 | SH | DFND | 1,2 | 0 | 800,000 | 0 | ||
| VENTYX BIOSCIENCES INC | COM | 92332V107 | 13,138,789 | 400,695 | SH | DFND | 1,2 | 0 | 400,695 | 0 | ||
| VERVE THERAPEUTICS INC | COM | 92539P101 | 5,805,000 | 300,000 | SH | DFND | 1,2 | 0 | 300,000 | 0 | ||
| VIKING THERAPEUTICS INC | COM | 92686J106 | 12,173,320 | 1,295,034 | SH | DFND | 1,2 | 0 | 1,295,034 | 0 | ||
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 33,515,500 | 850,000 | SH | DFND | 1,2 | 0 | 850,000 | 0 | ||