The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 4,593 35,495 SH   DFND 1 0 35,495 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 5,493 15,007 SH   DFND 1 0 15,007 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 1,380 3,770 SH   DFND   0 3,770 0
ALCON AG ORD SHS H01301128 1,798 25,733 SH   DFND   0 25,733 0
ALCON AG ORD SHS H01301128 5,806 83,074 SH   DFND 3 0 83,074 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 659 5,800 SH   DFND   0 5,800 0
ALPHABET INC CAP STK CL A 02079K305 3,147 1,444 SH   DFND   0 1,444 0
ALPHABET INC CAP STK CL A 02079K305 2,582 1,185 SH   DFND 1 0 1,185 0
ALPHABET INC CAP STK CL C 02079K107 4,988 2,280 SH   DFND 1 0 2,280 0
AMBRX BIOPHARMA INC SPONSORED ADS 02290A102 5,121 1,932,591 SH   DFND 2 0 1,932,591 0
AMERICAN WELL CORP CL A 03044L105 8,773 2,030,767 SH   DFND   0 2,030,767 0
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105 58,537 18,407,656 SH   DFND   0 18,407,656 0
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105 9,901 3,113,645 SH   DFND 2 0 3,113,645 0
ANHEUSER BUSCH INBEV SA/NV SPONSORED ADR 03524A108 5,706 105,765 SH   DFND 3 0 105,765 0
ANALOG DEVICES INC COM 032654105 1,928 13,200 SH   DFND 1 0 13,200 0
ANALOG DEVICES INC COM 032654105 4,984 34,117 SH   DFND 3 0 34,117 0
ANALOG DEVICES INC COM 032654105 4,238 29,009 SH   DFND   0 29,009 0
APPLE INC COM 037833100 4,673 34,180 SH   DFND 1 0 34,180 0
AURORA MOBILE LTD ADS 051857100 9,571 9,028,932 SH   DFND   0 9,028,932 0
BECTON DICKINSON & CO COM 075887109 2,103 8,530 SH   DFND 1 0 8,530 0
BECTON DICKINSON & CO COM 075887109 7,724 31,330 SH   DFND 3 0 31,330 0
BECTON DICKINSON & CO COM 075887109 2,141 8,688 SH   DFND   0 8,688 0
BIONTECH SE SPONSORED ADS 09075V102 149,643 1,003,640 SH   DFND 2 0 1,003,640 0
BUTTERFLY NETWORK INC COM CL A 124155102 32,900 10,716,630 SH   DFND 2 0 10,716,630 0
CARMAX INC COM 143130102 697 7,700 SH   DFND   0 7,700 0
CHECK CAP LTD SHS M2361E203 40 127,559 SH   DFND 2 0 127,559 0
CISCO SYS INC COM 17275R102 4,525 106,118 SH   DFND 1 0 106,118 0
CLARIVATE PLC ORD SHS G21810109 1,479 106,735 SH   DFND 1 0 106,735 0
CLARIVATE PLC ORD SHS G21810109 2,100 151,491 SH   DFND   0 151,491 0
COCA COLA CO COM 191216100 6,656 105,809 SH   DFND 1 0 105,809 0
CONTRAFECT CORP COM NEW 212326300 2,288 745,385 SH   DFND 2 0 745,385 0
CYMABAY THERAPEUTICS INC COM 23257D103 546 185,000 SH   DFND   0 185,000 0
CYMABAY THERAPEUTICS INC COM 23257D103 232 78,529 SH   DFND 3 0 78,529 0
DIAGEO PLC SPON ADR NEW 25243Q205 4,263 24,483 SH   DFND 3 0 24,483 0
DIGITALBRIDGE GROUP INC NOTE 5.000% 4/1 19624RAA4 7,868 8,000,000 SH   DFND 1 0 8,000,000 0
DISNEY WALT CO COM 254687106 768 8,135 SH   DFND 1 0 8,135 0
DISNEY WALT CO COM 254687106 1,853 19,627 SH   DFND   0 19,627 0
FISERV INC COM 337738108 3,121 35,078 SH   DFND 1 0 35,078 0
FISERV INC COM 337738108 4,758 53,475 SH   DFND   0 53,475 0
GALLAGHER ARTHUR J & CO COM 363576109 8,497 52,114 SH   DFND 3 0 52,114 0
GALLAGHER ARTHUR J & CO COM 363576109 999 6,124 SH   DFND   0 6,124 0
HELLO GROUP INC NOTE 1.250% 7/0 60879BAB3 28,269 30,523,000 SH   DFND 1 0 30,523,000 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 667 17,500 SH   DFND   0 17,500 0
HUIZE HLDG LTD SPONSORED ADS 44473E105 446 360,000 SH   DFND   0 360,000 0
HYPERFINE INC COM CL A 44916K106 3,885 1,742,020 SH   DFND 2 0 1,742,020 0
INTEL CORP COM 458140100 3,882 103,758 SH   DFND 1 0 103,758 0
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 1,811 15,200 SH   DFND 1 0 15,200 0
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 5,601 47,017 SH   DFND 3 0 47,017 0
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 4,053 34,024 SH   DFND   0 34,024 0
JOHNSON & JOHNSON COM 478160104 6,451 36,341 SH   DFND 1 0 36,341 0
KLA CORP COM NEW 482480100 205 641 SH   DFND 1 0 641 0
KLA CORP COM NEW 482480100 737 2,310 SH   DFND   0 2,310 0
KONINKLIJKE PHILIPS N V NY REGIS SHS NEW 500472303 2,551 118,508 SH   DFND 3 0 118,508 0
MERCK & CO INC COM 58933Y105 5,234 57,405 SH   DFND 3 0 57,405 0
MICROSOFT CORP COM 594918104 7,493 29,176 SH   DFND 1 0 29,176 0
MICROSOFT CORP COM 594918104 7,038 27,405 SH   DFND 3 0 27,405 0
MICROSOFT CORP COM 594918104 2,354 9,163 SH   DFND   0 9,163 0
NATURES SUNSHINE PRODS INC COM 639027101 31,253 2,929,001 SH   DFND 2 0 2,929,001 0
NETEASE INC SPONSORED ADS 64110W102 2,369 25,370 SH   DFND 1 0 25,370 0
NIKE INC CL B 654106103 3,575 34,985 SH   DFND 1 0 34,985 0
ONCORUS INC COM 68236R103 1,213 962,323 SH   DFND 2 0 962,323 0
PFIZER INC COM 717081103 5,719 109,082 SH   DFND 1 0 109,082 0
PHILIP MORRIS INTL INC COM 718172109 7,737 78,355 SH   DFND 3 0 78,355 0
PHILIP MORRIS INTL INC COM 718172109 325 3,294 SH   DFND   0 3,294 0
PROCTER AND GAMBLE CO COM 742718109 5,550 38,596 SH   DFND 1 0 38,596 0
QUANTUM SI INC COM CL A 74765K105 1,726 743,935 SH   DFND 2 0 743,935 0
SAP SE SPON ADR 803054204 5,018 55,318 SH   DFND 3 0 55,318 0
SCHWAB CHARLES CORP COM 808513105 865 13,690 SH   DFND 1 0 13,690 0
SCHWAB CHARLES CORP COM 808513105 1,534 24,282 SH   DFND   0 24,282 0
SERA PROGNOSTICS INC CLASS A COM 81749D107 909 554,148 SH   DFND 2 0 554,148 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 5,662 69,257 SH   DFND 3 0 69,257 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 4,889 59,800 SH   DFND   0 59,800 0
TRIP COM GROUP LTD ADS 89677Q107 2,513 91,537 SH   DFND   0 91,537 0
TWITTER INC NOTE 3/1 90184LAN2 7,128 8,000,000 SH   DFND 1 0 8,000,000 0
UNITEDHEALTH GROUP INC COM 91324P102 515 1,000 SH   DFND   0 1,000 0
UNITED PARCEL SERVICE INC CL B 911312106 5,089 27,880 SH   DFND 1 0 27,880 0
VANECK ETF TRUST FALLEN ANGEL HG 92189F437 14,041 519,668 SH   DFND 1 0 519,668 0
VANGUARD INDEX FDS S&P 500 ETF SHS 922908363 4,098 11,818 SH   DFND 3 0 11,818 0
VERISK ANALYTICS INC COM 92345Y106 955 5,520 SH   DFND 1 0 5,520 0
VERISK ANALYTICS INC COM 92345Y106 4,796 27,706 SH   DFND 3 0 27,706 0
VERISK ANALYTICS INC COM 92345Y106 1,327 7,667 SH   DFND   0 7,667 0
VERRICA PHARMACEUTICALS INC COM 92511W108 295 153,395 SH   DFND   0 153,395 0
VERRICA PHARMACEUTICALS INC COM 92511W108 248 129,013 SH   DFND 3 0 129,013 0
VIEWRAY INC COM 92672L107 41,127 15,519,500 SH   DFND   0 15,519,500 0
VISA INC COM CL A 92826C839 1,537 7,803 SH   DFND   0 7,803 0
VISA INC COM CL A 92826C839 6,931 35,204 SH   DFND 1 0 35,204 0
WEIBO CORP NOTE 1.250% 11/1 948596AC5 80,577 81,730,000 SH   DFND 1 0 81,730,000 0
WEIBO CORP NOTE 1.250% 11/1 948596AC5 986 1,000,000 SH   DFND   0 1,000,000 0
WELLS FARGO CO NEW COM 949746101 858 21,900 SH   DFND   0 21,900 0
WYNDHAM HOTELS & RESORTS INC COM 098311A05 642 9,760 SH   DFND   0 9,760 0