The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 124,094 916,496 SH   DFND   0 916,496 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 12,004 3,201,066 SH   DFND   0 3,201,066 0
AERIE PHARMACEUTICALS INC COM 00771V108 7,642 1,088,566 SH   DFND   0 1,088,566 0
AERIE PHARMACEUTICALS INC NOTE 1.500%10/0 00771VAB4 40,252 48,150,000 PRN   DFND   0 48,150,000 0
ALLENA PHARMACEUTICALS COM 018119107 168 284,285 SH   DFND   0 284,285 0
ANTHEM INC COM 036752103 19,809 42,734 SH   DFND   0 42,734 0
ARCUS BIOSCIENCES INC COM 03969F109 138,853 3,431,010 SH   DFND   0 3,431,010 0
ASTRAZENECA PLC SPONSORED ADR 046353108 45,770 785,748 SH   DFND   0 785,748 0
AVANTOR INC COM 05352A100 87,637 2,079,657 SH   DFND   0 2,079,657 0
BCLS ACQUISITION CORP COM CL A G0904B105 4,548 464,103 SH   DFND   0 464,103 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 41,077 464,940 SH   DFND   0 464,940 0
BIOMARIN PHARMACEUTICAL INC NOTE 0.599% 8/0 09061GAH4 48,118 45,910,000 PRN   DFND   0 45,910,000 0
BUTTERFLY NETWORK INC COM CL A 124155102 12,231 1,828,311 SH   DFND   0 1,828,311 0
CANO HEALTH INC COM CL A 13781Y103 17,059 1,914,639 SH   DFND   0 1,914,639 0
CARDINAL HEALTH INC COM 14149Y108 32,942 639,783 SH   DFND   0 639,783 0
CARIBOU BIOSCIENCES INC COM 142038108 59,418 4,092,309 SH   DFND   0 4,092,309 0
CATALENT INC COM 148806102 41,827 326,700 SH   DFND   0 326,700 0
CENTENE CORP DEL COM 15135B101 91,668 1,112,480 SH   DFND   0 1,112,480 0
CYTOKINETICS INC COM NEW 23282W605 112,355 2,465,016 SH   DFND   0 2,465,016 0
DANAHER CORPORATION COM 235851102 57,804 175,690 SH   DFND   0 175,690 0
DEXCOM INC COM 252131107 2,400 4,469 SH   DFND   0 4,469 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 53,542 3,805,370 SH   DFND   0 3,805,370 0
EDWARDS LIFESCIENCES CORP COM 28176E108 48,386 373,492 SH   DFND   0 373,492 0
ERASCA INC COM 29479A108 76,954 5,191,405 SH   DFND   0 5,191,405 0
FLUIDIGM CORP DEL COM 34385P108 3,844 980,505 SH   DFND   0 980,505 0
GILEAD SCIENCES INC COM 375558103 5,590 76,993 SH   DFND   0 76,993 0
HCA HEALTHCARE INC COM 40412C101 50,259 195,621 SH   DFND   0 195,621 0
HERON THERAPEUTICS INC COM 427746102 32,068 3,512,348 SH   DFND   0 3,512,348 0
HORIZON THERAPEUTICS PUB L SHS G46188101 117,657 1,091,840 SH   DFND   0 1,091,840 0
HUMANA INC COM 444859102 64,671 139,420 SH   DFND   0 139,420 0
ICON PLC SHS G4705A100 48,989 158,183 SH   DFND   0 158,183 0
ICU MED INC COM 44930G107 52,354 220,587 SH   DFND   0 220,587 0
INCYTE CORP COM 45337C102 9,500 129,428 SH   DFND   0 129,428 0
INTELLIA THERAPEUTICS INC COM 45826J105 21,073 178,222 SH   DFND   0 178,222 0
IO BIOTECH INC COM 449778109 7,744 1,362,144 SH   DFND   0 1,362,144 0
IQVIA HLDGS INC COM 46266C105 67,160 238,039 SH   DFND   0 238,039 0
IRHYTHM TECHNOLOGIES INC COM 450056106 61,667 523,982 SH   DFND   0 523,982 0
ISHARES TR CALL 464287906 41,635 272,800 SH Call DFND   0 272,800 0
IVERIC BIO INC COM 46583P102 16,807 1,005,216 SH   DFND   0 1,005,216 0
JIYA ACQUISITION CORP COM CL A 47760M102 4,534 464,103 SH   DFND   0 464,103 0
JOHNSON & JOHNSON COM 478160104 55,593 324,972 SH   DFND   0 324,972 0
JOUNCE THERAPEUTICS INC COM 481116101 33,173 3,972,868 SH   DFND   0 3,972,868 0
KARUNA THERAPEUTICS INC COM 48576A100 23,199 177,091 SH   DFND   0 177,091 0
KINNATE BIOPHARMA INC COM 49705R105 4,683 264,293 SH   DFND   0 264,293 0
LILLY ELI & CO COM 532457108 82,491 298,643 SH   DFND   0 298,643 0
MCKESSON CORP COM 58155Q103 43,997 177,000 SH   DFND   0 177,000 0
MIRATI THERAPEUTICS INC COM 60468T105 46,273 315,449 SH   DFND   0 315,449 0
MOLINA HEALTHCARE INC COM 60855R100 22,294 70,088 SH   DFND   0 70,088 0
MYRIAD GENETICS INC COM 62855J104 55,909 2,025,681 SH   DFND   0 2,025,681 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 33,562 394,058 SH   DFND   0 394,058 0
NEVRO CORP COM 64157F103 39,330 485,135 SH   DFND   0 485,135 0
NOVAVAX INC COM NEW 670002401 12,685 88,663 SH   DFND   0 88,663 0
OAK STR HEALTH INC COM 67181A107 9,258 279,357 SH   DFND   0 279,357 0
OUTSET MED INC COM 690145107 135,516 2,940,255 SH   DFND   0 2,940,255 0
PARDES BIOSCIENCES INC COM 69945Q105 5,918 361,528 SH   DFND   0 361,528 0
PENUMBRA INC COM 70975L107 50,881 177,088 SH   DFND   0 177,088 0
PFIZER INC COM 717081103 79,327 1,343,384 SH   DFND   0 1,343,384 0
PMV PHARMACEUTICALS INC COM 69353Y103 6,661 288,334 SH   DFND   0 288,334 0
PRAXIS PRECISION MEDICINES I COM 74006W108 12,527 635,904 SH   DFND   0 635,904 0
PROCEPT BIOROBOTICS CORP COM 74276L105 1,626 65,000 SH   DFND   0 65,000 0
PULMONX CORP COM 745848101 6,709 209,193 SH   DFND   0 209,193 0
SEAGEN INC COM 81181C104 41,514 268,527 SH   DFND   0 268,527 0
SOPHIA GENETICS SA ORDINARY SHARES H82027105 27,525 1,952,152 SH   DFND   0 1,952,152 0
SPDR SER TR CALL 78464A900 27,553 246,100 SH Call DFND   0 246,100 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 46,046 2,103,512 SH   DFND   0 2,103,512 0
TENET HEALTHCARE CORP COM NEW 88033G407 42,963 525,927 SH   DFND   0 525,927 0
THERMO FISHER SCIENTIFIC INC COM 883556102 41,464 62,143 SH   DFND   0 62,143 0
UNITEDHEALTH GROUP INC COM 91324P102 56,016 111,554 SH   DFND   0 111,554 0
UNIVERSAL HLTH SVCS INC CL B 913903100 61,633 475,340 SH   DFND   0 475,340 0
WATERS CORP COM 941848103 43,830 117,634 SH   DFND   0 117,634 0
WEREWOLF THERAPEUTICS INC COM 95075A107 4,764 400,000 SH   DFND   0 400,000 0