The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | 27,972 | 4,007,413 | SH | DFND | 1 | 0 | 4,007,413 | 0 | |
| 89BIO INC | COM | 282559103 | 12,552 | 3,898,000 | SH | DFND | 1 | 0 | 3,898,000 | 0 | |
| AADI BIOSCIENCE INC | COM | 00032Q104 | 10,830 | 879,085 | SH | DFND | 1 | 0 | 879,085 | 0 | |
| AC IMMUNE SA | SHS | H00263105 | 26,816 | 7,428,379 | SH | DFND | 1 | 0 | 7,428,379 | 0 | |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 55,513 | 3,976,543 | SH | DFND | 1 | 0 | 3,976,543 | 0 | |
| AILERON THERAPEUTICS INC | COM | 00887A105 | 1,369 | 5,265,555 | SH | DFND | 1 | 0 | 5,265,555 | 0 | |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 10,852 | 1,275,240 | SH | DFND | 1 | 0 | 1,275,240 | 0 | |
| AN2 THERAPEUTICS INC | COM | 037326105 | 12,529 | 1,616,665 | SH | DFND | 1 | 0 | 1,616,665 | 0 | |
| ANGION BIOMEDICA CORP | COM | 03476J107 | 1,221 | 1,071,297 | SH | DFND | 1 | 0 | 1,071,297 | 0 | |
| ANNEXON INC | COM | 03589W102 | 14,253 | 3,780,694 | SH | DFND | 1 | 0 | 3,780,694 | 0 | |
| ARCUS BIOSCIENCES INC | COM | 03969F109 | 100,370 | 3,960,948 | SH | DFND | 1 | 0 | 3,960,948 | 0 | |
| BIONOMICS LIMITED | ADS | 09063M205 | 555 | 80,971 | SH | DFND | 1 | 0 | 80,971 | 0 | |
| CALITHERA BIOSCIENCES INC | COM NEW | 13089P507 | 1,143 | 464,742 | SH | DFND | 1 | 0 | 464,742 | 0 | |
| CALLIDITAS THERAPEUTICS AB | SPONSERED ADS | 13124Q106 | 13,478 | 750,000 | SH | DFND | 1 | 0 | 750,000 | 0 | |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 4,152 | 154,000 | SH | DFND | 1 | 0 | 154,000 | 0 | |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 | 33,575 | 6,894,345 | SH | DFND | 1 | 0 | 6,894,345 | 0 | |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 3,352 | 6,861,127 | SH | DFND | 1 | 0 | 6,861,127 | 0 | |
| CINCOR PHARMA INC | COM | 17240Y109 | 30,980 | 1,644,393 | SH | DFND | 1 | 0 | 1,644,393 | 0 | |
| COGENT BIOSCIENCES INC | COM | 19240Q201 | 20,360 | 2,257,174 | SH | DFND | 1 | 0 | 2,257,174 | 0 | |
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 15,278 | 3,629,000 | SH | DFND | 1 | 0 | 3,629,000 | 0 | |
| CONTRAFECT CORP | COM NEW | 212326300 | 12,195 | 3,972,300 | SH | DFND | 1 | 0 | 3,972,300 | 0 | |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 1,357 | 1,370,947 | SH | DFND | 1 | 0 | 1,370,947 | 0 | |
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 68,612 | 3,678,947 | SH | DFND | 1 | 0 | 3,678,947 | 0 | |
| CTI BIOPHARMA CORP | COM | 12648L601 | 53,310 | 8,929,690 | SH | DFND | 1 | 0 | 8,929,690 | 0 | |
| CULLINAN ONCOLOGY INC | COM | 230031106 | 96,266 | 7,509,059 | SH | DFND | 1 | 0 | 7,509,059 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 10,621 | 5,803,700 | SH | DFND | 1 | 0 | 5,803,700 | 0 | |
| ELEDON PHARMACEUTICALS INC | COM | 28617K101 | 5,677 | 2,326,710 | SH | DFND | 1 | 0 | 2,326,710 | 0 | |
| ELEVATION ONCOLOGY INC | COM | 28623U101 | 3,237 | 2,312,200 | SH | DFND | 1 | 0 | 2,312,200 | 0 | |
| EQRX INC | COM | 26886C107 | 49,942 | 10,648,527 | SH | DFND | 1 | 0 | 10,648,527 | 0 | |
| ERYTECH PHARMA | SPONSORED ADR | 29604W108 | 1,440 | 1,314,656 | SH | DFND | 1 | 0 | 1,314,656 | 0 | |
| ESSA PHARMA INC | COM NEW | 29668H708 | 11,651 | 3,698,629 | SH | DFND | 1 | 0 | 3,698,629 | 0 | |
| FORWARD PHARMA A/S | SPONSORD ADS NEW | 34986J204 | 2,225 | 513,791 | SH | DFND | 1 | 0 | 513,791 | 0 | |
| GALMED PHARMACEUTICALS LTD | SHS | M47238106 | 1,224 | 1,799,694 | SH | DFND | 1 | 0 | 1,799,694 | 0 | |
| GENERATION BIO CO | COM | 37148K100 | 10,273 | 1,556,032 | SH | DFND | 1 | 0 | 1,556,032 | 0 | |
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 92,566 | 9,275,158 | SH | DFND | 1 | 0 | 9,275,158 | 0 | |
| GLYCOMIMETICS INC | COM | 38000Q102 | 5,707 | 9,544,262 | SH | DFND | 1 | 0 | 9,544,262 | 0 | |
| HILLEVAX INC | COM | 43157M102 | 4,181 | 382,513 | SH | DFND | 1 | 0 | 382,513 | 0 | |
| IDEAYA BIOSCIENCES INC | COM | 45166A102 | 38,569 | 2,794,859 | SH | DFND | 1 | 0 | 2,794,859 | 0 | |
| IKENA ONCOLOGY INC | COM | 45175G108 | 11,089 | 2,503,071 | SH | DFND | 1 | 0 | 2,503,071 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 4,017 | 6,353,645 | SH | DFND | 1 | 0 | 6,353,645 | 0 | |
| INVENTIVA SA | ADS | 46124U107 | 3,993 | 686,040 | SH | DFND | 1 | 0 | 686,040 | 0 | |
| IONIS PHARMACEUTICALS INC | COM | 462222100 | 47,259 | 1,276,574 | SH | DFND | 1 | 0 | 1,276,574 | 0 | |
| ITEOS THERAPEUTICS INC | COM | 46565G104 | 39,742 | 1,929,201 | SH | DFND | 1 | 0 | 1,929,201 | 0 | |
| JANUX THERAPEUTICS INC | COM | 47103J105 | 17,953 | 1,470,334 | SH | DFND | 1 | 0 | 1,470,334 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 58,725 | 3,203,783 | SH | DFND | 1 | 0 | 3,203,783 | 0 | |
| KYMERA THERAPEUTICS INC | COM | 501575104 | 81,492 | 4,138,758 | SH | DFND | 1 | 0 | 4,138,758 | 0 | |
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 26,317 | 14,149,179 | SH | DFND | 1 | 0 | 14,149,179 | 0 | |
| MEI PHARMA INC | COM NEW | 55279B202 | 2,137 | 3,532,057 | SH | DFND | 1 | 0 | 3,532,057 | 0 | |
| MERUS N V | COM | N5749R100 | 92,404 | 4,081,431 | SH | DFND | 1 | 0 | 4,081,431 | 0 | |
| MOLECULAR PARTNERS AG | ADS | 60853G106 | 2,983 | 443,221 | SH | DFND | 1 | 0 | 443,221 | 0 | |
| MOLECULAR TEMPLATES INC | COM | 608550109 | 4,555 | 4,996,565 | SH | DFND | 1 | 0 | 4,996,565 | 0 | |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 114,194 | 21,751,284 | SH | DFND | 1 | 0 | 21,751,284 | 0 | |
| NUVALENT INC | COM | 670703107 | 22,595 | 1,666,282 | SH | DFND | 1 | 0 | 1,666,282 | 0 | |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 30,979 | 7,611,503 | SH | DFND | 1 | 0 | 7,611,503 | 0 | |
| OVID THERAPEUTICS INC | COM | 690469101 | 14,730 | 6,851,051 | SH | DFND | 1 | 0 | 6,851,051 | 0 | |
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 9,500 | 5,080,320 | SH | DFND | 1 | 0 | 5,080,320 | 0 | |
| POINT BIOPHARMA GLOBAL INC | COM | 730541109 | 22,935 | 3,367,826 | SH | DFND | 1 | 0 | 3,367,826 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 8,755 | 1,106,838 | SH | DFND | 1 | 0 | 1,106,838 | 0 | |
| PYXIS ONCOLOGY INC | COMMON STOCK | 747324101 | 6,994 | 2,938,851 | SH | DFND | 1 | 0 | 2,938,851 | 0 | |
| RAIN THERAPEUTICS INC | COM | 75082Q105 | 19,609 | 3,526,729 | SH | DFND | 1 | 0 | 3,526,729 | 0 | |
| RELAY THERAPEUTICS INC | COM | 75943R102 | 73,445 | 4,384,805 | SH | DFND | 1 | 0 | 4,384,805 | 0 | |
| RELMADA THERAPEUTICS INC | COM | 75955J402 | 31,509 | 1,659,220 | SH | DFND | 1 | 0 | 1,659,220 | 0 | |
| REPARE THERAPEUTICS INC | COM | 760273102 | 116,005 | 8,291,988 | SH | DFND | 1 | 0 | 8,291,988 | 0 | |
| REPLIMUNE GROUP INC | COM | 76029N106 | 16,196 | 926,529 | SH | DFND | 1 | 0 | 926,529 | 0 | |
| REVOLUTION MEDICINES INC | COM | 76155X100 | 43,961 | 2,255,588 | SH | DFND | 1 | 0 | 2,255,588 | 0 | |
| REZOLUTE INC | COM NEW | 76200L309 | 616 | 190,815 | SH | DFND | 1 | 0 | 190,815 | 0 | |
| SELECTA BIOSCIENCES INC | COM | 816212104 | 2,257 | 1,723,133 | SH | DFND | 1 | 0 | 1,723,133 | 0 | |
| SILENCE THERAPEUTICS PLC | ADS | 82686Q101 | 7,900 | 666,666 | SH | DFND | 1 | 0 | 666,666 | 0 | |
| SPERO THERAPEUTICS INC | COM | 84833T103 | 2,289 | 3,089,615 | SH | DFND | 1 | 0 | 3,089,615 | 0 | |
| SUTRO BIOPHARMA INC | COM | 869367102 | 17,964 | 3,447,946 | SH | DFND | 1 | 0 | 3,447,946 | 0 | |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 45,347 | 2,356,934 | SH | DFND | 1 | 0 | 2,356,934 | 0 | |
| TYRA BIOSCIENCES INC | COM | 90240B106 | 17,677 | 2,472,327 | SH | DFND | 1 | 0 | 2,472,327 | 0 | |
| VERASTEM INC | COM | 92337C104 | 23,171 | 19,974,658 | SH | DFND | 1 | 0 | 19,974,658 | 0 | |
| VIRACTA THERAPEUTICS INC | COM | 92765F108 | 14,025 | 3,614,662 | SH | DFND | 1 | 0 | 3,614,662 | 0 | |
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 20,178 | 1,744,012 | SH | DFND | 1 | 0 | 1,744,012 | 0 | |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 | 827 | 140,000 | SH | DFND | 1 | 0 | 140,000 | 0 | |
| X4 PHARMACEUTICALS INC | COM | 98420X103 | 818 | 847,879 | SH | DFND | 1 | 0 | 847,879 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 48,610 | 1,597,966 | SH | DFND | 1 | 0 | 1,597,966 | 0 | |
| XOMA CORP DEL | COM NEW | 98419J206 | 78,660 | 3,530,543 | SH | DFND | 1 | 0 | 3,530,543 | 0 | |