The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
908 DEVICES INC COM 65443P102 8,193 498,041 SH   SOLE   469,412 0 28,629
ABSCI CORPORATION COM 00091E109 995 317,772 SH   SOLE   317,772 0 0
AC IMMUNE SA SHS H00263105 3,348 1,059,462 SH   SOLE   1,059,462 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 1,876 263,491 SH   SOLE   263,491 0 0
AFFIMED N V COM N01045108 1,193 579,131 SH   SOLE   579,131 0 0
ALBIREO PHARMA INC COM 01345P106 5,168 266,917 SH   SOLE   266,917 0 0
ALECTOR INC COM 014442107 1,380 145,840 SH   SOLE   145,840 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 113,856 1,423,374 SH   SOLE   1,268,582 0 154,792
ALLISON TRANSMISSION HLDGS I COM 01973R101 78 2,311 SH   SOLE   2,311 0 0
ALLY FINL INC COM 02005N100 17,937 644,530 SH   SOLE   644,530 0 0
ALPHA TEKNOVA INC COM 02080L102 1,127 337,391 SH   SOLE   337,391 0 0
ALPHABET INC CAP STK CL A 02079K305 9,760 102,042 SH   SOLE   102,042 0 0
ALPHABET INC CAP STK CL C 02079K107 24,709 256,980 SH   SOLE   256,980 0 0
ALTIMMUNE INC COM NEW 02155H200 1,516 118,730 SH   SOLE   118,730 0 0
AMBARELLA INC SHS G037AX101 103 1,842 SH   SOLE   1,842 0 0
ANALOG DEVICES INC COM 032654105 2,528 18,145 SH   SOLE   18,145 0 0
APPLIED MATLS INC COM 038222105 1,773 21,644 SH   SOLE   21,644 0 0
ARCUS BIOSCIENCES INC COM 03969F109 1,616 61,780 SH   SOLE   61,780 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 87 145,558 SH   SOLE   145,558 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 2,379 1,450,328 SH   SOLE   1,450,328 0 0
AT&T INC COM 00206R102 67 4,366 SH   SOLE   4,366 0 0
AZIYO BIOLOGICS INC CL A COM 05479K106 1,355 188,181 SH   SOLE   188,181 0 0
BALL CORP COM 058498106 117 2,424 SH   SOLE   2,424 0 0
BEST BUY INC COM 086516101 70 1,108 SH   SOLE   1,108 0 0
BIO RAD LABS INC CL A 090572207 8,431 20,211 SH   SOLE   20,211 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 2,793 221,699 SH   SOLE   221,699 0 0
BLOCK INC CL A 852234103 11,459 208,377 SH   SOLE   208,377 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 2,165 32,862 SH   SOLE   32,862 0 0
BOOKING HOLDINGS INC COM 09857L108 82,969 50,492 SH   SOLE   42,717 0 7,775
BRUNSWICK CORP COM 117043109 2,302 35,178 SH   SOLE   35,178 0 0
BTRS HOLDINGS INC COM CL 1 11778X104 27,728 2,994,437 SH   SOLE   2,994,437 0 0
CALIFORNIA RES CORP COM STOCK 13057Q305 77 2,013 SH   SOLE   2,013 0 0
CAMECO CORP COM 13321L108 81 3,020 SH   SOLE   3,020 0 0
CENTOGENE N V COM N1976T109 2,662 2,377,150 SH   SOLE   2,377,150 0 0
CIENA CORP COM NEW 171779309 50,536 1,249,966 SH   SOLE   1,121,138 0 128,828
CIGNA CORP NEW COM 125523100 82 296 SH   SOLE   296 0 0
CISCO SYS INC COM 17275R102 857 21,426 SH   SOLE   21,426 0 0
COGENT BIOSCIENCES INC COM 19240Q201 7,630 511,390 SH   SOLE   486,557 0 24,833
COHERUS BIOSCIENCES INC COM 19249H103 5,285 549,899 SH   SOLE   549,899 0 0
CORE LABORATORIES N V COM N22717107 215 15,955 SH   SOLE   15,955 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 1,783 1,229,545 SH   SOLE   1,229,545 0 0
DENALI THERAPEUTICS INC COM 24823R105 1,564 50,971 SH   SOLE   50,971 0 0
DINGDONG CAYMAN LTD ADS 25445D101 28,312 7,952,801 SH   SOLE   7,812,532 0 140,269
DOORDASH INC CL A 25809K105 7,466 150,984 SH   SOLE   150,984 0 0
EBAY INC. COM 278642103 835 22,679 SH   SOLE   22,679 0 0
EQUIFAX INC COM 294429105 25,348 147,863 SH   SOLE   147,863 0 0
ERICSSON ADR B SEK 10 294821608 2,473 430,900 SH   SOLE   430,900 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 9,581 1,430,001 SH   SOLE   1,159,685 0 270,316
EXAGEN INC COM 30068X103 951 351,071 SH   SOLE   295,604 0 55,467
EXSCIENTIA PLC ADS 30223G102 23,079 2,811,120 SH   SOLE   2,774,963 0 36,157
F45 TRAINING HLDGS INC COM 30322L101 3,409 1,103,358 SH   SOLE   1,103,358 0 0
FOX CORP CL A COM 35137L105 36 1,177 SH   SOLE   1,177 0 0
FREEPORT-MCMORAN INC CL B 35671D857 28,641 1,047,983 SH   SOLE   847,907 0 200,076
FULL TRUCK ALLIANCE CO LTD SPONSORED ADS 35969L108 1,304 199,091 SH   SOLE   199,091 0 0
GENERAL ELECTRIC CO COM NEW 369604301 56,937 919,668 SH   SOLE   627,096 0 292,572
GENETRON HLDGS LTD ADS 37186H100 584 746,861 SH   SOLE   746,861 0 0
GILEAD SCIENCES INC COM 375558103 49,157 796,837 SH   SOLE   576,216 0 220,621
H WORLD GROUP LTD SPONSORED ADS 44332N106 45,918 1,369,043 SH   SOLE   1,369,043 0 0
HANESBRANDS INC COM 410345102 54 7,697 SH   SOLE   7,697 0 0
HCA HEALTHCARE INC COM 40412C101 74 401 SH   SOLE   401 0 0
HELLO GROUP INC ADS 423403104 46 9,871 SH   SOLE   9,871 0 0
HERBALIFE NUTRITION LTD COM SHS G4412G101 57 2,859 SH   SOLE   2,859 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103 2,130 240,391 SH   SOLE   240,391 0 0
ICOSAVAX INC COM 45114M109 5,953 1,883,768 SH   SOLE   1,729,238 0 154,530
IDEAYA BIOSCIENCES INC COM 45166A102 15,091 1,011,467 SH   SOLE   906,532 0 104,935
IMMATICS N.V SHS N44445109 2,571 257,120 SH   SOLE   257,120 0 0
IMMUNOVANT INC COM 45258J102 3,678 659,075 SH   SOLE   659,075 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 649 545,508 SH   SOLE   545,508 0 0
INHIBRX INC COM 45720L107 2,624 146,210 SH   SOLE   146,210 0 0
INTEL CORP COM 458140100 215 8,340 SH   SOLE   8,340 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 82,734 915,701 SH   SOLE   770,929 0 144,772
IRIS ENERGY LTD ORDINARY SHARES Q4982L109 11,456 2,773,913 SH   SOLE   2,408,785 0 365,128
JD.COM INC SPON ADR CL A 47215P106 29,385 584,186 SH   SOLE   584,186 0 0
KALERA PUBLIC LIMITED CO ORDINARY SHARES G52251108 615 462,249 SH   SOLE   336,627 0 125,622
KYNDRYL HLDGS INC COMMON STOCK 50155Q100 2 241 SH   SOLE   241 0 0
LAM RESEARCH CORP COM 512807108 16,264 44,436 SH   SOLE   44,436 0 0
LAREDO PETROLEUM INC COM 516806205 39 623 SH   SOLE   623 0 0
LEAP THERAPEUTICS INC COM 52187K101 1,169 1,327,952 SH   SOLE   1,327,952 0 0
LGI HOMES INC COM 50187T106 24,494 301,019 SH   SOLE   301,019 0 0
LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854 895 15,300 SH   SOLE   15,300 0 0
LUFAX HOLDING LTD ADS REP SHS CL A 54975P102 21 8,281 SH   SOLE   8,281 0 0
MAGELLAN MIDSTREAM PRTNRS LP COM UNIT RP LP 559080106 78 1,644 SH   SOLE   1,644 0 0
MELCO RESORTS AND ENTMNT LTD ADR 585464100 13,699 2,066,285 SH   SOLE   2,066,285 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1,962 290,298 SH   SOLE   290,298 0 0
MERUS N V COM N5749R100 2,930 146,264 SH   SOLE   146,264 0 0
META PLATFORMS INC CL A 30303M102 38,402 283,034 SH   SOLE   283,034 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 245,255 4,018,598 SH   SOLE   3,514,863 0 503,735
MICRON TECHNOLOGY INC COM 595112103 84,854 1,693,702 SH   SOLE   1,549,961 0 143,741
MICROSOFT CORP COM 594918104 5,196 22,312 SH   SOLE   22,312 0 0
MOSAIC CO NEW COM 61945C103 137,380 2,842,540 SH   SOLE   2,479,068 0 363,472
MYOVANT SCIENCES LTD COM G637AM102 5,426 302,120 SH   SOLE   302,120 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 6,480 507,405 SH   SOLE   476,286 0 31,119
NETFLIX INC COM 64110L106 4,356 18,503 SH   SOLE   18,503 0 0
NOAH HLDGS LTD SPON ADS CL A 65487X102 32,576 2,465,977 SH   SOLE   2,465,977 0 0
OMEGA THERAPEUTICS INC COMMON STOCK 68217N105 3,420 631,079 SH   SOLE   604,278 0 26,801
ONEMAIN HLDGS INC COM 68268W103 65 2,188 SH   SOLE   2,188 0 0
ORACLE CORP COM 68389X105 456 7,459 SH   SOLE   7,459 0 0
PARDES BIOSCIENCES INC COM 69945Q105 2,250 1,215,967 SH   SOLE   1,215,967 0 0
PAYPAL HLDGS INC COM 70450Y103 1,796 20,870 SH   SOLE   20,870 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 153 12,376 SH   SOLE   12,376 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 1,404 1,220,798 SH   SOLE   1,220,798 0 0
PLANET FITNESS INC CL A 72703H101 10,911 189,227 SH   SOLE   189,227 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 20,852 353,356 SH   SOLE   311,813 0 41,543
PROTHENA CORP PLC SHS G72800108 2,966 48,914 SH   SOLE   48,914 0 0
QUANTERIX CORP COM 74766Q101 12,737 1,155,818 SH   SOLE   1,109,845 0 45,973
RECURSION PHARMACEUTICALS IN CL A 75629V104 23,961 2,251,971 SH   SOLE   2,206,677 0 45,294
ROBLOX CORP CL A 771049103 4,739 132,222 SH   SOLE   132,222 0 0
ROIVANT SCIENCES LTD SHS G76279101 1,628 505,577 SH   SOLE   505,577 0 0
RYANAIR HOLDINGS PLC SPONSORED ADS 783513203 292 5,000 SH   SOLE   5,000 0 0
SCHLUMBERGER LTD COM STK 806857108 56,304 1,568,350 SH   SOLE   1,393,866 0 174,484
SILVERCREST METALS INC COM 828363101 9,745 1,762,177 SH   SOLE   1,177,130 0 585,047
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 2,203 881,068 SH   SOLE   881,068 0 0
SIX FLAGS ENTMT CORP NEW COM 83001A102 3,516 198,629 SH   SOLE   198,629 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 2,256 26,457 SH   SOLE   26,457 0 0
STANLEY BLACK & DECKER INC COM 854502101 63 842 SH   SOLE   842 0 0
SUNCOR ENERGY INC NEW COM 867224107 113,754 4,016,785 SH   SOLE   3,412,118 0 604,667
SUZANO S A SPON ADS 86959K105 35,023 4,245,182 SH   SOLE   4,245,182 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 1,118 226,309 SH   SOLE   226,309 0 0
THIRD HARMONIC BIO INC COM 88427A107 338 17,825 SH   SOLE   17,825 0 0
TRIP COM GROUP LTD ADS 89677Q107 178,904 6,550,870 SH   SOLE   5,529,267 0 1,021,603
TWITTER INC COM 90184L102 11,615 264,933 SH   SOLE   264,933 0 0
ULTA BEAUTY INC COM 90384S303 11,377 28,358 SH   SOLE   28,358 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 73 829 SH   SOLE   829 0 0
WARNER BROS DISCOVERY INC COM SER A 934423104 35 3,026 SH   SOLE   3,026 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 2,161 598,612 SH   SOLE   598,612 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107 494 109,530 SH   SOLE   109,530 0 0
WESTERN DIGITAL CORP. COM 958102105 1,953 59,988 SH   SOLE   59,988 0 0
YUM CHINA HLDGS INC COM 98850P109 14,211 300,257 SH   SOLE   300,257 0 0
ZAI LAB LTD ADR 98887Q104 5,037 147,272 SH   SOLE   147,272 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADS A 98980A105 382,435 15,914,881 SH   SOLE   13,884,282 0 2,030,599
ZYMEWORKS INC COM 98985W102 2,300 373,992 SH   SOLE   373,992 0 0