The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109   31,797,252 872,592 SH   SOLE 1,2,3 872,592 0 0
908 DEVICES INC COM 65443P102   2,377,440 312,000 SH   SOLE 1,2,3 312,000 0 0
AADI BIOSCIENCE INC COM 00032Q104   9,811,114 764,701 SH   SOLE 1,2,3 764,701 0 0
ACADIA PHARMACEUTICALS INC COM 004225108   58,441,333 3,670,938 SH   SOLE 1,2,3 3,670,938 0 0
ADICET BIO INC COM 007002108   37,918,760 4,241,472 SH   SOLE 1,2,3 4,241,472 0 0
AKOYA BIOSCIENCES INC COM 00974H104   4,630,110 483,815 SH   SOLE 1,2,3 483,815 0 0
ALLAKOS INC COM 01671P100   13,838,270 1,643,500 SH   SOLE 1,2,3 1,643,500 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   400,050,979 1,683,362 SH   SOLE 1,2,3 1,683,362 0 0
APYX MEDICAL CORPORATION COM 03837C106   7,951,973 3,398,279 SH   SOLE 1,2,3 3,398,279 0 0
ARGENX SE SPONSORED ADR 04016X101   182,669,932 482,195 SH   SOLE 1,2,3 482,195 0 0
ARYA SCIENCES ACQU CORP IV CL A G31659108   5,050,000 500,000 SH   SOLE 1,2,3 500,000 0 0
ARYA SCIENCES ACQUISITN CORP CLASS A ORD SHS G31658100   5,045,000 500,000 SH   SOLE 1,2,3 500,000 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104   41,112,283 5,741,939 SH   SOLE 1,2,3 5,741,939 0 0
AVIDITY BIOSCIENCES INC COM 05370A108   124,387,510 5,605,566 SH   SOLE 1,2,3 5,605,566 0 0
AXONICS INC COM 05465P101   55,337,424 884,974 SH   SOLE 1,2,3 884,974 0 0
AXSOME THERAPEUTICS INC COM 05464T104   229,884,577 2,980,482 SH   SOLE 1,2,3 2,980,482 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   37,254,175 1,258,587 SH   SOLE 1,2,3 1,258,587 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106   3,957,881 1,602,381 SH   SOLE 1,2,3 1,602,381 0 0
C4 THERAPEUTICS INC COM STK 12529R107   16,634,885 2,819,472 SH   SOLE 1,2,3 2,819,472 0 0
CASTLE BIOSCIENCES INC COM 14843C105   12,170,062 516,995 SH   SOLE 1,2,3 516,995 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   137,463,463 3,084,215 SH   SOLE 1,2,3 3,084,215 0 0
CINCOR PHARMA INC COM 17240Y109   17,079,474 1,389,705 SH   SOLE 1,2,3 1,389,705 0 0
CUTERA INC COM 232109108   79,537,409 1,798,675 SH   SOLE 1,2,3 1,798,675 0 0
CYTOKINETICS INC COM NEW 23282W605   117,949,752 2,574,198 SH   SOLE 1,2,3 2,574,198 0 0
DERMTECH INC COM 24984K105   4,811,490 2,718,356 SH   SOLE 1,2,3 2,718,356 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108   155,862,160 2,374,138 SH   SOLE 1,2,3 2,374,138 0 0
EXAGEN INC COM 30068X103   3,274,406 1,364,336 SH   SOLE 1,2,3 1,364,336 0 0
FULCRUM THERAPEUTICS INC COM 359616109   36,351,071 4,993,279 SH   SOLE 1,2,3 4,993,279 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106   21,082,262 2,168,957 SH   SOLE 1,2,3 2,168,957 0 0
GLOBUS MED INC CL A 379577208   55,530,565 747,685 SH   SOLE 1,2,3 747,685 0 0
GUARDANT HEALTH INC COM 40131M109   11,720,126 430,887 SH   SOLE 1,2,3 430,887 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109   9,980,000 1,000,000 SH   SOLE 1,2 1,000,000 0 0
ILLUMINA INC COM 452327109   114,116,625 564,375 SH   SOLE 1,2,3 564,375 0 0
IMMATICS N.V SHS N44445109   7,359,950 845,000 SH   SOLE 1,2,3 845,000 0 0
IMMUNIC INC COM 4525EP101   5,405,806 3,861,290 SH   SOLE 1,2,3 3,861,290 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105   317,270,507 5,559,322 SH   SOLE 1,2,3 5,559,322 0 0
IVERIC BIO INC COM 46583P102   17,583,776 821,288 SH   SOLE 1,2,3 821,288 0 0
JOHNSON & JOHNSON COM 478160104   3,202,135 18,127 SH   SOLE 1,2,3 18,127 0 0
JOUNCE THERAPEUTICS INC COM 481116101   5,668,039 5,106,341 SH   SOLE 1,2,3 5,106,341 0 0
MASIMO CORP COM 574795100   222,145,889 1,501,493 SH   SOLE 1,2,3 1,501,493 0 0
MEDICUS SCIENCES ACQUISITION *W EXP 02/12/202 G5960S124   3,000 33,331 SH   SOLE 1,2,3 33,331 0 0
MEDICUS SCIENCES ACQUISITION CL A SHS G5960S108   3,021,000 300,000 SH   SOLE 1,2,3 300,000 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107   17,087,804 4,315,102 SH   SOLE 1,2,3 4,315,102 0 0
MIRATI THERAPEUTICS INC COM 60468T105   165,069,495 3,643,114 SH   SOLE 1,2,3 3,643,114 0 0
MIROMATRIX MED INC COM 60471P108   837,200 280,000 SH   SOLE 1,2,3 280,000 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102   9,242,893 1,214,572 SH   SOLE 1,2,3 1,214,572 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104   5,250,000 500,000 SH   SOLE 1,2,3 500,000 0 0
NATERA INC COM 632307104   104,814,898 2,609,283 SH   SOLE 1,2,3 2,609,283 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108   1,080,000 600,000 SH   SOLE 1,2,3 600,000 0 0
NYXOAH S A SHS B6S7WD106   1,347,265 269,993 SH   SOLE 1,2,3 269,993 0 0
OLINK HLDG AB SPONSORED ADS 680710100   24,921,079 981,918 SH   SOLE 1,2,3 981,918 0 0
OUTSET MED INC COM 690145107   23,487,215 909,652 SH   SOLE 1,2,3 909,652 0 0
OYSTER PT PHARMA INC COM 69242L106   25,746,593 2,304,977 SH   SOLE 1,2,3 2,304,977 0 0
PENUMBRA INC COM 70975L107   155,359,613 698,371 SH   SOLE 1,2,3 698,371 0 0
PMV PHARMACEUTICALS INC COM 69353Y103   37,905,204 4,356,920 SH   SOLE 1,2,3 4,356,920 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108   368,973,330 3,354,303 SH   SOLE 1,2,3 3,354,303 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   39,188,567 3,591,986 SH   SOLE 1,2,3 3,591,986 0 0
PTC THERAPEUTICS INC COM 69366J200   214,339,322 5,615,387 SH   SOLE 1,2,3 5,615,387 0 0
PULMONX CORP COM 745848101   2,318,250 275,000 SH   SOLE 1,2,3 275,000 0 0
REGENXBIO INC COM 75901B107   41,852,901 1,845,366 SH   SOLE 1,2,3 1,845,366 0 0
RELMADA THERAPEUTICS INC COM 75955J402   7,216,706 2,067,824 SH   SOLE 1,2,3 2,067,824 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   346,149,698 17,687,772 SH   SOLE 1,2,3 17,687,772 0 0
ROIVANT SCIENCES LTD SHS G76279101   6,413,709 802,717 SH   SOLE 1,2,3 802,717 0 0
SCIENCE 37 HOLDINGS INC COM 808644108   1,073,752 2,586,108 SH   SOLE 1,2,3 2,586,108 0 0
SIGHT SCIENCES INC COM 82657M105   8,123,594 665,323 SH   SOLE 1,2,3 665,323 0 0
STOKE THERAPEUTICS INC COM 86150R107   35,729,155 3,870,981 SH   SOLE 1,2,3 3,870,981 0 0
SUMMIT HEALTHCRE ACQUISTN CO UNIT 06/03/2026 G8566R128   5,060,000 500,000 SH   SOLE 1,2,3 500,000 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103   37,355,513 2,548,125 SH   SOLE 1,2,3 2,548,125 0 0
TELA BIO INC COM 872381108   4,489,186 390,364 SH   SOLE 1,2,3 390,364 0 0
TENAYA THERAPEUTICS INC COM 87990A106   4,942,088 2,458,750 SH   SOLE 1,2,3 2,458,750 0 0
TERNS PHARMACEUTICALS INC COM 880881107   10,180,000 1,000,000 SH   SOLE 1,2,3 1,000,000 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102   239,825,495 435,500 SH   SOLE 1,2,3 435,500 0 0
THIRD HARMONIC BIO INC COM 88427A107   2,621,654 609,687 SH   SOLE 1,2,3 609,687 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   183,787,172 3,966,915 SH   SOLE 1,2,3 3,966,915 0 0
UROGEN PHARMA LTD COM M96088105   7,605,706 857,464 SH   SOLE 1,2,3 857,464 0 0
VENTYX BIOSCIENCES INC COM 92332V107   50,882,801 1,551,778 SH   SOLE 1,2,3 1,551,778 0 0
VERICEL CORP COM 92346J108   81,651,471 3,099,904 SH   SOLE 1,2,3 3,099,904 0 0