The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aerovate Therapeutics, Inc. COMM 008064107 68,897 3,758,686 SH   SOLE   3,758,686 0 0
Akouos, Inc. COMM 00973J101 7,197 1,515,074 SH   SOLE   1,515,074 0 0
Ascendis Pharma A/S ADR 04351P101 58,659 499,824 SH   SOLE   499,824 0 0
Bolt Biotherapeutics, Inc. COMM 097702104 7,547 2,754,437 SH   SOLE   2,754,437 0 0
Checkmate Pharmaceuticals Inc COMM 162818108 11,505 3,606,707 SH   SOLE   3,606,707 0 0
Cincor Pharma, Inc. COMM 17240Y109 97,767 5,573,949 SH   SOLE   5,573,949 0 0
Fusion Pharmaceuticals Inc COMM 36118A100 607 78,066 SH   SOLE   78,066 0 0
Galera Therapeutics, Inc COMM 36338D108 7,339 3,083,712 SH   SOLE   3,083,712 0 0
Inozyme Pharma, Inc. COMM 45790W108 8,296 2,028,308 SH   SOLE   2,028,308 0 0
Karuna Therapeutics, Inc. COMM 48576A100 247,550 1,952,441 SH   SOLE   1,952,441 0 0
Natera Inc COMM 632307104 126,131 3,100,560 SH   SOLE   3,100,560 0 0
Nextcure, Inc COMM 65343E108 12,985 2,671,856 SH   SOLE   2,671,856 0 0
Nucana Plc Ordinary Shares GB00BYWYV 2,398 2,400,000 SH   SOLE   2,400,000 0 0
Nucana Plc ADR 67022C106 5,594 5,599,999 SH   SOLE   5,599,999 0 0
ObsEva SA COMM H5861P103 7,172 4,749,623 SH   SOLE   4,749,623 0 0
PDS Biotechnology Corporation COMM 70465T107 883 142,635 SH   SOLE   142,635 0 0
Synlogic Inc. COMM 87166L100 1,380 574,972 SH   SOLE   574,972 0 0
Vera Therapeutics, Inc. CL A 92337R101 74,732 3,181,442 SH   SOLE   3,181,442 0 0
Y-mAbs Therapeutics, Inc COMM 984241109 26,068 2,194,278 SH   SOLE   2,194,278 0 0
Adicet Bio Inc COMM 007002108 8,313 416,289 SH   SOLE   416,289 0 0
Amylyx Pharmaceuticals Inc COMM 03237H101 1,285 100,000 SH   SOLE   100,000 0 0
AstraZeneca PLC ADR 046353108 36,746 553,903 SH   SOLE   553,903 0 0
Bicycle Therapeutics PLC ADR 088786108 7,177 163,559 SH   SOLE   163,559 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 13,611 176,533 SH   SOLE   176,533 0 0
CTI Biopharma Corp COMM 12648L601 9,119 1,952,691 SH   SOLE   1,952,691 0 0
ChemoCentryx Inc COMM 16383L106 14,382 573,684 SH   SOLE   573,684 0 0
ChemoCentryx Inc CALL 16383L906 7,521 300,000 SH Call SOLE   300,000 0 0
Cytokinetics Inc COMM 23282W605 2,317 62,944 SH   SOLE   62,944 0 0
Dexcom Inc COMM 252131107 20,600 40,265 SH   SOLE   40,265 0 0
Fulcrum Therapeutics Inc COMM 359616109 5,428 229,509 SH   SOLE   229,509 0 0
Geron Corp COMM 374163103 2,590 1,904,762 SH   SOLE   1,904,762 0 0
Geron Corp COMM 374163103 1,360 1,000,000 SH Call SOLE   1,000,000 0 0
Guardant Health Inc COMM 40131M109 15,897 239,995 SH   SOLE   239,995 0 0
Heron Therapeutics Inc COMM 427746102 63 11,060 SH   SOLE   11,060 0 0
Horizon Therapeutics PLC COMM G46188101 24,503 232,894 SH   SOLE   232,894 0 0
Immatics NV COMM N44445109 10,132 1,268,063 SH   SOLE   1,268,063 0 0
ImmunoGen Inc COMM 45253H101 6,798 1,428,169 SH   SOLE   1,428,169 0 0
Inhibrx Inc COMM 45720L107 11,466 514,640 SH   SOLE   514,640 0 0
Insmed Inc COMM 457669307 126 5,368 SH   SOLE   5,368 0 0
Insulet Corp COMM 45784P101 284 1,066 SH   SOLE   1,066 0 0
Intercept Pharmaceuticals Inc COMM 45845P108 1,627 100,000 SH Call SOLE   100,000 0 0
Invesco QQQ Trust Series 1 COMM 46090E103 63,445 175,000 SH Put SOLE   175,000 0 0
Iveric Bio Inc COMM 46583P102 17,187 1,021,211 SH   SOLE   1,021,211 0 0
Jounce Therapeutics Inc COMM 481116101 10,057 1,481,219 SH   SOLE   1,481,219 0 0
Karuna Therapeutics Inc COMM 48576A100 81 636 SH   SOLE   636 0 0
Mink Therapeutics Inc COMM 603693102 745 331,002 SH   SOLE   331,002 0 0
Natera Inc COMM 632307104 98 2,400 SH   SOLE   2,400 0 0
PTC Therapeutics Inc COMM 69366J200 130 3,480 SH   SOLE   3,480 0 0
Pfizer Inc COMM 717081103 2,556 49,378 SH   SOLE   49,378 0 0
Protagonist Therapeutics Inc COMM 74366E102 12,963 547,441 SH   SOLE   547,441 0 0
Protagonist Therapeutics Inc COMM 74366E102 2,368 100,000 SH Call SOLE   100,000 0 0
Protagonist Therapeutics Inc COMM 74366E102 2,368 100,000 SH Call SOLE   100,000 0 0
Reata Pharmaceuticals Inc COMM 75615P103 19,739 602,545 SH   SOLE   602,545 0 0
Regenxbio Inc COMM 75901B107 20,381 614,085 SH   SOLE   614,085 0 0
Sarepta Therapeutics Inc COMM 803607100 6,943 88,880 SH   SOLE   88,880 0 0
Sierra Oncology Inc COMM 82640U404 18,342 572,297 SH   SOLE   572,297 0 0
Spdr S&P Biotech Etf COMM 78464A870 17,976 200,000 SH Put SOLE   200,000 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 12,463 717,064 SH   SOLE   717,064 0 0
Travere Therapeutics Inc COMM 89422G107 16,963 658,249 SH   SOLE   658,249 0 0
United Therapeutics Corp COMM 91307C102 35,735 199,183 SH   SOLE   199,183 0 0
Vertex Pharmaceuticals Inc COMM 92532F100 24,793 95,003 SH   SOLE   95,003 0 0
Xencor Inc COMM 98401F105 7,310 273,992 SH   SOLE   273,992 0 0
Zoetis Inc COMM 98978V103 20,099 106,574 SH   SOLE   106,574 0 0
iShares Russell 2000 ETF COMM 464287655 30,791 150,000 SH Put SOLE   150,000 0 0