The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADICET BIO INC COM 007002108 2,195 154,708 SH   SOLE   154,708 0 0
ALBIREO PHARMA INC COM 01345P106 312 16,093 SH   SOLE   16,093 0 0
ALKERMES PLC SHS G01767105 13,248 593,000 SH   SOLE   593,000 0 0
ALLOGENE THERAPEUTICS COM 019770106 539 50,000 SH   SOLE   50,000 0 0
ALNYLAM PHARMS. COM 02043Q107 7,597 38,000 SH   SOLE   38,000 0 0
AMGEN INC COM COM 031162100 3,662 16,246 SH   SOLE   16,246 0 0
ARVINAS INC COM 04335A105 756 17,000 SH   SOLE   17,000 0 0
ASCENDIS PHARMA ADR Sponsored ADR 04351P101 3,036 29,400 SH   SOLE   29,400 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 4,313 573,530 SH   SOLE   573,530 0 0
AXSOME THERAPEUTICS COM 05464T104 625 14,000 SH   SOLE   14,000 0 0
BEAM THERAPEUTICS INC COM 07373V105 1,119 23,500 SH   SOLE   23,500 0 0
BEIGENE ADR Sponsored ADR 07725L102 2,117 15,700 SH   SOLE   15,700 0 0
BIOCRYST PHARMS. COM 09058V103 718 57,000 SH   SOLE   57,000 0 0
BIOGEN INC COM 09062X103 12,149 45,500 SH   SOLE   45,500 0 0
BIOMARIN PHARM. COM 09061G101 4,971 58,656 SH   SOLE   58,656 0 0
BLACK DIAMOND THERAPEUTIC COM 0920E3105 75 44,000 SH   SOLE   44,000 0 0
CARIBOU BIOSCIENCES INC COM 142038108 2,716 257,892 SH   SOLE   257,892 0 0
CHINOOK THERAPEUTICS COM 16961L106 6,685 340,389 SH   SOLE   340,389 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 1,345 200,800 SH   SOLE   200,800 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 2,235 34,200 SH   SOLE   34,200 0 0
DENALI THERAPEUTICS COM 24823R105 1,166 38,000 SH   SOLE   38,000 0 0
DYNE THERAPEUTICS COM 26818M108 4,439 350,068 SH   SOLE   350,068 0 0
EXELIXIS INC COM 30161Q104 8,509 543,000 SH   SOLE   543,000 0 0
FATE THERAPEUTICS COM 31189P102 2,712 121,000 SH   SOLE   121,000 0 0
FULCRUM THERAPEUTICS INC COM 359616109 1,563 193,741 SH   SOLE   193,741 0 0
GALAPAGOS NV SPONSORED ADR 36315X101 5,251 123,300 SH   SOLE   123,300 0 0
GILEAD SCIENCES COM 375558103 12,880 208,784 SH   SOLE   208,784 0 0
GUARDANT HEALTH COM 40131M109 4,004 74,500 SH   SOLE   74,500 0 0
HARMONY BIOSCIENCES HLDGS COM 413197104 11,715 264,500 SH   SOLE   264,500 0 0
HORIZON THERAPEUTICS SHS G4617B105 28,158 454,973 SH   SOLE   454,973 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103 602 68,000 SH   SOLE   68,000 0 0
IDEAYA BIOSCIENCES COM 45166A102 1,625 109,000 SH   SOLE   109,000 0 0
ILLUMINA INC COM 452327109 4,766 25,000 SH   SOLE   25,000 0 0
I-MAB-SPONSORED ADR SPONSORED ADS 44975P103 2,024 507,239 SH   SOLE   507,239 0 0
INCYTE CORP COM 45337C102 19,253 289,000 SH   SOLE   289,000 0 0
INSMED INC COM 457669307 864 40,100 SH   SOLE   40,100 0 0
INTELLIA THERAPEUTICS COM 45826J105 1,343 24,000 SH   SOLE   24,000 0 0
INTRA-CELLULAR THERAPIES COM 46116X101 10,303 221,856 SH   SOLE   221,856 0 0
IOVANCE BIOTHERAPEUTICS COM 462260100 536 56,000 SH   SOLE   56,000 0 0
IRONWOOD PHARMACEUTICALS INC COM 46333X108 621 60,000 SH   SOLE   60,000 0 0
JAZZ PHARMS. SHS USD G50871105 2,291 17,200 SH   SOLE   17,200 0 0
KALVISTA PHARMS. COM 483497103 4,587 316,133 SH   SOLE   316,133 0 0
KRYSTAL BIOTECH COM 501147102 3,132 45,000 SH   SOLE   45,000 0 0
LEGEND BIOTECH SPONSORED ADS 52490G102 1,551 38,000 SH   SOLE   38,000 0 0
MADRIGAL PHARMS. COM 558868105 348 5,350 SH   SOLE   5,350 0 0
MIRATI THERAPEUTICS INC COM 60468T105 9,498 136,000 SH   SOLE   136,000 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 193 9,219 SH   SOLE   9,219 0 0
NEUROCRINE BIOSCIENCES COM 64125C109 3,185 30,000 SH   SOLE   30,000 0 0
NOVAVAX INC COM 670002401 2,414 132,500 SH   SOLE   132,500 0 0
NOVOCURE LTD ORD SHS G6674U108 2,431 32,000 SH   SOLE   32,000 0 0
PTC THERAPEUTICS COM 69366J200 1,055 21,000 SH   SOLE   21,000 0 0
REGENERON PHARMS. COM 75886F107 7,715 11,200 SH   SOLE   11,200 0 0
RELMADA THERAPEUTICS COM 75955J402 370 10,000 SH   SOLE   10,000 0 0
REVANCE THERAPEUTICS INC COM 761330109 3,240 120,000 SH   SOLE   120,000 0 0
ROCKET PHARMS. COM 77313F106 1,005 63,000 SH   SOLE   63,000 0 0
SANOFI SPONSORED ADR 80105N105 5,456 143,500 SH   SOLE   143,500 0 0
SEAGEN INC COM 81181C104 22,739 166,200 SH   SOLE   166,200 0 0
SUPERNUS PHARMS. COM 868459108 10,070 297,500 SH   SOLE   297,500 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 4,582 186,019 SH   SOLE   186,019 0 0
ULTRAGENYX PHARM. COM 90400D108 7,197 174,052 SH   SOLE   174,052 0 0
UNIQURE NV SHS N90064101 10,209 544,500 SH   SOLE   544,500 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 3,139 15,000 SH   SOLE   15,000 0 0
VERA THERAPEUTICS CL A 92337R101 5,994 281,257 SH   SOLE   281,257 0 0
UNITED THERAPEUTICS CORP DEL COM 92556V106 3,101 364,000 SH   SOLE   364,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105 918 25,500 SH   SOLE   25,500 0 0
Zai Lab Ltd ADR (V1 Ord) ADR 98887Q104 2,692 78,958 SH   SOLE   78,958 0 0