The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADICET BIO INC | COM | 007002108 | 19,908 | 1,400,000 | SH | DFND | 1 | 1,400,000 | 0 | 0 | |
| AEROVATE THERAPEUTICS INC | COM | 008064107 | 38,643 | 2,330,691 | SH | DFND | 1 | 2,330,691 | 0 | 0 | |
| AKOUOS INC | COM | 00973J101 | 2,667 | 394,500 | SH | DFND | 1 | 394,500 | 0 | 0 | |
| ALTIMMUNE INC | COM NEW | 02155H200 | 43,965 | 3,442,863 | SH | DFND | 1 | 3,442,863 | 0 | 0 | |
| ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 6,815 | 712,079 | SH | DFND | 1 | 712,079 | 0 | 0 | |
| AMBRX BIOPHARMA INC | SPONSORED ADS | 02290A102 | 2,523 | 2,336,389 | SH | DFND | 1 | 2,336,389 | 0 | 0 | |
| AMYLYX PHARMACEUTICALS INC | COM | 03237H101 | 17,172 | 610,000 | SH | DFND | 1 | 610,000 | 0 | 0 | |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 100,947 | 1,478,000 | SH | DFND | 1 | 1,478,000 | 0 | 0 | |
| ARCELLX INC | COMMON STOCK | 03940C100 | 57,233 | 3,049,173 | SH | DFND | 1 | 3,049,173 | 0 | 0 | |
| ARCUTIS BIOTHERAPEUTICS INC | COM | 03969K108 | 19,110 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 | 5,163 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| ASTRIA THERAPEUTICS INC | COM | 04635X102 | 10,848 | 1,200,000 | SH | DFND | 1 | 1,200,000 | 0 | 0 | |
| ATEA PHARMACEUTICALS INC | COM | 04683R106 | 8,803 | 1,547,181 | SH | DFND | 1 | 1,547,181 | 0 | 0 | |
| ATRECA INC | CL A COM | 04965G109 | 501 | 319,057 | SH | DFND | 1 | 319,057 | 0 | 0 | |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 839 | 392,167 | SH | DFND | 1 | 392,167 | 0 | 0 | |
| AVIDITY BIOSCIENCES INC | COM | 05370A108 | 32,858 | 2,012,115 | SH | DFND | 1 | 2,012,115 | 0 | 0 | |
| AXONICS INC | COM | 05465P101 | 22,699 | 322,240 | SH | DFND | 1 | 322,240 | 0 | 0 | |
| BIOATLA INC | COM | 09077B104 | 16,795 | 2,181,115 | SH | DFND | 1 | 2,181,115 | 0 | 0 | |
| BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 27,950 | 184,894 | SH | DFND | 1 | 184,894 | 0 | 0 | |
| BIOMEA FUSION INC | COM | 09077A106 | 31,011 | 3,170,872 | SH | DFND | 1 | 3,170,872 | 0 | 0 | |
| BRIDGEBIO PHARMA INC | COM | 10806X102 | 14,604 | 1,469,179 | SH | DFND | 1 | 1,469,179 | 0 | 0 | |
| CABALETTA BIO INC | COM | 12674W109 | 750 | 1,154,424 | SH | DFND | 1 | 1,154,424 | 0 | 0 | |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 | 7,930 | 1,972,728 | SH | DFND | 1 | 1,972,728 | 0 | 0 | |
| CHEMOMAB THERAPEUTICS LTD | SPONSORED ADS | 16385C104 | 718 | 288,169 | SH | DFND | 1 | 288,169 | 0 | 0 | |
| COGENT BIOSCIENCES INC | COM | 19240Q201 | 21,634 | 1,450,000 | SH | DFND | 1 | 1,450,000 | 0 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 14,341 | 296,000 | SH | DFND | 1 | 296,000 | 0 | 0 | |
| DESIGN THERAPEUTICS INC | COM | 25056L103 | 83,600 | 5,000,000 | SH | DFND | 1 | 5,000,000 | 0 | 0 | |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 | 30,032 | 3,051,989 | SH | DFND | 1 | 3,051,989 | 0 | 0 | |
| ELEDON PHARMACEUTICALS INC | COM | 28617K101 | 3,377 | 1,223,500 | SH | DFND | 1 | 1,223,500 | 0 | 0 | |
| ELEVATION ONCOLOGY INC | COM | 28623U101 | 2,206 | 1,952,032 | SH | DFND | 1 | 1,952,032 | 0 | 0 | |
| ERASCA INC | COM | 29479A108 | 81,943 | 10,505,554 | SH | DFND | 1 | 10,505,554 | 0 | 0 | |
| GALECTO INC | COM | 36322Q107 | 1,928 | 1,020,238 | SH | DFND | 1 | 1,020,238 | 0 | 0 | |
| GELESIS HLDGS INC | COM | 36850R204 | 676 | 626,107 | SH | DFND | 1 | 626,107 | 0 | 0 | |
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 6,891 | 593,043 | SH | DFND | 1 | 593,043 | 0 | 0 | |
| GOSSAMER BIO INC | COM | 38341P102 | 38,317 | 3,198,382 | SH | DFND | 1 | 3,198,382 | 0 | 0 | |
| GRAPHITE BIO INC | COM | 38870X104 | 633 | 199,547 | SH | DFND | 1 | 199,547 | 0 | 0 | |
| GREENLIGHT BIOSCIENCS HLDS P | COMMON STOCK | 39536G105 | 23,807 | 10,261,560 | SH | DFND | 1 | 10,261,560 | 0 | 0 | |
| HARPOON THERAPEUTICS INC | COM | 41358P106 | 524 | 540,600 | SH | DFND | 1 | 540,600 | 0 | 0 | |
| ICOSAVAX INC | COM | 45114M109 | 2,034 | 643,825 | SH | DFND | 1 | 643,825 | 0 | 0 | |
| IDEAYA BIOSCIENCES INC | COM | 45166A102 | 6,241 | 418,320 | SH | DFND | 1 | 418,320 | 0 | 0 | |
| IMMUNEERING CORP | CLASS A COM | 45254E107 | 32,738 | 2,286,181 | SH | DFND | 1 | 2,286,181 | 0 | 0 | |
| IMV INC | COM | 44974L103 | 122 | 234,374 | SH | DFND | 1 | 234,374 | 0 | 0 | |
| IVERIC BIO INC | COM | 46583P102 | 8,970 | 500,000 | SH | Put | DFND | 1 | 500,000 | 0 | 0 |
| KARUNA THERAPEUTICS INC | COM | 48576A100 | 33,740 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| KEROS THERAPEUTICS INC | COM | 492327101 | 3,762 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| LILLY ELI & CO | COM | 532457108 | 9,701 | 30,000 | SH | DFND | 1 | 30,000 | 0 | 0 | |
| LONGBOARD PHARMACEUTICALS IN | COM | 54300N103 | 7,880 | 2,118,283 | SH | DFND | 1 | 2,118,283 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 40,158 | 575,000 | SH | DFND | 1 | 575,000 | 0 | 0 | |
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 | 24,459 | 2,993,717 | SH | DFND | 1 | 2,993,717 | 0 | 0 | |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 47,064 | 6,065,001 | SH | DFND | 1 | 6,065,001 | 0 | 0 | |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 5,746 | 2,082,000 | SH | DFND | 1 | 2,082,000 | 0 | 0 | |
| ORCHARD THERAPEUTICS PLC | SPON ADS | 68570P101 | 128 | 256,649 | SH | DFND | 1 | 256,649 | 0 | 0 | |
| PHARVARIS N V | COM | N69605108 | 9,262 | 1,207,500 | SH | DFND | 1 | 1,207,500 | 0 | 0 | |
| PLIANT THERAPEUTICS INC | COM | 729139105 | 16,352 | 782,788 | SH | DFND | 1 | 782,788 | 0 | 0 | |
| POSEIDA THERAPEUTICS INC | COM | 73730P108 | 6,531 | 1,850,000 | SH | DFND | 1 | 1,850,000 | 0 | 0 | |
| PROMETHEUS BIOSCIENCES INC | COM | 74349U108 | 116,790 | 1,979,158 | SH | DFND | 1 | 1,979,158 | 0 | 0 | |
| PYXIS ONCOLOGY INC | COMMON STOCK | 747324101 | 1,318 | 668,855 | SH | DFND | 1 | 668,855 | 0 | 0 | |
| RAIN THERAPEUTICS INC | COM | 75082Q105 | 11,354 | 2,326,660 | SH | DFND | 1 | 2,326,660 | 0 | 0 | |
| REVOLUTION MEDICINES INC | COM | 76155X100 | 39,343 | 1,995,066 | SH | DFND | 1 | 1,995,066 | 0 | 0 | |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 13,862 | 868,550 | SH | DFND | 1 | 868,550 | 0 | 0 | |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 22,108 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| STOKE THERAPEUTICS INC | COM | 86150R107 | 13,967 | 1,087,807 | SH | DFND | 1 | 1,087,807 | 0 | 0 | |
| TALARIS THERAPEUTICS INC | COM | 87410C104 | 2,369 | 900,649 | SH | DFND | 1 | 900,649 | 0 | 0 | |
| TANGO THERAPEUTICS INC | COM | 87583X109 | 14,903 | 4,116,949 | SH | DFND | 1 | 4,116,949 | 0 | 0 | |
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 | 33,751 | 1,971,422 | SH | DFND | 1 | 1,971,422 | 0 | 0 | |
| TYRA BIOSCIENCES INC | COM | 90240B106 | 6,540 | 743,988 | SH | DFND | 1 | 743,988 | 0 | 0 | |
| VECTIVBIO HLDG AG | ORD SHS | H9060V101 | 15,220 | 2,536,617 | SH | DFND | 1 | 2,536,617 | 0 | 0 | |
| VENTYX BIOSCIENCES INC | COM | 92332V107 | 27,252 | 780,646 | SH | DFND | 1 | 780,646 | 0 | 0 | |
| VERVE THERAPEUTICS INC | COM | 92539P101 | 20,610 | 600,000 | SH | DFND | 1 | 600,000 | 0 | 0 | |
| VIGIL NEUROSCIENCE INC | COM | 92673K108 | 5,613 | 616,786 | SH | DFND | 1 | 616,786 | 0 | 0 | |
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 26,868 | 1,310,000 | SH | DFND | 1 | 1,310,000 | 0 | 0 | |
| X4 PHARMACEUTICALS INC | COM | 98420X103 | 1,420 | 830,654 | SH | DFND | 1 | 830,654 | 0 | 0 | |
| Y-MABS THERAPEUTICS INC | COM | 984241109 | 2,163 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |