The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AKOUOS INC COM 00973J101 5,044 1,061,990 SH   SOLE   1,061,990 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 54,490 500,827 SH   SOLE   500,827 0 0
ALIGOS THERAPEUTICS INC COM 01626L105 4,193 1,950,000 SH   SOLE   1,950,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 4,082 25,000 SH   SOLE   25,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 24,245 2,560,211 SH   SOLE   2,560,211 0 0
ARCELLX, INC. COMMON STOCK 03940C100 56,317 4,016,878 SH   SOLE   4,016,878 0 0
APPLE INC COM 037833100 106,666 610,879 SH   SOLE   610,879 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210 143,671 215,099 SH   SOLE   215,099 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 14,534 227,526 SH   SOLE   227,526 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 12,341 4,503,991 SH   SOLE   4,503,991 0 0
BOSTON SCIENTIFIC CORP COM 101137107 153,402 3,463,577 SH   SOLE   3,463,577 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 165,251 2,921,171 SH   SOLE   2,921,171 0 0
CABLE ONE INC COM 12685J105 23,242 15,873 SH   SOLE   15,873 0 0
CATALENT INC COM 148806102 141,032 1,271,707 SH   SOLE   1,271,707 0 0
CHECKMATE PHARMACEUTICALS IN COM 162818108 6,897 2,161,990 SH   SOLE   2,161,990 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 9,326 424,897 SH   SOLE   424,897 0 0
CYTEIR THERAPEUTICS INC COM 23284P103 18,248 4,840,413 SH   SOLE   4,840,413 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 54,196 5,587,207 SH   SOLE   5,587,207 0 0
GALECTO INC COM 36322Q107 5,495 2,497,791 SH   SOLE   2,497,791 0 0
GALERA THERAPEUTICS INC COM 36338D108 5,852 2,459,021 SH   SOLE   2,459,021 0 0
INARI MED INC COM 45332Y109 11,160 123,122 SH   SOLE   123,122 0 0
INOGEN INC COM 45780L104 34,778 1,072,735 SH   SOLE   1,072,735 0 0
INSMED INC COM PAR $.01 457669307 16,587 705,838 SH   SOLE   705,838 0 0
INSPIRE MED SYS INC COM 457730109 10,639 41,448 SH   SOLE   41,448 0 0
IO BIOTECH INC COM 449778109 17,373 3,277,932 SH   SOLE   3,277,932 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 13,928 836,518 SH   SOLE   836,518 0 0
KINNATE BIOPHARMA INC COM 49705R105 7,029 624,236 SH   SOLE   624,236 0 0
LAVA THERAPEUTICS NV SHS N51517105 14,640 3,327,312 SH   SOLE   3,327,312 0 0
MARQETA INC CLASS A COM 57142B104 4,875 441,558 SH   SOLE   441,558 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 16,243 2,530,003 SH   SOLE   2,530,003 0 0
MINERVA SURGICAL INC COM 60343F106 9,220 2,048,892 SH   SOLE   2,048,892 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 48,444 2,200,000 SH   SOLE   2,200,000 0 0
MORPHIC HLDG INC COM 61775R105 65,638 1,634,811 SH   SOLE   1,634,811 0 0
NKARTA INC COM 65487U108 31,794 2,793,863 SH   SOLE   2,793,863 0 0
PHARVARIS N V COM N69605108 9,366 516,321 SH   SOLE   516,321 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 2,553 250,000 SH   SOLE   250,000 0 0
PULMONX CORP COM 745848101 10,176 410,155 SH   SOLE   410,155 0 0
RALLYBIO CORP COM 75120L100 3,043 435,944 SH   SOLE   435,944 0 0
RENEO PHARMACEUTICALS INC COM 75974E103 10,085 3,430,377 SH   SOLE   3,430,377 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 9,719 612,822 SH   SOLE   612,822 0 0
SALESFORCE.COM, INC. COM 79466L302 63,484 299,000 SH   SOLE   299,000 0 0
SEASPINE HLDGS CORP COM 81255T108 10,442 858,752 SH   SOLE   858,752 0 0
SILK RD MED INC COM 82710M100 11,399 276,068 SH   SOLE   276,068 0 0
SPERO THERAPEUTICS INC COM 84833T103 4,079 468,902 SH   SOLE   468,902 0 0
SPRUCE BIOSCIENCES INC COM 85209E109 9,074 4,514,336 SH   SOLE   4,514,336 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 47,832 458,780 SH   SOLE   458,780 0 0
TREACE MED CONCEPTS INC COM 89455T109 9,463 500,421 SH   SOLE   500,421 0 0
VANGUARD INDEX FDS TOTAL STK MKT 922908769 347,322 1,525,550 SH   SOLE   1,525,550 0 0
VECTIVBIO HLDG AG ORD SHS H9060V101 15,922 3,380,402 SH   SOLE   3,380,402 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 3,798 761,205 SH   SOLE   761,205 0 0
VERVE THERAPEUTICS INC COM 92539P101 17,115 750,000 SH   SOLE   750,000 0 0