The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   4,439,135 481,677 SH   DFND   481,677 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   24,936,476 17,079,779 SH   DFND   17,079,779 0 0
ADDEX THERAPEUTICS LTD SPONSORED ADS 00654J107   113,418 1,080,000 SH   DFND   1,080,000 0 0
AFFIMED NV COM N01045108   5,488,845 4,426,488 SH   DFND   4,426,488 0 0
AIRSPAN NETWORKS HOLDINGS INC COM 00951K104   1,810,813 1,382,300 SH   DFND   1,382,300 0 0
AIRSPAN NETWORKS HOLDINGS INC *W EXP 08/13/2023 00951K146   212 69,928 SH   DFND   69,928 0 0
AIRSPAN NETWORKS HOLDINGS INC *W EXP 08/13/2023 00951K138   110 69,928 SH   DFND   69,928 0 0
AIRSPAN NETWORKS HOLDINGS INC *W EXP 08/13/2023 00951K120   61 69,928 SH   DFND   69,928 0 0
AKARI THERAPEUTICS PLC SPONSORED ADR 00972G108   212,473 452,167 SH   DFND   452,167 0 0
ALLAKOS INC COM 01671P100   51,759,929 6,147,260 SH   DFND   6,147,260 0 0
ARCELLX INC COMMON STOCK 03940C100   147,008,217 4,745,262 SH   DFND   4,745,262 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102   17,149,683 3,969,834 SH   DFND   3,969,834 0 0
BERKSHIRE GREY INC COM CL A 084656107   23,058,728 38,183,023 SH   DFND   38,183,023 0 0
BILL COM HLDGS INC COM 090043100   6,839,038 66,070 SH   DFND   66,070 0 0
BLACK DIAMOND THERAPEUTICS INC COM 09203E105   6,207,763 3,448,757 SH   DFND   3,448,757 0 0
BRIGHT HEALTH GROUP INC COM 10920V107   141,778,040 218,153,623 SH   DFND   218,153,623 0 0
BUZZFEED INC CLASS A COM 12430A102   10,574,252 15,333,892 SH   DFND   15,333,892 0 0
CELCUITY INC COM 15102K100   17,512,514 1,250,001 SH   DFND   1,250,001 0 0
CHAMPIONS ONCOLOGY INC COM NEW 15870P307   7,728,877 1,713,720 SH   DFND   1,713,720 0 0
CLOUDFLARE INC CL A COM 18915M107   84,715,538 1,873,823 SH   DFND   1,873,823 0 0
COURSERA INC COM 22266M104   187,715,707 15,867,769 SH   DFND   15,867,769 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108   64,546,265 1,587,854 SH   DFND   1,587,854 0 0
CTI BIOPHARMA CORP COM 12648L601   22,150,955 3,685,683 SH   DFND   3,685,683 0 0
CVRX INC COM 126638105   43,499,446 2,370,542 SH   DFND   2,370,542 0 0
DESKTOP METAL INC COM CL A 25058X105   19,582,541 14,398,927 SH   DFND   14,398,927 0 0
EARGO INC COM 270087109   2,599,114 4,520,198 SH   DFND   4,520,198 0 0
FISCALNOTE HOLDINGS INC COM CL A 337655104   9,652,558 1,694,323 SH   DFND   1,694,323 0 0
GERON CORP COM 374163103   39,491,208 16,318,681 SH   DFND   16,318,681 0 0
GLYCOMIMETICS INC COM 38000Q102   27,172,149 8,967,706 SH   DFND   8,967,706 0 0
GOSSAMER BIO INC COM 38341P102   7,524,271 3,467,406 SH   DFND   3,467,406 0 0
INOZYME PHARMA INC COM 45790W108   2,559,573 2,437,689 SH   DFND   2,437,689 0 0
INVENTIVA SA ADS 46124U107   7,004,324 1,462,586 SH   DFND   1,462,586 0 0
IONQ INC COM 46222L108   50,421,160 14,614,829 SH   DFND   14,614,829 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302   4,550,166 2,382,286 SH   DFND   2,382,286 0 0
MARKER THERAPEUTICS INC COM 57055L107   2,848,918 10,714,285 SH   DFND   10,714,285 0 0
MEI PHARMA INC COM NEW 55279B202   2,078,656 8,533,072 SH   DFND   8,533,072 0 0
MINERVA SURGICAL INC COM 60343F106   2,233,805 9,999,125 SH   DFND   9,999,125 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   81,631,739 4,186,243 SH   DFND   4,186,243 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102   58,538,388 7,692,298 SH   DFND   7,692,298 0 0
NEXTNAV INC COMMON STOCK 65345N106   23,994,227 8,189,156 SH   DFND   8,189,156 0 0
NKARTA INC COM 65487U108   21,376,998 3,568,781 SH   DFND   3,568,781 0 0
OBSEVA SA COM H5861P103   665,052 4,586,563 SH   DFND   4,586,563 0 0
OYSTER PT PHARMA INC COM 69242L106   66,185,456 5,925,287 SH   DFND   5,925,287 0 0
REGULUS THERAPEUTICS INC COM 75915K200   1,979,806 1,445,114 SH   DFND   1,445,114 0 0
RENEO PHARMACEUTICALS INC COM 75974E103   11,150,201 4,785,494 SH   DFND   4,785,494 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   142,977,919 4,909,956 SH   DFND   4,909,956 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107   2,693,662 2,992,958 SH   DFND   2,992,958 0 0
SAVARA INC COM 805111101   37,413,793 24,137,931 SH   DFND   24,137,931 0 0
SENTI BIOSCIENCES INC COM 81726A100   5,345,198 4,426,151 SH   DFND   4,426,151 0 0
SYNLOGIC INC COM 87166L100   3,213,994 4,228,940 SH   DFND   4,228,940 0 0
TREVI THERAPEUTICS INC COM 89532M101   21,950,226 11,373,174 SH   DFND   11,373,174 0 0
TUYA INC SPONSERED ADS 90114C107   9,425,162 4,934,640 SH   DFND   4,934,640 0 0
VERONA PHARMA PLC SPONSERED ADS 925050106   145,929,596 5,584,753 SH   DFND   5,584,753 0 0
WHEELS UP EXPERIENCE INC COM CL A 96328L106   1,093,097 1,061,259 SH   DFND   1,061,259 0 0
X4 PHARMACEUTICALS INC COM 98420X103   11,654,635 11,736,793 SH   DFND   11,736,793 0 0
XERIS BIOPHARMA HOLDINGS INC COM 98422E103   4,318,224 3,246,785 SH   DFND   3,246,785 0 0
ZEROFOX HLDGS INC COM 98955G103   80,983,075 18,068,513 SH   DFND   18,068,513 0 0