The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 7,238 254,134 SH   DFND 2 254,134 0 0
ABBOTT LABS COM 002824100 151,899 1,569,851 SH   DFND 2 1,569,851 0 0
ABBVIE INC COM 00287Y109 2,281 16,997 SH   DFND 2 16,997 0 0
ABIOMED INC COM 003654100 40,867 166,355 SH   DFND 2 166,355 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 71 906 SH   DFND 2 906 0 0
ACCOLADE INC COM 00437E102 33,536 2,936,638 SH   DFND 3 2,936,638 0 0
ACCOLADE INC COM 00437E102 7,254 635,232 SH   DFND 2 635,232 0 0
ADAPTIVE BIOTECHNOLOGIES COM 00650F109 23,351 3,279,620 SH   DFND 3 3,279,620 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 1,049 8,627 SH   DFND 2 8,627 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 113,991 4,030,792 SH   DFND 1,2 4,030,792 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 792 28,000 SH   DFND 2 28,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108 1,418 41,634 SH   DFND 2 41,634 0 0
ALIGN TECHNOLOGY INC COM 016255101 15,521 74,939 SH   DFND 2 74,939 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 184,147 920,000 SH   DFND 1,2 920,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 7,358 36,762 SH   DFND 2 36,762 0 0
ALPHABET INC CAP STK CL C 02079K107 577 6,000 SH   DFND 2 6,000 0 0
AMEDISYS INC COM 023436108 50,602 522,800 SH   DFND 3 522,800 0 0
AMEDISYS INC COM 023436108 7,369 76,134 SH   DFND 2 76,134 0 0
AMERICAN WELL CORP CL A 03044L105 6,353 1,769,703 SH   DFND 2 1,769,703 0 0
AMERISOURCEBERGEN CORP COM 03073E105 1,612 11,910 SH   DFND 2 11,910 0 0
AMGEN INC COM 031162100 10,187 45,196 SH   DFND 2 45,196 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 66,384 971,944 SH   DFND 3 971,944 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 2,425 35,500 SH   DFND 2 35,500 0 0
ARCUS BIOSCIENCES INC COM 03969F109 2,184 83,500 SH   DFND 2 83,500 0 0
ARGENX SE SPONSORED ADR 04016X101 322,168 892,503 SH   DFND 1,2 892,503 0 0
ARGENX SE SPONSORED ADR 04016X101 9,690 26,843 SH   DFND 2 26,843 0 0
ARVINAS INC COM 04335A105 95,049 2,136,412 SH   DFND 1,2 2,136,412 0 0
ARVINAS INC COM 04335A105 2,418 54,350 SH   DFND 2 54,350 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 2,457 44,400 SH   DFND 2 44,400 0 0
ATRICURE INC COM 04963C209 25,120 642,447 SH   DFND 3 642,447 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 21,405 2,846,457 SH   DFND 3 2,846,457 0 0
AVALARA INC COM 05338G106 119 1,300 SH   DFND 2 1,300 0 0
AVANTOR INC COM 05352A100 9,859 503,007 SH   DFND 2 503,007 0 0
AXONICS INC COM 05465P101 81,956 1,163,490 SH   DFND 3 1,163,490 0 0
AXONICS INC COM 05465P101 72,533 1,029,710 SH   DFND 2 1,029,710 0 0
AXSOME THERAPEUTICS INC COM 05464T104 22,155 496,524 SH   DFND 3 496,524 0 0
BAXTER INTL INC COM 071813109 17,211 319,548 SH   DFND 2 319,548 0 0
BEAM THERAPEUTICS INC COM 07373V105 27,065 568,121 SH   DFND 1,2 568,121 0 0
BEAM THERAPEUTICS INC COM 07373V105 172 3,600 SH   DFND 2 3,600 0 0
BECTON DICKINSON & CO COM 075887109 74,612 334,838 SH   DFND 2 334,838 0 0
BEIGENE LTD SPONSORED ADR 07725L102 940 7,000 SH   DFND 2 7,000 0 0
BERKELEY LTS INC COM 084310101 1,101 385,014 SH   DFND 2 385,014 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 2,282 98,100 SH   DFND 2 98,100 0 0
BIOGEN INC COM 09062X103 7,672 28,735 SH   DFND 2 28,735 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 4,535 53,493 SH   DFND 2 53,493 0 0
BIONTECH SE SPONSORED ADS 09075V102 20,715 153,580 SH   DFND 2 153,580 0 0
BIO RAD LABS INC CL A 090572207 42,472 101,818 SH   DFND 3 101,818 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 7,933 4,694,113 SH   DFND 1,2 4,694,113 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 39 23,000 SH   DFND 2 23,000 0 0
BOSTON SCIENTIFIC CORP COM 101137107 147,331 3,804,047 SH   DFND 2 3,804,047 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 502 7,062 SH   DFND 2 7,062 0 0
CARDINAL HEALTH INC COM 14149Y108 61 918 SH   DFND 2 918 0 0
CAREDX INC COM 14167L103 44,277 2,601,446 SH   DFND 3 2,601,446 0 0
CARIBOU BIOSCIENCES INC COM 142038108 699 66,300 SH   DFND 2 66,300 0 0
CASTLE BIOSCIENCES INC COM 14843C105 24,564 941,871 SH   DFND 3 941,871 0 0
CATALENT INC COM 148806102 34 473 SH   DFND 2 473 0 0
CELLDEX THERAPEUTICS INC COM NEW 15117B202 50,598 1,800,000 SH   DFND 1,2 1,800,000 0 0
CENTENE CORP DEL COM 15135B101 41,118 528,440 SH   DFND 2 528,440 0 0
CHARLES RIV LABS INC COM 159864107 51,757 262,993 SH   DFND 3 262,993 0 0
CIGNA CORP NEW COM 125523100 52,359 188,701 SH   DFND 2 188,701 0 0
COOPER COS INC COM NEW 216648402 21,459 81,313 SH   DFND 2 81,313 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 58,070 888,605 SH   DFND 1,2 888,605 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 2,594 39,700 SH   DFND 2 39,700 0 0
CVS HEALTH CORP COM 126650100 21,469 225,114 SH   DFND 2 225,114 0 0
CYTOKINETICS INC COM NEW 23282W605 3,450 71,200 SH   DFND 2 71,200 0 0
DANAHER CORPORATION COM 235851102 94,905 367,435 SH   DFND 2 367,435 0 0
DENALI THERAPEUTICS INC COM 24823R105 951 31,000 SH   DFND 2 31,000 0 0
DESIGN THERAPEUTICS INC COM 25056L103 583 34,881 SH   DFND 2 34,881 0 0
DEXCOM INC COM 252131107 69,301 860,460 SH   DFND 2 860,460 0 0
DOLBY LABORATORIES INC COM CL A 25659T107 104 1,600 SH   DFND 2 1,600 0 0
DOXIMITY INC CL A 26622P107 5,846 193,439 SH   DFND 2 193,439 0 0
DR. REDDYS LABS LTD ADR 256135203 664 12,400 SH   DFND 2 12,400 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 84,755 1,025,715 SH   DFND 2 1,025,715 0 0
ELEVANCE HEALTH INC COM 036752103 45,647 100,492 SH   DFND 3 100,492 0 0
ELEVANCE HEALTH INC COM 036752103 46,332 102,000 SH   DFND 2 102,000 0 0
ELI LILLY & CO COM 532457108 3,069 9,490 SH   DFND 2 9,490 0 0
ENVISTA HOLDINGS CORP COM 29415F104 27 822 SH   DFND 2 822 0 0
EQUINIX INC COM 29444U700 23 40 SH   DFND 2 40 0 0
ESPERION THERAPEUTICS INC COM 29664W105 28,100 4,194,064 SH   DFND 1,2 4,194,064 0 0
ESPERION THERAPEUTICS INC COM 29664W105 209 31,200 SH   DFND 2 31,200 0 0
ESSA PHARMA INC COM NEW 29668H708 10,701 5,879,583 SH   DFND 1,2 5,879,583 0 0
ESSA PHARMA INC COM NEW 29668H708 35 19,000 SH   DFND 2 19,000 0 0
ESTEE LAUDER COMPANIES CL A 518439104 291 1,348 SH   DFND 2 1,348 0 0
EVERTEC INC COM 30040P103 23 739 SH   DFND 2 739 0 0
EVOLENT HEALTH INC CL A 30050B101 38,618 1,074,816 SH   DFND 3 1,074,816 0 0
EVOLENT HEALTH INC CL A 30050B101 28,537 794,239 SH   DFND 2 794,239 0 0
EXACT SCIENCES CORP COM 30063P105 36,702 1,129,653 SH   DFND 3 1,129,653 0 0
EXELIXIS INC COM 30161Q104 41,623 2,654,500 SH   DFND 1,2 2,654,500 0 0
EXELIXIS INC COM 30161Q104 298 19,000 SH   DFND 2 19,000 0 0
FATE THERAPEUTICS INC COM 31189P102 81,988 3,658,536 SH   DFND 1,2 3,658,536 0 0
FATE THERAPEUTICS INC COM 31189P102 1,962 87,550 SH   DFND 2 87,550 0 0
GENERATION BIO CO COM 37148K100 19,160 3,608,280 SH   DFND 1,2 3,608,280 0 0
GENERATION BIO CO COM 37148K100 101 19,000 SH   DFND 2 19,000 0 0
GILEAD SCIENCES INC COM 375558103 6,037 97,854 SH   DFND 2 97,854 0 0
GLOBUS MEDICAL INC CL A 379577208 38,551 647,163 SH   DFND 2 647,163 0 0
GRUPO AEROPORTUARIO DEL SURE SPON ADR SER B 40051E202 27 135 SH   DFND 2 135 0 0
GUARDANT HEALTH INC COM 40131M109 3,342 62,083 SH   DFND 2 62,083 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 36,792 930,500 SH   DFND 2 930,500 0 0
HARMONY BIOSCIENCES HOLDINGS COM 413197104 29,107 657,188 SH   DFND 2 657,188 0 0
HCA HEALTHCARE INC COM 40412C101 52,525 285,789 SH   DFND 2 285,789 0 0
HOLOGIC INC COM 436440101 16,221 251,412 SH   DFND 2 251,412 0 0
HOMOLOGY MEDICINES INC COM 438083107 2,612 1,622,522 SH   DFND 1,2 1,622,522 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 18,681 301,850 SH   DFND 2 301,850 0 0
HUMANA INC COM 444859102 65,115 134,206 SH   DFND 2 134,206 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103 15,947 1,758,075 SH   DFND 3 1,758,075 0 0
IDEXX LABORATORIES INC COM 45168D104 35,454 108,822 SH   DFND 2 108,822 0 0
ILLUMINA INC COM 452327109 16,394 85,927 SH   DFND 2 85,927 0 0
INCYTE CORP COM 45337C102 179,333 2,691,077 SH   DFND 1,2 2,691,077 0 0
INCYTE CORP COM 45337C102 3,545 53,200 SH   DFND 2 53,200 0 0
INFOSYS LTD SPONSORED ADR 456788108 20 1,130 SH   DFND 2 1,130 0 0
INHIBRX INC COM 45720L107 781 43,500 SH   DFND 2 43,500 0 0
INSMED INC COM PAR $.01 457669307 69,245 3,214,704 SH   DFND 3 3,214,704 0 0
INSPIRE MEDICAL SYSTEMS INC COM 457730109 71,262 401,768 SH   DFND 2 401,768 0 0
INSULET CORP COM 45784P101 85,785 373,953 SH   DFND 2 373,953 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 1,706 30,478 SH   DFND 2 30,478 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 153,153 3,291,479 SH   DFND 1,2 3,291,479 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 1,759 37,800 SH   DFND 2 37,800 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 32,583 173,831 SH   DFND 3 173,831 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 135,755 724,261 SH   DFND 2 724,261 0 0
IONIS PHARMACEUTICALS INC COM 462222100 408,243 9,230,000 SH   DFND 1,2 9,230,000 0 0
IONIS PHARMACEUTICALS INC COM 462222100 10,323 233,400 SH   DFND 2 233,400 0 0
IPG PHOTONICS CORP COM 44980X109 89 1,050 SH   DFND 2 1,050 0 0
IQVIA HOLDINGS INC COM 46266C105 29,024 160,227 SH   DFND 2 160,227 0 0
ISHARES TR MSCI CHINA ETF 46429B671 174 4,100 SH   DFND 2 4,100 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 75,984 570,063 SH   DFND 3 570,063 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 33,826 253,776 SH   DFND 2 253,776 0 0
JOHNSON & JOHNSON COM 478160104 5,010 30,671 SH   DFND 2 30,671 0 0
JUMIA TECHNOLOGIES AG SPONSORED ADS 48138M105 105 18,000 SH   DFND 2 18,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 25,830 3,000,000 SH   DFND 1,2 3,000,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 267 31,000 SH   DFND 2 31,000 0 0
KOSMOS ENERGY LTD COM 500688106 1,646 318,300 SH   DFND 2 318,300 0 0
KRYSTAL BIOTECH INC COM 501147102 1,276 18,300 SH   DFND 2 18,300 0 0
LABORATORY CRP OF AMER HLDGS COM NEW 50540R409 799 3,900 SH   DFND 2 3,900 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 25,519 625,461 SH   DFND 2 625,461 0 0
MACROGENICS INC COM 556099109 25,173 7,275,564 SH   DFND 1,2 7,275,564 0 0
MACROGENICS INC COM 556099109 173 49,950 SH   DFND 2 49,950 0 0
MARKETAXESS HOLDINGS INC COM 57060D108 147 662 SH   DFND 2 662 0 0
MCKESSON CORP COM 58155Q103 999 2,938 SH   DFND 2 2,938 0 0
MEDTRONIC PLC SHS G5960L103 49,736 615,926 SH   DFND 2 615,926 0 0
MERCADOLIBRE INC COM 58733R102 141 170 SH   DFND 2 170 0 0
MERCK & CO. INC. COM 58933Y105 417 4,844 SH   DFND 2 4,844 0 0
MERSANA THERAPEUTICS INC COM 59045L106 26,136 3,866,200 SH   DFND 1,2 3,866,200 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1,463 216,400 SH   DFND 2 216,400 0 0
MERUS NV COM N5749R100 509 25,400 SH   DFND 2 25,400 0 0
MODERNA INC COM 60770K107 177,606 1,501,951 SH   DFND 1,2 1,501,951 0 0
MODERNA INC COM 60770K107 6,841 57,850 SH   DFND 2 57,850 0 0
MOLECULAR TEMPLATES INC COM 608550109 8,391 11,192,003 SH   DFND 1,2 11,192,003 0 0
MOLECULAR TEMPLATES INC COM 608550109 64 86,000 SH   DFND 2 86,000 0 0
MOLINA HEALTHCARE INC COM 60855R100 79,356 240,590 SH   DFND 2 240,590 0 0
MYOVANT SCIENCES LTD COM G637AM102 105,473 5,872,639 SH   DFND 1,2 5,872,639 0 0
MYOVANT SCIENCES LTD COM G637AM102 718 40,000 SH   DFND 2 40,000 0 0
NEKTAR THERAPEUTICS COM 640268108 47 14,800 SH   DFND 2 14,800 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 297,222 2,798,437 SH   DFND 1,2 2,798,437 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 6,023 56,709 SH   DFND 2 56,709 0 0
NEUROPACE INC COM 641288105 1,456 388,368 SH   DFND 2 388,368 0 0
NEVRO CORP COM 64157F103 12,155 260,835 SH   DFND 2 260,835 0 0
OLINK HOLDING AB SPONSORED ADS 680710100 2,799 230,522 SH   DFND 2 230,522 0 0
OMNICELL INC COM 68213N109 36,055 414,284 SH   DFND 2 414,284 0 0
OPTHEA LTD SPONSORED ADS 68386J208 283 47,000 SH   DFND 2 47,000 0 0
OPTION CARE HEALTH INC COM NEW 68404L201 82,740 2,629,172 SH   DFND 3 2,629,172 0 0
OUTSET MEDICAL INC COM 690145107 27,200 1,707,475 SH   DFND 3 1,707,475 0 0
OUTSET MEDICAL INC COM 690145107 11,310 709,981 SH   DFND 2 709,981 0 0
PACIFIC BIOSCIENCES OF CALIF COM 69404D108 17,360 2,990,461 SH   DFND 3 2,990,461 0 0
PACIFIC BIOSCIENCES OF CALIF COM 69404D108 14,217 2,449,090 SH   DFND 2 2,449,090 0 0
PENUMBRA INC COM 70975L107 35,981 189,774 SH   DFND 2 189,774 0 0
PFIZER INC COM 717081103 33,577 767,300 SH   DFND 2 767,300 0 0
PHREESIA INC COM 71944F106 16,980 666,419 SH   DFND 2 666,419 0 0
PRIVIA HEALTH GROUP INC COM 74276R102 17,542 515,030 SH   DFND 2 515,030 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105 24,431 589,262 SH   DFND 2 589,262 0 0
PULMONX CORP COM 745848101 2,888 173,336 SH   DFND 2 173,336 0 0
REGENERON PHARMACEUTICALS COM 75886F107 11,979 17,389 SH   DFND 2 17,389 0 0
RELAY THERAPEUTICS INC COM 75943R102 92,181 4,120,720 SH   DFND 1,2 4,120,720 0 0
RELAY THERAPEUTICS INC COM 75943R102 1,881 84,100 SH   DFND 2 84,100 0 0
RELMADA THERAPEUTICS INC COM 75955J402 1,969 53,187 SH   DFND 2 53,187 0 0
REPLIGEN CORP COM 759916109 1,235 6,600 SH   DFND 2 6,600 0 0
RESMED INC COM 761152107 18,471 84,612 SH   DFND 2 84,612 0 0
REVOLUTION MEDICINES INC COM 76155X100 90,763 4,602,562 SH   DFND 1,2 4,602,562 0 0
REVOLUTION MEDICINES INC COM 76155X100 1,530 77,600 SH   DFND 2 77,600 0 0
SAGE THERAPEUTICS INC COM 78667J108 115,533 2,950,278 SH   DFND 1,2 2,950,278 0 0
SAGE THERAPEUTICS INC COM 78667J108 799 20,400 SH   DFND 2 20,400 0 0
SAREPTA THERAPEUTICS INC COM 803607100 80,860 731,504 SH   DFND 3 731,504 0 0
SAREPTA THERAPEUTICS INC COM 803607100 2,697 24,394 SH   DFND 2 24,394 0 0
SCHOLAR ROCK HOLDING CORP COM 80706P103 14,780 2,132,725 SH   DFND 1,2 2,132,725 0 0
SCHOLAR ROCK HOLDING CORP COM 80706P103 134 19,300 SH   DFND 2 19,300 0 0
SEAGEN INC COM 81181C104 5,874 42,926 SH   DFND 2 42,926 0 0
SEER INC COM CL A 81578P106 1,054 136,133 SH   DFND 2 136,133 0 0
SHOCKWAVE MEDICAL INC COM 82489T104 76,784 276,132 SH   DFND 2 276,132 0 0
SIGHT SCIENCES INC COM 82657M105 1,871 294,606 SH   DFND 2 294,606 0 0
SILK ROAD MEDICAL INC COM 82710M100 47,131 1,047,356 SH   DFND 3 1,047,356 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 179 2,100 SH   DFND 2 2,100 0 0
SPDR S&P 500 ETF TRUST TR UNIT 78462F103 643 1,800 SH   DFND 2 1,800 0 0
SPDR S&P SER TR S&P OILGAS EXP 78468R556 486 3,900 SH   DFND 2 3,900 0 0
STRYKER CORPORATION COM 863667101 96,598 476,932 SH   DFND 2 476,932 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 4,038 119,278 SH   DFND 2 119,278 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 53 770 SH   DFND 2 770 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 49,785 1,040,448 SH   DFND 3 1,040,448 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 25,148 525,567 SH   DFND 2 525,567 0 0
TELADOC HEALTH INC COM 87918A105 9,894 390,286 SH   DFND 2 390,286 0 0
TELEFLEX INC COM 879369106 6,342 31,480 SH   DFND 2 31,480 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 36,591 72,144 SH   DFND 2 72,144 0 0
TRANSMEDICS GROUP INC COM 89377M109 27,290 653,814 SH   DFND 2 653,814 0 0
UNITED MICROELECTRONICS CORP SPON ADR NEW 910873405 15 2,698 SH   DFND 2 2,698 0 0
UNITED THERAPEUTICS CORP COM 91307C102 63 301 SH   DFND 2 301 0 0
UNITEDHEALTH GROUP INC COM 91324P102 66,442 131,557 SH   DFND 3 131,557 0 0
UNITEDHEALTH GROUP INC COM 91324P102 83,431 165,197 SH   DFND 2 165,197 0 0
VANECK ETF TRUST GOLD MINERS ETF 92189F106 323 13,400 SH   DFND 2 13,400 0 0
VANECK ETF TRUST JUNIOR GOLD MINE 92189F791 147 5,000 SH   DFND 2 5,000 0 0
VEEVA SYSTEMS INC CL A COM 922475108 25,984 157,591 SH   DFND 2 157,591 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 275,214 950,523 SH   DFND 1,2 950,523 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 35,020 120,952 SH   DFND 3 120,952 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 25,089 86,651 SH   DFND 2 86,651 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 946 46,100 SH   DFND 2 46,100 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 16,225 4,494,458 SH   DFND 1,2 4,494,458 0 0
XENCOR INC COM 98401F105 660 25,400 SH   DFND 2 25,400 0 0
ZAI LAB LTD ADR 98887Q104 1,278 36,600 SH   DFND 2 36,600 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 27,734 265,270 SH   DFND 2 265,270 0 0
ZOETIS INC CL A 98978V103 36 246 SH   DFND 2 246 0 0