The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107 687 40,273 SH   DFND 1,2 40,273 0 0
ABCELLERA BIOLOGICS INC COM 00288U106 122 12,521 SH   DFND 1,2 12,521 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 726 29,984 SH   DFND 1,2 29,984 0 0
AFFIMED N V COM N01045108 355 81,172 SH   DFND 1,2 81,172 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 709 41,950 SH   DFND 1,2 41,950 0 0
ARGENX SE SPONSORED ADR 04016X101 350 1,110 SH   DFND 1,2 1,110 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 489 4,168 SH   DFND 1,2 4,168 0 0
BEAM THERAPEUTICS INC COM 07373V105 3,146 54,903 SH   DFND 1,2 54,903 0 0
BEIGENE LTD SPONSORED ADR 07725L102 2,267 12,022 SH   DFND 1,2 12,022 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 471 6,115 SH   DFND 1,2 6,115 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 3,197 1,166,952 SH   DFND 1,2 1,166,952 0 0
CERUS CORP COM 157085101 78 14,172 SH   DFND 1,2 14,172 0 0
CHEMOCENTRYX INC COM 16383L106 898 35,830 SH   DFND 1,2 35,830 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109 114 11,445 SH   DFND 1,2 11,445 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 590 370,950 SH   DFND 1,2 370,950 0 0
DYNE THERAPEUTICS INC COM 26818M108 112 11,629 SH   DFND 1,2 11,629 0 0
EARGO INC COM 270087109 15,271 2,886,724 SH   DFND 1,2 2,886,724 0 0
ENTRADA THERAPEUTICS INC COM 29384C108 1,630 173,582 SH   DFND 1,2 173,582 0 0
EXACT SCIENCES CORP COM 30063P105 1,221 17,464 SH   DFND 1,2 17,464 0 0
EXELIXIS INC COM 30161Q104 1,455 64,200 SH   DFND 1,2 64,200 0 0
EXSCIENTIA PLC ADS 30223G102 11,091 770,200 SH   DFND 1,2 770,200 0 0
FIBROGEN INC COM 31572Q808 177 14,756 SH   DFND 1,2 14,756 0 0
GALERA THERAPEUTICS INC COM 36338D108 1,459 613,223 SH   DFND 1,2 613,223 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 37,398 768,708 SH   DFND 1,2 768,708 0 0
ILLUMINA INC COM 452327109 45,299 129,647 SH   DFND 1,2 129,647 0 0
INCYTE CORP COM 45337C102 2,731 34,391 SH   DFND 1,2 34,391 0 0
INVITAE CORP COM 46185L103 1,243 156,004 SH   DFND 1,2 156,004 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 1,160 78,720 SH   DFND 1,2 78,720 0 0
KARUNA THERAPEUTICS INC COM 48576A100 29,772 234,811 SH   DFND 1,2 234,811 0 0
KODIAK SCIENCES INC COM 50015M109 151 19,622 SH   DFND 1,2 19,622 0 0
OTONOMY INC COM 68906L105 2,043 851,080 SH   DFND 1,2 851,080 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 1,318 144,840 SH   DFND 1,2 144,840 0 0
RANI THERAPEUTICS HLDGS INC COM CL A 753018100 6,663 493,584 SH   DFND 1,2 493,584 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 271 8,265 SH   DFND 1,2 8,265 0 0
REPLIMUNE GROUP INC COM 76029N106 1,265 74,479 SH   DFND 1,2 74,479 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 313 56,768 SH   DFND 1,2 56,768 0 0
SAREPTA THERAPEUTICS INC COM 803607100 306 3,917 SH   DFND 1,2 3,917 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 543 142,900 SH   DFND 1,2 142,900 0 0
SEAGEN INC COM 81181C104 6,784 47,096 SH   DFND 1,2 47,096 0 0
SIERRA ONCOLOGY INC COM NEW 82640U404 1,698 52,979 SH   DFND 1,2 52,979 0 0
SOMALOGIC INC CLASS A COM 83444K105 13,606 1,696,558 SH   DFND 1,2 1,696,558 0 0
SYNLOGIC INC COM 87166L100 165 68,634 SH   DFND 1,2 68,634 0 0
TCR2 THERAPEUTICS INC COM 87808K106 53 19,335 SH   DFND 1,2 19,335 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 5,416 210,563 SH   DFND 1,2 210,563 0 0
XENON PHARMACEUTICALS INC COM 98420N105 6,049 197,880 SH   DFND 1,2 197,880 0 0