The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
23ANDME HOLDING CO CLASS A COM 90138Q108   1,428 661,009 SH   DFND 1,2,3,4,5,6 661,009 0 0
89BIO INC COM 282559103   5,092 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
AC IMMUNE SA SHS H00263105   2,040 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102   2,030 2,255,375 SH   DFND 1,2,3,4,5,6 2,255,375 0 0
ADAGENE INC ADS 005329107   1,325 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AGENUS INC COM NEW 00847G705   34,800 14,500,000 SH   DFND 1,2,3,4,5,6 14,500,000 0 0
ALLOVIR INC COM 019818103   28,611 5,577,167 SH   DFND 1,2,3,4,5,6 5,577,167 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100   8,769 1,193,030 SH   DFND 1,2,3,4,5,6 1,193,030 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105   5,635 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
AMBRX BIOPHARMA INC SPONSORED ADS 02290A102   4,886 2,152,291 SH   DFND 1,2,3,4,5,6 2,152,291 0 0
AMICUS THERAPEUTICS INC COM 03152W109   48,840 4,000,000 SH   DFND 1,2,3,4,5,6 4,000,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   46,539 900,000 SH   DFND 1,2,3,4,5,6 900,000 0 0
APPLIED THERAPEUTICS INC COM 03828A101   304 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
APTINYX INC COM 03836N103   1,745 6,116,493 SH   DFND 1,2,3,4,5,6 6,116,493 0 0
ARAVIVE INC COM 03890D108   6,036 4,572,515 SH   DFND 1,2,3,4,5,6 4,572,515 0 0
AURA BIOSCIENCES INC COM 05153U107   4,305 410,000 SH   DFND 1,2,3,4,5,6 410,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102   4,320 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108   11,095 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102   131,964 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102   21,994 100,000 SH Call DFND 1,2,3,4,5,6 100,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204   30,414 3,700,000 SH   DFND 1,2,3,4,5,6 3,700,000 0 0
BIOHAVEN LTD COM G1110E107   6,940 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105   2,964 1,646,517 SH   DFND 1,2,3,4,5,6 1,646,517 0 0
BRIDGEBIO PHARMA INC COM 10806X102   1,905 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
CARDIFF ONCOLOGY INC COM 14147L108   1,050 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
CARIBOU BIOSCIENCES INC COM 142038108   662 105,347 SH   DFND 1,2,3,4,5,6 105,347 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128   59,926 1,900,000 SH   DFND 1,2,3,4,5,6 1,900,000 0 0
CIDARA THERAPEUTICS INC COM 171757107   170 224,675 SH   DFND 1,2,3,4,5,6 224,675 0 0
CODIAK BIOSCIENCES INC COM 192010106   80 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
CONTRAFECT CORP COM NEW 212326300   144 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
CORVUS PHARMACEUTICALS INC COM 221015100   425 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
CULLINAN ONCOLOGY INC COM 230031106   2,638 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
CURIS INC COM NEW 231269200   715 1,300,000 SH   DFND 1,2,3,4,5,6 1,300,000 0 0
CYCLERION THERAPEUTICS INC COM 23255M105   1,816 2,768,069 SH   DFND 1,2,3,4,5,6 2,768,069 0 0
CYCLERION THERAPEUTICS INC COM 23255M105   7 11,053 SH   DFND 1,2,3,4 11,053 0 0
CYTOKINETICS INC COM NEW 23282W605   45,820 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
DENALI THERAPEUTICS INC COM 24823R105   22,248 800,000 SH   DFND 1,2,3,4,5,6 800,000 0 0
DYNE THERAPEUTICS INC COM 26818M108   6,085 525,000 SH   DFND 1,2,3,4,5,6 525,000 0 0
EQRX INC COM 26886C107   4,920 2,000,000 SH   DFND 1,2,3,4,5,6 2,000,000 0 0
ERASCA INC COM 29479A108   20,303 4,710,682 SH   DFND 1,2,3,4,5,6 4,710,682 0 0
EVOTEC AG SPONSORED ADS 30050E105   9,299 1,149,425 SH   DFND 1,2,3,4,5,6 1,149,425 0 0
EXSCIENTIA PLC ADS 30223G102   2,932 550,000 SH   DFND 1,2,3,4,5,6 550,000 0 0
FATE THERAPEUTICS INC COM 31189P102   26,234 2,600,000 SH   DFND 1,2,3,4,5,6 2,600,000 0 0
FOGHORN THERAPEUTICS INC COM 344174107   10,978 1,720,720 SH   DFND 1,2,3,4,5,6 1,720,720 0 0
FUSION PHARMACEUTICALS INC COM 36118A100   2,363 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
GENERATION BIO CO COM 37148K100   11,060 2,814,191 SH   DFND 1,2,3,4,5,6 2,814,191 0 0
GOSSAMER BIO INC COM 38341P102   7,045 3,246,624 SH   DFND 1,2,3,4,5,6 3,246,624 0 0
GRAPHITE BIO INC COM 38870X104   2,324 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
GRITSTONE BIO INC COM 39868T105   6,404 1,856,194 SH   DFND 1,2,3,4,5,6 1,856,194 0 0
HARPOON THERAPEUTICS INC COM 41358P106   726 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
HIPPO HLDGS INC COM NEW 433539202   326 24,000 SH   DFND 1,2,3,4,5,6 24,000 0 0
HOOKIPA PHARMA INC COM 43906K100   1,498 1,849,616 SH   DFND 1,2,3,4,5,6 1,849,616 0 0
I MAB SPONSORED ADS 44975P103   3,553 850,000 SH   DFND 1,2,3,4,5,6 850,000 0 0
IGM BIOSCIENCES INC COM 449585108   41,675 2,450,000 SH   DFND 1,2,3,4,5,6 2,450,000 0 0
IGM BIOSCIENCES INC COM 449585108   851 50,000 SH Call DFND 1,2,3,4,5,6 50,000 0 0
IKENA ONCOLOGY INC COM 45175G108   4,122 1,549,513 SH   DFND 1,2,3,4,5,6 1,549,513 0 0
IMMUNIC INC COM 4525EP101   1,785 1,274,713 SH   DFND 1,2,3,4,5,6 1,274,713 0 0
IMMUTEP LTD SPONSORED ADS 45257L108   1,750 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
INSMED INC COM PAR $0.01 457669307   9,990 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
INSTIL BIO INC COM 45783C101   284 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105   9,595 275,000 SH   DFND 1,2,3,4,5,6 275,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108   1,369 110,532 SH   DFND 1,2,3,4 110,532 0 0
ITEOS THERAPEUTICS INC COM 46565G104   7,812 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
IVERIC BIO INC COM 46583P102   21,410 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
KARUNA THERAPEUTICS INC COM 48576A100   29,475 150,000 SH   DFND 1,2,3,4,5,6 150,000 0 0
KE HLDGS INC SPONSORED ADS 482497104   6,980 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
KE HLDGS INC SPONSORED ADS 482497104   11,168 800,000 SH Call DFND 1,2,3,4,5,6 800,000 0 0
KINETA INC COM 49461C102   197 31,055 SH   DFND 1,2,3,4,5,6 31,055 0 0
KINNATE BIOPHARMA INC COM 49705R105   763 125,000 SH   DFND 1,2,3,4,5,6 125,000 0 0
KRONOS BIO INC COM 50107A104   2,500 1,542,954 SH   DFND 1,2,3,4,5,6 1,542,954 0 0
KRYSTAL BIOTECH INC COM 501147102   31,688 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
KURA ONCOLOGY INC COM 50127T109   21,097 1,700,000 SH   DFND 1,2,3,4,5,6 1,700,000 0 0
KYMERA THERAPEUTICS INC COM 501575104   49,920 2,000,000 SH   DFND 1,2,3,4,5,6 2,000,000 0 0
LAVA THERAPEUTICS NV SHS N51517105   700 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
LEAP THERAPEUTICS INC COM 52187K101   1,800 4,000,000 SH   DFND 1,2,3,4,5,6 4,000,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302   6,716 3,516,214 SH   DFND 1,2,3,4,5,6 3,516,214 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302   164,760 86,262,020 SH   DFND 1,2,3,4 67,662,150 0 0
LYELL IMMUNOPHARMA INC COM 55083R104   2,429 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
MEI PHARMA INC COM NEW 55279B202   244 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
MEREO BIOPHARMA GROUP PLC SPONSORED ADS 589492107   1,125 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
MERSANA THERAPEUTICS INC COM 59045L106   12,892 2,200,000 SH   DFND 1,2,3,4,5,6 2,200,000 0 0
METACRINE INC COM 59101E103   414 924,898 SH   DFND 1,2,3,4,5,6 924,898 0 0
MINK THERAPEUTICS INC COM 603693102   756 289,588 SH   DFND 1,2,3,4,5,6 289,588 0 0
MIRATI THERAPEUTICS INC COM 60468T105   83,042 1,832,758 SH   DFND 1,2,3,4,5,6 1,832,758 0 0
MIRATI THERAPEUTICS INC COM 60468T105   22,655 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
MIRION TECHNOLOGIES INC COM CL A 60471A101   3,305 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
MORPHIC HLDG INC COM 61775R105   57,513 2,150,000 SH   DFND 1,2,3,4,5,6 2,150,000 0 0
NANOBIOTIX SPONSORED ADS 63009J107   3,670 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
NATERA INC COM 632307104   8,034 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
NEXIMMUNE INC COM 65344D109   292 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
OATLY GROUP AB SPONSORED ADS 67421J108   2,610 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106   638 260,500 SH   DFND 1,2,3,4,5,6 260,500 0 0
OMEGA THERAPEUTICS INC COM 68217N105   12,982 2,273,530 SH   DFND 1,2,3,4,5,6 2,273,530 0 0
ORCHARD THERAPEUTICS PLC SPONSORED ADS 68570P101   669 1,803,858 SH   DFND 1,2,3,4,5,6 1,803,858 0 0
ORIC PHARMACEUTICALS INC COM 68622P109   2,356 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
OVID THERAPEUTICS INC COM 690469101   4,650 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
PALO ALTO NETWORKS INC COM 697435105   279 2,000 SH   DFND 1,2,3,4,5,6 2,000 0 0
PORTAGE FINTECH ACQUISITN CO CLASS A ORD SHS G7185D106   3,819 380,000 SH   DFND 1,2,3,4,5,6 380,000 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108   2,856 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
RECURSION PHARMACEUTICALS IN CL A 75629V104   7,403 960,204 SH   DFND 1,2,3,4,5,6 960,204 0 0
RELAY THERAPEUTICS INC COM 75943R102   21,733 1,454,716 SH   DFND 1,2,3,4,5,6 1,454,716 0 0
REPARE THERAPEUTICS INC COM 760273102   10,297 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
REPLIMUNE GROUP INC COM 76029N106   19,040 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
REVOLUTION MEDICINES INC COM 76155X100   23,820 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
RUBIUS THERAPEUTICS INC COM 78116T103   357 2,042,666 SH   DFND 1,2,3,4,5,6 2,042,666 0 0
SAGE THERAPEUTICS INC COM 78667J108   28,605 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
SANA BIOTECHNOLOGY INC COM 799566104   1,580 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103   81,271 8,980,270 SH   DFND 1,2,3,4,5,6 8,980,270 0 0
SCHRODINGER INC COM 80810D103   13,083 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
SEA LTD SPONSORED ADS 81141R100   8,975 172,500 SH   DFND 1,2,3,4,5,6 172,500 0 0
SEER INC COM CL A 81578P106   27,550 4,750,000 SH   DFND 1,2,3,4,5,6 4,750,000 0 0
SELECTA BIOSCIENCES INC COM 816212104   5,518 4,883,200 SH   DFND 1,2,3,4,5,6 4,883,200 0 0
SENTI BIOSCIENCES INC COM 81726A100   78 55,555 SH   DFND 1,2,3,4,5,6 55,555 0 0
SOLID BIOSCIENCES INC COM NEW 83422E204   4,892 909,219 SH   DFND 1,2,3,4,5,6 909,219 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   52,020 2,000,000 SH   DFND 1,2,3,4,5,6 2,000,000 0 0
SQZ BIOTECHNOLOGIES CO COM 78472W104   1,189 1,606,309 SH   DFND 1,2,3,4,5,6 1,606,309 0 0
STOKE THERAPEUTICS INC COM 86150R107   2,308 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
SYROS PHARMACEUTICALS INC COM NEW 87184Q206   5,255 1,463,829 SH   DFND 1,2,3,4,5,6 1,463,829 0 0
TALARIS THERAPEUTICS INC COM 87410C104   2,106 2,064,262 SH   DFND 1,2,3,4,5,6 2,064,262 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106   3,256 1,440,882 SH   DFND 1,2,3,4,5,6 1,440,882 0 0
TCR2 THERAPEUTICS INC COM 87808K106   749 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
TESLA INC COM 88160R101   776 6,300 SH   DFND 1,2,3,4,5,6 6,300 0 0
TRAVERE THERAPEUTICS INC COM 89422G107   10,515 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
VERVE THERAPEUTICS INC COM 92539P101   5,805 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
VIGIL NEUROSCIENCE INC COM 92673K108   28,042 2,243,352 SH   DFND 1,2,3,4,5,6 2,243,352 0 0
VOR BIOPHARMA INC COM 929033108   19,123 2,875,581 SH   DFND 1,2,3,4,5,6 2,875,581 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105   21,000 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
WW INTL INC COM 98262P101   57,199 14,818,300 SH   DFND 1,2,3,4,6 14,818,300 0 0
XILIO THERAPEUTICS INC COM 98422T100   1,211 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
Y-MABS THERAPEUTICS INC COM 984241109   1,952 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
ZYMEWORKS INC COM 98985W102   3,537 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0