The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADICET BIO INC | COM | 007002108 | 26,280 | 1,800,000 | SH | DFND | 1 | 1,800,000 | 0 | 0 | |
| AEROVATE THERAPEUTICS INC | COM | 008064107 | 27,051 | 1,730,691 | SH | DFND | 1 | 1,730,691 | 0 | 0 | |
| AKERO THERAPEUTICS INC | COM | 00973Y108 | 3,816 | 403,787 | SH | DFND | 1 | 403,787 | 0 | 0 | |
| AKOUOS INC | COM | 00973J101 | 1,850 | 394,500 | SH | DFND | 1 | 394,500 | 0 | 0 | |
| ALTIMMUNE INC | COM NEW | 02155H200 | 35,100 | 3,000,000 | SH | DFND | 1 | 3,000,000 | 0 | 0 | |
| ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 5,761 | 712,079 | SH | DFND | 1 | 712,079 | 0 | 0 | |
| AMBRX BIOPHARMA INC | SPONSORED ADS | 02290A102 | 6,589 | 2,486,386 | SH | DFND | 1 | 2,486,386 | 0 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 1,015 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 42,959 | 950,000 | SH | DFND | 1 | 950,000 | 0 | 0 | |
| ARCELLX INC | COMMON STOCK | 03940C100 | 27,572 | 1,525,000 | SH | DFND | 1 | 1,525,000 | 0 | 0 | |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 | 4,648 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| ASTRIA THERAPEUTICS INC | COM | 04635X102 | 900 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| ATEA PHARMACEUTICALS INC | COM | 04683R106 | 10,985 | 1,547,181 | SH | DFND | 1 | 1,547,181 | 0 | 0 | |
| ATRECA INC | CL A COM | 04965G109 | 571 | 319,057 | SH | DFND | 1 | 319,057 | 0 | 0 | |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 1,110 | 392,167 | SH | DFND | 1 | 392,167 | 0 | 0 | |
| AVIDITY BIOSCIENCES INC | COM | 05370A108 | 29,236 | 2,012,115 | SH | DFND | 1 | 2,012,115 | 0 | 0 | |
| AXONICS INC | COM | 05465P101 | 18,261 | 322,240 | SH | DFND | 1 | 322,240 | 0 | 0 | |
| AXSOME THERAPEUTICS INC | COM | 05464T104 | 7,852 | 205,000 | SH | DFND | 1 | 205,000 | 0 | 0 | |
| BIOATLA INC | COM | 09077B104 | 5,809 | 2,038,215 | SH | DFND | 1 | 2,038,215 | 0 | 0 | |
| BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 26,941 | 184,894 | SH | DFND | 1 | 184,894 | 0 | 0 | |
| BIOMEA FUSION INC | COM | 09077A106 | 37,987 | 3,170,872 | SH | DFND | 1 | 3,170,872 | 0 | 0 | |
| BRIDGEBIO PHARMA INC | COM | 10806X102 | 13,340 | 1,469,179 | SH | DFND | 1 | 1,469,179 | 0 | 0 | |
| CABALETTA BIO INC | COM | 12674W109 | 1,224 | 1,154,424 | SH | DFND | 1 | 1,154,424 | 0 | 0 | |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 5,392 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 | 14,256 | 2,927,273 | SH | DFND | 1 | 2,927,273 | 0 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 35,312 | 1,425,000 | SH | DFND | 1 | 1,425,000 | 0 | 0 | |
| CHEMOMAB THERAPEUTICS LTD | SPONSORED ADS | 16385C104 | 1,066 | 288,168 | SH | DFND | 1 | 288,168 | 0 | 0 | |
| COGENT BIOSCIENCES INC | COM | 19240Q201 | 6,765 | 750,000 | SH | DFND | 1 | 750,000 | 0 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 15,716 | 400,000 | SH | DFND | 1 | 400,000 | 0 | 0 | |
| DESIGN THERAPEUTICS INC | COM | 25056L103 | 77,000 | 5,500,000 | SH | DFND | 1 | 5,500,000 | 0 | 0 | |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 | 30,646 | 3,850,000 | SH | DFND | 1 | 3,850,000 | 0 | 0 | |
| ELEDON PHARMACEUTICALS INC | COM | 28617K101 | 3,184 | 1,305,095 | SH | DFND | 1 | 1,305,095 | 0 | 0 | |
| ELEVATION ONCOLOGY INC | COM | 28623U101 | 2,776 | 1,983,168 | SH | DFND | 1 | 1,983,168 | 0 | 0 | |
| ERASCA INC | COM | 29479A108 | 58,516 | 10,505,554 | SH | DFND | 1 | 10,505,554 | 0 | 0 | |
| FORMA THERAPEUTICS HLDGS INC | SHS | 34633R104 | 21,856 | 3,172,204 | SH | DFND | 1 | 3,172,204 | 0 | 0 | |
| GALECTO INC | COM | 36322Q107 | 1,765 | 1,020,238 | SH | DFND | 1 | 1,020,238 | 0 | 0 | |
| GELESIS HLDGS INC | COM | 36850R204 | 970 | 626,108 | SH | DFND | 1 | 626,108 | 0 | 0 | |
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 6,069 | 608,123 | SH | DFND | 1 | 608,123 | 0 | 0 | |
| GOSSAMER BIO INC | COM | 38341P102 | 1,660 | 198,382 | SH | DFND | 1 | 198,382 | 0 | 0 | |
| GRAPHITE BIO INC | COM | 38870X104 | 549 | 199,547 | SH | DFND | 1 | 199,547 | 0 | 0 | |
| GREENLIGHT BIOSCIENCS HLDS P | COMMON STOCK | 39536G105 | 15,234 | 6,960,540 | SH | DFND | 1 | 6,960,540 | 0 | 0 | |
| HARPOON THERAPEUTICS INC | COM | 41358P106 | 1,033 | 540,600 | SH | DFND | 1 | 540,600 | 0 | 0 | |
| HORIZON THERAPEUTICS PUB L | SHS | G46188101 | 21,336 | 267,500 | SH | DFND | 1 | 267,500 | 0 | 0 | |
| ICOSAVAX INC | COM | 45114M109 | 3,732 | 651,393 | SH | DFND | 1 | 651,393 | 0 | 0 | |
| IMMUNEERING CORP | CLASS A COM | 45254E107 | 12,368 | 2,286,181 | SH | DFND | 1 | 2,286,181 | 0 | 0 | |
| IMV INC | COM | 44974L103 | 155 | 234,374 | SH | DFND | 1 | 234,374 | 0 | 0 | |
| INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 15,697 | 275,000 | SH | DFND | 1 | 275,000 | 0 | 0 | |
| KARUNA THERAPEUTICS INC | COM | 48576A100 | 15,814 | 125,000 | SH | DFND | 1 | 125,000 | 0 | 0 | |
| KEROS THERAPEUTICS INC | COM | 492327101 | 2,763 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| KEZAR LIFE SCIENCES INC | COM | 49372L100 | 9,924 | 1,200,000 | SH | DFND | 1 | 1,200,000 | 0 | 0 | |
| LONGBOARD PHARMACEUTICALS IN | COM | 54300N103 | 7,024 | 2,273,221 | SH | DFND | 1 | 2,273,221 | 0 | 0 | |
| MEIRAGTX HLDGS PLC | COM | G59665102 | 1,136 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 20,139 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 | 28,949 | 2,993,717 | SH | DFND | 1 | 2,993,717 | 0 | 0 | |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 30,886 | 6,065,001 | SH | DFND | 1 | 6,065,001 | 0 | 0 | |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 8,474 | 2,082,000 | SH | DFND | 1 | 2,082,000 | 0 | 0 | |
| ORCHARD THERAPEUTICS PLC | ADS | 68570P101 | 150 | 256,649 | SH | DFND | 1 | 256,649 | 0 | 0 | |
| PHARVARIS N V | COM | N69605108 | 25,326 | 1,145,953 | SH | DFND | 1 | 1,145,953 | 0 | 0 | |
| PLIANT THERAPEUTICS INC | COM | 729139105 | 3,864 | 482,413 | SH | DFND | 1 | 482,413 | 0 | 0 | |
| PROMETHEUS BIOSCIENCES INC | COM | 74349U108 | 57,283 | 2,029,158 | SH | DFND | 1 | 2,029,158 | 0 | 0 | |
| PYXIS ONCOLOGY INC | COMMON STOCK | 747324101 | 1,592 | 668,854 | SH | DFND | 1 | 668,854 | 0 | 0 | |
| RAIN THERAPEUTICS INC | COM | 75082Q105 | 12,936 | 2,326,660 | SH | DFND | 1 | 2,326,660 | 0 | 0 | |
| RENOVACOR INC | COM | 75989E106 | 1,014 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| REVOLUTION MEDICINES INC | COM | 76155X100 | 38,884 | 1,995,066 | SH | DFND | 1 | 1,995,066 | 0 | 0 | |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 11,951 | 868,550 | SH | DFND | 1 | 868,550 | 0 | 0 | |
| SPDR SER TR | S&P BIOTECH | 78464A870 | 33,422 | 450,000 | SH | Call | DFND | 1 | 450,000 | 0 | 0 |
| SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 11,694 | 475,000 | SH | DFND | 1 | 475,000 | 0 | 0 | |
| STOKE THERAPEUTICS INC | COM | 86150R107 | 14,370 | 1,087,807 | SH | DFND | 1 | 1,087,807 | 0 | 0 | |
| TALARIS THERAPEUTICS INC | COM | 87410C104 | 5,298 | 1,174,723 | SH | DFND | 1 | 1,174,723 | 0 | 0 | |
| TANGO THERAPEUTICS INC | COM | 87583X109 | 20,421 | 4,507,843 | SH | DFND | 1 | 4,507,843 | 0 | 0 | |
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 | 27,375 | 1,875,000 | SH | DFND | 1 | 1,875,000 | 0 | 0 | |
| TURNING POINT THERAPEUTICS I | COM | 90041T108 | 186,938 | 2,484,220 | SH | DFND | 1 | 2,484,220 | 0 | 0 | |
| TYRA BIOSCIENCES INC | COM | 90240B106 | 5,320 | 743,988 | SH | DFND | 1 | 743,988 | 0 | 0 | |
| VECTIVBIO HLDG AG | ORD SHS | H9060V101 | 15,338 | 2,840,389 | SH | DFND | 1 | 2,840,389 | 0 | 0 | |
| VENTYX BIOSCIENCES INC | COM | 92332V107 | 9,547 | 780,643 | SH | DFND | 1 | 780,643 | 0 | 0 | |
| VERVE THERAPEUTICS INC | COM | 92539P101 | 10,707 | 700,710 | SH | DFND | 1 | 700,710 | 0 | 0 | |
| VIGIL NEUROSCIENCE INC | COM | 92673K108 | 1,591 | 616,786 | SH | DFND | 1 | 616,786 | 0 | 0 | |
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 10,153 | 877,500 | SH | DFND | 1 | 877,500 | 0 | 0 | |
| X4 PHARMACEUTICALS INC | COM | 98420X103 | 100 | 103,980 | SH | DFND | 1 | 103,980 | 0 | 0 | |
| Y-MABS THERAPEUTICS INC | COM | 984241109 | 2,270 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |