The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACLARIS THERAPEUTICS INC COM 00461U105 7,532 539,545 SH   SOLE   539,545 0 0
AKERO THERAPEUTICS INC COM 00973Y108 2,460 260,325 SH   SOLE   260,325 0 0
ALIGOS THERAPEUTICS INC COM 01626L105 71 58,392 SH   SOLE   58,392 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 5,834 40,000 SH Call SOLE   40,000 0 0
AMRYT PHARMA PLC SPONSORED ADS 03217L106 1,232 176,309 SH   SOLE   176,309 0 0
ANAVEX LIFE SCIENCES CORP COM NEW 032797300 9,180 917,100 SH Put SOLE   917,100 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 5,869 129,795 SH   SOLE   129,795 0 0
APOLLO ENDOSURGERY INC COM 03767D108 3,923 1,074,879 SH   SOLE   1,074,879 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 14,442 1,562,957 SH   SOLE   1,562,957 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 566 53,521 SH   SOLE   53,521 0 0
BIOGEN INC COM 09062X103 4,247 20,825 SH   SOLE   20,825 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 3,843 26,374 SH   SOLE   26,374 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 971 36,000 SH Put SOLE   36,000 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 979 36,322 SH   SOLE   36,322 0 0
CERUS CORP COM 157085101 11,077 2,093,861 SH   SOLE   2,093,861 0 0
CHEMOCENTRYX INC COM 16383L106 645 26,036 SH   SOLE   26,036 0 0
CODEXIS INC COM 192005106 1,443 137,960 SH   SOLE   137,960 0 0
COGENT BIOSCIENCES INC COM 19240Q201 7,405 820,954 SH   SOLE   820,954 0 0
COMPUGEN LTD ORD M25722105 193 104,150 SH   SOLE   104,150 0 0
CONTRAFECT CORP COM NEW 212326300 4,798 1,562,900 SH Put SOLE   1,562,900 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 2,602 139,539 SH   SOLE   139,539 0 0
CTI BIOPHARMA CORP COM 12648L601 8,239 1,380,111 SH   SOLE   1,380,111 0 0
CULLINAN ONCOLOGY INC COM 230031106 2,732 213,090 SH   SOLE   213,090 0 0
CVRX INC COM 126638105 1,756 292,145 SH   SOLE   292,145 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109 1,888 105,476 SH   SOLE   105,476 0 0
ELIEM THERAPEUTICS INC COM 28658R106 2,153 713,009 SH   SOLE   713,009 0 0
ELOXX PHARMACEUTICALS INC COM 29014R103 281 1,041,499 SH   SOLE   1,041,499 0 0
EVOGENE LTD SHS M4119S104 156 202,322 SH   SOLE   202,322 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209 1,555 197,640 SH   SOLE   197,640 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 650 94,386 SH   SOLE   94,386 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 5,758 72,187 SH   SOLE   72,187 0 0
HUMANIGEN INC COM NEW 444863203 1,383 781,100 SH Put SOLE   781,100 0 0
IMMATICS N.V SHS N44445109 3,093 355,103 SH   SOLE   355,103 0 0
IMMUNOGEN INC COM 45253H101 1,874 416,479 SH   SOLE   416,479 0 0
INSMED INC COM PAR $.01 457669307 4,190 212,482 SH   SOLE   212,482 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 17,921 313,962 SH   SOLE   313,962 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 45,546 162,500 SH Put SOLE   162,500 0 0
IVERIC BIO INC COM 46583P102 4,145 430,900 SH Put SOLE   430,900 0 0
KRYSTAL BIOTECH INC COM 501147102 6,912 105,277 SH   SOLE   105,277 0 0
MEDICUS SCIENCES ACQUISITION *W EXP 02/12/202 G5960S124 9 49,990 SH   SOLE   49,990 0 0
MEIRAGTX HLDGS PLC COM G59665102 394 52,066 SH   SOLE   52,066 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 175 156,195 SH   SOLE   156,195 0 0
MERSANA THERAPEUTICS INC COM 59045L106 3,927 850,000 SH   SOLE   850,000 0 0
MERUS N V COM N5749R100 10,621 469,113 SH   SOLE   469,113 0 0
MIRATI THERAPEUTICS INC COM 60468T105 2,444 36,403 SH   SOLE   36,403 0 0
MIRATI THERAPEUTICS INC COM 60468T105 6,773 100,900 SH Call SOLE   100,900 0 0
MORPHIC HLDG INC COM 61775R105 9,085 418,660 SH   SOLE   418,660 0 0
NGM BIOPHARMACEUTICALS INC COM 62921N105 1,132 88,303 SH   SOLE   88,303 0 0
NKARTA INC COM 65487U108 1,365 110,763 SH   SOLE   110,763 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 4,849 1,082,304 SH   SOLE   1,082,304 0 0
OTONOMY INC COM 68906L105 2,166 1,041,273 SH   SOLE   1,041,273 0 0
PHREESIA INC COM 71944F106 1,954 78,111 SH   SOLE   78,111 0 0
POLYPID LTD SHS M8001Q118 750 161,572 SH   SOLE   161,572 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 982 380,606 SH   SOLE   380,606 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 8,517 301,700 SH Put SOLE   301,700 0 0
REGENXBIO INC COM 75901B107 2,572 104,129 SH   SOLE   104,129 0 0
RENOVACOR INC *W EXP 99/99/999 75989E114 6 104,828 SH   SOLE   104,828 0 0
SEAGEN INC COM 81181C104 7,217 40,787 SH   SOLE   40,787 0 0
SERES THERAPEUTICS INC COM 81750R102 1,193 347,761 SH   SOLE   347,761 0 0
SILVERBACK THERAPEUTICS INC COM 82835W108 887 209,108 SH   SOLE   209,108 0 0
SPDR SER TR S&P BIOTECH 78464A870 15,470 208,300 SH Call SOLE   208,300 0 0
STEREOTAXIS INC COM NEW 85916J409 678 368,648 SH   SOLE   368,648 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 2,075 107,852 SH   SOLE   107,852 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 3,824 16,227 SH   SOLE   16,227 0 0
VERACYTE INC COM 92337F107 14,304 718,789 SH   SOLE   718,789 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 2,935 10,414 SH   SOLE   10,414 0 0
VERU INC COM 92536C103 8,819 780,400 SH Put SOLE   780,400 0 0
VIEWRAY INC COM 92672L107 1,942 732,740 SH   SOLE   732,740 0 0
XENON PHARMACEUTICALS INC COM 98420N105 7,077 232,630 SH   SOLE   232,630 0 0
ZYMEWORKS INC COM 98985W102 1,104 208,330 SH   SOLE   208,330 0 0