The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
111 INC ADS 68247Q102 1,840 686,431 SH   DFND 1,2,3,4,5,6 686,431 0 0
23ANDME HOLDING CO CLASS A COM 90138Q108 1,890 661,009 SH   DFND 1,2,3,4,5,6 661,009 0 0
AC IMMUNE SA SHS H00263105 3,160 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 5,097 2,255,375 SH   DFND 1,2,3,4,5,6 2,255,375 0 0
ADAGENE INC ADS 005329107 1,280 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 358 1,300 SH   DFND 1,2,3,4,5,6 1,300 0 0
AGENUS INC COM NEW 00847G705 8,200 4,000,000 SH   DFND 1,2,3,4,5,6 4,000,000 0 0
ALLOVIR INC COM 019818103 44,004 5,577,167 SH   DFND 1,2,3,4,5,6 5,577,167 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 8,590 1,193,030 SH   DFND 1,2,3,4,5,6 1,193,030 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 4,785 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
AMBRX BIOPHARMA INC SPONSORED ADS 02290A102 2,324 2,152,291 SH   DFND 1,2,3,4,5,6 2,152,291 0 0
AMICUS THERAPEUTICS INC COM 03152W109 41,760 4,000,000 SH   DFND 1,2,3,4,5,6 4,000,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 68,300 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
APPLIED THERAPEUTICS INC COM 03828A101 372 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
APTINYX INC COM 03836N103 2,251 6,116,493 SH   DFND 1,2,3,4,5,6 6,116,493 0 0
ARAVIVE INC COM 03890D108 1,072 1,311,291 SH   DFND 1,2,3,4,5,6 1,311,291 0 0
ARGENX SE SPONSORED ADR 04016X101 52,958 150,000 SH   DFND 1,2,3,4,5,6 150,000 0 0
ASTRIA THERAPEUTICS INC COM 04635X102 301 33,333 SH   DFND 1,2,3,4,5,6 33,333 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 7,520 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AVANTOR INC COM 05352A100 882 45,000 SH   DFND 1,2,3,4,5,6 45,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 4,083 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
AXCELLA HEALTH INC COM 05454B105 1,218 712,500 SH   DFND 1,2,3,4,5,6 712,500 0 0
BEIGENE LTD SPONSORED ADR 07725L102 87,633 650,000 SH   DFND 1,2,3,4,5,6 650,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 6,741 50,000 SH Call DFND 1,2,3,4,5,6 50,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 63,360 6,000,000 SH   DFND 1,2,3,4,5,6 6,000,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 2,783 1,646,517 SH   DFND 1,2,3,4,5,6 1,646,517 0 0
BRIDGEBIO PHARMA INC COM 10806X102 2,485 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
CARDIFF ONCOLOGY INC COM 14147L108 1,155 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
CARIBOU BIOSCIENCES INC COM 142038108 1,111 105,347 SH   DFND 1,2,3,4,5,6 105,347 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 56,520 2,000,000 SH   DFND 1,2,3,4,5,6 2,000,000 0 0
CIDARA THERAPEUTICS INC COM 171757107 141 224,675 SH   DFND 1,2,3,4,5,6 224,675 0 0
CODIAK BIOSCIENCES INC COM 192010106 156 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 3,840 573,062 SH   DFND 1,2,3,4,5,6 573,062 0 0
CONTRAFECT CORP COM NEW 212326300 252 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 409 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
CULLINAN ONCOLOGY INC COM 230031106 3,205 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
CURIS INC COM NEW 231269200 910 1,300,000 SH   DFND 1,2,3,4,5,6 1,300,000 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 2,381 2,768,069 SH   DFND 1,2,3,4,5,6 2,768,069 0 0
CYCLERION THERAPEUTICS INC COM 23255M105 10 11,053 SH   DFND 1,2,3,4 11,053 0 0
CYTOKINETICS INC COM NEW 23282W605 48,450 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
DENALI THERAPEUTICS INC COM 24823R105 18,414 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
DYNE THERAPEUTICS INC COM 26818M108 6,668 525,000 SH   DFND 1,2,3,4,5,6 525,000 0 0
EQRX INC COM 26886C107 19,800 4,000,000 SH   DFND 1,2,3,4,5,6 4,000,000 0 0
ERASCA INC COM 29479A108 24,743 3,172,221 SH   DFND 1,2,3,4,5,6 3,172,221 0 0
EVOTEC AG SPONSORED ADS 30050E105 10,103 1,149,425 SH   DFND 1,2,3,4,5,6 1,149,425 0 0
EXSCIENTIA PLC ADS 30223G102 4,516 550,000 SH   DFND 1,2,3,4,5,6 550,000 0 0
FATE THERAPEUTICS INC COM 31189P102 58,266 2,600,000 SH   DFND 1,2,3,4,5,6 2,600,000 0 0
FOGHORN THERAPEUTICS INC COM 344174107 14,764 1,720,720 SH   DFND 1,2,3,4,5,6 1,720,720 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 2,258 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
GENERATION BIO CO COM 37148K100 14,943 2,814,191 SH   DFND 1,2,3,4,5,6 2,814,191 0 0
GOSSAMER BIO INC COM 38341P102 38,895 3,246,624 SH   DFND 1,2,3,4,5,6 3,246,624 0 0
GRAPHITE BIO INC COM 38870X104 2,219 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
GRITSTONE BIO INC COM 39868T105 1,928 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
HARPOON THERAPEUTICS INC COM 41358P106 970 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
HIPPO HLDGS INC COM NEW 433539202 445 24,000 SH   DFND 1,2,3,4,5,6 24,000 0 0
HOOKIPA PHARMA INC COM 43906K100 2,478 1,849,616 SH   DFND 1,2,3,4,5,6 1,849,616 0 0
IGM BIOSCIENCES INC COM 449585108 55,713 2,450,000 SH   DFND 1,2,3,4,5,6 2,450,000 0 0
IGM BIOSCIENCES INC COM 449585108 1,137 50,000 SH Call DFND 1,2,3,4,5,6 50,000 0 0
IKENA ONCOLOGY INC COM 45175G108 5,501 1,549,513 SH   DFND 1,2,3,4,5,6 1,549,513 0 0
I MAB SPONSORED ADS 44975P103 3,409 850,000 SH   DFND 1,2,3,4,5,6 850,000 0 0
IMMUNIC INC COM 4525EP101 2,212 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
IMMUTEP LTD SPONSORED ADS 45257L108 1,560 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
INSTIL BIO INC COM 45783C101 2,178 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 15,389 275,000 SH   DFND 1,2,3,4,5,6 275,000 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1,145 110,532 SH   DFND 1,2,3,4 110,532 0 0
ITEOS THERAPEUTICS INC COM 46565G104 7,620 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
IVERIC BIO INC COM 46583P102 13,455 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
IVERIC BIO INC COM 46583P102 8,970 500,000 SH Call DFND 1,2,3,4,5,6 500,000 0 0
KARUNA THERAPEUTICS INC COM 48576A100 28,116 125,000 SH   DFND 1,2,3,4,5,6 125,000 0 0
KINNATE BIOPHARMA INC COM 49705R105 1,494 125,000 SH   DFND 1,2,3,4,5,6 125,000 0 0
KRONOS BIO INC COM 50107A104 5,169 1,542,954 SH   DFND 1,2,3,4,5,6 1,542,954 0 0
KRYSTAL BIOTECH INC COM 501147102 34,850 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
KURA ONCOLOGY INC COM 50127T109 15,026 1,100,000 SH   DFND 1,2,3,4,5,6 1,100,000 0 0
KYMERA THERAPEUTICS INC COM 501575104 32,655 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
LAVA THERAPEUTICS NV SHS N51517105 914 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
LEAP THERAPEUTICS INC COM 52187K101 3,520 4,000,000 SH   DFND 1,2,3,4,5,6 4,000,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 8,439 3,516,214 SH   DFND 1,2,3,4,5,6 3,516,214 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 207,029 86,262,020 SH   DFND 1,2,3,4 86,262,020 0 0
LYELL IMMUNOPHARMA INC COM 55083R104 5,131 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200 1,044 157,000 SH   DFND 1,2,3,4,5,6 157,000 0 0
MEI PHARMA INC COM NEW 55279B202 387 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107 1,292 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
MERSANA THERAPEUTICS INC COM 59045L106 14,872 2,200,000 SH   DFND 1,2,3,4,5,6 2,200,000 0 0
METACRINE INC COM 59101E103 449 924,898 SH   DFND 1,2,3,4,5,6 924,898 0 0
MINERVA NEUROSCIENCES INC COM NEW 603380205 2,308 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
MINK THERAPEUTICS INC COM 603693102 611 289,588 SH   DFND 1,2,3,4,5,6 289,588 0 0
MIRATI THERAPEUTICS INC COM 60468T105 92,538 1,325,000 SH   DFND 1,2,3,4,5,6 1,325,000 0 0
MIRION TECHNOLOGIES INC COM CL A 60471A101 3,735 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
MORPHIC HLDG INC COM 61775R105 60,845 2,150,000 SH   DFND 1,2,3,4,5,6 2,150,000 0 0
NANOBIOTIX SPONSORED ADS 63009J107 3,540 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
NATERA INC COM 632307104 4,382 100,000 SH   DFND 1,2,3,4,5,6 100,000 0 0
NEXIMMUNE INC COM 65344D109 666 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
OATLY GROUP AB SPONSORED ADS 67421J108 3,945 1,500,000 SH   DFND 1,2,3,4,5,6 1,500,000 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 719 260,500 SH   DFND 1,2,3,4,5,6 260,500 0 0
OMEGA ALPHA SPAC CL A G6749V107 7,448 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
OMEGA THERAPEUTICS INC COM 68217N105 12,323 2,273,530 SH   DFND 1,2,3,4,5,6 2,273,530 0 0
ORCHARD THERAPEUTICS PLC SPON ADS 68570P101 902 1,803,858 SH   DFND 1,2,3,4,5,6 1,803,858 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 1,280 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
OVID THERAPEUTICS INC COM 690469101 4,600 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
PORTAGE FINTECH ACQUISITN CO CLASS A ORD SHS G7185D106 3,713 380,000 SH   DFND 1,2,3,4,5,6 380,000 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 2,724 1,200,000 SH   DFND 1,2,3,4,5,6 1,200,000 0 0
RECURSION PHARMACEUTICALS IN CL A 75629V104 4,788 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
RELAY THERAPEUTICS INC COM 75943R102 32,542 1,454,716 SH   DFND 1,2,3,4,5,6 1,454,716 0 0
REPARE THERAPEUTICS INC COM 760273102 8,491 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
REPLIMUNE GROUP INC COM 76029N106 15,543 900,000 SH   DFND 1,2,3,4,5,6 900,000 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 886 2,042,666 SH   DFND 1,2,3,4,5,6 2,042,666 0 0
SAGE THERAPEUTICS INC COM 78667J108 29,370 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
SANA BIOTECHNOLOGY INC COM 799566104 2,400 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 60,638 8,750,034 SH   DFND 1,2,3,4,5,6 8,750,034 0 0
SCHRODINGER INC COM 80810D103 17,486 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
SEA LTD SPONSORED ADS 81141R100 9,669 172,500 SH   DFND 1,2,3,4,5,6 172,500 0 0
SEAGEN INC COM 81181C104 47,891 350,000 SH   DFND 1,2,3,4,5,6 350,000 0 0
SEAGEN INC COM 81181C104 13,683 100,000 SH Call DFND 1,2,3,4,5,6 100,000 0 0
SEER INC COM CL A 81578P106 36,765 4,750,000 SH   DFND 1,2,3,4,5,6 4,750,000 0 0
SELECTA BIOSCIENCES INC COM 816212104 8,008 4,883,200 SH   DFND 1,2,3,4,5,6 4,883,200 0 0
SENTI BIOSCIENCES INC COM 81726A100 2,291 1,055,555 SH   DFND 1,2,3,4,5,6 1,055,555 0 0
SIGILON THERAPEUTICS INC COM 82657L107 139 276,000 SH   DFND 1,2,3,4,5,6 276,000 0 0
SOLID BIOSCIENCES INC COM 83422E105 1,400 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 396,600 5,000,000 SH Call DFND 1,2,3,4,5,6 5,000,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 1,000 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 58,584 2,053,403 SH   DFND 1,2,3,4,5,6 2,053,403 0 0
SQZ BIOTECHNOLOGIES CO COM 78472W104 3,662 1,606,309 SH   DFND 1,2,3,4,5,6 1,606,309 0 0
STOKE THERAPEUTICS INC COM 86150R107 3,210 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
SYROS PHARMACEUTICALS INC COM NEW 87184Q206 9,427 1,463,829 SH   DFND 1,2,3,4,5,6 1,463,829 0 0
TALARIS THERAPEUTICS INC COM 87410C104 5,429 2,064,262 SH   DFND 1,2,3,4,5,6 2,064,262 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106 2,009 1,040,882 SH   DFND 1,2,3,4,5,6 1,040,882 0 0
TCR2 THERAPEUTICS INC COM 87808K106 1,350 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
THIRD HARMONIC BIO INC COM 88427A107 3,794 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
VERVE THERAPEUTICS INC COM 92539P101 13,740 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
VIGIL NEUROSCIENCE INC COM 92673K108 20,799 2,285,574 SH   DFND 1,2,3,4,5,6 2,285,574 0 0
VOR BIOPHARMA INC COM 929033108 2,189 550,000 SH   DFND 1,2,3,4,5,6 550,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 10,830 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
WW INTL INC COM 98262P101 58,236 14,818,300 SH   DFND 1,2,3,4,6 14,818,300 0 0
XILIO THERAPEUTICS INC COM 98422T100 1,310 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0
Y-MABS THERAPEUTICS INC COM 984241109 5,768 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
YUMANITY THERAPEUTICS INC COM 98872L102 341 217,391 SH   DFND 1,2,3,4,5,6 217,391 0 0
ZYMEWORKS INC COM 98985W102 2,768 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0