UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Form
(Amendment No. 1)
CURRENT REPORT
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Explanatory Note
| Item 7.01 | Regulation FD Disclosure. |
On December 19, 2022, Wave Life Sciences Ltd. (the “Company” or “Wave”) issued a press release announcing a positive update from the initial cohort of the Phase 1b/2a proof-of-concept study of WVE-N531, the Company’s exon 53 exon-skipping oligonucleotide for the treatment of Duchenne muscular dystrophy (“DMD”). High muscle concentrations of WVE-N531 and exon skipping were observed six weeks after initiating biweekly multidosing with 10 mgs/kg, achieving proof-of-concept in the study. WVE-N531 also appeared safe and well-tolerated. The initial cohort is an open-label, intra-patient dose escalation clinical trial evaluating WVE-N531 as a treatment for boys with DMD who are amenable to exon 53 skipping. A copy of the press release is attached hereto as Exhibit 99.1 and incorporated by reference herein.
The press release also indicated that Wave management will host an investor conference call at 8:30 a.m. ET on December 19, 2022 to discuss these results. For purposes of the call, and in connection with the announcement described above, the Company plans to share an investor slide presentation during the investor conference call, which will be available on the “For Investors & Media” section of the Company’s website at http://ir.wavelifesciences.com/.
The information in this Item 7.01 is being furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that Section, nor shall it be deemed incorporated by reference into any registration statement or other filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing.
| Item 8.01 | Other Events. |
The information set forth in the press release referred to in Item 7.01 above, other than the second, third and sixth paragraphs thereof, is incorporated by reference into this Item 8.01 of this Current Report on Form 8-K.
| Item 9.01 | Financial Statements and Exhibits. |
| (d) | Exhibits |
The following exhibit relating to Item 7.01 is furnished and not filed:
| Exhibit No. |
Description | |
| 99.1 | Press Release issued by Wave Life Sciences Ltd. dated December 19, 2022 | |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document) | |
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
| WAVE LIFE SCIENCES LTD. | ||||||
| By: | /s/ Paul B. Bolno, M.D. | |||||
| Paul B. Bolno, M.D. | ||||||
| President and Chief Executive Officer | ||||||
| Date: December 19, 2022 | ||||||