The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 42,566 317,163 SH   DFND   0 317,163 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 10,020 9,320,584 SH   DFND   0 9,320,584 0
AERIE PHARMACEUTICALS INC NOTE 1.500%10/0 00771VAB4 47,381 48,150,000 PRN   DFND   0 48,150,000 0
APELLIS PHARMACEUTICALS INC COM 03753U106 8,324 121,880 SH   DFND   0 121,880 0
ARCUS BIOSCIENCES INC COM 03969F109 88,505 3,383,233 SH   DFND   0 3,383,233 0
ARGENX SE SPONSORED ADR 04016X101 36,976 104,732 SH   DFND   0 104,732 0
ASTRAZENECA PLC SPONSORED ADR 046353108 31,632 576,800 SH   DFND   0 576,800 0
AVANTOR INC COM 05352A100 40,761 2,079,657 SH   DFND   0 2,079,657 0
AXSOME THERAPEUTICS INC COM 05464T104 74,057 1,659,733 SH   DFND   0 1,659,733 0
BCLS ACQUISITION CORP COM CL A G0904B105 4,650 464,103 SH   DFND   0 464,103 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 27,246 2,162,411 SH   DFND   0 2,162,411 0
BIOGEN INC COM 09062X103 44,536 166,800 SH Call DFND   0 166,800 0
BIOGEN INC COM 09062X103 37,200 139,326 SH   DFND   0 139,326 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 15,259 180,000 SH Call DFND   0 180,000 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 94,599 1,115,949 SH   DFND   0 1,115,949 0
BIOMARIN PHARMACEUTICAL INC NOTE 0.599% 8/0 09061GAH4 45,604 45,910,000 PRN   DFND   0 45,910,000 0
BLUEPRINT MEDICINES CORP COM 09627Y109 8,590 130,366 SH   DFND   0 130,366 0
CANO HEALTH INC COM CL A 13781Y103 6,736 776,893 SH   DFND   0 776,893 0
CARDINAL HEALTH INC COM 14149Y108 42,661 639,783 SH   DFND   0 639,783 0
CARIBOU BIOSCIENCES INC COM 142038108 63,300 6,000,000 SH   DFND   0 6,000,000 0
CELCUITY INC COM 15102K100 1,410 140,426 SH   DFND   0 140,426 0
CENTENE CORP DEL COM 15135B101 86,562 1,112,480 SH   DFND   0 1,112,480 0
CIGNA CORP NEW COM 125523100 39,207 141,300 SH   DFND   0 141,300 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 4,267 397,711 SH   DFND   0 397,711 0
CYTOKINETICS INC COM NEW 23282W605 119,430 2,465,016 SH   DFND   0 2,465,016 0
DANAHER CORPORATION COM 235851102 45,379 175,690 SH   DFND   0 175,690 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 39,728 3,805,370 SH   DFND   0 3,805,370 0
DYNAVAX TECHNOLOGIES CORP NOTE 2.500% 5/1 268158AD4 6,328 5,000,000 PRN   DFND   0 5,000,000 0
EDITAS MEDICINE INC COM 28106W103 15,656 1,279,054 SH   DFND   0 1,279,054 0
EDWARDS LIFESCIENCES CORP COM 28176E108 39,684 480,256 SH   DFND   0 480,256 0
ELEVANCE HEALTH INC COM 036752103 11,719 25,800 SH   DFND   0 25,800 0
ERASCA INC COM 29479A108 56,667 7,264,981 SH   DFND   0 7,264,981 0
ESSA PHARMA INC COM NEW 29668H708 2,690 1,478,252 SH   DFND   0 1,478,252 0
GENERATION BIO CO COM 37148K100 16,003 3,013,712 SH   DFND   0 3,013,712 0
HCA HEALTHCARE INC COM 40412C101 32,206 175,235 SH   DFND   0 175,235 0
HORIZON THERAPEUTICS PUB L SHS G46188101 67,574 1,091,840 SH   DFND   0 1,091,840 0
HUMANA INC COM 444859102 80,574 166,066 SH   DFND   0 166,066 0
ICON PLC SHS G4705A100 24,763 134,740 SH   DFND   0 134,740 0
ICU MED INC COM 44930G107 24,134 160,250 SH   DFND   0 160,250 0
INTELLIA THERAPEUTICS INC COM 45826J105 19,299 344,868 SH   DFND   0 344,868 0
IO BIOTECH INC COM 449778109 5,851 2,159,155 SH   DFND   0 2,159,155 0
IQVIA HLDGS INC COM 46266C105 41,496 229,081 SH   DFND   0 229,081 0
IRHYTHM TECHNOLOGIES INC COM 450056106 61,853 493,721 SH   DFND   0 493,721 0
ITEOS THERAPEUTICS INC COM 46565G104 10,248 537,954 SH   DFND   0 537,954 0
IVERIC BIO INC COM 46583P102 4,598 256,284 SH   DFND   0 256,284 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 76,233 571,936 SH   DFND   0 571,936 0
JIYA ACQUISITION CORP COM CL A 47760M102 4,627 464,103 SH   DFND   0 464,103 0
JOHNSON & JOHNSON COM 478160104 22,502 137,746 SH   DFND   0 137,746 0
JOUNCE THERAPEUTICS INC COM 481116101 9,581 4,094,488 SH   DFND   0 4,094,488 0
KARUNA THERAPEUTICS INC COM 48576A100 29,307 130,293 SH   DFND   0 130,293 0
LILLY ELI & CO COM 532457108 96,566 298,643 SH   DFND   0 298,643 0
MCKESSON CORP COM 58155Q103 35,962 105,811 SH   DFND   0 105,811 0
MERCK & CO INC COM 58933Y105 31,048 360,520 SH   DFND   0 360,520 0
MOLINA HEALTHCARE INC COM 60855R100 47,424 143,779 SH   DFND   0 143,779 0
MYRIAD GENETICS INC COM 62855J104 14,160 742,138 SH   DFND   0 742,138 0
NEVRO CORP COM 64157F103 26,262 563,560 SH   DFND   0 563,560 0
NEVRO CORP NOTE 2.750% 4/0 64157FAC7 8,519 9,000,000 PRN   DFND   0 9,000,000 0
OAK STR HEALTH INC COM 67181A107 17,724 722,844 SH   DFND   0 722,844 0
OAK STR HEALTH INC NOTE 3/1 67181AAB3 48,857 63,000,000 PRN   DFND   0 63,000,000 0
OUTSET MED INC COM 690145107 11,620 729,413 SH   DFND   0 729,413 0
PARDES BIOSCIENCES INC COM 69945Q105 528 285,170 SH   DFND   0 285,170 0
PENUMBRA INC COM 70975L107 39,342 207,500 SH Call DFND   0 207,500 0
PENUMBRA INC COM 70975L107 68,262 360,030 SH   DFND   0 360,030 0
PMV PHARMACEUTICALS INC COM 69353Y103 10,176 855,164 SH   DFND   0 855,164 0
POINT BIOPHARMA GLOBAL INC COM 730541109 34,903 4,515,216 SH   DFND   0 4,515,216 0
PRAXIS PRECISION MEDICINES I COM 74006W108 7,851 3,458,525 SH   DFND   0 3,458,525 0
PROCEPT BIOROBOTICS CORP COM 74276L105 21,457 517,526 SH   DFND   0 517,526 0
PROTHENA CORP PLC SHS G72800108 4,881 80,500 SH Call DFND   0 80,500 0
PROTHENA CORP PLC SHS G72800108 50,944 840,238 SH   DFND   0 840,238 0
PULMONX CORP COM 745848101 3,327 199,703 SH   DFND   0 199,703 0
SANA BIOTECHNOLOGY INC COM 799566104 4,149 691,464 SH   DFND   0 691,464 0
SEAGEN INC COM 81181C104 49,972 365,215 SH   DFND   0 365,215 0
SELECT SECTOR SPDR TR TECHNOLOGY 81369Y803 45,552 383,500 SH Put DFND   0 383,500 0
SIGHT SCIENCES INC COM 82657M105 1,446 227,692 SH   DFND   0 227,692 0
SOPHIA GENETICS SA ORDINARY SHARES H82027105 2,314 879,913 SH   DFND   0 879,913 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 30,976 1,289,073 SH   DFND   0 1,289,073 0
TENET HEALTHCARE CORP COM NEW 88033G407 28,090 544,583 SH   DFND   0 544,583 0
THERMO FISHER SCIENTIFIC INC COM 883556102 31,518 62,143 SH   DFND   0 62,143 0
UNIQURE NV SHS N90064101 44,899 2,393,311 SH   DFND   0 2,393,311 0
UNITEDHEALTH GROUP INC COM 91324P102 56,339 111,554 SH   DFND   0 111,554 0
VEEVA SYS INC CL A COM 922475108 33,370 202,387 SH   DFND   0 202,387 0
VERVE THERAPEUTICS INC COM 92539P101 40,149 1,168,808 SH   DFND   0 1,168,808 0
WATERS CORP COM 941848103 31,706 117,634 SH   DFND   0 117,634 0
WEREWOLF THERAPEUTICS INC COM 95075A107 12,699 2,815,654 SH   DFND   0 2,815,654 0
ZAI LAB LTD ADR 98887Q104 808 23,612 SH   DFND   0 23,612 0