The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 111 INC | ADS | 68247Q102 | 2,570 | 966,349 | SH | DFND | 1,2,3,4,5 | 966,349 | 0 | 0 | |
| 23ANDME HOLDING CO | CLASS A COM | 90138Q108 | 2,532 | 661,009 | SH | DFND | 1,2,3,4,5 | 661,009 | 0 | 0 | |
| AC IMMUNE SA | SHS | H00263105 | 4,000 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| ACHILLES THERAPEUTICS PLC | SPONSORED ADS | 00449L102 | 6,631 | 2,255,375 | SH | DFND | 1,2,3,4,5 | 2,255,375 | 0 | 0 | |
| ADAGENE INC | ADS | 005329107 | 3,500 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| ADAGIO THERAPEUTICS INC | COM | 00534A102 | 4,560 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| ADVERUM BIOTECHNOLOGIES INC | COM | 00773U108 | 3,930 | 3,000,000 | SH | DFND | 1,2,3,4,5 | 3,000,000 | 0 | 0 | |
| AGENUS INC | COM NEW | 00847G705 | 13,530 | 5,500,000 | SH | DFND | 1,2,3,4,5 | 5,500,000 | 0 | 0 | |
| ALLOVIR INC | COM | 019818103 | 15,683 | 2,323,371 | SH | DFND | 1,2,3,4,5 | 2,323,371 | 0 | 0 | |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 106,139 | 650,000 | SH | DFND | 1,2,3,4,5 | 650,000 | 0 | 0 | |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 5,319 | 593,030 | SH | DFND | 1,2,3,4,5 | 593,030 | 0 | 0 | |
| ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 8,450 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
| AMBRX BIOPHARMA INC | SPONSORED ADS | 02290A102 | 8,867 | 2,152,291 | SH | DFND | 1,2,3,4,5 | 2,152,291 | 0 | 0 | |
| AMICUS THERAPEUTICS INC | COM | 03152W109 | 37,880 | 4,000,000 | SH | DFND | 1,2,3,4,5 | 4,000,000 | 0 | 0 | |
| AMYLYX PHARMACEUTICALS INC | COM | 03237H101 | 964 | 75,000 | SH | DFND | 1,2,3,4,5 | 75,000 | 0 | 0 | |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 10,162 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | |
| APPLIED THERAPEUTICS INC | COM | 03828A101 | 844 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
| APTINYX INC | COM | 03836N103 | 13,884 | 6,116,493 | SH | DFND | 1,2,3,4,5 | 6,116,493 | 0 | 0 | |
| ARAVIVE INC | COM | 03890D108 | 2,531 | 1,311,291 | SH | DFND | 1,2,3,4,5 | 1,311,291 | 0 | 0 | |
| ARGENX SE | SPONSORED ADR | 04016X101 | 185,245 | 587,500 | SH | DFND | 1,2,3,4,5 | 587,500 | 0 | 0 | |
| ASTRIA THERAPEUTICS INC | COM | 04635X102 | 224 | 33,333 | SH | DFND | 1,2,3,4,5 | 33,333 | 0 | 0 | |
| ATARA BIOTHERAPEUTICS INC | COM | 046513107 | 9,290 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| AURINIA PHARMACEUTICALS INC | COM | 05156V102 | 12,380 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| AVIDITY BIOSCIENCES INC | COM | 05370A108 | 4,618 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
| AXCELLA HEALTH INC | COM | 05454B105 | 1,831 | 712,500 | SH | DFND | 1,2,3,4,5 | 712,500 | 0 | 0 | |
| BEIGENE LTD | SPONSORED ADR | 07725L102 | 125,419 | 665,000 | SH | DFND | 1,2,3,4,5 | 665,000 | 0 | 0 | |
| BELLUS HEALTH INC NEW | COM NEW | 07987C204 | 58,480 | 8,500,000 | SH | DFND | 1,2,3,4,5 | 8,500,000 | 0 | 0 | |
| BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 4,561 | 1,646,517 | SH | DFND | 1,2,3,4,5 | 1,646,517 | 0 | 0 | |
| BRIDGEBIO PHARMA INC | COM | 10806X102 | 2,538 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
| CARDIFF ONCOLOGY INC | COM | 14147L108 | 1,860 | 750,000 | SH | DFND | 1,2,3,4,5 | 750,000 | 0 | 0 | |
| CARIBOU BIOSCIENCES INC | COM | 142038108 | 967 | 105,347 | SH | DFND | 1,2,3,4,5 | 105,347 | 0 | 0 | |
| CEREVEL THERAPEUTICS HLDNG I | COM | 15678U128 | 52,515 | 1,500,000 | SH | DFND | 1,2,3,4,5 | 1,500,000 | 0 | 0 | |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 187 | 224,675 | SH | DFND | 1,2,3,4,5 | 224,675 | 0 | 0 | |
| CODIAK BIOSCIENCES INC | COM | 192010106 | 1,254 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | |
| CONTRAFECT CORP | COM NEW | 212326300 | 5,475 | 1,500,000 | SH | DFND | 1,2,3,4,5 | 1,500,000 | 0 | 0 | |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 820 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
| CULLINAN ONCOLOGY INC | COM | 230031106 | 2,618 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
| CURIS INC | COM NEW | 231269200 | 3,094 | 1,300,000 | SH | DFND | 1,2,3,4,5 | 1,300,000 | 0 | 0 | |
| CYCLERION THERAPEUTICS INC | COM | 23255M105 | 3,073 | 2,768,069 | SH | DFND | 1,2,3,4,5 | 2,768,069 | 0 | 0 | |
| CYCLERION THERAPEUTICS INC | COM | 23255M105 | 12 | 11,053 | SH | DFND | 1,2,3,4 | 11,053 | 0 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 36,810 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| DENALI THERAPEUTICS INC | COM | 24823R105 | 19,302 | 600,000 | SH | DFND | 1,2,3,4,5 | 600,000 | 0 | 0 | |
| DESIGN THERAPEUTICS INC | COM | 25056L103 | 6,460 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
| DYNAMICS SPECIAL PURPOSE COR | CLASS A COM | 268010105 | 4,935 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
| DYNE THERAPEUTICS INC | COM | 26818M108 | 5,061 | 525,000 | SH | DFND | 1,2,3,4,5 | 525,000 | 0 | 0 | |
| EQRX INC | COM | 26886C107 | 16,520 | 4,000,000 | SH | DFND | 1,2,3,4,5 | 4,000,000 | 0 | 0 | |
| ERASCA INC | COM | 29479A108 | 27,281 | 3,172,221 | SH | DFND | 1,2,3,4,5 | 3,172,221 | 0 | 0 | |
| EVOTEC AG | SPONSORED ADS | 30050E105 | 17,391 | 1,149,425 | SH | DFND | 1,2,3,4,5 | 1,149,425 | 0 | 0 | |
| EXSCIENTIA PLC | ADS | 30223G102 | 7,920 | 550,000 | SH | DFND | 1,2,3,4,5 | 550,000 | 0 | 0 | |
| FATE THERAPEUTICS INC | COM | 31189P102 | 77,540 | 2,000,000 | SH | DFND | 1,2,3,4,5 | 2,000,000 | 0 | 0 | |
| FOGHORN THERAPEUTICS INC | COM | 344174107 | 26,207 | 1,720,720 | SH | DFND | 1,2,3,4,5 | 1,720,720 | 0 | 0 | |
| FORMA THERAPEUTICS HLDGS INC | SHS | 34633R104 | 9,300 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| FUSION PHARMACEUTICALS INC | COM | 36118A100 | 5,828 | 750,000 | SH | DFND | 1,2,3,4,5 | 750,000 | 0 | 0 | |
| GENERATION BIO CO | COM | 37148K100 | 20,656 | 2,814,191 | SH | DFND | 1,2,3,4,5 | 2,814,191 | 0 | 0 | |
| GINKGO BIOWORKS HOLDINGS INC | CL A SHS | 37611X100 | 202 | 50,000 | SH | DFND | 1,2,3,4,5 | 50,000 | 0 | 0 | |
| GOSSAMER BIO INC | COM | 38341P102 | 20,476 | 2,358,968 | SH | DFND | 1,2,3,4,5 | 2,358,968 | 0 | 0 | |
| GRAPHITE BIO INC | COM | 38870X104 | 3,570 | 700,000 | SH | DFND | 1,2,3,4,5 | 700,000 | 0 | 0 | |
| GRITSTONE BIO INC | COM | 39868T105 | 3,090 | 750,000 | SH | DFND | 1,2,3,4,5 | 750,000 | 0 | 0 | |
| HARPOON THERAPEUTICS INC | COM | 41358P106 | 4,970 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| HIPPO HLDGS INC | COMMON STOCK | 433539103 | 1,194 | 600,000 | SH | DFND | 1,2,3,4,5 | 600,000 | 0 | 0 | |
| HOOKIPA PHARMA INC | COM | 43906K100 | 4,217 | 1,849,616 | SH | DFND | 1,2,3,4,5 | 1,849,616 | 0 | 0 | |
| IGM BIOSCIENCES INC | COM | 449585108 | 53,460 | 2,000,000 | SH | DFND | 1,2,3,4,5 | 2,000,000 | 0 | 0 | |
| IKENA ONCOLOGY INC | COM | 45175G108 | 9,452 | 1,549,513 | SH | DFND | 1,2,3,4,5 | 1,549,513 | 0 | 0 | |
| I MAB | SPONSORED ADS | 44975P103 | 13,804 | 850,000 | SH | DFND | 1,2,3,4,5 | 850,000 | 0 | 0 | |
| IMMUNIC INC | COM | 4525EP101 | 7,910 | 700,000 | SH | DFND | 1,2,3,4,5 | 700,000 | 0 | 0 | |
| IMMUNOCORE HLDGS PLC | ADS | 45258D105 | 5,980 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | |
| IMMUTEP LTD | SPONSORED ADS | 45257L108 | 2,740 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| INSTIL BIO INC | COM | 45783C101 | 4,838 | 450,000 | SH | DFND | 1,2,3,4,5 | 450,000 | 0 | 0 | |
| INTEL CORP | COM | 458140100 | 14,856 | 300,000 | SH | Call | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 |
| INTELLIA THERAPEUTICS INC | COM | 45826J105 | 19,984 | 275,000 | SH | DFND | 1,2,3,4,5 | 275,000 | 0 | 0 | |
| IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 1,390 | 110,532 | SH | DFND | 1,2,3,4 | 110,532 | 0 | 0 | |
| ITEOS THERAPEUTICS INC | COM | 46565G104 | 12,872 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
| KALEIDO BIOSCIENCES INC | COM | 483347100 | 826 | 500,500 | SH | DFND | 1,2,3,4,5 | 500,500 | 0 | 0 | |
| KINNATE BIOPHARMA INC | COM | 49705R105 | 1,408 | 125,000 | SH | DFND | 1,2,3,4,5 | 125,000 | 0 | 0 | |
| KRONOS BIO INC | COM | 50107A104 | 11,156 | 1,542,954 | SH | DFND | 1,2,3,4,5 | 1,542,954 | 0 | 0 | |
| KRYSTAL BIOTECH INC | COM | 501147102 | 33,270 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 16,884 | 1,050,000 | SH | DFND | 1,2,3,4,5 | 1,050,000 | 0 | 0 | |
| KYMERA THERAPEUTICS INC | COM | 501575104 | 42,320 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| LAVA THERAPEUTICS NV | SHS | N51517105 | 880 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | |
| LEAP THERAPEUTICS INC | COM | 52187K101 | 7,000 | 4,000,000 | SH | DFND | 1,2,3,4,5 | 4,000,000 | 0 | 0 | |
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 7,349 | 3,516,214 | SH | DFND | 1,2,3,4,5 | 3,516,214 | 0 | 0 | |
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 141,414 | 67,662,150 | SH | DFND | 1,2,3,4 | 67,662,150 | 0 | 0 | |
| LYELL IMMUNOPHARMA INC | COM | 55083R104 | 3,535 | 700,000 | SH | DFND | 1,2,3,4,5 | 700,000 | 0 | 0 | |
| MARINUS PHARMACEUTICALS INC | COM NEW | 56854Q200 | 9,350 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| MEI PHARMA INC | COM NEW | 55279B202 | 603 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| MEREO BIOPHARMA GROUP PLC | ADS | 589492107 | 1,680 | 1,500,000 | SH | DFND | 1,2,3,4,5 | 1,500,000 | 0 | 0 | |
| MERSANA THERAPEUTICS INC | COM | 59045L106 | 8,778 | 2,200,000 | SH | DFND | 1,2,3,4,5 | 2,200,000 | 0 | 0 | |
| METACRINE INC | COM | 59101E103 | 564 | 924,898 | SH | DFND | 1,2,3,4,5 | 924,898 | 0 | 0 | |
| MINK THERAPEUTICS INC | COM | 603693102 | 652 | 289,588 | SH | DFND | 1,2,3,4,5 | 289,588 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 110,997 | 1,350,000 | SH | DFND | 1,2,3,4,5 | 1,350,000 | 0 | 0 | |
| MIRION TECHNOLOGIES INC | COM CL A | 60471A101 | 4,035 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
| MORPHIC HLDG INC | COM | 61775R105 | 66,248 | 1,650,000 | SH | DFND | 1,2,3,4,5 | 1,650,000 | 0 | 0 | |
| NANOBIOTIX SA | SPONSORED ADS | 63009J107 | 7,440 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| NEXIMMUNE INC | COM | 65344D109 | 5,052 | 1,200,000 | SH | DFND | 1,2,3,4,5 | 1,200,000 | 0 | 0 | |
| OATLY GROUP AB | SPONSORED ADS | 67421J108 | 7,515 | 1,500,000 | SH | DFND | 1,2,3,4,5 | 1,500,000 | 0 | 0 | |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 1,110 | 260,500 | SH | DFND | 1,2,3,4,5 | 260,500 | 0 | 0 | |
| OMEGA ALPHA SPAC | CL A | G6749V107 | 7,365 | 750,000 | SH | DFND | 1,2,3,4,5 | 750,000 | 0 | 0 | |
| OMEGA THERAPEUTICS INC | COMMON STOCK | 68217N105 | 14,187 | 2,273,530 | SH | DFND | 1,2,3,4,5 | 2,273,530 | 0 | 0 | |
| ORCHARD THERAPEUTICS PLC | ADS | 68570P101 | 1,284 | 1,803,858 | SH | DFND | 1,2,3,4,5 | 1,803,858 | 0 | 0 | |
| ORIC PHARMACEUTICALS INC | COM | 68622P109 | 2,136 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
| OVID THERAPEUTICS INC | COM | 690469101 | 7,850 | 2,500,000 | SH | DFND | 1,2,3,4,5 | 2,500,000 | 0 | 0 | |
| PORTAGE FINTECH ACQUISITN CO | CLASS A ORD SHS | G7185D106 | 3,773 | 380,000 | SH | DFND | 1,2,3,4,5 | 380,000 | 0 | 0 | |
| PRAXIS PRECISION MEDICINES I | COM | 74006W108 | 12,252 | 1,200,000 | SH | DFND | 1,2,3,4,5 | 1,200,000 | 0 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 18,946 | 800,100 | SH | DFND | 1,2,3,4,5 | 800,100 | 0 | 0 | |
| RECURSION PHARMACEUTICALS IN | CL A | 75629V104 | 3,222 | 450,000 | SH | DFND | 1,2,3,4,5 | 450,000 | 0 | 0 | |
| RELAY THERAPEUTICS INC | COM | 75943R102 | 20,951 | 700,000 | SH | DFND | 1,2,3,4,5 | 700,000 | 0 | 0 | |
| REPARE THERAPEUTICS INC | COM | 760273102 | 9,968 | 700,000 | SH | DFND | 1,2,3,4,5 | 700,000 | 0 | 0 | |
| REPLIMUNE GROUP INC | COM | 76029N106 | 15,282 | 900,000 | SH | DFND | 1,2,3,4,5 | 900,000 | 0 | 0 | |
| RUBIUS THERAPEUTICS INC | COM | 78116T103 | 20,396 | 3,701,580 | SH | DFND | 1,2,3,4,5 | 3,701,580 | 0 | 0 | |
| SAGE THERAPEUTICS INC | COM | 78667J108 | 24,825 | 750,000 | SH | DFND | 1,2,3,4,5 | 750,000 | 0 | 0 | |
| SAGE THERAPEUTICS INC | COM | 78667J108 | 8,275 | 250,000 | SH | Call | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 |
| SANA BIOTECHNOLOGY INC | COM | 799566104 | 3,304 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
| SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 31,581 | 2,450,000 | SH | DFND | 1,2,3,4,5 | 2,450,000 | 0 | 0 | |
| SCHRODINGER INC | COM | 80810D103 | 23,884 | 700,000 | SH | DFND | 1,2,3,4,5 | 700,000 | 0 | 0 | |
| SEA LTD | SPONSORED ADS | 81141R100 | 6,888 | 57,500 | SH | DFND | 1,2,3,4,5 | 57,500 | 0 | 0 | |
| SEAGEN INC | COM | 81181C104 | 93,633 | 650,000 | SH | DFND | 1,2,3,4,5 | 650,000 | 0 | 0 | |
| SEER INC | COM CL A | 81578P106 | 72,390 | 4,750,000 | SH | DFND | 1,2,3,4,5 | 4,750,000 | 0 | 0 | |
| SELECTA BIOSCIENCES INC | COM | 816212104 | 4,920 | 4,000,000 | SH | DFND | 1,2,3,4,5 | 4,000,000 | 0 | 0 | |
| SIGILON THERAPEUTICS INC | COM | 82657L107 | 406 | 276,000 | SH | DFND | 1,2,3,4,5 | 276,000 | 0 | 0 | |
| SOLID BIOSCIENCES INC | COM | 83422E105 | 3,600 | 3,000,000 | SH | DFND | 1,2,3,4,5 | 3,000,000 | 0 | 0 | |
| SPERO THERAPEUTICS INC | COM | 84833T103 | 4,350 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
| SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 47,974 | 850,000 | SH | DFND | 1,2,3,4,5 | 850,000 | 0 | 0 | |
| SQZ BIOTECHNOLOGIES CO | COM | 78472W104 | 7,726 | 1,606,309 | SH | DFND | 1,2,3,4,5 | 1,606,309 | 0 | 0 | |
| STOKE THERAPEUTICS INC | COM | 86150R107 | 5,263 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
| SYROS PHARMACEUTICALS INC | COM | 87184Q107 | 4,165 | 3,500,000 | SH | DFND | 1,2,3,4,5 | 3,500,000 | 0 | 0 | |
| TALARIS THERAPEUTICS INC | COM | 87410C104 | 20,312 | 2,064,262 | SH | DFND | 1,2,3,4,5 | 2,064,262 | 0 | 0 | |
| TAYSHA GENE THERAPIES INC | COM SHS | 877619106 | 6,787 | 1,040,882 | SH | DFND | 1,2,3,4,5 | 1,040,882 | 0 | 0 | |
| TCR2 THERAPEUTICS INC | COM | 87808K106 | 2,070 | 750,000 | SH | DFND | 1,2,3,4,5 | 750,000 | 0 | 0 | |
| TG THERAPEUTICS INC | COM | 88322Q108 | 7,608 | 800,000 | SH | DFND | 1,2,3,4,5 | 800,000 | 0 | 0 | |
| VERVE THERAPEUTICS INC | COM | 92539P101 | 9,128 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
| VIGIL NEUROSCIENCE INC | COM | 92673K108 | 7,882 | 1,121,191 | SH | DFND | 1,2,3,4,5 | 1,121,191 | 0 | 0 | |
| VOR BIOPHARMA INC | COM | 929033108 | 3,322 | 550,000 | SH | DFND | 1,2,3,4,5 | 550,000 | 0 | 0 | |
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 2,000 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
| WW INTL INC | COM | 98262P101 | 151,591 | 14,818,300 | SH | DFND | 1,2,3,4,6 | 14,818,300 | 0 | 0 | |
| XILIO THERAPEUTICS INC | COM | 98422T100 | 3,182 | 450,000 | SH | DFND | 1,2,3,4,5 | 450,000 | 0 | 0 | |
| XP INC | CL A | G98239109 | 1,054 | 35,000 | SH | DFND | 1,2,3,4,5 | 35,000 | 0 | 0 | |
| Y-MABS THERAPEUTICS INC | COM | 984241109 | 4,752 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
| YUMANITY THERAPEUTICS INC | COM | 98872L102 | 326 | 217,391 | SH | DFND | 1,2,3,4,5 | 217,391 | 0 | 0 | |
| ZYMEWORKS INC | COM | 98985W102 | 2,948 | 450,000 | SH | DFND | 1,2,3,4,5 | 450,000 | 0 | 0 | |