The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 3,792 654,862 SH   SOLE 654,862 0 0
ACCURAY INC COM 004397105 1,959 941,800 SH   SOLE 941,800 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 377 351,064 SH   SOLE 351,064 0 0
ADICET BIO INC COM 007002108 13,307 935,766 SH   SOLE 935,766 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 4,648 307,232 SH   SOLE 307,232 0 0
AERIE PHARMACEUTICALS INC NOTE 1.500%10/0 00771VAB4 1,476 1,500,000 PRN   SOLE 1,500,000 0 0
AFFIMED N V COM N01045108 1,414 686,282 SH   SOLE 686,282 0 0
ALECTOR INC COM 014442107 5,037 532,438 SH   SOLE 532,438 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 4,504 65,946 SH   SOLE 65,946 0 0
ARCUS BIOSCIENCES INC COM 03969F109 4,675 178,717 SH   SOLE 178,717 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 14,014 135,712 SH   SOLE 135,712 0 0
ATRICURE INC COM 04963C209 2,816 72,029 SH   SOLE 72,029 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 1,062 496,150 SH   SOLE 496,150 0 0
AXOGEN INC COM 05463X106 3,959 332,103 SH   SOLE 332,103 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 2,842 122,200 SH   SOLE 122,200 0 0
BIOHAVEN LTD COM G1110E107 967 153,564 SH   SOLE 153,564 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 16,644 110,100 SH   SOLE 110,100 0 0
BIOMEA FUSION INC COM 09077A106 339 34,625 SH   SOLE 34,625 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 530 313,600 SH   SOLE 313,600 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 17,213 261,235 SH   SOLE 261,235 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106 794 220,000 SH   SOLE 220,000 0 0
CARDIOVASCULAR SYS INC COM 141619106 3,978 286,988 SH   SOLE 286,988 0 0
CENTURY THERAPEUTICS INC COM 15673T100 4,701 475,367 SH   SOLE 475,367 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 508 47,390 SH   SOLE 47,390 0 0
COMPASS THERAPEUTICS INC COM 20454B104 429 188,094 SH   SOLE 188,094 0 0
COMPUGEN LTD ORD M25722105 135 205,202 SH   SOLE 205,202 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 5,961 1,703,235 SH   SOLE 1,703,235 0 0
CYTOKINETICS INC COM NEW 23282W605 8,915 183,995 SH   SOLE 183,995 0 0
DEXCOM INC COM 252131107 5,843 72,552 SH   SOLE 72,552 0 0
DICE THERAPEUTICS INC COM 23345J104 1,592 78,500 SH   SOLE 78,500 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 7,686 781,112 SH   SOLE 781,112 0 0
FATE THERAPEUTICS INC COM 31189P102 12,100 539,940 SH   SOLE 539,940 0 0
F-STAR THERAPEUTICS INC COM 30315R107 2,954 576,881 SH   SOLE 576,881 0 0
GALAPAGOS NV SPON ADR 36315X101 1,820 42,675 SH   SOLE 42,675 0 0
GAMIDA CELL LTD SHS M47364100 978 614,896 SH   SOLE 614,896 0 0
GENFIT S A ADS 372279109 686 187,940 SH   SOLE 187,940 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 612 52,631 SH   SOLE 52,631 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 8,035 538,561 SH   SOLE 538,561 0 0
IKENA ONCOLOGY INC COM 45175G108 435 122,517 SH   SOLE 122,517 0 0
INOGEN INC COM 45780L104 364 15,000 SH   SOLE 15,000 0 0
ISHARES TR NASDAQ BIOTECH INDX ETF 464287556 11,988 102,500 SH   SOLE 102,500 0 0
ITEOS THERAPEUTICS INC COM 46565G104 1,859 97,560 SH   SOLE 97,560 0 0
IVERIC BIO INC COM 46583P102 7,202 401,476 SH   SOLE 401,476 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 3,705 255,313 SH   SOLE 255,313 0 0
KARUNA THERAPEUTICS INC COM 48576A100 6,497 28,886 SH   SOLE 28,886 0 0
KEROS THERAPEUTICS INC COM 492327101 1,467 39,000 SH   SOLE 39,000 0 0
KINNATE BIOPHARMA INC COM 49705R105 933 78,074 SH   SOLE 78,074 0 0
KURA ONCOLOGY INC COM 50127T109 2,818 206,329 SH   SOLE 206,329 0 0
LARIMAR THERAPEUTICS INC COM 517125100 1,840 574,996 SH   SOLE 574,996 0 0
LINEAGE CELL THERAPEUTICS IN COM 53566P109 158 140,000 SH   SOLE 140,000 0 0
MACROGENICS INC COM 556099109 346 100,000 SH   SOLE 100,000 0 0
MASIMO CORP COM 574795100 423 3,000 SH   SOLE 3,000 0 0
MEDICENNA THERAPEUTICS CORP COM 58490H107 548 660,000 SH   SOLE 660,000 0 0
MEDIWOUND LTD ORD SHS M68830104 1,986 1,428,571 SH   SOLE 1,428,571 0 0
MEI PHARMA INC COM NEW 55279B202 683 1,767,146 SH   SOLE 1,767,146 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107 944 1,096,513 SH   SOLE 1,096,513 0 0
MERSANA THERAPEUTICS INC COM 59045L106 2,554 377,763 SH   SOLE 377,763 0 0
MERUS N V COM N5749R100 5,546 276,893 SH   SOLE 276,893 0 0
MIRATI THERAPEUTICS INC COM 60468T105 5,001 71,600 SH   SOLE 71,600 0 0
MORPHIC HLDG INC COM 61775R105 5,532 195,467 SH   SOLE 195,467 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 8,513 80,155 SH   SOLE 80,155 0 0
NEURONETICS INC COM 64131A105 998 313,717 SH   SOLE 313,717 0 0
NEXTCURE INC COM 65343E108 516 187,696 SH   SOLE 187,696 0 0
NGM BIOPHARMACEUTICALS INC COM 62921N105 980 74,953 SH   SOLE 74,953 0 0
NURIX THERAPEUTICS INC COM 67080M103 7,384 566,695 SH   SOLE 566,695 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 1,323 413,526 SH   SOLE 413,526 0 0
OTONOMY INC COM 68906L105 434 1,470,199 SH   SOLE 1,470,199 0 0
PARDES BIOSCIENCES INC COM 69945Q105 887 479,386 SH   SOLE 479,386 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 57 321,856 SH   SOLE 321,856 0 0
PROQR THERAPEUTICS NV SHS EURO N71542109 483 649,383 SH   SOLE 649,383 0 0
REGULUS THERAPEUTICS INC COM 75915K309 944 555,555 SH   SOLE 555,555 0 0
REUNION NEUROSCIENCE INC COM 76134G103 138 96,585 SH   SOLE 96,585 0 0
REVOLUTION MEDICINES INC COM 76155X100 9,461 479,785 SH   SOLE 479,785 0 0
SAGE THERAPEUTICS INC COM 78667J108 7,061 180,306 SH   SOLE 180,306 0 0
SCYNEXIS INC COM NEW 811292200 958 399,064 SH   SOLE 399,064 0 0
SPDR SP BIOTECH ETF ETF 78464A870 44,895 566,000 SH   SOLE 566,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 250 125,000 SH   SOLE 125,000 0 0
STEREOTAXIS INC COM NEW 85916J409 24,625 13,680,554 SH   SOLE 13,680,554 0 0
SURFACE ONCOLOGY INC COM 86877M209 1,144 1,100,000 SH   SOLE 1,100,000 0 0
SUTRO BIOPHARMA INC COM 869367102 451 81,200 SH   SOLE 81,200 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 8,542 355,487 SH   SOLE 355,487 0 0
SYROS PHARMACEUTICALS INC COM NEW 87184Q206 1,712 265,878 SH   SOLE 265,878 0 0
THESEUS PHARMACEUTICALS INC COM 88369M101 475 81,899 SH   SOLE 81,899 0 0
VENUS CONCEPT INC COM 92332W105 426 968,187 SH   SOLE 968,187 0 0
VIGIL NEUROSCIENCE INC COM 92673K108 1,969 216,395 SH   SOLE 216,395 0 0
VIKING THERAPEUTICS INC COM 92686J106 1,503 552,400 SH   SOLE 552,400 0 0
XENON PHARMACEUTICALS INC COM 98420N105 13,546 375,223 SH   SOLE 375,223 0 0