The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 37,713 246,235 SH   DFND   0 246,235 0
ACADIA PHARMACEUTICALS INC COM 004225108 5,425 384,995 SH   DFND   0 384,995 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 15,487 9,109,780 SH   DFND   0 9,109,780 0
AERIE PHARMACEUTICALS INC NOTE 1.500%10/0 00771VAB4 41,088 48,150,000 PRN   DFND   0 48,150,000 0
AERIE PHARMACEUTICALS INC COM 00771V108 5,246 699,531 SH   DFND   0 699,531 0
ARCUS BIOSCIENCES INC COM 03969F109 84,799 3,346,458 SH   DFND   0 3,346,458 0
ARGENX SE SPONSORED ADR 04016X101 39,681 104,732 SH   DFND   0 104,732 0
ASTRAZENECA PLC SPONSORED ADR 046353108 38,109 576,800 SH   DFND   0 576,800 0
AVANTOR INC COM 05352A100 64,677 2,079,657 SH   DFND   0 2,079,657 0
AXSOME THERAPEUTICS INC COM 05464T104 52,111 1,360,596 SH   DFND   0 1,360,596 0
BAXTER INTL INC COM 071813109 20,805 323,907 SH   DFND   0 323,907 0
BCLS ACQUISITION CORP COM CL A G0904B105 4,595 464,103 SH   DFND   0 464,103 0
BECTON DICKINSON & CO COM 075887109 32,221 130,697 SH   DFND   0 130,697 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 22,878 2,162,411 SH   DFND   0 2,162,411 0
BIOCRYST PHARMACEUTICALS INC CALL 09058V903 5,819 550,000 SH Call DFND   0 550,000 0
BIOGEN INC CALL 09062X903 34,017 166,800 SH Call DFND   0 166,800 0
BIOMARIN PHARMACEUTICAL INC NOTE 0.599% 8/0 09061GAH4 45,566 45,910,000 PRN   DFND   0 45,910,000 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 69,559 839,371 SH   DFND   0 839,371 0
CARDINAL HEALTH INC COM 14149Y108 33,441 639,783 SH   DFND   0 639,783 0
CARIBOU BIOSCIENCES INC COM 142038108 32,580 6,000,000 SH   DFND   0 6,000,000 0
CATALENT INC COM 148806102 23,428 218,366 SH   DFND   0 218,366 0
CENTENE CORP DEL COM 15135B101 94,127 1,112,480 SH   DFND   0 1,112,480 0
CIGNA CORP NEW COM 125523100 37,235 141,300 SH   DFND   0 141,300 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 4,250 392,764 SH   DFND   0 392,764 0
CYTOKINETICS INC COM NEW 23282W605 96,850 2,465,016 SH   DFND   0 2,465,016 0
DANAHER CORPORATION COM 235851102 44,541 175,690 SH   DFND   0 175,690 0
DYNAVAX TECHNOLOGIES CORP NOTE 2.500% 5/1 268158AD4 7,479 5,000,000 PRN   DFND   0 5,000,000 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 47,910 3,805,370 SH   DFND   0 3,805,370 0
EDITAS MEDICINE INC COM 28106W103 7,449 629,684 SH   DFND   0 629,684 0
EDWARDS LIFESCIENCES CORP COM 28176E108 32,155 338,155 SH   DFND   0 338,155 0
ELEVANCE HEALTH INC COM 036752103 20,623 42,734 SH   DFND   0 42,734 0
ERASCA INC COM 29479A108 32,759 5,881,382 SH   DFND   0 5,881,382 0
ESSA PHARMA INC COM NEW 29668H708 3,029 961,716 SH   DFND   0 961,716 0
GENERATION BIO CO COM 37148K100 18,193 2,773,313 SH   DFND   0 2,773,313 0
HORIZON THERAPEUTICS PUB L SHS G46188101 87,085 1,091,840 SH   DFND   0 1,091,840 0
HUMANA INC COM 444859102 77,731 166,066 SH   DFND   0 166,066 0
ICON PLC SHS G4705A100 34,278 158,183 SH   DFND   0 158,183 0
ICU MED INC COM 44930G107 39,813 242,185 SH   DFND   0 242,185 0
INTELLIA THERAPEUTICS INC COM 45826J105 8,451 163,280 SH   DFND   0 163,280 0
IO BIOTECH INC COM 449778109 8,472 1,814,097 SH   DFND   0 1,814,097 0
IO BIOTECH INC COM 449778109 1,611 345,058 SH   DFND   0 345,058 0
IQVIA HLDGS INC COM 46266C105 48,106 221,696 SH   DFND   0 221,696 0
IRHYTHM TECHNOLOGIES INC COM 450056106 53,337 493,721 SH   DFND   0 493,721 0
ITEOS THERAPEUTICS INC COM 46565G104 11,082 537,954 SH   DFND   0 537,954 0
IVERIC BIO INC COM 46583P102 8,716 906,016 SH   DFND   0 906,016 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 89,228 571,936 SH   DFND   0 571,936 0
JIYA ACQUISITION CORP COM CL A 47760M102 4,585 464,103 SH   DFND   0 464,103 0
JOHNSON & JOHNSON COM 478160104 109,180 615,064 SH   DFND   0 615,064 0
JOUNCE THERAPEUTICS INC COM 481116101 11,967 3,949,668 SH   DFND   0 3,949,668 0
KARUNA THERAPEUTICS INC COM 48576A100 16,483 130,293 SH   DFND   0 130,293 0
KARUNA THERAPEUTICS INC CALL 48576A900 12,651 100,000 SH Call DFND   0 100,000 0
LILLY ELI & CO COM 532457108 96,829 298,643 SH   DFND   0 298,643 0
MCKESSON CORP COM 58155Q103 34,517 105,811 SH   DFND   0 105,811 0
MERCK & CO INC COM 58933Y105 88,617 971,998 SH   DFND   0 971,998 0
MOLINA HEALTHCARE INC COM 60855R100 40,202 143,779 SH   DFND   0 143,779 0
MYRIAD GENETICS INC COM 62855J104 21,391 1,177,250 SH   DFND   0 1,177,250 0
NEVRO CORP COM 64157F103 28,902 659,410 SH   DFND   0 659,410 0
OAK STR HEALTH INC COM 67181A107 10,172 618,761 SH   DFND   0 618,761 0
PARDES BIOSCIENCES INC COM 69945Q105 2,460 801,204 SH   DFND   0 801,204 0
PENUMBRA INC COM 70975L107 22,761 182,786 SH   DFND   0 182,786 0
PFIZER INC COM 717081103 70,434 1,343,384 SH   DFND   0 1,343,384 0
PMV PHARMACEUTICALS INC COM 69353Y103 17,302 1,214,164 SH   DFND   0 1,214,164 0
PRAXIS PRECISION MEDICINES I COM 74006W108 8,079 3,297,347 SH   DFND   0 3,297,347 0
PROCEPT BIOROBOTICS CORP COM 74276L105 11,686 357,492 SH   DFND   0 357,492 0
PROTHENA CORP PLC SHS G72800108 9,370 345,114 SH   DFND   0 345,114 0
SANA BIOTECHNOLOGY INC COM 799566104 6,126 952,733 SH   DFND   0 952,733 0
SEAGEN INC COM 81181C104 49,967 282,395 SH   DFND   0 282,395 0
SEAGEN INC CALL 81181C904 7,078 40,000 SH Call DFND   0 40,000 0
SIGHT SCIENCES INC COM 82657M105 6,979 776,281 SH   DFND   0 776,281 0
SOPHIA GENETICS SA ORDINARY SHARES H82027105 6,393 1,766,062 SH   DFND   0 1,766,062 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 11,174 580,768 SH   DFND   0 580,768 0
TENET HEALTHCARE CORP COM NEW 88033G407 28,623 544,583 SH   DFND   0 544,583 0
THERMO FISHER SCIENTIFIC INC COM 883556102 33,761 62,143 SH   DFND   0 62,143 0
UNIQURE NV SHS N90064101 41,686 2,236,370 SH   DFND   0 2,236,370 0
UNITEDHEALTH GROUP INC COM 91324P102 57,297 111,554 SH   DFND   0 111,554 0
UNIVERSAL HLTH SVCS INC CL B 913903100 31,966 317,411 SH   DFND   0 317,411 0
VEEVA SYS INC CL A COM 922475108 40,081 202,387 SH   DFND   0 202,387 0
VERVE THERAPEUTICS INC COM 92539P101 12,914 845,186 SH   DFND   0 845,186 0
WATERS CORP COM 941848103 38,935 117,634 SH   DFND   0 117,634 0
WEREWOLF THERAPEUTICS INC COM 95075A107 7,079 1,730,723 SH   DFND   0 1,730,723 0