The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 5,529 955,000 SH   DFND 1,2 0 955,000 0
ACLARIS THERAPEUTICS INC COM 00461U105 16,043 1,019,282 SH   DFND 1,2 0 1,019,282 0
ACUMEN PHARMACEUTICALS INC COM 00509G209 12,036 1,200,000 SH   DFND 1,2 0 1,200,000 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 1,315 2,500,000 SH   DFND 1,2 0 2,500,000 0
ALKERMES PLC SHS G01767105 11,332 507,500 SH   DFND 1,2 0 507,500 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 24,829 3,448,521 SH   DFND 1,2 0 3,448,521 0
BRIDGEBIO PHARMA INC COM 10806X102 10,437 1,050,000 SH   DFND 1,2 0 1,050,000 0
CINCOR PHARMA INC COM 17240Y109 9,889 301,324 SH   DFND 1,2 0 301,324 0
CYMABAY THERAPEUTICS INC COM 23257D103 2,798 799,439 SH   DFND 1,2 0 799,439 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109 1,415 70,621 SH   DFND 1,2 0 70,621 0
GALAPAGOS NV SPON ADR 36315X101 13,065 306,411 SH   DFND 1,2 0 306,411 0
GENERATION BIO CO COM 37148K100 4,381 825,077 SH   DFND 1,2 0 825,077 0
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103 1,446 449,049 SH   DFND 1,2 0 449,049 0
HERON THERAPEUTICS INC COM 427746102 23,484 5,645,161 SH   DFND 1,2 0 5,645,161 0
IMMUNOCORE HLDGS PLC ADS 45258D105 3,686 78,527 SH   DFND 1,2 0 78,527 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 1,465 105,000 SH   DFND 1,2 0 105,000 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 28,657 215,000 SH   DFND 1,2 0 215,000 0
KALVISTA PHARMACEUTICALS INC COM 483497103 22,515 1,551,719 SH   DFND 1,2 0 1,551,719 0
LARIMAR THERAPEUTICS INC COM 517125100 3,632 1,135,000 SH   DFND 1,2 0 1,135,000 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 6,207 95,500 SH   DFND 1,2 0 95,500 0
MAGENTA THERAPEUTICS INC COM 55910K108 1,437 1,019,091 SH   DFND 1,2 0 1,019,091 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 6,200 674,656 SH   DFND 1,2 0 674,656 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104 3,818 492,000 SH   DFND 1,2 0 492,000 0
NEKTAR THERAPEUTICS COM 640268108 1,433 447,820 SH   DFND 1,2 0 447,820 0
NGM BIOPHARMACEUTICALS INC COM 62921N105 4,137 316,256 SH   DFND 1,2 0 316,256 0
PIERIS PHARMACEUTICALS INC COM 720795103 2,260 1,965,449 SH   DFND 1,2 0 1,965,449 0
PLIANT THERAPEUTICS INC COM 729139105 21,762 1,041,737 SH   DFND 1,2 0 1,041,737 0
POINT BIOPHARMA GLOBAL INC COM 730541109 27,526 3,560,984 SH   DFND 1,2 0 3,560,984 0
PRECISION BIOSCIENCES INC COM 74019P108 3,524 2,710,805 SH   DFND 1,2 0 2,710,805 0
RAPT THERAPEUTICS INC COM 75382E109 7,579 315,000 SH   DFND 1,2 0 315,000 0
RELMADA THERAPEUTICS INC COM 75955J402 18,880 510,000 SH   DFND 1,2 0 510,000 0
REPLIMUNE GROUP INC COM 76029N106 6,735 390,000 SH   DFND 1,2 0 390,000 0
SEAGEN INC COM 81181C104 10,467 76,500 SH   DFND 1,2 0 76,500 0
SILENCE THERAPEUTICS PLC ADS 82686Q101 692 68,915 SH   DFND 1,2 0 68,915 0
TRAVERE THERAPEUTICS INC COM 89422G107 23,805 966,108 SH   DFND 1,2 0 966,108 0
TRICIDA INC COM 89610F101 9,118 870,000 SH   DFND 1,2 0 870,000 0
UROGEN PHARMA LTD COM M96088105 7,267 873,424 SH   DFND 1,2 0 873,424 0
VAXCYTE INC COM 92243G108 14,400 600,000 SH   DFND 1,2 0 600,000 0
VENTYX BIOSCIENCES INC COM 92332V107 9,425 269,967 SH   DFND 1,2 0 269,967 0
XENON PHARMACEUTICALS INC COM 98420N105 30,685 850,000 SH   DFND 1,2 0 850,000 0