The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 4,924 41,600 SH   DFND 1,2,3,4 41,600 0 0
ADICET BIO INC COM 007002108 5,492 275,000 SH   DFND 1,2,3,4 275,000 0 0
ALCOA CORP COM 013872106 33,149 368,200 SH   DFND 1,2,3,4 368,200 0 0
ALLEGHANY CORP MD COM 017175100 8,047 9,500 SH   DFND 1,2,3,4 9,500 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 6,058 37,100 SH Put DFND 1,2,3,4 37,100 0 0
AMAZON COM INC COM 023135106 36,674 11,250 SH   DFND 1,2,3,4 11,250 0 0
AMN HEALTHCARE SVCS INC COM 001744101 10,433 100,000 SH Put DFND 1,2,3,4 100,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 7,622 150,000 SH Put DFND 1,2,3,4 150,000 0 0
API GROUP CORP COM STK 00187Y100 21,979 1,045,128 SH   DFND 1,2,3,4 1,045,128 0 0
APOLLO GLOBAL MGMT INC COM 03769M106 6,199 100,000 SH   DFND 1,2,3,4 100,000 0 0
AZEK CO INC CL A 05478C105 12,867 518,000 SH   DFND 1,2,3,4 518,000 0 0
BEYOND AIR INC COM 08862L103 668 100,000 SH Call DFND 1,2,3,4 100,000 0 0
BEYOND AIR INC COM 08862L103 5,212 780,228 SH   DFND 1,2,3,4 780,228 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 16,162 136,306 SH   DFND 1,2,3,4 136,306 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 23,714 200,000 SH Call DFND 1,2,3,4 200,000 0 0
BLOOMIN BRANDS INC COM 094235108 8,063 367,500 SH   DFND 1,2,3,4 367,500 0 0
CARA THERAPEUTICS INC COM 140755109 14,373 1,183,000 SH   DFND 1,2,3,4 1,183,000 0 0
CHARLES RIV LABS INTL INC COM 159864107 14,255 50,200 SH   DFND 1,2,3,4 50,200 0 0
CHART INDS INC COM 16115Q308 4,223 24,585 SH   DFND 1,2,3,4 24,585 0 0
CROWN HLDGS INC COM 228368106 19,472 155,665 SH   DFND 1,2,3,4 155,665 0 0
CURIS INC COM NEW 231269200 3,772 1,585,000 SH   DFND 1,2,3,4 1,585,000 0 0
DISCOVER FINL SVCS COM 254709108 6,277 56,965 SH   DFND 1,2,3,4 56,965 0 0
DISNEY WALT CO COM 254687106 4,115 30,000 SH   DFND 1,2,3,4 30,000 0 0
DOCUSIGN INC COM 256163106 2,678 25,000 SH Put DFND 1,2,3,4 25,000 0 0
DOLLAR TREE INC COM 256746108 2,242 14,000 SH   DFND 1,2,3,4 14,000 0 0
DUCKHORN PORTFOLIO INC COM 26414D106 6,031 331,531 SH   DFND 1,2,3,4 331,531 0 0
ENCOMPASS HEALTH CORP COM 29261A100 8,960 126,000 SH   DFND 1,2,3,4 126,000 0 0
ENVVENO MEDICAL CORPORATION COM 29415J106 1,396 219,180 SH   DFND 1,2,3,4 219,180 0 0
EQUITABLE HLDGS INC COM 29452E101 7,728 250,000 SH   DFND 1,2,3,4 250,000 0 0
EUCRATES BIOMEDICAL ACQU COR *W EXP 10/23/202 G3141W122 11 66,665 SH   DFND 1,2,3,4 66,665 0 0
EUCRATES BIOMEDICAL ACQU COR SHS G3141W106 1,968 200,000 SH   DFND 1,2,3,4 200,000 0 0
FLUENCE ENERGY INC COM CL A 34379V103 4,944 377,145 SH   DFND 1,2,3,4 377,145 0 0
FOGHORN THERAPEUTICS INC COM 344174107 826 54,241 SH   DFND 1,2,3,4 54,241 0 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 2,465 1,972,056 SH   DFND 1,2,3,4 1,972,056 0 0
GILEAD SCIENCES INC COM 375558103 5,945 100,000 SH Put DFND 1,2,3,4 100,000 0 0
GREAT ELM GROUP INC COM NEW 39037G109 2,279 1,259,049 SH   DFND 1,2,3,4 1,259,049 0 0
GTY TECHNOLOGY HOLDINGS INC COM 362409104 3,746 1,159,600 SH   DFND 1,2,3,4 1,159,600 0 0
GUARDANT HEALTH INC COM 40131M109 6,624 100,000 SH Call DFND 1,2,3,4 100,000 0 0
GUARDANT HEALTH INC COM 40131M109 9,658 145,800 SH   DFND 1,2,3,4 145,800 0 0
HERSHEY CO COM 427866108 2,036 9,400 SH   DFND 1,2,3,4 9,400 0 0
IMAGO BIOSCIENCES INC COM 45250K107 5,012 260,118 SH   DFND 1,2,3,4 260,118 0 0
INFLARX NV COM N44821101 135 73,860 SH   DFND 1,2,3,4 73,860 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 16,351 54,200 SH   DFND 1,2,3,4 54,200 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 6,344 17,500 SH Call DFND 1,2,3,4 17,500 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 132,327 365,000 SH Put DFND 1,2,3,4 365,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 40,028 195,000 SH Put DFND 1,2,3,4 195,000 0 0
JASPER THERAPEUTICS INC COM 471871103 1,917 540,000 SH   DFND 1,2,3,4 540,000 0 0
MEDICUS SCIENCES ACQUISITION *W EXP 02/12/202 G5960S124 12 33,332 SH   DFND 1,2,3,4 33,332 0 0
MEDICUS SCIENCES ACQUISITION CL A SHS G5960S108 2,934 300,000 SH   DFND 1,2,3,4 300,000 0 0
META PLATFORMS INC CL A 30303M102 34,156 153,605 SH   DFND 1,2,3,4 153,605 0 0
MIRION TECHNOLOGIES INC COM CL A 60471A101 5,649 700,000 SH   DFND 1,2,3,4 700,000 0 0
MOLECULAR TEMPLATES INC COM 608550109 3,524 1,021,317 SH   DFND 1,2,3,4 1,021,317 0 0
MOLSON COORS BEVERAGE CO CL B 60871R209 2,068 38,750 SH   DFND 1,2,3,4 38,750 0 0
NEXIMMUNE INC COM 65344D109 497 117,962 SH   DFND 1,2,3,4 117,962 0 0
NUVATION BIO INC COM CL A 67080N101 2,228 423,500 SH   DFND 1,2,3,4 423,500 0 0
OPTINOSE INC COM 68404V100 4,940 2,000,000 SH   DFND 1,2,3,4 2,000,000 0 0
OVERSTOCK COM INC DEL COM 690370101 2,640 60,000 SH Put DFND 1,2,3,4 60,000 0 0
OVERSTOCK COM INC DEL COM 690370101 3,080 70,000 SH   DFND 1,2,3,4 70,000 0 0
PALO ALTO NETWORKS INC COM 697435105 11,983 19,250 SH   DFND 1,2,3,4 19,250 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 4,232 414,489 SH   DFND 1,2,3,4 414,489 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 3,776 100,000 SH   DFND 1,2,3,4 100,000 0 0
RADIUS HEALTH INC COM NEW 750469207 2,649 300,000 SH Call DFND 1,2,3,4 300,000 0 0
RADIUS HEALTH INC COM NEW 750469207 5,077 575,000 SH   DFND 1,2,3,4 575,000 0 0
RAPT THERAPEUTICS INC COM 75382E109 23,932 1,088,321 SH   DFND 1,2,3,4 1,088,321 0 0
REGENERON PHARMACEUTICALS COM 75886F107 17,461 25,000 SH Put DFND 1,2,3,4 25,000 0 0
SCYNEXIS INC COM NEW 811292200 3,116 797,048 SH   DFND 1,2,3,4 797,048 0 0
SIGNATURE BK NEW YORK N Y COM 82669G104 7,337 25,000 SH   DFND 1,2,3,4 25,000 0 0
SOL GEL TECHNOLOGIES SHS M8694L103 6,146 832,800 SH   DFND 1,2,3,4 832,800 0 0
SOVOS BRANDS INC COM 84612U107 3,940 277,834 SH   DFND 1,2,3,4 277,834 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 94,844 210,000 SH Put DFND 1,2,3,4 210,000 0 0
SPDR SER TR S&P OILGAS EXP 78468R556 38,898 289,100 SH   DFND 1,2,3,4 289,100 0 0
SYNOVUS FINL CORP COM NEW 87161C501 7,840 160,000 SH   DFND 1,2,3,4 160,000 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 11,629 100,000 SH Call DFND 1,2,3,4 100,000 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 20,048 172,400 SH   DFND 1,2,3,4 172,400 0 0
TECK RESOURCES LTD CL B 878742204 28,267 699,850 SH   DFND 1,2,3,4 699,850 0 0
TRILOGY METALS INC NEW COM 89621C105 590 561,900 SH   DFND 1,2,3,4 561,900 0 0
UNITED RENTALS INC COM 911363109 24,618 69,305 SH   DFND 1,2,3,4 69,305 0 0
UNITEDHEALTH GROUP INC COM 91324P102 9,536 18,700 SH   DFND 1,2,3,4 18,700 0 0
VINCERX PHARMA INC COM NEW 92731L106 1,540 385,000 SH   DFND 1,2,3,4 385,000 0 0
WELLS FARGO CO NEW COM 949746101 8,723 180,000 SH   DFND 1,2,3,4 180,000 0 0
WILLSCOT MOBIL MINI HLDNG CO COM CL A 971378104 12,758 326,029 SH   DFND 1,2,3,4 326,029 0 0
WNS HLDGS LTD SPON ADR 92932M101 3,420 40,000 SH   DFND 1,2,3,4 40,000 0 0