The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADDEX THERAPEUTICS LTD SPONSORED ADS 00654J107 254 50,000 SH   DFND   50,000 0 0
ALECTOR INC COM 014442107 4,839 339,569 SH   DFND   339,569 0 0
AMRYT PHARMA PLC SHS 03217L106 3,719 449,737 SH   DFND   449,737 0 0
APTINYX INC COM 03836N103 7,468 3,290,079 SH   DFND   3,290,079 0 0
ARAVIVE INC COM 03890D108 1,827 946,423 SH   DFND   946,423 0 0
ARVINAS INC COM 04335A105 86,785 1,289,521 SH   DFND   1,289,521 0 0
AVROBIO INC COM 05455M100 417 315,550 SH   DFND   315,550 0 0
CHIMERIX INC COM 16934W106 5,609 1,224,600 SH   DFND   1,224,600 0 0
COGENT BIOSCIENCES INC. COM 19240Q201 3,756 501,530 SH   DFND   501,530 0 0
CRINETICS PHARMACEUTICALS INC COM 22663K107 3,095 141,000 SH   DFND   141,000 0 0
DECIPHERA PHARMACEUTICALS INC COM 24344T101 11,213 1,209,571 SH   DFND   1,209,571 0 0
DICE THERAPEUTICS INC COM 23345J104 10,650 556,693 SH   DFND   556,693 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 15,071 1,553,661 SH   DFND   1,553,661 0 0
HARPOON THERAPEUTICS INC COM 41358P106 15,689 3,156,699 SH   DFND   3,156,699 0 0
ITERUM THERAPEUTICS PLC SHS G6333L101 517 1,456,303 SH   DFND   1,456,303 0 0
PASSAGE BIO COM 702712100 7,744 2,497,922 SH   DFND   2,497,922 0 0
PDS BIOTECHNOLOGY CORP COM 70465T107 726 117,242 SH   DFND   117,242 0 0
RALLYBIO CORPORATION COM 75120L100 16,065 2,301,603 SH   DFND   2,301,603 0 0
RENOVACOR CORPORATION COM 75989E106 2,851 672,288 SH   DFND   672,288 0 0
SIERRA ONCOLOGY INC COM 82640U107 4,023 125,511 SH   DFND   125,511 0 0
X4 PHARMACEUTICALS INC COM 98420X103 586 335,000 SH   DFND   335,000 0 0