The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABSCI CORPORATION COM 00091E109 2,799 894,346 SH   SOLE   894,346 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 5,371 341,239 SH   SOLE   341,239 0 0
ACUMEN PHARMACEUTICALS INC COM 00509G209 4,012 400,000 SH   SOLE   400,000 0 0
ADMA BIOLOGICS INC COM 000899104 26,568 10,933,387 SH   SOLE   10,933,387 0 0
AGILE THERAPEUTICS INC COM NEW 00847L209 158 532,361 SH   SOLE   532,361 0 0
AKERO THERAPEUTICS INC COM 00973Y108 14,642 430,000 SH   SOLE   430,000 0 0
ALBIREO PHARMA INC COM 01345P106 45,692 2,360,139 SH   SOLE   2,360,139 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 60,609 11,350,085 SH   SOLE   11,350,085 0 0
AMICUS THERAPEUTICS INC COM 03152W109 285,773 27,372,917 SH   SOLE   27,372,917 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101 154,038 5,472,033 SH   SOLE   5,472,033 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 25,025 366,400 SH   SOLE   366,400 0 0
ARCELLX INC COMMON STOCK 03940C100 46,276 2,465,405 SH   SOLE   2,465,405 0 0
ARCUS BIOSCIENCES INC COM 03969F109 17,435 666,477 SH   SOLE   666,477 0 0
ARTIVION INC COM 228903100 16,667 1,204,229 SH   SOLE   1,204,229 0 0
ASTRIA THERAPEUTICS INC COM 04635X102 11,582 1,281,197 SH   SOLE   1,281,197 0 0
ATHENEX INC COM 04685N103 4,178 15,532,467 SH   SOLE   15,532,467 0 0
ATHIRA PHARMA INC COM 04746L104 14,248 4,797,278 SH   SOLE   4,797,278 0 0
AXOGEN INC COM 05463X106 11,320 949,626 SH   SOLE   949,626 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 108,209 10,247,073 SH   SOLE   10,247,073 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 28,523 336,481 SH   SOLE   336,481 0 0
BRIDGEBIO PHARMA INC COM 10806X102 16,869 1,697,033 SH   SOLE   1,697,033 0 0
C4 THERAPEUTICS INC COM STK 12529R107 6,720 766,231 SH   SOLE   766,231 0 0
CAREMAX INC COM CL A 14171W103 24,070 3,394,939 SH   SOLE   3,394,939 0 0
CAREMAX INC *W EXP 06/08/202 14171W111 113 60,000 SH   SOLE   60,000 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 184,021 6,511,727 SH   SOLE   6,511,727 0 0
CHEMOCENTRYX INC COM 16383L106 9,954 192,680 SH   SOLE   192,680 0 0
CINCOR PHARMA INC COM 17240Y109 108,524 3,306,649 SH   SOLE   3,306,649 0 0
CLOVER HEALTH INVESTMENTS CO COM CL A 18914F103 2,550 1,500,000 SH   SOLE   1,500,000 0 0
COGENT BIOSCIENCES INC COM 19240Q201 47,855 3,207,441 SH   SOLE   3,207,441 0 0
COHERUS BIOSCIENCES INC COM 19249H103 16,021 1,667,123 SH   SOLE   1,667,123 0 0
COHERUS BIOSCIENCES INC NOTE 1.500% 4/1 19249HAB9 3,592 4,500,000 PRN   SOLE   4,500,000 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 14,409 2,150,641 SH   SOLE   2,150,641 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 104,505 5,321,032 SH   SOLE   5,321,032 0 0
CTI BIOPHARMA CORP COM 12648L601 4,279 735,165 SH   SOLE   735,165 0 0
CYTEK BIOSCIENCES INC COM 23285D109 18,982 1,289,534 SH   SOLE   1,289,534 0 0
DARIOHEALTH CORP COM NEW 23725P209 1,518 327,869 SH   SOLE   327,869 0 0
DICE THERAPEUTICS INC COM 23345J104 13,941 687,424 SH   SOLE   687,424 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 27,268 330,000 SH   SOLE   330,000 0 0
ENVVENO MEDICAL CORPORATION COM 29415J106 4,909 781,615 SH   SOLE   781,615 0 0
EQRX INC *W EXP 12/17/202 26886C115 205 250,000 SH   SOLE   250,000 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 31,578 578,253 SH   SOLE   578,253 0 0
FULCRUM THERAPEUTICS INC COM 359616109 2,379 294,118 SH   SOLE   294,118 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 158,145 2,322,247 SH   SOLE   2,322,247 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 18,239 411,804 SH   SOLE   411,804 0 0
HEALTH CATALYST INC COM 42225T107 3,783 389,962 SH   SOLE   389,962 0 0
HILLEVAX INC COM 43157M102 13,072 764,907 SH   SOLE   764,907 0 0
HYPERFINE INC COM CL A 44916K106 751 927,388 SH   SOLE   927,388 0 0
ICOSAVAX INC COM 45114M109 296 93,591 SH   SOLE   93,591 0 0
IMMATICS N.V SHS N44445109 25,000 2,500,000 SH   SOLE   2,500,000 0 0
INARI MED INC COM 45332Y109 5,085 70,000 SH   SOLE   70,000 0 0
INHIBRX INC COM 45720L107 51,837 2,887,860 SH   SOLE   2,887,860 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 98,181 10,248,624 SH   SOLE   10,248,624 0 0
ISOPLEXIS CORP COM 465005106 7,044 4,095,498 SH   SOLE   4,095,498 0 0
IVERIC BIO INC COM 46583P102 18,553 1,034,169 SH   SOLE   1,034,169 0 0
KRONOS BIO INC COM 50107A104 7,223 2,156,151 SH   SOLE   2,156,151 0 0
LANDOS BIOPHARMA INC COM 515069102 9,665 14,869,915 SH   SOLE   14,869,915 0 0
LARIMAR THERAPEUTICS INC COM 517125100 9,152 2,860,000 SH   SOLE   2,860,000 0 0
LEAP THERAPEUTICS INC COM 52187K101 6,575 7,472,148 SH   SOLE   7,472,148 0 0
LIANBIO SPONSORED ADS 53000N108 115,116 57,558,451 SH   SOLE   57,558,451 0 0
LYRA THERAPEUTICS INC COM 55234L105 45,825 9,146,730 SH   SOLE   9,146,730 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 21,513 331,023 SH   SOLE   331,023 0 0
MEIRAGTX HLDGS PLC COM G59665102 58,561 6,963,277 SH   SOLE   6,963,277 0 0
MIRATI THERAPEUTICS INC COM 60468T105 194,490 2,784,796 SH   SOLE   2,784,796 0 0
MORPHIC HLDG INC COM 61775R105 10,278 363,197 SH   SOLE   363,197 0 0
MOTUS GI HLDGS INC COM NEW 62014P405 221 90,027 SH   SOLE   90,027 0 0
NANOBIOTIX SPONSORED ADS 63009J107 3,752 1,059,800 SH   SOLE   1,059,800 0 0
NATERA INC COM 632307104 5,258 120,000 SH   SOLE   120,000 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 19,315 9,111,151 SH   SOLE   9,111,151 0 0
NEPTUNE WELLNESS SOLUTIONS I COM NEW 64079L204 87 57,142 SH   SOLE   57,142 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 10,626 100,050 SH   SOLE   100,050 0 0
NEVRO CORP COM 64157F103 6,990 150,000 SH   SOLE   150,000 0 0
NUVALENT INC COM 670703107 32,173 1,655,007 SH   SOLE   1,655,007 0 0
OUTSET MED INC COM 690145107 18,616 1,168,630 SH   SOLE   1,168,630 0 0
PEAR THERAPEUTICS INC COM 704723105 1,837 900,548 SH   SOLE   900,548 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 3,865 500,000 SH   SOLE   500,000 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 2,648 750,000 SH   SOLE   750,000 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105 10,934 263,720 SH   SOLE   263,720 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 86,657 1,468,512 SH   SOLE   1,468,512 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 859 290,051 SH   SOLE   290,051 0 0
PROTHENA CORP PLC SHS G72800108 13,945 230,000 SH   SOLE   230,000 0 0
PROVENTION BIO INC COM 74374N102 498 110,728 SH   SOLE   110,728 0 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101 3,012 1,528,812 SH   SOLE   1,528,812 0 0
QUOTIENT LTD SHS G73268107 2,430 16,200,818 SH   SOLE   16,200,818 0 0
RAIN THERAPEUTICS INC COM 75082Q105 12,120 2,483,619 SH   SOLE   2,483,619 0 0
RAPT THERAPEUTICS INC COM 75382E109 41,218 1,713,134 SH   SOLE   1,713,134 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 2,513 100,000 SH   SOLE   100,000 0 0
RELAY THERAPEUTICS INC COM 75943R102 43,467 1,943,097 SH   SOLE   1,943,097 0 0
RELMADA THERAPEUTICS INC COM 75955J402 88,236 2,383,478 SH   SOLE   2,383,478 0 0
REVANCE THERAPEUTICS INC COM 761330109 21,834 808,671 SH   SOLE   808,671 0 0
REVOLUTION MEDICINES INC COM 76155X100 6,123 310,500 SH   SOLE   310,500 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 7,980 500,000 SH   SOLE   500,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 27,967 253,000 SH   SOLE   253,000 0 0
SCIENCE 37 HOLDINGS INC COM 808644108 2,415 1,500,000 SH   SOLE   1,500,000 0 0
SEAGEN INC COM 81181C104 43,313 316,544 SH   SOLE   316,544 0 0
SEMA4 HOLDINGS CORP COM CL A 81663L101 4,390 5,000,000 SH   SOLE   5,000,000 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 8,841 3,536,274 SH   SOLE   3,536,274 0 0
SOLID BIOSCIENCES INC COM 83422E105 6,258 13,412,552 SH   SOLE   13,412,552 0 0
SOMALOGIC INC CLASS A COM 83444K105 4,350 1,500,000 SH   SOLE   1,500,000 0 0
SONENDO INC COM 835431107 655 612,204 SH   SOLE   612,204 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 99,015 3,470,563 SH   SOLE   3,470,563 0 0
SURROZEN INC COM 86889P109 12 6,017 SH   SOLE   6,017 0 0
SURROZEN INC *W EXP 08/01/203 86889P117 31 166,666 SH   SOLE   166,666 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 22,194 1,296,416 SH   SOLE   1,296,416 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 2,236 90,748 SH   SOLE   90,748 0 0
TRAVERE THERAPEUTICS INC NOTE 2.250% 3/0 89422GAA5 45,980 45,000,000 PRN   SOLE   45,000,000 0 0
TREACE MED CONCEPTS INC COM 89455T109 35,356 1,601,979 SH   SOLE   1,601,979 0 0
TRICIDA INC COM 89610F101 5,240 500,000 SH Put SOLE   500,000 0 0
TYRA BIOSCIENCES INC COM 90240B106 4,346 494,403 SH   SOLE   494,403 0 0
VBI VACCINES INC CDA COM NEW 91822J103 37,157 52,335,002 SH   SOLE   52,335,002 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 51,583 5,047,264 SH   SOLE   5,047,264 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 14,714 5,038,983 SH   SOLE   5,038,983 0 0
VERU INC COM 92536C103 44,847 3,893,000 SH   SOLE   3,893,000 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 25,034 1,220,575 SH   SOLE   1,220,575 0 0
XENON PHARMACEUTICALS INC COM 98420N105 76,624 2,122,535 SH   SOLE   2,122,535 0 0
Y-MABS THERAPEUTICS INC COM 984241109 3,057 212,018 SH   SOLE   212,018 0 0
ZYMEWORKS INC COM 98985W102 27,060 4,400,099 SH   SOLE   4,400,099 0 0