The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 2SEVENTY BIO INC | COMMON STOCK | 901384107 | 10,820 | 819,672 | SH | DFND | 819,672 | 0 | 0 | ||
| AKOUOS INC | COM | 00973J101 | 3,921 | 836,120 | SH | DFND | 836,120 | 0 | 0 | ||
| COMPASS THERAPEUTICS INC | COM | 20454B104 | 7,499 | 2,829,712 | SH | DFND | 2,829,712 | 0 | 0 | ||
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 2,192 | 2,214,184 | SH | DFND | 2,214,184 | 0 | 0 | ||
| CULLINAN ONCOLOGY INC | COM | 230031106 | 39,070 | 3,047,609 | SH | DFND | 3,047,609 | 0 | 0 | ||
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 1,197 | 190,000 | SH | DFND | 190,000 | 0 | 0 | ||
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 4 | 25,100 | SH | Call | DFND | 25,100 | 0 | 0 | |
| ENTRADA THERAPEUTICS INC | COM | 29384C108 | 1,991 | 163,496 | SH | DFND | 163,496 | 0 | 0 | ||
| FREELINE THERAPEUTICS HLDGS | SPONSORED ADS | 35655L107 | 4,230 | 4,862,319 | SH | DFND | 4,862,319 | 0 | 0 | ||
| G1 THERAPEUTICS INC | COM | 3621LQ109 | 3,790 | 767,235 | SH | DFND | 767,235 | 0 | 0 | ||
| IKENA ONCOLOGY INC | COM | 45175G108 | 4,833 | 1,090,937 | SH | DFND | 1,090,937 | 0 | 0 | ||
| INOZYME PHARMA INC | COM | 45790W108 | 9,701 | 2,033,802 | SH | DFND | 2,033,802 | 0 | 0 | ||
| KEROS THERAPEUTICS INC | COM | 492327101 | 2,858 | 103,429 | SH | DFND | 103,429 | 0 | 0 | ||
| KEZAR LIFE SCIENCES INC | COM | 49372L100 | 15,223 | 1,840,793 | SH | DFND | 1,840,793 | 0 | 0 | ||
| KEZAR LIFE SCIENCES INC | COM | 49372L100 | 5 | 100,000 | SH | Call | DFND | 100,000 | 0 | 0 | |
| LARIMAR THERAPEUTICS INC | COM | 517125100 | 2,970 | 1,515,148 | SH | DFND | 1,515,148 | 0 | 0 | ||
| NKARTA INC | COM | 65487U108 | 4,411 | 358,013 | SH | DFND | 358,013 | 0 | 0 | ||
| OMEGA THERAPEUTICS INC | COMMON STOCK | 68217N105 | 4,012 | 1,055,882 | SH | DFND | 1,055,882 | 0 | 0 | ||
| ONCORUS INC | COM | 68236R103 | 2,983 | 2,367,436 | SH | DFND | 2,367,436 | 0 | 0 | ||
| ORCHARD THERAPEUTICS PLC | ADS | 68570P101 | 3,101 | 5,307,751 | SH | DFND | 5,307,751 | 0 | 0 | ||
| OVID THERAPEUTICS INC | COM | 690469101 | 1,859 | 864,822 | SH | DFND | 864,822 | 0 | 0 | ||
| PHASEBIO PHARMACEUTICALS INC | COM | 717224109 | 450 | 750,000 | SH | DFND | 750,000 | 0 | 0 | ||
| PLIANT THERAPEUTICS INC | COM | 729139105 | 24,886 | 3,106,807 | SH | DFND | 3,106,807 | 0 | 0 | ||
| PRECISION BIOSCIENCES INC | COM | 74019P108 | 4,806 | 3,003,751 | SH | DFND | 3,003,751 | 0 | 0 | ||
| PROMETHEUS BIOSCIENCES INC | COM | 74349U108 | 47,200 | 1,671,976 | SH | DFND | 1,671,976 | 0 | 0 | ||
| REPARE THERAPEUTICS INC | COM | 760273102 | 37,028 | 2,646,781 | SH | DFND | 2,646,781 | 0 | 0 | ||
| SPDR SER TR | S&P BIOTECH | 78464A870 | 372 | 157,000 | SH | Put | DFND | 157,000 | 0 | 0 | |
| VECTIVBIO HLDG AG | ORD SHS | H9060V101 | 20,424 | 3,782,199 | SH | DFND | 3,782,199 | 0 | 0 | ||