The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADAPTIMMUNE THERAPEUTICS PLC | ADR | 00653A107 | 29,040 | 17,082,612 | SH | DFND | 17,082,612 | 0 | 0 | ||
| ADDEX THERAPEUTICS LTD | SPONSORED ADS | 00654J107 | 1,083 | 941,448 | SH | DFND | 941,448 | 0 | 0 | ||
| AFFIMED NV | COM | N01045108 | 12,261 | 4,426,488 | SH | DFND | 4,426,488 | 0 | 0 | ||
| AIRSPAN NETWORKS HOLDINGS INC | COM | 00951K104 | 4,589 | 1,534,633 | SH | DFND | 1,534,633 | 0 | 0 | ||
| AKARI THERAPEUTICS PLC | ADR | 00972G108 | 452 | 452,167 | SH | DFND | 452,167 | 0 | 0 | ||
| AKOUOS INC | COM | 00973J101 | 20,160 | 4,298,488 | SH | DFND | 4,298,488 | 0 | 0 | ||
| ALLAKOS INC | COM | 01671P100 | 6,776 | 2,164,704 | SH | DFND | 2,164,704 | 0 | 0 | ||
| ARCELLX INC | COM | 03940C100 | 112,703 | 6,750,264 | SH | DFND | 6,750,264 | 0 | 0 | ||
| AURINIA PHARMACEUTICALS INC | COM | 05156V102 | 39,897 | 3,969,834 | SH | DFND | 3,969,834 | 0 | 0 | ||
| AVEO PHARMACEUTICALS INC | COM | 053588307 | 25,931 | 3,952,957 | SH | DFND | 3,952,957 | 0 | 0 | ||
| BERKSHIRE GREY INC | COM CL A | 084656107 | 55,429 | 38,226,621 | SH | DFND | 38,226,621 | 0 | 0 | ||
| BILL COM HLDGS INC | COM | 090043100 | 6,904 | 66,100 | SH | DFND | 66,100 | 0 | 0 | ||
| BLACK DIAMOND THERAPEUTICS INC | COM | 09203E105 | 8,487 | 3,449,845 | SH | DFND | 3,449,845 | 0 | 0 | ||
| BRIGHT HEALTH GROUP INC | COM | 10920V107 | 397,146 | 218,212,126 | SH | DFND | 218,212,126 | 0 | 0 | ||
| BUZZFEED INC | CL A COM | 12430A102 | 23,614 | 15,333,892 | SH | DFND | 15,333,892 | 0 | 0 | ||
| CHAMPIONS ONCOLOGY INC | COM NEW | 15870P307 | 13,710 | 1,713,720 | SH | DFND | 1,713,720 | 0 | 0 | ||
| CLOUDFLARE INC | CL A COM | 18915M107 | 82,141 | 1,877,510 | SH | DFND | 1,877,510 | 0 | 0 | ||
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 96,624 | 1,590,002 | SH | DFND | 1,590,002 | 0 | 0 | ||
| CTI BIOPHARMA CORP | COM NEW | 12648L601 | 48,042 | 8,047,228 | SH | DFND | 8,047,228 | 0 | 0 | ||
| COURSERA INC | COM | 22266M104 | 225,005 | 15,867,769 | SH | DFND | 15,867,769 | 0 | 0 | ||
| CVRX INC | COM | 126638105 | 14,249 | 2,370,858 | SH | DFND | 2,370,858 | 0 | 0 | ||
| DESKTOP METAL INC | COM CL A | 25058X105 | 31,697 | 14,407,594 | SH | DFND | 14,407,594 | 0 | 0 | ||
| EARGO INC | COM | 270087109 | 3,399 | 4,520,849 | SH | DFND | 4,520,849 | 0 | 0 | ||
| GERON CORP | COM | 374163103 | 25,294 | 16,318,681 | SH | DFND | 16,318,681 | 0 | 0 | ||
| GLOBAL E ONLINE LTD | SHS | M5216V106 | 7,920 | 436,282 | SH | DFND | 436,282 | 0 | 0 | ||
| GLYCOMIMETICS INC | COM | 38000Q102 | 5,434 | 9,089,041 | SH | DFND | 9,089,041 | 0 | 0 | ||
| IMARA INC | COM | 45249V107 | 1,228 | 1,006,722 | SH | DFND | 1,006,722 | 0 | 0 | ||
| INOZYME PHARMA INC | COM | 45790W108 | 10,494 | 2,444,379 | SH | DFND | 2,444,379 | 0 | 0 | ||
| INVENTIVA SA | ADS | 46124U107 | 31,599 | 5,572,953 | SH | DFND | 5,572,953 | 0 | 0 | ||
| IONQ INC | COM | 46222L108 | 115,413 | 26,350,067 | SH | DFND | 26,350,067 | 0 | 0 | ||
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 4,431 | 2,382,286 | SH | DFND | 2,382,286 | 0 | 0 | ||
| LUMOS PHARMA INC | COM | 55028X109 | 503 | 65,374 | SH | DFND | 65,374 | 0 | 0 | ||
| MARKER THERAPEUTICS INC | COM | 57055L107 | 3,536 | 10,714,285 | SH | DFND | 10,714,285 | 0 | 0 | ||
| MEI PHARMA INC | COM NEW | 55279B202 | 5,163 | 8,533,072 | SH | DFND | 8,533,072 | 0 | 0 | ||
| METROMILE INC | COM | 591697107 | 8,610 | 9,384,285 | SH | DFND | 9,384,285 | 0 | 0 | ||
| MINERVA SURGICAL INC | COM | 60343F106 | 23,505 | 10,001,937 | SH | DFND | 10,001,937 | 0 | 0 | ||
| MIRUM PHARMACEUTICALS INC | COM | 604749101 | 81,495 | 4,187,801 | SH | DFND | 4,187,801 | 0 | 0 | ||
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 | 74,490 | 7,703,205 | SH | DFND | 7,703,205 | 0 | 0 | ||
| NEXTNAV INC | COM | 65345N106 | 18,589 | 8,189,156 | SH | DFND | 8,189,156 | 0 | 0 | ||
| NKARTA INC | COM | 65487U108 | 44,003 | 3,571,640 | SH | DFND | 3,571,640 | 0 | 0 | ||
| OBSEVA SA | COM | H5861P103 | 7,384 | 4,586,563 | SH | DFND | 4,586,563 | 0 | 0 | ||
| OYSTER PT PHARMA INC | COM | 69242L106 | 25,656 | 5,925,287 | SH | DFND | 5,925,287 | 0 | 0 | ||
| PALO ALTO NETWORKS INC | COM | 697435105 | 15,389 | 32,796 | SH | DFND | 32,796 | 0 | 0 | ||
| PHASEBIO PHARMACEUTICALS INC | COM | 717224109 | 3,986 | 6,643,702 | SH | DFND | 6,643,702 | 0 | 0 | ||
| REGULUS THERAPEUTICS INC | COM NEW | 75915K200 | 2,991 | 1,445,115 | SH | DFND | 1,445,115 | 0 | 0 | ||
| RENEO PHARMACEUTICALS INC | COM | 75974E103 | 12,685 | 4,786,921 | SH | DFND | 4,786,921 | 0 | 0 | ||
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 20,386 | 4,912,306 | SH | DFND | 4,912,306 | 0 | 0 | ||
| SATSUMA PHARMACEUTICALS INC | COM | 80405P107 | 13,012 | 3,142,958 | SH | DFND | 3,142,958 | 0 | 0 | ||
| SAVARA INC | COM | 805111101 | 36,690 | 24,137,931 | SH | DFND | 24,137,931 | 0 | 0 | ||
| SENTI BIOSCIENCES INC | COM | 81726A100 | 7,455 | 4,429,725 | SH | DFND | 4,429,725 | 0 | 0 | ||
| SYNLOGIC INC | COM | 87166L100 | 4,864 | 4,229,410 | SH | DFND | 4,229,410 | 0 | 0 | ||
| TRACON PHARMACEUTICALS INC | COM | 89237H209 | 693 | 346,719 | SH | DFND | 346,719 | 0 | 0 | ||
| TREVI THERAPEUTICS INC | COM | 89532M101 | 31,959 | 11,373,174 | SH | DFND | 11,373,174 | 0 | 0 | ||
| VERONA PHARMA PLC | ADS | 925050106 | 21,405 | 5,108,563 | SH | DFND | 5,108,563 | 0 | 0 | ||
| VISTAGEN THERAPEUTICS INC | COM | 92840H202 | 14,346 | 16,302,596 | SH | DFND | 16,302,596 | 0 | 0 | ||
| WHEELS UP EXPERIENCE INC | COM CL A | 96328L106 | 2,069 | 1,061,259 | SH | DFND | 1,061,259 | 0 | 0 | ||
| XERIS BIOPHARMA HOLDINGS INC | COM | 98422E103 | 5,000 | 3,246,785 | SH | DFND | 3,246,785 | 0 | 0 | ||