The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aerovate Therapeutics Inc COM 008064107 62,319 3,758,686 SH   SOLE   3,758,686 0 0
Akouos Inc COM 00973J101 10,242 1,515,074 SH   SOLE   1,515,074 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 51,612 499,824 SH   SOLE   499,824 0 0
Bolt Biotherapeutics Inc COM 097702104 4,077 2,754,437 SH   SOLE   2,754,437 0 0
Cincor Pharma Inc COM 17240Y109 199,347 6,073,949 SH   SOLE   6,073,949 0 0
Fusion Pharmaceuticals Inc COM 36118A100 352 117,099 SH   SOLE   117,099 0 0
Galera Therapeutics Inc COM 36338D108 5,366 3,083,712 SH   SOLE   3,083,712 0 0
Inozyme Pharm Inc COM 45790W108 9,796 3,655,308 SH   SOLE   3,655,308 0 0
Karuna Therapeutics Inc COM 48576A100 466,154 2,072,441 SH   SOLE   2,072,441 0 0
Natera Inc COM 632307104 135,867 3,100,560 SH   SOLE   3,100,560 0 0
Nextcure Inc COM 65343E108 7,348 2,671,856 SH   SOLE   2,671,856 0 0
Nucana Biomed SPONSORED ADR 67022C106 5,852 5,599,999 SH   SOLE   5,599,999 0 0
Nucana Biomed Ordinary Shares GB00BYWYV 2,508 2,400,000 SH   SOLE   2,400,000 0 0
ObsEva SA COM H5861P103 675 4,749,623 SH   SOLE   4,749,623 0 0
PDS Biotechnology Corporation COM 70465T107 424 142,635 SH   SOLE   142,635 0 0
Synlogic Inc COM 87166L100 546 574,972 SH   SOLE   574,972 0 0
Vera Therapeutics Inc CL A 92337R101 67,797 3,181,442 SH   SOLE   3,181,442 0 0
Y-mAbs Therapeutics Inc COM 984241109 31,641 2,194,278 SH   SOLE   2,194,278 0 0
Adicet Bio Inc COM 007002108 6,996 491,965 SH   SOLE   491,965 0 0
Agenus Inc COM 00847G705 4,997 2,437,465 SH   SOLE   2,437,465 0 0
Arcus Biosciences Inc COM 03969F109 9,976 381,345 SH   SOLE   381,345 0 0
Arcutis Biotherapeutics Inc COM 03969K108 5,242 274,330 SH   SOLE   274,330 0 0
AstraZeneca PLC SPONSORED ADR 046353108 38,491 701,878 SH   SOLE   701,878 0 0
Biomarin Pharmaceutical Inc COM 09061G101 24,986 294,750 SH   SOLE   294,750 0 0
CTI Biopharma Corp COM 12648L601 21,024 3,612,376 SH   SOLE   3,612,376 0 0
Chinook Therapeutics Inc COM 16961L106 5,660 287,901 SH   SOLE   287,901 0 0
CinCor Pharma Inc COM 17240Y109 197 6,000 SH   SOLE   6,000 0 0
Cytokinetics Inc COM 23282W605 15,539 320,722 SH   SOLE   320,722 0 0
Dexcom Inc COM 252131107 16,587 205,948 SH   SOLE   205,948 0 0
Edwards Lifesciences Corp COM 28176E108 12,163 147,200 SH   SOLE   147,200 0 0
Lilly Eli & Co COM 532457108 14,712 45,500 SH   SOLE   45,500 0 0
Fulcrum Therapeutics Inc COM 359616109 6,450 797,262 SH   SOLE   797,262 0 0
Geron Corp COM 374163103 2,783 1,189,208 SH   SOLE   1,189,208 0 0
Geron Corp COM 374163103 2,509 1,072,100 SH Call SOLE   1,072,100 0 0
Gilead Sciences Inc COM 375558103 29,759 482,400 SH   SOLE   482,400 0 0
Health Care Select Sector SPDR SBI HEALTHCARE 81369Y209 36,333 300,000 SH Put SOLE   300,000 0 0
IDEAYA Biosciences Inc COM 45166A102 9,769 654,756 SH   SOLE   654,756 0 0
Immatics NV SHS N44445109 5,325 532,516 SH   SOLE   532,516 0 0
ImmunoGen Inc COM 45253H101 2,401 502,393 SH   SOLE   502,393 0 0
Inhibrx Inc COM 45720L107 8,081 450,177 SH   SOLE   450,177 0 0
Inhibrx Inc COM 45720L107 6,283 350,000 SH Put SOLE   350,000 0 0
Insmed Inc COM PAR $.01 457669307 4,753 220,665 SH   SOLE   220,665 0 0
Intuitive Surgical Inc COM 46120E602 18,050 96,300 SH   SOLE   96,300 0 0
Invesco QQQ Trust Series 1 UNIT SER 1 46090E103 40,089 150,000 SH Put SOLE   150,000 0 0
Iveric Bio Inc COM 46583P102 14,723 820,665 SH   SOLE   820,665 0 0
Karuna Therapeutics Inc COM 48576A100 154 683 SH   SOLE   683 0 0
Merck & Co Inc COM 58933Y105 25,836 300,000 SH Call SOLE   300,000 0 0
Merck & Co Inc COM 58933Y105 50,248 583,468 SH   SOLE   583,468 0 0
NGM Biopharmaceuticals Inc COM 62921N105 1,962 150,000 SH Call SOLE   150,000 0 0
Natera Inc COM 632307104 105 2,400 SH   SOLE   2,400 0 0
Prometheus Biosciences Inc COM 74349U108 8,248 139,774 SH   SOLE   139,774 0 0
Reata Pharmaceuticals Inc CL A 75615P103 20,566 818,376 SH   SOLE   818,376 0 0
Regenxbio Inc COM 75901B107 5,655 213,959 SH   SOLE   213,959 0 0
Sanofi SA SPONSORED ADR 80105N105 48,078 1,264,546 SH   SOLE   1,264,546 0 0
Sarepta Therapeutics Inc COM 803607100 15,635 141,440 SH   SOLE   141,440 0 0
Syndax Pharmaceuticals Inc COM 87164F105 12,616 525,002 SH   SOLE   525,002 0 0
Travere Therapeutics Inc COM 89422G107 9,725 394,678 SH   SOLE   394,678 0 0
United Therapeutics Corp COM 91307C102 30,897 147,564 SH   SOLE   147,564 0 0
Zentalis Pharmaceuticals Inc COM 98943L107 12,636 583,357 SH   SOLE   583,357 0 0
iRhythm Technologies Inc COM 450056106 17,551 140,095 SH   SOLE   140,095 0 0
iShares Russell 2000 ETF RUSSELL 2000 ETF 464287655 32,984 200,000 SH Put SOLE   200,000 0 0