The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABCELLERA BIOLOGICS INC COM 00288U106 11,145 1,126,915 SH   SOLE   1,126,915 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 40,061 500,827 SH   SOLE   500,827 0 0
ALIGOS THERAPEUTICS INC COM 01626L105 2,145 1,950,000 SH   SOLE   1,950,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 20,016 100,000 SH   SOLE   100,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 21,924 2,100,000 SH   SOLE   2,100,000 0 0
ARCELLX, INC. COMMON STOCK 03940C100 59,912 3,191,878 SH   SOLE   3,191,878 0 0
APPLE INC COM 037833100 63,763 461,379 SH   SOLE   461,379 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210 94,189 226,770 SH   SOLE   226,770 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 26,914 317,500 SH   SOLE   317,500 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 20,866 316,674 SH   SOLE   316,674 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 5,482 3,703,991 SH   SOLE   3,703,991 0 0
BOSTON SCIENTIFIC CORP COM 101137107 68,279 1,762,942 SH   SOLE   1,762,942 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 102,586 2,508,830 SH   SOLE   2,508,830 0 0
CABLE ONE INC COM 12685J105 68,264 80,023 SH   SOLE   80,023 0 0
CATALENT INC COM 148806102 118,155 1,632,878 SH   SOLE   1,632,878 0 0
CORCEPT THERAPEUTICS INC COM 218352102 85,324 3,327,768 SH   SOLE   3,327,768 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 12,405 631,627 SH   SOLE   631,627 0 0
CYTEIR THERAPEUTICS INC COM 23284P103 7,566 3,940,413 SH   SOLE   3,940,413 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 59,746 6,071,703 SH   SOLE   6,071,703 0 0
GALECTO INC COM 36322Q107 4,721 2,497,791 SH   SOLE   2,497,791 0 0
GALERA THERAPEUTICS INC COM 36338D108 4,279 2,459,021 SH   SOLE   2,459,021 0 0
INARI MED INC COM 45332Y109 15,487 213,200 SH   SOLE   213,200 0 0
INSMED INC COM PAR $.01 457669307 16,586 770,000 SH   SOLE   770,000 0 0
INSPIRE MED SYS INC COM 457730109 10,802 60,900 SH   SOLE   60,900 0 0
IO BIOTECH INC COM 449778109 8,883 3,277,932 SH   SOLE   3,277,932 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 5,152 598,377 SH   SOLE   598,377 0 0
KINNATE BIOPHARMA INC COM 49705R105 9,748 815,707 SH   SOLE   815,707 0 0
LAVA THERAPEUTICS NV SHS N51517105 15,206 3,327,312 SH   SOLE   3,327,312 0 0
MARQETA INC CLASS A COM 57142B104 3,144 441,558 SH   SOLE   441,558 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 18,380 2,000,000 SH   SOLE   2,000,000 0 0
MINERVA SURGICAL INC COM 60343F106 17,194 1,862,877 SH   SOLE   1,862,877 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 35,385 1,684,193 SH   SOLE   1,684,193 0 0
NKARTA INC COM 65487U108 10,833 823,200 SH   SOLE   823,200 0 0
PHARVARIS N V COM N69605108 4,679 610,000 SH   SOLE   610,000 0 0
PULMONX CORP COM 745848101 8,506 510,555 SH   SOLE   510,555 0 0
RALLYBIO CORP COM 75120L100 9,129 630,921 SH   SOLE   630,921 0 0
RENEO PHARMACEUTICALS INC COM 75974E103 11,492 3,430,377 SH   SOLE   3,430,377 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 10,100 632,822 SH   SOLE   632,822 0 0
SALESFORCE.COM, INC. COM 79466L302 83,211 578,500 SH   SOLE   578,500 0 0
SEAGEN INC. COM 81181C104 10,262 75,000 SH   SOLE   75,000 0 0
SEASPINE HLDGS CORP COM 81255T108 2,987 525,867 SH   SOLE   525,867 0 0
SILK RD MED INC COM 82710M100 12,398 275,511 SH   SOLE   275,511 0 0
STERIS PLC SHS USD G8473T100 77,767 467,687 SH   SOLE   467,687 0 0
STRYKER CORPORATION COM 863667101 161,412 796,941 SH   SOLE   796,941 0 0
SPERO THERAPEUTICS INC COM 84833T103 938 468,902 SH   SOLE   468,902 0 0
SPRUCE BIOSCIENCES INC COM 85209E109 6,185 4,514,336 SH   SOLE   4,514,336 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 48,731 710,780 SH   SOLE   710,780 0 0
TREACE MED CONCEPTS INC COM 89455T109 12,984 588,308 SH   SOLE   588,308 0 0
VAXCYTE INC COM 92243G108 19,769 823,705 SH   SOLE   823,705 0 0
VANGUARD INDEX FDS TOTAL STK MKT 922908769 500,838 1,525,550 SH   SOLE   1,525,550 0 0
VECTIVBIO HLDG AG ORD SHS H9060V101 20,037 3,339,484 SH   SOLE   3,339,484 0 0
VERVE THERAPEUTICS INC COM 92539P101 31,297 911,111 SH   SOLE   911,111 0 0