The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 4,508 1,400,000 SH   DFND 1,2 1,400,000 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 15,119 1,083,000 SH   DFND 1,2 1,083,000 0 0
ACUMEN PHARMACEUTICALS INC COM 00509G209 7,121 1,515,000 SH   DFND 1,2 1,515,000 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 1,263 2,500,000 SH   DFND 1,2 2,500,000 0 0
ALKERMES PLC SHS G01767105 10,773 361,636 SH   DFND 1,2 361,636 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 21,878 150,000 SH Put DFND 1,2 150,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 4,585 538,819 SH   DFND 1,2 538,819 0 0
ANAPTYSBIO INC COM 032724106 9,198 453,118 SH   DFND 1,2 453,118 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 7,265 500,000 SH   DFND 1,2 500,000 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 5,889 336,731 SH   DFND 1,2 336,731 0 0
CINCOR PHARMA INC COM 17240Y109 12,608 669,200 SH   DFND 1,2 669,200 0 0
CYTOKINETICS INC COM NEW 23282W605 23,967 610,000 SH   DFND 1,2 610,000 0 0
GALAPAGOS NV SPON ADR 36315X101 20,088 360,000 SH   DFND 1,2 360,000 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 29,642 190,000 SH   DFND 1,2 190,000 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 15,055 1,530,000 SH   DFND 1,2 1,530,000 0 0
KARUNA THERAPEUTICS INC COM 48576A100 6,945 54,900 SH Put DFND 1,2 54,900 0 0
KARUNA THERAPEUTICS INC COM 48576A100 18,850 149,000 SH   DFND 1,2 149,000 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 11,667 1,204,028 SH   DFND 1,2 1,204,028 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 1,404 1,170,000 SH   DFND 1,2 1,170,000 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104 2,268 432,000 SH   DFND 1,2 432,000 0 0
NEKTAR THERAPEUTICS COM 640268108 11,970 3,150,000 SH   DFND 1,2 3,150,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 7,311 75,000 SH   DFND 1,2 75,000 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 4,698 2,512,500 SH   DFND 1,2 2,512,500 0 0
PLIANT THERAPEUTICS INC COM 729139105 2,862 357,263 SH   DFND 1,2 357,263 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 16,484 2,420,501 SH   DFND 1,2 2,420,501 0 0
PRECISION BIOSCIENCES INC COM 74019P108 9,209 5,755,396 SH   DFND 1,2 5,755,396 0 0
RELMADA THERAPEUTICS INC COM 75955J402 13,293 700,000 SH   DFND 1,2 700,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 14,535 193,900 SH   DFND 1,2 193,900 0 0
SILENCE THERAPEUTICS PLC ADS 82686Q101 4,757 401,449 SH   DFND 1,2 401,449 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 23,533 971,233 SH   DFND 1,2 971,233 0 0
TRICIDA INC COM 89610F101 11,275 1,164,763 SH   DFND 1,2 1,164,763 0 0
UROGEN PHARMA LTD COM M96088105 7,153 873,424 SH   DFND 1,2 873,424 0 0
VAXCYTE INC COM 92243G108 21,437 985,153 SH   DFND 1,2 985,153 0 0
VENTYX BIOSCIENCES INC COM 92332V107 4,760 389,223 SH   DFND 1,2 389,223 0 0
XENON PHARMACEUTICALS INC COM 98420N105 33,594 1,104,334 SH   DFND 1,2 1,104,334 0 0