The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 1,158 200,000 SH   SOLE   200,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 5,317 325,000 SH   SOLE   325,000 0 0
ACUMEN PHARMACEUTICALS INC COM 00509G209 3,511 350,000 SH   SOLE   350,000 0 0
AEROVATE THERAPEUTICS INC COM 008064107 3,316 200,000 SH   SOLE   200,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108 1,392 40,900 SH Call SOLE   40,900 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 560 2,800 SH   SOLE   2,800 0 0
ALTIMMUNE INC COM NEW 02155H200 6,028 472,054 SH   SOLE   472,054 0 0
ALTIMMUNE INC COM NEW 02155H200 10,762 842,600 SH Call SOLE   842,600 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101 7,037 250,000 SH Call SOLE   250,000 0 0
ANEBULO PHARMACEUTICALS INC COM 034569103 437 156,203 SH   SOLE   156,203 0 0
ARDELYX INC COM 039697107 3,784 3,178,825 SH   SOLE   3,178,825 0 0
ARK ETF TR GENOMIC REV ETF 00214Q302 3,171 96,462 SH   SOLE   96,462 0 0
ARK ETF TR INNOVATION ETF 00214Q104 171 4,519 SH   SOLE   4,519 0 0
ARVINAS INC COM 04335A105 4,450 100,000 SH Call SOLE   100,000 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 146 820,455 SH   SOLE   820,455 0 0
ASTRIA THERAPEUTICS INC COM 04635X102 6,322 699,440 SH   SOLE   699,440 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 556 260,087 SH   SOLE   260,087 0 0
AXSOME THERAPEUTICS INC COM 05464T104 18,188 407,600 SH Put SOLE   407,600 0 0
BELLICUM PHARMACEUTICALS INC COM NEW 079481404 537 448,101 SH   SOLE   448,101 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 8,977 850,134 SH   SOLE   850,134 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 900 85,200 SH Call SOLE   85,200 0 0
BIOGEN INC COM 09062X103 14,204 53,200 SH Put SOLE   53,200 0 0
BIOGEN INC COM 09062X103 2,926 10,962 SH   SOLE   10,962 0 0
BIOGEN INC COM 09062X103 18,825 70,500 SH Call SOLE   70,500 0 0
BLUEBIRD BIO INC COM 09609G100 2,928 462,628 SH   SOLE   462,628 0 0
BRAINSTORM CELL THERAPEUTICS COM NEW 10501E201 839 189,935 SH   SOLE   189,935 0 0
CABALETTA BIO INC COM 12674W109 109 168,623 SH   SOLE   168,623 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 8,924 317,476 SH   SOLE   317,476 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 5,033 178,100 SH   SOLE   178,100 0 0
CHEMOMAB THERAPEUTICS LTD SPONSORED ADS 16385C104 612 245,896 SH   SOLE   245,896 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 0 283,464 SH   SOLE   283,464 0 0
CINCOR PHARMA INC COM 17240Y109 1,481 45,100 SH   SOLE   45,100 0 0
CLENE INC COMMON STOCK 185634102 496 177,400 SH Put SOLE   177,400 0 0
CLENE INC COMMON STOCK 185634102 903 322,600 SH Call SOLE   322,600 0 0
CLOVIS ONCOLOGY INC COM 189464100 430 361,518 SH   SOLE   361,518 0 0
COGENT BIOSCIENCES INC COM 19240Q201 2,429 162,766 SH   SOLE   162,766 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 283 219,501 SH   SOLE   219,501 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 66 397,168 SH   SOLE   397,168 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 2,268 122,600 SH Call SOLE   122,600 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 9,107 492,275 SH   SOLE   492,275 0 0
DESIGN THERAPEUTICS INC COM 25056L103 811 48,500 SH Put SOLE   48,500 0 0
DICE THERAPEUTICS INC COM 23345J104 10,223 504,100 SH Put SOLE   504,100 0 0
DICE THERAPEUTICS INC COM 23345J104 15,188 748,900 SH Call SOLE   748,900 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101 612 221,830 SH   SOLE   221,830 0 0
ERYTECH PHARMA SPONSORED ADR 29604W108 2 3,019 SH   SOLE   3,019 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 14,278 2,131,147 SH   SOLE   2,131,147 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 1,339 200,000 SH Call SOLE   200,000 0 0
FINCH THERAPEUTICS GROUP INC COM 31773D101 397 237,553 SH   SOLE   237,553 0 0
GERON CORP COM 374163103 1,170 500,000 SH Call SOLE   500,000 0 0
GOSSAMER BIO INC COM 38341P102 6,308 526,600 SH Call SOLE   526,600 0 0
GOSSAMER BIO INC COM 38341P102 7,313 610,407 SH   SOLE   610,407 0 0
GOSSAMER BIO INC COM 38341P102 209 17,400 SH Put SOLE   17,400 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 4,593 74,219 SH   SOLE   74,219 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 5,267 85,100 SH Call SOLE   85,100 0 0
IMMATICS N.V SHS N44445109 490 49,031 SH   SOLE   49,031 0 0
IMMUNOVANT INC COM 45258J102 4,529 811,700 SH   SOLE   811,700 0 0
INSMED INC COM PAR $.01 457669307 2,154 100,000 SH Call SOLE   100,000 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 1,189 85,200 SH   SOLE   85,200 0 0
INVENTIVA SA ADS 46124U107 48 13,236 SH   SOLE   13,236 0 0
IVERIC BIO INC COM 46583P102 17,559 978,783 SH   SOLE   978,783 0 0
IVERIC BIO INC COM 46583P102 7,856 437,900 SH Call SOLE   437,900 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 6,273 728,586 SH   SOLE   728,586 0 0
KRYSTAL BIOTECH INC COM 501147102 6,635 95,200 SH Put SOLE   95,200 0 0
LYRA THERAPEUTICS INC COM 55234L105 1,722 343,685 SH   SOLE   343,685 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 1,657 180,300 SH Call SOLE   180,300 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 3,107 338,000 SH Put SOLE   338,000 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 7,863 855,616 SH   SOLE   855,616 0 0
OCULAR THERAPEUTIX INC COM 67576A100 1,099 265,000 SH   SOLE   265,000 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 3,482 450,406 SH   SOLE   450,406 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 168 74,200 SH Call SOLE   74,200 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 10,504 178,000 SH Call SOLE   178,000 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 13,641 231,181 SH   SOLE   231,181 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 558 188,664 SH   SOLE   188,664 0 0
PROTHENA CORP PLC SHS G72800108 4,050 66,800 SH Call SOLE   66,800 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 463 18,400 SH Put SOLE   18,400 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 3,470 138,100 SH Call SOLE   138,100 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 102 4,064 SH   SOLE   4,064 0 0
RELMADA THERAPEUTICS INC COM 75955J402 28,703 775,300 SH Put SOLE   775,300 0 0
RELMADA THERAPEUTICS INC COM 75955J402 28,701 775,300 SH Call SOLE   775,300 0 0
RENEO PHARMACEUTICALS INC COM 75974E103 521 155,819 SH   SOLE   155,819 0 0
RENOVACOR INC COM 75989E106 725 288,119 SH   SOLE   288,119 0 0
REVANCE THERAPEUTICS INC COM 761330109 2,700 100,000 SH   SOLE   100,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 6,180 157,805 SH   SOLE   157,805 0 0
SAREPTA THERAPEUTICS INC COM 803607100 9,418 85,200 SH Call SOLE   85,200 0 0
SAREPTA THERAPEUTICS INC COM 803607100 1,858 16,809 SH   SOLE   16,809 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 815 136,059 SH   SOLE   136,059 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 2,400 400,000 SH Call SOLE   400,000 0 0
SCPHARMACEUTICALS INC COM 810648105 3,126 479,383 SH   SOLE   479,383 0 0
SEAGEN INC COM 81181C104 20,525 150,000 SH Call SOLE   150,000 0 0
SERES THERAPEUTICS INC COM 81750R102 843 131,310 SH   SOLE   131,310 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 21,431 60,000 SH Put SOLE   60,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 11,898 150,000 SH Put SOLE   150,000 0 0
SPECTRUM PHARMACEUTICALS INC COM 84763A108 76 176,980 SH   SOLE   176,980 0 0
STEALTH BIOTHERAPEUTICS CORP SPONSORED ADS 85789A105 134 435,516 SH   SOLE   435,516 0 0
STOKE THERAPEUTICS INC COM 86150R107 4,734 368,700 SH Put SOLE   368,700 0 0
SYNLOGIC INC COM 87166L100 292 306,757 SH   SOLE   306,757 0 0
TERNS PHARMACEUTICALS INC COM 880881107 5,326 904,119 SH   SOLE   904,119 0 0
TRACON PHARMACEUTICALS INC COM NEW 89237H209 4,618 2,765,530 SH   SOLE   2,765,530 0 0
TRICIDA INC COM 89610F101 7,628 727,900 SH Put SOLE   727,900 0 0
TRICIDA INC COM 89610F101 6,054 577,600 SH Call SOLE   577,600 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 193 315,131 SH   SOLE   315,131 0 0
VIKING THERAPEUTICS INC COM 92686J106 1,260 463,156 SH   SOLE   463,156 0 0
X4 PHARMACEUTICALS INC COM 98420X103 973 568,612 SH   SOLE   568,612 0 0
XENON PHARMACEUTICALS INC COM 98420N105 5,794 160,486 SH   SOLE   160,486 0 0