The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
908 DEVICES INC COM 65443P102 11,907 626,366 SH   SOLE   597,737 0 28,629
ABSCI CORPORATION COM 00091E109 2,511 297,823 SH   SOLE   297,823 0 0
AC IMMUNE SA SHS H00263105 4,250 1,062,462 SH   SOLE   1,062,462 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 2,015 145,165 SH   SOLE   145,165 0 0
ALBIREO PHARMA INC COM 01345P106 7,957 266,744 SH   SOLE   266,744 0 0
ALECTOR INC COM 014442107 1,505 105,614 SH   SOLE   105,614 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 113,640 1,044,483 SH   SOLE   918,648 0 125,835
ALLY FINL INC COM 02005N100 28,052 645,162 SH   SOLE   645,162 0 0
ALPHA TEKNOVA INC COM 02080L102 2,337 169,237 SH   SOLE   169,237 0 0
ALPHABET INC CAP STK CL A 02079K305 18,435 6,628 SH   SOLE   6,628 0 0
ALPHABET INC CAP STK CL C 02079K107 56,628 20,275 SH   SOLE   20,275 0 0
AMBARELLA INC SHS G037AX101 193 1,842 SH   SOLE   1,842 0 0
AMGEN INC COM 031162100 90 372 SH   SOLE   372 0 0
ANALOG DEVICES INC COM 032654105 2,997 18,145 SH   SOLE   18,145 0 0
APPLIED MATLS INC COM 038222105 1,883 14,285 SH   SOLE   14,285 0 0
ARCUS BIOSCIENCES INC COM 03969F109 1,950 61,780 SH   SOLE   61,780 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 131 145,558 SH   SOLE   145,558 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 3,934 1,909,498 SH   SOLE   1,909,498 0 0
AT&T INC COM 00206R102 129 5,451 SH   SOLE   5,451 0 0
AZIYO BIOLOGICS INC COM CL A 05479K106 1,120 188,181 SH   SOLE   188,181 0 0
BARRICK GOLD CORP COM 067901108 175,092 7,137,871 SH   SOLE   5,676,094 0 1,461,777
BIO RAD LABS INC CL A 090572207 8,282 14,704 SH   SOLE   14,704 0 0
BIOATLA INC COM 09077B104 456 91,262 SH   SOLE   91,262 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 3,605 221,699 SH   SOLE   221,699 0 0
BLOCK INC CL A 852234103 16,990 125,298 SH   SOLE   125,298 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 1,732 27,121 SH   SOLE   27,121 0 0
BOOKING HOLDINGS INC COM 09857L108 110,574 47,084 SH   SOLE   40,646 0 6,438
BTRS HOLDINGS INC COM CL 1 11778X104 18,033 2,410,886 SH   SOLE   2,410,886 0 0
CALIFORNIA RES CORP COM STOCK 13057Q305 90 2,013 SH   SOLE   2,013 0 0
CARVANA CO CL A 146869102 882 7,396 SH   SOLE   7,396 0 0
CENTOGENE N V COM N1976T109 9,588 2,277,150 SH   SOLE   2,277,150 0 0
CIENA CORP COM NEW 171779309 76,044 1,254,226 SH   SOLE   1,125,398 0 128,828
CIGNA CORP NEW COM 125523100 86 359 SH   SOLE   359 0 0
CISCO SYS INC COM 17275R102 1,991 35,700 SH   SOLE   35,700 0 0
CLEVELAND-CLIFFS INC NEW COM 185899101 3,086 95,813 SH   SOLE   95,813 0 0
COGENT BIOSCIENCES INC COM 19240Q201 7,870 1,050,699 SH   SOLE   1,025,866 0 24,833
COGNYTE SOFTWARE LTD ORD SHS M25133105 322 28,506 SH   SOLE   28,506 0 0
COHERUS BIOSCIENCES INC COM 19249H103 6,908 535,108 SH   SOLE   535,108 0 0
CORE LABORATORIES N V COM N22717107 278 8,781 SH   SOLE   8,781 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 2,617 980,085 SH   SOLE   980,085 0 0
DENALI THERAPEUTICS INC COM 24823R105 1,640 50,971 SH   SOLE   50,971 0 0
DINGDONG CAYMAN LTD ADS 25445D101 7,205 2,029,706 SH   SOLE   2,029,706 0 0
DISH NETWORK CORPORATION CL A 25470M109 505 15,940 SH   SOLE   15,940 0 0
DOORDASH INC CL A 25809K105 16,029 136,778 SH   SOLE   136,778 0 0
EBAY INC. COM 278642103 1,299 22,679 SH   SOLE   22,679 0 0
EPIZYME INC COM 29428V104 7,594 6,603,870 SH   SOLE   6,603,870 0 0
EQUIFAX INC COM 294429105 35,500 149,727 SH   SOLE   149,727 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 12,589 2,713,176 SH   SOLE   2,442,860 0 270,316
EXAGEN INC COM 30068X103 3,212 400,000 SH   SOLE   344,533 0 55,467
EXSCIENTIA PLC ADS 30223G102 26,798 1,860,960 SH   SOLE   1,824,803 0 36,157
F45 TRAINING HLDGS INC COM 30322L101 4,981 465,526 SH   SOLE   465,526 0 0
FOX CORP CL A COM 35137L105 40 1,016 SH   SOLE   1,016 0 0
FREEPORT-MCMORAN INC CL B 35671D857 62,884 1,264,246 SH   SOLE   1,043,952 0 220,294
FULL TRUCK ALLIANCE CO LTD SPONSORED ADS 35969L108 1,328 199,091 SH   SOLE   199,091 0 0
GENERAL ELECTRIC CO COM NEW 369604301 79,355 867,263 SH   SOLE   627,096 0 240,167
GENETRON HLDGS LTD ADS 37186H100 2,883 1,316,642 SH   SOLE   1,316,642 0 0
GILEAD SCIENCES INC COM 375558103 64,775 1,089,569 SH   SOLE   832,830 0 256,739
HANESBRANDS INC COM 410345102 83 5,599 SH   SOLE   5,599 0 0
HCA HEALTHCARE INC COM 40412C101 82 327 SH   SOLE   327 0 0
HELLO GROUP INC ADS 423403104 57 9,871 SH   SOLE   9,871 0 0
HERBALIFE NUTRITION LTD COM SHS G4412G101 70 2,294 SH   SOLE   2,294 0 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 50,127 1,519,462 SH   SOLE   1,519,462 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103 3,617 191,156 SH   SOLE   191,156 0 0
ICOSAVAX INC COM 45114M109 10,410 1,478,733 SH   SOLE   1,437,009 0 41,724
IDEAYA BIOSCIENCES INC COM 45166A102 10,659 952,561 SH   SOLE   847,626 0 104,935
IMMATICS N.V SHS N44445109 2,656 332,356 SH   SOLE   332,356 0 0
IMMUNOVANT INC COM 45258J102 3,783 686,660 SH   SOLE   686,660 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 622 545,508 SH   SOLE   545,508 0 0
INHIBRX INC COM 45720L107 1,937 86,929 SH   SOLE   86,929 0 0
INTEL CORP COM 458140100 799 16,130 SH   SOLE   16,130 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 90,093 681,904 SH   SOLE   613,060 0 68,844
INTERNATIONAL BUSINESS MACHS COM 459200101 185 1,426 SH   SOLE   1,426 0 0
IRIS ENERGY LTD ORDINARY SHARES Q4982L109 42,885 2,736,734 SH   SOLE   2,371,606 0 365,128
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 54 9,491 SH   SOLE   9,491 0 0
JD.COM INC SPON ADR CL A 47215P106 30,222 522,239 SH   SOLE   522,239 0 0
KYNDRYL HLDGS INC COMMON STOCK 50155Q100 3 241 SH   SOLE   241 0 0
LAM RESEARCH CORP COM 512807108 63,534 118,179 SH   SOLE   103,783 0 14,396
LAMB WESTON HLDGS INC COM 513272104 21,820 364,213 SH   SOLE   364,213 0 0
LAREDO PETROLEUM INC COM 516806205 41 523 SH   SOLE   523 0 0
LEAP THERAPEUTICS INC COM 52187K101 2,324 1,327,952 SH   SOLE   1,327,952 0 0
LGI HOMES INC COM 50187T106 23,399 239,545 SH   SOLE   207,311 0 32,234
LIBERTY GLOBAL PLC SHS CL A G5480U104 378 14,800 SH   SOLE   14,800 0 0
LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854 1,083 15,500 SH   SOLE   15,500 0 0
LUMEN TECHNOLOGIES INC COM 550241103 686 60,907 SH   SOLE   60,907 0 0
MAGELLAN MIDSTREAM PRTNRS LP COM UNIT RP LP 559080106 129 2,631 SH   SOLE   2,631 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 930 320,698 SH   SOLE   320,698 0 0
MELCO RESORTS AND ENTMNT LTD ADR 585464100 15,786 2,066,285 SH   SOLE   2,066,285 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1,977 495,481 SH   SOLE   495,481 0 0
MERUS N V COM N5749R100 4,146 156,801 SH   SOLE   156,801 0 0
META PLATFORMS INC CL A 30303M102 61,317 275,757 SH   SOLE   275,757 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 305,590 4,066,939 SH   SOLE   3,641,467 0 425,472
MICRON TECHNOLOGY INC COM 595112103 210,822 2,706,662 SH   SOLE   2,348,653 0 358,009
MICROSOFT CORP COM 594918104 7,555 24,504 SH   SOLE   24,504 0 0
MOSAIC CO NEW COM 61945C103 216,515 3,255,860 SH   SOLE   2,875,990 0 379,870
MOTOROLA SOLUTIONS INC COM NEW 620076307 341 1,406 SH   SOLE   1,406 0 0
MYOVANT SCIENCES LTD COM G637AM102 2,600 195,211 SH   SOLE   195,211 0 0
MYT NETHERLANDS PARENT B V ADS 55406W103 246 20,118 SH   SOLE   20,118 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 12,187 350,719 SH   SOLE   319,600 0 31,119
NOAH HLDGS LTD SPON ADS CL A 65487X102 43,524 1,849,717 SH   SOLE   1,849,717 0 0
OATLY GROUP AB SPONSORED ADS 67421J108 3,312 661,043 SH   SOLE   661,043 0 0
OMEGA THERAPEUTICS INC COMMON STOCK 68217N105 2,587 414,513 SH   SOLE   387,712 0 26,801
ONECONNECT FINL TECHNOLOGY C SPONSORED ADS 68248T105 1,411 1,000,847 SH   SOLE   1,000,847 0 0
OPENDOOR TECHNOLOGIES INC COM 683712103 954 110,247 SH   SOLE   110,247 0 0
ORACLE CORP COM 68389X105 805 9,727 SH   SOLE   9,727 0 0
PARDES BIOSCIENCES INC COM 69945Q105 9,030 1,250,678 SH   SOLE   1,250,678 0 0
PAYPAL HLDGS INC COM 70450Y103 1,556 13,457 SH   SOLE   13,457 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 177 11,957 SH   SOLE   11,957 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 3,116 1,028,322 SH   SOLE   1,028,322 0 0
PLANET FITNESS INC CL A 72703H101 5,910 69,960 SH   SOLE   69,960 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 16,296 431,567 SH   SOLE   390,024 0 41,543
PROTHENA CORP PLC SHS G72800108 2,213 60,512 SH   SOLE   60,512 0 0
QUANTERIX CORP COM 74766Q101 17,395 595,935 SH   SOLE   549,962 0 45,973
RECURSION PHARMACEUTICALS IN CL A 75629V104 15,298 2,136,604 SH   SOLE   2,091,310 0 45,294
ROBLOX CORP CL A 771049103 28,833 623,542 SH   SOLE   584,438 0 39,104
ROIVANT SCIENCES LTD SHS G76279101 1,599 323,643 SH   SOLE   323,643 0 0
SANGAMO THERAPEUTICS INC COM 800677106 1,269 218,336 SH   SOLE   218,336 0 0
SILVERCREST METALS INC COM 828363101 24,988 2,804,448 SH   SOLE   2,089,651 0 714,797
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 1,662 263,443 SH   SOLE   263,443 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 44,923 337,061 SH   SOLE   254,531 0 82,530
SPROUTS FMRS MKT INC COM 85208M102 41 1,290 SH   SOLE   1,290 0 0
SUNCOR ENERGY INC NEW COM 867224107 96,301 2,957,922 SH   SOLE   2,721,325 0 236,597
SUZANO S A SPON ADS 86959K105 14,424 1,241,314 SH   SOLE   1,241,314 0 0
SYNEOS HEALTH INC CL A 87166B102 7,604 93,940 SH   SOLE   93,940 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 8,738 2,903,022 SH   SOLE   2,903,022 0 0
TRIP COM GROUP LTD ADS 89677Q107 265,873 11,499,707 SH   SOLE   10,478,104 0 1,021,603
ULTA BEAUTY INC COM 90384S303 11,293 28,358 SH   SOLE   28,358 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 84 580 SH   SOLE   580 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 95 363 SH   SOLE   363 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 2,672 1,336,105 SH   SOLE   1,336,105 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107 939 213,381 SH   SOLE   213,381 0 0
WESTERN DIGITAL CORP. COM 958102105 2,584 52,044 SH   SOLE   52,044 0 0
YUM CHINA HLDGS INC COM 98850P109 4,535 109,179 SH   SOLE   109,179 0 0
ZAI LAB LTD ADR 98887Q104 4,583 104,205 SH   SOLE   104,205 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADS A 98980A105 372,640 14,905,595 SH   SOLE   13,410,826 0 1,494,769
ZYMEWORKS INC COM 98985W102 1,541 235,299 SH   SOLE   235,299 0 0