The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
908 DEVICES INC COM 65443P102 11,740 570,157 SH   SOLE   541,528 0 28,629
ABSCI CORPORATION COM 00091E109 989 297,823 SH   SOLE   297,823 0 0
AC IMMUNE SA SHS H00263105 3,825 1,059,462 SH   SOLE   1,059,462 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 2,384 294,659 SH   SOLE   294,659 0 0
AFFIMED N V COM N01045108 1,604 579,131 SH   SOLE   579,131 0 0
ALBIREO PHARMA INC COM 01345P106 4,544 228,821 SH   SOLE   228,821 0 0
ALECTOR INC COM 014442107 1,073 105,614 SH   SOLE   105,614 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 161,135 1,417,443 SH   SOLE   1,291,608 0 125,835
ALLISON TRANSMISSION HLDGS I COM 01973R101 89 2,311 SH   SOLE   2,311 0 0
ALLY FINL INC COM 02005N100 21,598 644,530 SH   SOLE   644,530 0 0
ALPHA TEKNOVA INC COM 02080L102 2,013 239,594 SH   SOLE   239,594 0 0
ALPHABET INC CAP STK CL A 02079K305 13,943 6,398 SH   SOLE   6,398 0 0
ALPHABET INC CAP STK CL C 02079K107 28,107 12,849 SH   SOLE   12,849 0 0
ALTIMMUNE INC COM NEW 02155H200 665 56,863 SH   SOLE   56,863 0 0
AMBARELLA INC SHS G037AX101 121 1,842 SH   SOLE   1,842 0 0
ANALOG DEVICES INC COM 032654105 2,651 18,145 SH   SOLE   18,145 0 0
APPLIED MATLS INC COM 038222105 1,969 21,644 SH   SOLE   21,644 0 0
ARCUS BIOSCIENCES INC COM 03969F109 1,566 61,780 SH   SOLE   61,780 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 72 145,558 SH   SOLE   145,558 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 3,342 1,591,272 SH   SOLE   1,591,272 0 0
AT&T INC COM 00206R102 92 4,366 SH   SOLE   4,366 0 0
AZIYO BIOLOGICS INC CL A COM STK 05479K106 1,330 188,181 SH   SOLE   188,181 0 0
BARRICK GOLD CORP COM 067901108 96,033 5,428,679 SH   SOLE   4,288,422 0 1,140,257
BIO RAD LABS INC CL A 090572207 7,278 14,704 SH   SOLE   14,704 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 2,346 221,699 SH   SOLE   221,699 0 0
BLOCK INC CL A 852234103 12,807 208,377 SH   SOLE   208,377 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 2,021 40,004 SH   SOLE   40,004 0 0
BOOKING HOLDINGS INC COM 09857L108 79,534 45,474 SH   SOLE   39,036 0 6,438
BTRS HOLDINGS INC COM CL 1 11778X104 14,912 2,994,437 SH   SOLE   2,994,437 0 0
CALIFORNIA RES CORP COM STOCK 13057Q305 78 2,013 SH   SOLE   2,013 0 0
CARVANA CO CL A 146869102 6,036 267,315 SH   SOLE   267,315 0 0
CENTOGENE N V COM N1976T109 5,383 2,271,150 SH   SOLE   2,271,150 0 0
CIENA CORP COM NEW 171779309 57,123 1,249,966 SH   SOLE   1,121,138 0 128,828
CIGNA CORP NEW COM 125523100 86 328 SH   SOLE   328 0 0
CISCO SYS INC COM 17275R102 926 21,718 SH   SOLE   21,718 0 0
COGENT BIOSCIENCES INC COM 19240Q201 8,131 901,412 SH   SOLE   876,579 0 24,833
COHERUS BIOSCIENCES INC COM 19249H103 4,332 598,304 SH   SOLE   598,304 0 0
CORE LABORATORIES N V COM N22717107 254 12,844 SH   SOLE   12,844 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 2,250 1,229,545 SH   SOLE   1,229,545 0 0
DENALI THERAPEUTICS INC COM 24823R105 1,500 50,971 SH   SOLE   50,971 0 0
DINGDONG CAYMAN LTD ADS 25445D101 20,680 3,739,560 SH   SOLE   3,739,560 0 0
DOORDASH INC CL A 25809K105 9,689 150,984 SH   SOLE   150,984 0 0
EBAY INC. COM 278642103 945 22,679 SH   SOLE   22,679 0 0
EPIZYME INC COM 29428V104 9,708 6,603,870 SH   SOLE   6,603,870 0 0
EQUIFAX INC COM 294429105 27,026 147,863 SH   SOLE   147,863 0 0
ERICSSON ADR B SEK 10 294821608 3,189 430,900 SH   SOLE   430,900 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 10,325 1,623,440 SH   SOLE   1,353,124 0 270,316
EXAGEN INC COM 30068X103 2,296 400,000 SH   SOLE   344,533 0 55,467
EXSCIENTIA PLC ADS 30223G102 22,898 2,102,660 SH   SOLE   2,066,503 0 36,157
F45 TRAINING HLDGS INC COM 30322L101 4,336 1,103,358 SH   SOLE   1,103,358 0 0
FOX CORP CL A COM 35137L105 41 1,287 SH   SOLE   1,287 0 0
FREEPORT-MCMORAN INC CL B 35671D857 30,657 1,047,743 SH   SOLE   847,667 0 200,076
FULL TRUCK ALLIANCE CO LTD SPONSORED ADS 35969L108 1,804 199,091 SH   SOLE   199,091 0 0
GENERAL ELECTRIC CO COM NEW 369604301 55,219 867,263 SH   SOLE   627,096 0 240,167
GENETRON HLDGS LTD ADS 37186H100 2,238 1,316,642 SH   SOLE   1,316,642 0 0
GILEAD SCIENCES INC COM 375558103 59,569 963,747 SH   SOLE   707,008 0 256,739
HANESBRANDS INC COM 410345102 88 8,542 SH   SOLE   8,542 0 0
HCA HEALTHCARE INC COM 40412C101 84 497 SH   SOLE   497 0 0
HELLO GROUP INC ADS 423403104 50 9,871 SH   SOLE   9,871 0 0
HERBALIFE NUTRITION LTD COM SHS G4412G101 76 3,695 SH   SOLE   3,695 0 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 58,544 1,536,578 SH   SOLE   1,536,578 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103 2,839 224,634 SH   SOLE   224,634 0 0
ICOSAVAX INC COM 45114M109 9,363 1,634,004 SH   SOLE   1,488,158 0 145,846
IDEAYA BIOSCIENCES INC COM 45166A102 12,738 923,044 SH   SOLE   818,109 0 104,935
IMMATICS N.V SHS N44445109 2,895 332,356 SH   SOLE   332,356 0 0
IMMUNOVANT INC COM 45258J102 3,033 777,590 SH   SOLE   777,590 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 345 545,508 SH   SOLE   545,508 0 0
INHIBRX INC COM 45720L107 1,817 160,099 SH   SOLE   160,099 0 0
INTEL CORP COM 458140100 171 4,575 SH   SOLE   4,575 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 77,921 828,591 SH   SOLE   718,326 0 110,265
IRIS ENERGY LTD ORDINARY SHARES Q4982L109 9,293 2,773,913 SH   SOLE   2,408,785 0 365,128
JD.COM INC SPON ADR CL A 47215P106 37,516 584,186 SH   SOLE   584,186 0 0
KALERA PUBLIC LIMITED CO ORDINARY SHARES G52251108 2,727 462,249 SH   SOLE   336,627 0 125,622
KYNDRYL HLDGS INC COMMON STOCK 50155Q100 2 241 SH   SOLE   241 0 0
LAM RESEARCH CORP COM 512807108 50,792 119,187 SH   SOLE   104,791 0 14,396
LAMB WESTON HLDGS INC COM 513272104 19,864 277,972 SH   SOLE   277,972 0 0
LAREDO PETROLEUM INC COM 516806205 36 528 SH   SOLE   528 0 0
LEAP THERAPEUTICS INC COM 52187K101 1,527 1,327,952 SH   SOLE   1,327,952 0 0
LGI HOMES INC COM 50187T106 36,011 414,391 SH   SOLE   382,157 0 32,234
LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854 971 15,300 SH   SOLE   15,300 0 0
LUFAX HOLDING LTD ADS REP SHS CL A 54975P102 43 7,246 SH   SOLE   7,246 0 0
MAGELLAN MIDSTREAM PRTNRS LP COM UNIT RP LP 559080106 126 2,631 SH   SOLE   2,631 0 0
MELCO RESORTS AND ENTMNT LTD ADR 585464100 11,881 2,066,285 SH   SOLE   2,066,285 0 0
MERSANA THERAPEUTICS INC COM 59045L106 2,289 495,481 SH   SOLE   495,481 0 0
MERUS N V COM N5749R100 3,234 142,860 SH   SOLE   142,860 0 0
META PLATFORMS INC CL A 30303M102 45,112 279,764 SH   SOLE   279,764 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 225,443 3,881,589 SH   SOLE   3,456,117 0 425,472
MICRON TECHNOLOGY INC COM 595112103 101,022 1,827,464 SH   SOLE   1,683,723 0 143,741
MICROSOFT CORP COM 594918104 5,730 22,312 SH   SOLE   22,312 0 0
MOSAIC CO NEW COM 61945C103 136,732 2,895,029 SH   SOLE   2,531,557 0 363,472
MOTOROLA SOLUTIONS INC COM NEW 620076307 295 1,406 SH   SOLE   1,406 0 0
MYOVANT SCIENCES LTD COM G637AM102 3,755 302,120 SH   SOLE   302,120 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 5,849 460,542 SH   SOLE   429,423 0 31,119
NOAH HLDGS LTD SPON ADS CL A 65487X102 43,020 2,126,526 SH   SOLE   2,126,526 0 0
OATLY GROUP AB SPONSORED ADS 67421J108 3,150 910,276 SH   SOLE   910,276 0 0
OMEGA THERAPEUTICS INC COMMON STOCK 68217N105 2,639 694,431 SH   SOLE   667,630 0 26,801
ONEMAIN HLDGS INC COM 68268W103 82 2,188 SH   SOLE   2,188 0 0
ORACLE CORP COM 68389X105 699 9,999 SH   SOLE   9,999 0 0
PARDES BIOSCIENCES INC COM 69945Q105 3,733 1,215,967 SH   SOLE   1,215,967 0 0
PAYPAL HLDGS INC COM 70450Y103 1,458 20,870 SH   SOLE   20,870 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 158 13,548 SH   SOLE   13,548 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 2,055 1,098,888 SH   SOLE   1,098,888 0 0
PLANET FITNESS INC CL A 72703H101 8,247 121,258 SH   SOLE   121,258 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 12,183 431,567 SH   SOLE   390,024 0 41,543
PROTHENA CORP PLC SHS G72800108 1,643 60,512 SH   SOLE   60,512 0 0
QUANTERIX CORP COM 74766Q101 10,361 639,990 SH   SOLE   594,017 0 45,973
RECURSION PHARMACEUTICALS IN CL A 75629V104 20,640 2,535,622 SH   SOLE   2,490,328 0 45,294
ROBLOX CORP CL A 771049103 4,345 132,222 SH   SOLE   132,222 0 0
ROIVANT SCIENCES LTD SHS G76279101 2,058 505,577 SH   SOLE   505,577 0 0
RYANAIR HOLDINGS PLC SPONSORED ADS 783513203 336 5,000 SH   SOLE   5,000 0 0
SANGAMO THERAPEUTICS INC COM 800677106 904 218,336 SH   SOLE   218,336 0 0
SILVERCREST METALS INC COM 828363101 12,562 2,056,005 SH   SOLE   1,470,958 0 585,047
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 1,640 429,336 SH   SOLE   429,336 0 0
SIX FLAGS ENTMT CORP NEW COM 83001A102 4,767 219,665 SH   SOLE   219,665 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 2,460 26,554 SH   SOLE   26,554 0 0
SPROUTS FMRS MKT INC COM 85208M102 45 1,758 SH   SOLE   1,758 0 0
SUNCOR ENERGY INC NEW COM 867224107 103,217 2,947,559 SH   SOLE   2,710,962 0 236,597
SUZANO S A SPON ADS 86959K105 40,130 4,233,144 SH   SOLE   4,233,144 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 2,510 515,336 SH   SOLE   515,336 0 0
TRIP COM GROUP LTD ADS 89677Q107 197,705 7,202,372 SH   SOLE   6,180,769 0 1,021,603
ULTA BEAUTY INC COM 90384S303 10,931 28,358 SH   SOLE   28,358 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 83 829 SH   SOLE   829 0 0
WARNER BROS DISCOVERY INC COM SER A 934423104 34 2,516 SH   SOLE   2,516 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 3,690 1,135,348 SH   SOLE   1,135,348 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107 873 213,381 SH   SOLE   213,381 0 0
WESTERN DIGITAL CORP. COM 958102105 2,689 59,988 SH   SOLE   59,988 0 0
YUM CHINA HLDGS INC COM 98850P109 19,194 395,751 SH   SOLE   395,751 0 0
ZAI LAB LTD ADR 98887Q104 5,107 147,272 SH   SOLE   147,272 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADS A 98980A105 420,600 15,322,408 SH   SOLE   13,683,459 0 1,638,949
ZYMEWORKS INC COM 98985W102 1,566 295,486 SH   SOLE   295,486 0 0