The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADICET BIO INC | COM | 007002108 | 14,978 | 750,000 | SH | DFND | 1 | 750,000 | 0 | 0 | |
| AEROVATE THERAPEUTICS INC | COM | 008064107 | 33,557 | 1,830,691 | SH | DFND | 1 | 1,830,691 | 0 | 0 | |
| AKERO THERAPEUTICS INC | COM | 00973Y108 | 5,730 | 403,787 | SH | DFND | 1 | 403,787 | 0 | 0 | |
| AKOUOS INC | COM | 00973J101 | 1,874 | 394,500 | SH | DFND | 1 | 394,500 | 0 | 0 | |
| ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 12,034 | 712,079 | SH | DFND | 1 | 712,079 | 0 | 0 | |
| AMBRX BIOPHARMA INC | SPONSORED ADS | 02290A102 | 10,244 | 2,486,386 | SH | DFND | 1 | 2,486,386 | 0 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 1,237 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 57,161 | 1,125,000 | SH | DFND | 1 | 1,125,000 | 0 | 0 | |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 | 5,868 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| ASTRIA THERAPEUTICS INC | COM | 04635X102 | 2,013 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| ATEA PHARMACEUTICALS INC | COM | 04683R106 | 11,171 | 1,547,181 | SH | DFND | 1 | 1,547,181 | 0 | 0 | |
| ATRECA INC | CL A COM | 04965G109 | 2,536 | 800,000 | SH | DFND | 1 | 800,000 | 0 | 0 | |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 1,635 | 392,167 | SH | DFND | 1 | 392,167 | 0 | 0 | |
| AVIDITY BIOSCIENCES INC | COM | 05370A108 | 37,164 | 2,012,115 | SH | DFND | 1 | 2,012,115 | 0 | 0 | |
| AXONICS INC | COM | 05465P101 | 20,172 | 322,240 | SH | DFND | 1 | 322,240 | 0 | 0 | |
| BEAM THERAPEUTICS INC | COM | 07373V105 | 5,160 | 90,045 | SH | DFND | 1 | 90,045 | 0 | 0 | |
| BIOATLA INC | COM | 09077B104 | 10,191 | 2,038,215 | SH | DFND | 1 | 2,038,215 | 0 | 0 | |
| BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 9,486 | 80,000 | SH | DFND | 1 | 80,000 | 0 | 0 | |
| BIOMEA FUSION INC | COM | 09077A106 | 14,142 | 3,170,872 | SH | DFND | 1 | 3,170,872 | 0 | 0 | |
| BRIDGEBIO PHARMA INC | COM | 10806X102 | 15,924 | 1,568,909 | SH | DFND | 1 | 1,568,909 | 0 | 0 | |
| CABALETTA BIO INC | COM | 12674W109 | 2,343 | 1,154,424 | SH | DFND | 1 | 1,154,424 | 0 | 0 | |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 | 22,334 | 2,489,894 | SH | DFND | 1 | 2,489,894 | 0 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 21,686 | 865,000 | SH | DFND | 1 | 865,000 | 0 | 0 | |
| CHEMOMAB THERAPEUTICS LTD | SPONSORED ADS | 16385C104 | 1,383 | 288,168 | SH | DFND | 1 | 288,168 | 0 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 14,724 | 400,000 | SH | DFND | 1 | 400,000 | 0 | 0 | |
| DESIGN THERAPEUTICS INC | COM | 25056L103 | 83,285 | 5,156,994 | SH | DFND | 1 | 5,156,994 | 0 | 0 | |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 | 45,424 | 4,682,874 | SH | DFND | 1 | 4,682,874 | 0 | 0 | |
| ELEDON PHARMACEUTICALS INC | COM | 28617K101 | 5,142 | 1,305,095 | SH | DFND | 1 | 1,305,095 | 0 | 0 | |
| ELEVATION ONCOLOGY INC | COM | 28623U101 | 4,998 | 1,983,165 | SH | DFND | 1 | 1,983,165 | 0 | 0 | |
| ERASCA INC | COM | 29479A108 | 90,348 | 10,505,554 | SH | DFND | 1 | 10,505,554 | 0 | 0 | |
| FORMA THERAPEUTICS HLDGS INC | SHS | 34633R104 | 37,836 | 4,068,351 | SH | DFND | 1 | 4,068,351 | 0 | 0 | |
| GALECTO INC | COM | 36322Q107 | 2,245 | 1,020,238 | SH | DFND | 1 | 1,020,238 | 0 | 0 | |
| GELESIS HLDGS INC | COM | 36850R204 | 2,751 | 626,108 | SH | DFND | 1 | 626,108 | 0 | 0 | |
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 11,123 | 608,123 | SH | DFND | 1 | 608,123 | 0 | 0 | |
| GOSSAMER BIO INC | COM | 38341P102 | 1,722 | 198,382 | SH | DFND | 1 | 198,382 | 0 | 0 | |
| GRAPHITE BIO INC | COM | 38870X104 | 1,036 | 203,153 | SH | DFND | 1 | 203,153 | 0 | 0 | |
| GREENLIGHT BIOSCIENCS HLDS P | COMMON STOCK | 39536G105 | 62,038 | 6,710,540 | SH | DFND | 1 | 6,710,540 | 0 | 0 | |
| HARPOON THERAPEUTICS INC | COM | 41358P106 | 2,687 | 540,600 | SH | DFND | 1 | 540,600 | 0 | 0 | |
| HELIX ACQUISITION CORP | COM CL A | G4444C102 | 33,273 | 3,280,000 | SH | DFND | 1 | 3,280,000 | 0 | 0 | |
| HORIZON THERAPEUTICS PUB L | SHS | G46188101 | 10,521 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| ICOSAVAX INC | COM | 45114M109 | 3,002 | 426,393 | SH | DFND | 1 | 426,393 | 0 | 0 | |
| IGM BIOSCIENCES INC | COM | 449585108 | 10,751 | 402,200 | SH | DFND | 1 | 402,200 | 0 | 0 | |
| IMMUNEERING CORP | CLASS A COM | 45254E107 | 14,898 | 2,302,626 | SH | DFND | 1 | 2,302,626 | 0 | 0 | |
| IMV INC | COM | 44974L103 | 337 | 234,374 | SH | DFND | 1 | 234,374 | 0 | 0 | |
| INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 9,178 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| ITEOS THERAPEUTICS INC | COM | 46565G104 | 3,218 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| KARUNA THERAPEUTICS INC | COM | 48576A100 | 19,018 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| KEROS THERAPEUTICS INC | COM | 492327101 | 5,438 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| LONGBOARD PHARMACEUTICALS IN | COM | 54300N103 | 12,139 | 2,273,221 | SH | DFND | 1 | 2,273,221 | 0 | 0 | |
| MEIRAGTX HLDGS PLC | COM | G59665102 | 2,078 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 4,111 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 | 42,091 | 3,002,199 | SH | DFND | 1 | 3,002,199 | 0 | 0 | |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 8,869 | 2,082,000 | SH | DFND | 1 | 2,082,000 | 0 | 0 | |
| ORCHARD THERAPEUTICS PLC | ADS | 68570P101 | 183 | 256,649 | SH | DFND | 1 | 256,649 | 0 | 0 | |
| PHARVARIS N V | COM | N69605108 | 12,420 | 684,888 | SH | DFND | 1 | 684,888 | 0 | 0 | |
| PLIANT THERAPEUTICS INC | COM | 729139105 | 3,382 | 482,413 | SH | DFND | 1 | 482,413 | 0 | 0 | |
| PRAXIS PRECISION MEDICINES I | COM | 74006W108 | 7,682 | 752,406 | SH | DFND | 1 | 752,406 | 0 | 0 | |
| PRECISION BIOSCIENCES INC | COM | 74019P108 | 1,067 | 346,524 | SH | DFND | 1 | 346,524 | 0 | 0 | |
| PROMETHEUS BIOSCIENCES INC | COM | 74349U108 | 68,853 | 1,823,444 | SH | DFND | 1 | 1,823,444 | 0 | 0 | |
| PYXIS ONCOLOGY INC | COMMON STOCK | 747324101 | 2,702 | 668,854 | SH | DFND | 1 | 668,854 | 0 | 0 | |
| RAIN THERAPEUTICS INC | COM | 75082Q105 | 11,796 | 2,326,660 | SH | DFND | 1 | 2,326,660 | 0 | 0 | |
| RENOVACOR INC | COM | 75989E106 | 2,120 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| REVOLUTION MEDICINES INC | COM | 76155X100 | 50,894 | 1,995,066 | SH | DFND | 1 | 1,995,066 | 0 | 0 | |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 13,775 | 868,550 | SH | DFND | 1 | 868,550 | 0 | 0 | |
| STOKE THERAPEUTICS INC | COM | 86150R107 | 22,898 | 1,087,807 | SH | DFND | 1 | 1,087,807 | 0 | 0 | |
| TALARIS THERAPEUTICS INC | COM | 87410C104 | 11,559 | 1,174,723 | SH | DFND | 1 | 1,174,723 | 0 | 0 | |
| TANGO THERAPEUTICS INC | COM | 87583X109 | 37,136 | 4,899,185 | SH | DFND | 1 | 4,899,185 | 0 | 0 | |
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 | 23,144 | 1,375,982 | SH | DFND | 1 | 1,375,982 | 0 | 0 | |
| TURNING POINT THERAPEUTICS I | COM | 90041T108 | 99,345 | 3,700,000 | SH | DFND | 1 | 3,700,000 | 0 | 0 | |
| TYRA BIOSCIENCES INC | COM | 90240B106 | 8,105 | 757,432 | SH | DFND | 1 | 757,432 | 0 | 0 | |
| VECTIVBIO HLDG AG | ORD SHS | H9060V101 | 9,790 | 2,078,485 | SH | DFND | 1 | 2,078,485 | 0 | 0 | |
| VENTYX BIOSCIENCES INC | COM | 92332V107 | 10,657 | 785,303 | SH | DFND | 1 | 785,303 | 0 | 0 | |
| VERVE THERAPEUTICS INC | COM | 92539P101 | 15,990 | 700,710 | SH | DFND | 1 | 700,710 | 0 | 0 | |
| VIGIL NEUROSCIENCE INC | COM | 92673K108 | 4,206 | 616,786 | SH | DFND | 1 | 616,786 | 0 | 0 | |
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 18,490 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| X4 PHARMACEUTICALS INC | COM | 98420X103 | 182 | 103,980 | SH | DFND | 1 | 103,980 | 0 | 0 | |
| Y-MABS THERAPEUTICS INC | COM | 984241109 | 1,782 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |